Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jeffrey E. DeClue"'
Autor:
Hongzhen Li, Peter B. Crino, Wen Li, David H. Gutmann, Erik J. Uhlmann, Jeffrey E. DeClue, Kevin C. Ess
Publikováno v:
Glia. 46:28-40
Individuals with tuberous sclerosis complex (TSC) exhibit a variety of neurologic abnormalities, including mental retardation, epilepsy, and autism. Examination of human TSC brains demonstrate dysplastic astrocytes and neurons, areas of abnormal neur
Autor:
Hongzhen Li, Shaowei Li, Richard Braverman, Douglas R. Lowy, William C. Vass, Jeffrey E. DeClue
Publikováno v:
Molecular Carcinogenesis. 37:98-109
We investigated the effects of overexpression of the tuberous sclerosis-1 and -2 (TSC1/2) gene products (hamartin and tuberin, respectively) in the human kidney epithelial cell line 293 with an inducible expression system. As we had observed previous
Autor:
Jeffrey E. DeClue, Steven Kaddu, Phuong-Anh Vu, Michael W. Johnson, Matthias Volkenandt, Harry V. Vinters, Christian A. Sander, Heidi Rust, Ingrid Fackler, Ralf Wienecke, Heinz Kutzner, Arno Rütten
Publikováno v:
Journal of Cutaneous Pathology. 30:174-177
Background: Angiofibromas occur sporadically, and they develop in most patients with tuberous sclerosis complex (TSC), which is associated with alterations of the tumor suppressor genes TSC1 or TSC2. Loss of tuberin, the protein product of TSC2, has
Autor:
Ralf Wienecke, Neil A. Swanson, Eckart Klemm, Sarolta Karparti, Jeffrey E. DeClue, Andrew Green
Publikováno v:
Journal of Cutaneous Pathology. 29:287-290
Background: Patients affected with tuberous sclerosis complex (TSC) are prone to the development of multiple benign tumors of the skin and other organs. Tuberin, the protein product of the tuberous-sclerosis-complex-2 tumor suppressor gene (TSC2) has
Autor:
Raymond S. Yeung, Ralf Wienecke, Jeffrey E. DeClue, Michael J. Flaig, Ingrid Fackler, Adelheid Rust, Christian A. Sander, Matthias Volkenandt, Phuong-Anh Nguyen-Vu
Publikováno v:
Journal of Cutaneous Pathology. 28:470-475
Background: Tuberous sclerosis complex (TSC) is an autosomal dominantly inherited disorder associated with an alteration of the TSC2 tumor suppressor gene which encodes for the protein product tuberin. The disease is characterized by the development
Autor:
Giovanna Benvenuto, Nancy Ratner, Bo Ling, William C. Vass, David Viskochil, Shaowei Li, Sue C. Heffelfinger, Jeffrey E. DeClue, Wen Rui
Publikováno v:
Journal of Clinical Investigation. 105:1233-1241
We have found that EGF-R expression is associated with the development of the Schwann cell-derived tumors characteristic of neurofibromatosis type 1 (NF1) and in animal models of this disease. This is surprising, because Schwann cells normally lack E
Autor:
Michael E. Mendelsohn, Takateru Izumi, Russell Ross, Margaret Wu, Jeffrey E. DeClue, Mark Majesky, Martha Vaughan, Victor J. Ferrans, Pauline M. Barnes, Joseph P. Lynch, Douglas B. Flieder, Rex C. Yung, Anne E. Tattersfield, Gerald J. Beck, Nilo A. Avila, Kateri Gabriele, Mary Ehrmantraut, Elbert P. Trulock, Barry L. Fanburg, Joel Moss, Anil Menon, Suzanne Oparil, Jean-François Cordier, Marilyn K. Glassberg, William D. Travis, Kurt R. Stenmark, Marco W T Schreurs, Peter B. O'Donovan, Eugene J. Sullivan, Clara C. Chen, Shan Chu, Mark D. Schluchter, Carol E. Vreim, Stephen Groft
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 159:679-683
Publikováno v:
Oncogene. 15:1611-1616
Several inherited predisposition to cancer syndromes are associated with the development of nervous system tumors. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder in which affected individuals are at risk for developing astrocytoma
Publikováno v:
Proceedings of the National Academy of Sciences. 93:9154-9159
The Tsc2 gene, which is mutationally inactivated in the germ line of some families with tuberous sclerosis, encodes a large, membrane-associated GTPase activating protein (GAP) designated tuberin. Studies of the Eker rat model of hereditary cancer st
Publikováno v:
Journal of Biological Chemistry. 270:16409-16414
Tuberous sclerosis (TSC) is a human genetic syndrome characterized by the development of benign tumors in a variety of tissues, as well as rare malignancies. Two different genetic loci have been implicated in TSC; one of these loci, the tuberous scle