Zobrazeno 1 - 10
of 175
pro vyhledávání: '"John Patrick Aggleton"'
Autor:
John Patrick Aggleton, Claudia Metzler-Baddeley, Rebecca Sims, Seralynne Denise Vann, Parisa A. Ghomroudi, Bethany M. Coad
Publikováno v:
Neurobiology of Aging. 113:39-54
Characterizing age- and risk-related hippocampal vulnerabilities may inform about the neural underpinnings of cognitive decline. We studied the impact of three risk-factors, Apolipoprotein (APOE)-ε4, a family history of dementia, and central obesity
Autor:
Mark Postans, John Patrick Aggleton, Thomas M. Lancaster, Chiara M Casella, Andrew D. Lawrence, Samuel C. Berry
Invasive tract-tracing studies in rodents implicate a direct connection between the subiculum and bed nucleus of the stria terminalis (BNST) as a key component of neural pathways mediating hippocampal regulation of the Hypothalamic-Pituitary-Adrenal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc0f1580a4c4edfae945132616a51a9
https://orca.cardiff.ac.uk/id/eprint/148388/2/1-s2.0-S1053811922002245-main.pdf
https://orca.cardiff.ac.uk/id/eprint/148388/2/1-s2.0-S1053811922002245-main.pdf
Autor:
John Patrick Aggleton, Emma Jane Kidd, Jilu P. Mole, John Evans, Claudia Metzler-Baddeley, Fabrizio Fasano, Rebecca Sims
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-25 (2020)
Scientific Reports
Scientific Reports
APOE-ε4 is a main genetic risk factor for developing late onset Alzheimer’s disease (LOAD) and is thought to interact adversely with other risk factors on the brain. However, evidence regarding the impact of APOE-ε4 on grey matter structure in as
Publikováno v:
The Journal of Neuroscience
The hippocampus is essential for normal memory but does not act in isolation. The anterior thalamic nuclei may represent one vital partner. Using DREADDs, the behavioral consequences of transiently disrupting anterior thalamic function were examined,
Autor:
John Evans, Jilu P. Mole, Derek K. Jones, Fabrizio Fasano, Claudia Metzler-Baddeley, Roland J. Baddeley, Rebecca Sims, John Patrick Aggleton
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-4 (2019)
Scientific Reports
Scientific Reports
Aging leads to gray and white matter decline but their causation remains unclear. We explored two classes of models of age and dementia risk related brain changes. The first class of models emphasises the importance of gray matter: age and risk-relat
Autor:
Matheus Cafalchio, Sean K. Martin, Bethany E. Frost, John Patrick Aggleton, Nurul Islam, Shane M. O'Mara
Publikováno v:
The Journal of Neuroscience
Just as hippocampal lesions are principally responsible for “temporal lobe” amnesia, lesions affecting the anterior thalamic nuclei seem principally responsible for a similar loss of memory, “diencephalic” amnesia. Compared with the former, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b42205512ddfe42e9e163dd051a7fc
https://orca.cardiff.ac.uk/id/eprint/140365/2/JNEUROSCI.2868-20.2021.full.pdf
https://orca.cardiff.ac.uk/id/eprint/140365/2/JNEUROSCI.2868-20.2021.full.pdf
Autor:
John Patrick Aggleton, Anna S. Mitchell, Han Y. Cheng, Mathias L. Mathiasen, Ningyu Zhang, Kate J. Jeffery, Eleonora Lomi
Retrosplenial cortex (RSC) lies at the interface between perceptual and memory networks in the brain and mediates between these, although it is not yet known how. It has two distinct subregions, granular (gRSC) and dysgranular (dRSC). The present stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f9f0c431ae1f0f8525f6308f93199b
https://doi.org/10.1101/2021.06.11.448056
https://doi.org/10.1101/2021.06.11.448056
Publikováno v:
Cerebral Cortex (New York, NY)
In a changing environment, organisms need to decide when to select items that resemble previously rewarded stimuli and when it is best to switch to other stimulus types. Here, we used chemogenetic techniques to provide causal evidence that activity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4dcb8d85b402a00dec9dd12db530fd1
https://orca.cardiff.ac.uk/id/eprint/136033/3/bhaa353.pdf
https://orca.cardiff.ac.uk/id/eprint/136033/3/bhaa353.pdf
Large-scale simultaneous in vivo recordings of neurons in multiple brain regions raises the question of the probability of recording direct interactions of neurons within, and between, multiple brain regions. In turn, identifying inter-regional commu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0be1366fea1f3af27fae615cc79cbe9
https://doi.org/10.1101/2020.12.07.415125
https://doi.org/10.1101/2020.12.07.415125
Autor:
Emma Craig, John Patrick Aggleton, Claudia Metzler-Baddeley, Seralynne Denise Vann, Rebecca C. Louch, Bethany M. Coad
Publikováno v:
Brain and Neuroscience Advances
The fornix is a key tract of the hippocampal formation, whose status is presumed to contribute to age-related cognitive decline. The precommissural and postcommissural fornix subdivisions form respective basal forebrain/frontal and diencephalic netwo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29b72ef9b0f18a4ffe77636fef78776