Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kelly M. Ramsbottom"'
Autor:
Tanja Fauti, Lisa Wellinger, Joseph A. Trapani, Axel Paehler, Daniela Geiss, Kelly M Ramsbottom, Laura Jarassier, Phillip Thienger, Leonie A. Cluse, Conor J. Kearney, Thomas Friess, Stephin J. Vervoort, Jane Oliaro, Daniel Rohle, Ricky W. Johnstone, Marina Bacac, Simon J. Hogg, Astrid Ruefli-Brasse, Dane M. Newman, Daniel Marbach, Jake Shortt, Jessica Michie
Publikováno v:
Cancer Immunology Research. 10:87-107
Targeting chromatin binding proteins and modifying enzymes can concomitantly affect tumor cell proliferation and survival, as well as enhance antitumor immunity and augment cancer immunotherapies. By screening a small-molecule library of epigenetics-
Autor:
Matteo Costacurta, Edwin D. Hawkins, Ricky W. Johnstone, Grant A. McArthur, Jane Oliaro, Paul J Neeson, Paul A. Beavis, Stephin J. Vervoort, Joe Jiang Zhu, Deborah Meyran, Conor J. Kearney, Emily J. Lelliott, Ian A. Parish, Pilar M. Dominguez, Laura Kirby, Nicole M. Haynes, Lydia Lim, Luciano G. Martelotto, Kelly M Ramsbottom, Magnus Zethoven, Isabella Y. Kong, Karen E. Sheppard, Jarrod J. Sandow, Izabela Todorovski
Publikováno v:
Cancer Discovery. 11:2582-2601
Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) are an approved treatment for hormone receptor–positive breast cancer and are currently under evaluation across hundreds of clinical trials for other cancer types. The clinical s
Autor:
Kelly M Ramsbottom, Conor J. Kearney, Stephin J. Vervoort, Lizzy Pijpers, Jessica Michie, Jane Oliaro, Ricky W. Johnstone, Madison J. Kelly, Andrew J. Freeman
Publikováno v:
Cell Reports, Vol 28, Iss 11, Pp 2784-2794.e5 (2019)
Summary: Despite the clinical success of cancer immunotherapies, the majority of patients fail to respond or develop resistance through disruption of pathways that promote neo-antigen presentation on MHC I molecules. Here, we conducted a series of un
Autor:
Jane Oliaro, Conor J. Kearney, Jessica Michie, Kelly M Ramsbottom, John Silke, Andrew J. Freeman, Stephin J. Vervoort
Publikováno v:
EMBO Rep
The success of cancer immunotherapy is limited to a subset of patients, highlighting the need to identify the processes by which tumors evade immunity. Using CRISPR/Cas9 screening, we reveal that melanoma cells lacking HOIP, the catalytic subunit of
Autor:
Daniel Marbach, Daniel Rohle, Daniela Geiss, Thomas Friess, Jake Shortt, Marina Bacac, Jane Oliaro, Kelly M Ramsbottom, Tanja Fauti, Astrid Ruefli-Brasse, Leonie A. Cluse, Dane M. Newman, Ricky W. Johnstone, Lisa Wellinger, Jessica Michie, Conor J. Kearney, Phillip Thienger, Stephin J. Vervoort, Axel Paehler, Laura Jarassier, Simon J. Hogg
Targeting chromatin binding proteins and modifying enzymes can concomitantly affect tumor cell proliferation and survival, as well as enhance anti-tumor immunity and augment cancer immunotherapies. By screening a small molecule library of epigenetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fefe47060c779d85135a4b24dcc425e
https://doi.org/10.1101/2021.02.15.429851
https://doi.org/10.1101/2021.02.15.429851
Autor:
Grant A. McArthur, Riyaben P. Patel, Carleen Cullinane, Claire Martin, Anthony T. Papenfuss, Amanda J Oliver, Kelly M Ramsbottom, Emily J. Lelliott, Nicole M. Haynes, Stefano Mangiola, Peter Lau, Lydia Lim, Jane Oliaro, Laura Kirby, Karen E. Sheppard, Magnus Zethoven, Luciano G. Martelotto, Alison Slater
Publikováno v:
Cancer immunology research. 9(2)
Combined inhibition of BRAF, MEK, and CDK4/6 is currently under evaluation in clinical trials for patients with melanoma harboring a BRAFV600 mutation. While this triple therapy has potent tumor-intrinsic effects, the impact of this combination on an
Autor:
Kelly M Ramsbottom, Ricky W. Johnstone, Capucine Picard, Conor J. Kearney, Andrew J. Freeman, Jessica Michie, Cindy S. Ma, Stuart G. Tangye, Stephin J. Vervoort, Jean-Laurent Casanova, Katrina L. Randall, Jane Peake, Jane Oliaro
Publikováno v:
The Journal of Immunology. 199:2118-2127
Mutations in the dedicator of cytokinesis 8 (DOCK8) gene cause an autosomal recessive form of hyper-IgE syndrome, characterized by chronic immunodeficiency with persistent microbial infection and increased incidence of malignancy. These manifestation
Autor:
Conor J. Kearney, John Silke, Kelly M Ramsbottom, Andrew J. Freeman, Jane Oliaro, Najoua Lalaoui
Publikováno v:
Cell Death & Differentiation. 24:1705-1716
Smac-mimetics are emerging as promising anti-cancer agents and are being evaluated in clinical trials for a variety of malignancies. Smac-mimetics can induce TNF production from a subset of tumor cells and simultaneously sensitize them to TNF-induced
Autor:
Laura Kirby, Shatha AbuHammad, Richard J. Young, Peter Lau, Grant A. McArthur, Claire Martin, Katrina Meeth, Karen E. Sheppard, Jessica Michie, Kelly M Ramsbottom, Nicole M. Haynes, Rachael Walker, Fernando Souza-Fonseca-Guimaraes, Jane Oliaro, Emily J. Lelliott, Carleen Cullinane, Alison Slater
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Both targeted therapy and immunotherapy have been used successfully to treat melanoma, but the development of resistance and poor response rates to the individual therapies has limited their success. Designing rational combinations of targeted therap
Autor:
Min Gu, Heather J. Melichar, Stephen B. Ting, David J. Izon, Edwin D. Hawkins, Carmen Molina-París, Raz Shimoni, Mandy J. Ludford-Menting, Patrick O. Humbert, Sarah M. Russell, Grant Lythe, Joseph Reynolds, Kim Pham, Kelly M Ramsbottom, Jane Oliaro, Mirren Charnley, Ellen A. Robey
Publikováno v:
The Journal of Cell Biology
T cell precursors undergo asymmetric cell division after T cell receptor genomic recombination, with stromal cell cues controlling the differential inheritance of fate determinants Numb and α-Adaptin by the daughters of a dividing DN3a T cell precur