Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Jingwu Xie"'
Autor:
Jun Wan, Jiali Han, Xiaoli Zhang, Yuan Lin, Ally Khan Somani, Hongji Dai, Jingwu Xie, Sheng Liu
Publikováno v:
Genes and Diseases, Vol 8, Iss 2, Pp 181-192 (2021)
Genes & Diseases
Genes & Diseases
The majority of non-melanoma skin cancer (NMSC) is cutaneous basal cell carcinoma (BCC) or squamous cell carcinoma (SCC), which are also called keratinocyte carcinomas, as both of them originate from keratinocytes. The incidence of keratinocyte carci
Autor:
Shuyi Fang, Xiaoli Zhang, Yunlong Liu, Jun Wan, Jingwu Xie, Mary Yinghua Zhang, Dongsheng Gu, Hongyu Gao
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-10 (2021)
Cell & Bioscience
Cell & Bioscience
We report our discovery of an important player in the development of skin fibrosis, a hallmark of scleroderma. Scleroderma is a fibrotic disease, affecting 70,000 to 150,000 Americans. Fibrosis is a pathological wound healing process that produces an
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies that has an unfavorable outcome and a high rate of relapse. Autophagy plays a vital role in the development of and therapeutic responses to leukemia. This study identif
Autor:
E. Gabriela Chiorean, Jingwu Xie, Dongsheng Gu, Beiqin Yu, Jun Wan, Xiaoli Zhang, Yanfei Jia, Yunshan Wang
Publikováno v:
Oncogene
Pancreatic cancer, mostly pancreatic ductal adenocarcinomas (PDAC), is one of the most lethal cancers, with a dismal median survival around 8 months. PDAC is notoriously resistant to chemotherapy. Thus far, numerous attempts using novel targeted ther
Publikováno v:
Molecular Carcinogenesis. 57:1608-1615
Colorectal cancer is a leading cause of cancer-related death worldwide. While early stage colorectal cancer can be removed by surgery, patients with advanced disease are treated by chemotherapy, with 5-Fluorouracil (5-FU) as a main ingredient. Howeve
Publikováno v:
Cells, Vol 10, Iss 2030, p 2030 (2021)
Cells
Cells
The hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment. However, chemoresistance becomes a substantial obstacle
Publikováno v:
Journal of Genetics and Genomics. 44:375-383
Gastric cancer is a leading cause of cancer-related mortality worldwide, and options to treat gastric cancer are limited. Fluorouracil (5Fu)-based chemotherapy is frequently used as a neoadjuvant or an adjuvant agent for gastric cancer therapy. Most
Publikováno v:
OncoTargets and therapy
The Hedgehog (Hh) pathway is critical for cell differentiation, tissue polarity, and stem cell maintenance during embryonic development, but is silent in adult tissues under normal conditions. However, aberrant Hh signaling activation has been implic
Autor:
Dongsheng Gu, Shaoxiong Chen, Hai Lin, Jingwu Xie, Safi Shahda, Xiaoli Zhang, Qipeng Fan, Jie Sun, Yunlong Liu
Publikováno v:
Cancers
Volume 10
Issue 11
Cancers, Vol 10, Iss 11, p 403 (2018)
Volume 10
Issue 11
Cancers, Vol 10, Iss 11, p 403 (2018)
Pancreatic cancer, mostly pancreatic ductal adenocarcinoma (PDAC), is one of the most lethal cancer types, with an estimated 44,330 death in 2018 in the US alone. While targeted therapies and immune checkpoint inhibitors have significantly improved t
Autor:
Dongsheng Gu, Xiaoben Liu, Seung Young Lee, Samuel Chen, Bing Song, Jingwu Xie, Shovik Bandyopadhyay, Stephen F. Konieczny, Junjie Li, Ji-Xin Cheng, Timothy L. Ratliff
Publikováno v:
Oncogene
Cancer cells are known to execute reprogramed metabolism of glucose, amino acids and lipids. Here, we report a significant role of cholesterol metabolism in cancer metastasis. By using label-free Raman spectromicroscopy, we found an aberrant accumula