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pro vyhledávání: '"John C, Gutheil"'
Autor:
John C. Gutheil
Publikováno v:
Current Oncology Reports. 2:582-586
The treatment of breast cancer has benefited substantially from the introduction of trastuzumab in 1998. Yet trastuzumab only represents the first of a series of newer biologic therapies that will change the manner in which patients with breast cance
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 655:147-152
In this paper we present a new HPLC method for the determination of novobiocin in human serum. The assay uses mitomycin C as an internal standard, protein precipitation with acetonitrile, an ODS reversed-phase column with an isocratic mobile phase of
Autor:
Eugene F. Cimino, Samuel W. Needleman, Vikram Kapil, John C. Gutheil, Gursharan Chana, Shrikant M. Mane
Publikováno v:
Pathology. 22:77-81
Activation of ras protooncogenes by any of several possible mutations in codons 12, 13 or 61 has been demonstrated in a variety of human malignancies, including acute non-lymphoblastic leukemia (ANLL). In situ staining for the ras gene product, p21,
Publikováno v:
Genes, chromosomescancer. 2(1)
RAS protooncogene activation has been repeatedly demonstrated in neoplastic cell DNA from patients with AML. Despite the convincing demonstration that activating RAS gene point mutations are critical in model systems, their precise prevalence and imp
Immunoprecipitation of cell lysates with RAP-5 does not specifically detect ras oncogene product p21
Publikováno v:
Human pathology. 20(12)
In the process of developing accurate quantitation of the ras protein (p21), we have screened available anti- ras antibodies for their utility in immunoprecipitation. Immunoprecipitation with the anti- ras antibody RAP-5 consistently failed to precip