Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Gary J. Schwartz"'
Autor:
Huidong Shi, Gary J. Schwartz, Fenfen Li, Bingzhong Xue, Shirong Wang, Rui Wu, Liqing Yu, Jia Jing, Xin Cui, Qiang Cao, Ke Li, Hang Shi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Activation of brown fat thermogenesis increases energy expenditure and alleviates obesity. Sympathetic nervous system (SNS) is important in brown/beige adipocyte thermogenesis. Here we discover a fat-derived “adipokine” neurotrophic factor neurot
Autor:
Han Eol Park, Jong Hwi Park, Minyoo Kim, Gary J. Schwartz, Ju Ae Jin, H. J. Kim, Benjamin H. Ahn, Myungsun Lee, Jung Weon Lee, Sung-Yon Kim, Hyun-Kyung Kim, Dong Yoon Kim, Gyuryang Heo, Sieun Jung, Myungmo An
Publikováno v:
Nature. 580:376-380
Mechanosensory feedback from the digestive tract to the brain is critical for limiting excessive food and water intake, but the underlying gut–brain communication pathways and mechanisms remain poorly understood1–12. Here we show that, in mice, n
Publikováno v:
Diabetes. 70
There is substantial evidence that neural regulation plays a critical role in glucose metabolism and hormone release. Targeting neural populations innervating the pancreas could provide an alternative therapy for diabetes. However, our understanding
Autor:
Katy A. van Galen, Sofie M. Adriaanse, Gary J. Schwartz, Susanne E. la Fleur, Eric Fliers, Mireille J. Serlie, Kasper W. ter Horst, Unga A. Unmehopa, Anouk Schrantee, Jan Booij, Ralph J. DiLeone
Publikováno v:
Metabolism: Clinical and Experimental, 123. W.B. Saunders Ltd
Metabolism: clinical and experimental, 123:154839. W.B. Saunders Ltd
Metabolism: clinical and experimental, 123:154839. W.B. Saunders Ltd
Background and aims Serotonergic and dopaminergic systems in the brain are essential for homeostatic and reward-associated regulation of food intake and systemic energy metabolism. It is largely unknown how fasting influences these systems or if such
Publikováno v:
Am J Physiol Endocrinol Metab
The arcuate nucleus (ARC) of the hypothalamus comprises two antagonistic neuron populations critical for energy balance, namely, the anorexigenic pro-opiomelanocortin (POMC) and the orexigenic agouti-related peptide (AgRP) neurons that act as agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fbd182c588c88ddf5b58882a603da6
https://europepmc.org/articles/PMC7988782/
https://europepmc.org/articles/PMC7988782/
Autor:
Shun Mei Liu, Hye Young Joung, Eunjin Kwon, Gary J. Schwartz, Streamson C. Chua, Young Hwan Jo
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The central melanocortin system plays a fundamental role in the control of feeding and body weight. Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) also regulate overall glucose homeostasis via insulin-dependent an
BackgroundSleeve gastrectomy (SG) is currently the most frequently performed bariatric surgery in the United States. The majority of patients undergoing SG are middle aged women. Most preclinical models of bariatric surgery, however, utilize juvenile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03e253953ab7bed20913206ac2b6b113
https://doi.org/10.1101/2020.10.04.325787
https://doi.org/10.1101/2020.10.04.325787
Publikováno v:
Diabetes. 69
The brain and peripheral organs communicate through the peripheral nervous system (PNS) comprised of autonomic (sympathetic and parasympathetic) and sensory nerves. Pancreas is densely innervated by the PNS and their cell bodies reside in several gan
Inhibiting the prostaglandin transporter PGT induces non-canonical thermogenesis at thermoneutrality
Autor:
Rajat Singh, Marina Garcia Macia, Victor J. Pai, Run Lu, Licheng Wu, Yuling Chi, Wade Koba, Gary J. Schwartz, Victor L. Schuster
/ SUMMARYProstaglandins play fundamental roles in adipose tissue function. While prostaglandin F2α inhibits adipogenesis, prostaglandin E2 promotes adipose beiging. PGF2α and PGE2 are both inactivated through uptake by the plasma membrane transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13bea2c6127d9952593cc08ae735fc0
https://doi.org/10.1101/836288
https://doi.org/10.1101/836288
Autor:
Genevieve Marcelin, Streamson C. Chua, Young Hwan Jo, Gary J. Schwartz, Jae Hoon Jeong, Clemence Blouet, Shun-Mei Liu
Publikováno v:
Molecular Metabolism, Vol 8, Iss, Pp 37-50 (2018)
Molecular Metabolism
Molecular Metabolism
Objective Bile acids have been implicated as important regulators of glucose metabolism via activation of FXR and GPBAR1. We have previously shown that FGF19 can modulate glucose handling by suppressing the activity of hypothalamic AGRP/NPY neurons.