Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jaeho Jung"'
Autor:
Seung-Woo Lee, Shinai Lee, Wonjun Son, Eunyoung Park, Yunji Park, Park Kyeongsu, Sora Kim, Ji-Hae Kim, Yeon-Woo Kang, Yangsoon Lee, Jonghwa Won, Han Wook Park, Yong-Gyu Son, Jung Uijung, Young-Min Kim, Dain Moon, Gihoon You, Hyekang Kim, Eom Jaehyun, Chung Hyejin, Jaeho Jung
Publikováno v:
Science Advances. 7
Cancer immunotherapy with 4-1BB agonists has limited further clinical development because of dose-limiting toxicity. Here, we developed a bispecific antibody (bsAb; B7-H3×4-1BB), targeting human B7-H3 (hB7-H3) and mouse or human 4-1BB, to restrict t
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Background4-1BB (CD137) is a co-stimulatory receptor that stimulates the function of multiple immune cells. Its ability to induce potent anti-tumor activity makes 4-1BB an attractive target for immuno-oncology. However, clinical development of a mono
Autor:
Hyung-Seung Jin, Gihoon You, Hyunjoo Kim, Yangmi Lim, Jung Uijung, Jeon Jaehyoung, Eunsil Sung, Shinai Lee, Jaeho Jung, Jiang Wenqing, Zhengyi Wang, Jonghwa Won, Kim Youngkwang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundPD-(L)1 inhibitor has revolutionized cancer treatment, but there are unmet clinical needs for PD-(L)1 inhibitor-resistant/refractory patients. Activation of T cells in tumor microenvironment by 4-1BB agonist antibodies is one of the promisi
Autor:
Minwoo Jeon, Han-Byul Lee, Seongju Jeong, Shin Hwang, Hyung-Don Kim, Zhengyi Wang, Hyunjoo Kim, Su-Hyung Park, Eun-Sil Sung, Jung Uijung, Jeon Jaehyoung, Eui-Cheol Shin, Yangmi Lim, Shinai Lee, Jiang Wenqing, Kim Youngkwang, Eunyoung Park, Youngeun Hong, Fang Lei, Son Yonggyu, Jonghwa Won, Jaeho Jung
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundStimulation of 4-1BB with agonistic antibodies is a promising strategy for improving the therapeutic efficacy of immune checkpoint inhibitors (ICIs) or for overcoming resistance to ICIs. However, dose-dependent hepatotoxicity was observed i
Autor:
Kyung Jin Lee, Bo-Eun Lee, Hyunejoo Kim, Eun-Sil Sung, Jongman Yoo, Chan Kwon Park, Jonghwa Won, Yoon Park, Jaeho Jung, Han-Byul Lee, Jihyo Kim, Eunyoung Park, Uijung Jung, Youngeun Hong, Minkyung Ko, Seung Joon Kim
Publikováno v:
Cancer Research. 81:1633-1633
PD-(L)1 blockade has demonstrated the remarkable success for cancer treatment, but significant unmet needs remain to fully achieve clinical benefit for PD-(L)1 resistant/refractory patients. Recent studies suggest that expression of Lymphocyte Activa
Publikováno v:
Computer Methods in Applied Mechanics and Engineering. 372:113401
In this paper, we propose a method that employs deep learning, an artificial intelligence technique, to generate stiffness matrices of finite elements. The proposed method is used to develop 4- and 8-node 2D solid finite elements. The deep learned fi
Publikováno v:
Cancer Research. 80:5644-5644
Background Claudin 18.2 (CLDN18.2) is a gastric-specific membrane protein. In the healthy tissue, CLDN18.2 expression is restricted to the short-lived differentiated cells of gastric mucosa as a component of tight junction with limited accessibility
Autor:
Han Wook Park, Yangsoon Lee, Yeon-Woo Kang, Gihoon You, Seung-Woo Lee, Park Kyeongsu, Jaeho Jung
Publikováno v:
Cancer Research. 80:6673-6673
4-1BB is a costimulatory receptor on activated T and NK cells, and the stimulation of 4-1BB by the natural ligand or agonistic mAb enhances cellular proliferation and effector functions. Immunotherapy targeting 4-1BB has been tested for cancer patien
Autor:
Dae Won Kim, Sung Byungje, Yangsoon Lee, KyeongBae Kim, Su Jin Ahn, Wonjun Son, Yeom Donghoon, J.K. Lee, Chung Hyejin, Weon-Kyoo You, Ju Young Park, Eun Jung Kim, Young Bong Park, Song Daehae, Mikyeong Ju, Eom Jaehyun, Ahn Jinhyung, Jaeho Jung, Moo Young Song, Jung Uijung, Jong Gyun Kim, Jun Hwan Kim, Eunjung Lee, Park Kyeongsu, Se-Woong Oh, Min Hyeok Jee, Kyoung Kyu Ahn, Byung Hyun Choi
Publikováno v:
Cancer Research. 80:6524-6524
4-1BB (TNFSF9, CD137) is a member of the tumor necrosis factor receptor superfamily that functions as a potent costimulator to immune cells, especially T-cell. Although current 4-1BB-targeted strong agonistic antibody exhibit a considerable anti-tumo
Publikováno v:
The Journal of Immunology. 167:49-56
Germinal center-B (GC-B) cells differentiate into memory B cells and plasma cells (PC) through interaction with T cells and follicular dendritic cells (FDC). Activated T cell and FDC play distinct roles in this process. The detailed kinetic experimen