Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Itaru Kojima"'
Autor:
Yosuke Masubuchi, Yuko Nakagawa, Johan Medina, Masahiro Nagasawa, Itaru Kojima, Mark M Rasenick, Takeshi Inagaki, Hiroshi Shibata
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181293 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0176841.].
Externí odkaz:
https://doaj.org/article/6b37699258714f75877732830120b6d3
Autor:
Yosuke Masubuchi, Yuko Nakagawa, Johan Medina, Masahiro Nagasawa, Itaru Kojima, Mark M Rasenick, Takeshi Inagaki, Hiroshi Shibata
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176841 (2017)
We previously reported that 3T3-L1 cells express a functional sweet taste receptor possibly as a T1R3 homomer that is coupled to Gs and negatively regulates adipogenesis by a Gαs-mediated but cAMP-independent mechanism. Here, we show that stimulatio
Externí odkaz:
https://doaj.org/article/4b19d67bb8e84d9ab3519b13872e9a91
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144053 (2015)
Glucose is a primary stimulator of insulin secretion in pancreatic β-cells. High concentration of glucose has been thought to exert its action solely through its metabolism. In this regard, we have recently reported that glucose also activates a cel
Externí odkaz:
https://doaj.org/article/85dcd73e6253412bb0c37d910a416cca
Autor:
Yosuke Masubuchi, Yuko Nakagawa, Jinhui Ma, Tsutomu Sasaki, Tadahiro Kitamura, Yoritsuna Yamamoto, Hitoshi Kurose, Itaru Kojima, Hiroshi Shibata
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54500 (2013)
BACKGROUND: Sweet taste receptor is expressed not only in taste buds but also in nongustatory organs such as enteroendocrine cells and pancreatic beta-cells, and may play more extensive physiological roles in energy metabolism. Here we examined the e
Externí odkaz:
https://doaj.org/article/90b07ffc46c4457d8a5b1ca8a81a1a03
Autor:
Sumiyo Morita, Akemi Hara, Itaru Kojima, Takuro Horii, Mika Kimura, Tadahiro Kitamura, Takahiro Ochiya, Katsumi Nakanishi, Ryo Matoba, Kenichi Matsubara, Izuho Hatada
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4212 (2009)
Dicer1, an essential component of RNA interference and the microRNA pathway, has many important roles in the morphogenesis of developing tissues. Dicer1 null mice have been reported to die at E7.5; therefore it is impossible to study its function in
Externí odkaz:
https://doaj.org/article/7e5d277bb37648ab9f57a5117461a8b2
Autor:
Yuko Nakagawa, Masahiro Nagasawa, Satoko Yamada, Akemi Hara, Hideo Mogami, Viacheslav O Nikolaev, Martin J Lohse, Noriatsu Shigemura, Yuzo Ninomiya, Itaru Kojima
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5106 (2009)
BACKGROUND:Sweet taste receptor is expressed in the taste buds and enteroendocrine cells acting as a sugar sensor. We investigated the expression and function of the sweet taste receptor in MIN6 cells and mouse islets. METHODOLOGY/PRINCIPAL FINDINGS:
Externí odkaz:
https://doaj.org/article/0f66c5983d664586ae47caaccbb9fce2
Autor:
Satoko Yamada, Kunihiko Terada, Yasuharu Ueno, Toshihiro Sugiyama, Masaharu Seno, Itaru Kojima M.D.
Publikováno v:
Cell Transplantation, Vol 14 (2005)
To apply cell transplantation for treatment of diabetes mellitus, a sufficient number of β-cell sources are required. In the present study, we examined whether an epithelial cell line obtained from normal adult rat liver, namely hepatic stem-like (H
Externí odkaz:
https://doaj.org/article/4c9261972ef34193be58adbf757c1470
Autor:
Itaru Kojima, Hiroyuki Morita, Yoshihiko Kitada, Kazuo Kajita, Koichiro Taguchi, Takahide Ikeda, Toshiko Kajita, Tatsuo Ishizuka, Motochika Asano, Masayuki Fuwa
Publikováno v:
The Journal of Endocrinology
Despite extensive investigation, the mechanisms underlying adipogenesis are not fully understood. We previously identified proliferative cells in adipose tissue expressing adipocyte-specific genes, which were named small proliferative adipocytes (SPA
Publikováno v:
Diabetes, Obesity and Metabolism. 19:54-62
Glucose is a primary stimulator of insulin secretion. It has been thought that glucose exerts its effect by a mechanism solely dependent on glucose metabolism. We show here that glucose induces rapid Ca2+ and cyclic AMP signals in β-cells. These rap
Publikováno v:
The FASEB Journal. 31:1368-1381
We have previously reported that transient receptor potential vanilloid 2 (TRPV2) can be activated by mechanical stimulation, which enhances axonal outgrowth in developing neurons; however, the molecular mechanisms that govern the contribution of TRP