Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Denise Giuvelis"'
Autor:
Lien D. Nguyen, Luca G. Nolte, Winston J. T. Tan, Denise Giuvelis, Joseph Santos-Sacchi, Edward Bilsky, Barbara E. Ehrlich
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Neuronal calcium sensor 1 (NCS1) regulates a wide range of cellular functions throughout the mammalian nervous systems. Altered NCS1 expression is associated with neurodevelopmental and neurodegenerative diseases. Previous studies focused on
Externí odkaz:
https://doaj.org/article/b6b8f1fb46154bcdb198d9beb1bac578
Autor:
Jung-Jin Lee, Francesca Asmus, Kylee Harrington, Rebecca Brackin, Ravin Davis, Jacob Liff, Kyle Bittinger, Bahman Rostama, Glenn W. Stevenson, Anyssa Fisher, Sarah Couture, Meghan May, Denise Giuvelis, Philomena Richard, Sebastien Sannajust, Tamara King, Emily Payne, Elizabeth Mutina, Lisa M. Mattei, Elliot S. Friedman
Publikováno v:
J Pain
The present experiments determined the effects of the narrow-spectrum antibiotic vancomycin on inflammatory pain-stimulated and pain-depressed behaviors in rats. Persistent inflammatory pain was modeled using dilute formalin (0.5%). Two weeks of oral
Autor:
Winston Tan, Joseph Santos-Sacchi, Denise Giuvelis, Edward J. Bilsky, Barbara E. Ehrlich, Luca G. Nolte, Lien D. Nguyen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Neuronal calcium sensor 1 (NCS1) regulates a wide range of cellular functions throughout the mammalian nervous systems. Altered NCS1 expression is associated with neurodevelopmental and neurodegenerative diseases. Previous studies focused on affectiv
Autor:
Jacob T. Beckley, Xiang Zhou, John C. Hunter, Dennis Monteleone, Anton Delwig, David C. Yeomans, Hassan Pajouhesh, George Luu, John Mulcahy, Denise Giuvelis, Sheri Klas, Ian D Meng
Publikováno v:
Pain
The voltage-gated sodium channel Nav1.7 is highly expressed in nociceptive afferents and is critically involved in pain signal transmission. Nav1.7 is a genetically validated pain target in humans because loss-of-function mutations cause congenital i
Autor:
Katherine Cone, Edward J. Bilsky, Glenn W. Stevenson, Denise Giuvelis, Lajos Szabo, Phillip Atherton, Jean M. Bidlack, Brooke St. Laurent, Julio Dutra, Robin Polt, Rebecca Krivitsky, James Cormier, Emily Warner
Publikováno v:
Psychopharmacology (Berl)
RATIONALE AND OBJECTIVES: The present study characterized the behavioral pharmacology of a novel, mixed-action delta-selective (78:1) opioid receptor agonist, BBI-11008. This glycopeptide drug candidate was tested in assays assessing antinociception
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd9f9facb07f765ae59c8e7f9dffcfd
https://europepmc.org/articles/PMC8106974/
https://europepmc.org/articles/PMC8106974/
Autor:
Katherine Cone, Denise Giuvelis, Phillip Atherton, Ivy Bergquist, Travis Pitre, Glenn W. Stevenson, Emily Warner, Edward J. Bilsky, Tamara King, Rebecca Krivitsky, Janell Lanpher
Publikováno v:
Drug Development Research. 76:432-441
There has been recent interest in characterizing the effects of pain-like states on motivated behaviors in order to quantify how pain modulates goal-directed behavior and the persistence of that behavior. The current set of experiments assessed the e
Autor:
Edward J. Bilsky, Glenn W. Stevenson, Phillip Atherton, Julio Dutra, Robin Polt, John M. Streicher, Denise Giuvelis, Justin LaVigne, Catherine Dunbar, Amy Luginbuhl, Katherine Cone, Brooke Bell
Publikováno v:
Pharmacology Biochemistry and Behavior. 132:49-55
Previous work in our laboratories provides preclinical evidence that mixed-action delta/mu receptor glycopeptides have equivalent efficacy for treating pain with reduced side effect profiles compared to widely used mu agonist analgesics such as morph
Autor:
Edward J. Bilsky, John J. Lowery, Jean M. Bidlack, Denise Giuvelis, Robin Polt, Tyler J. Raymond
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 336:767-778
We have previously reported the chemistry and antinociceptive properties of a series of glycosylated enkephalin analogs (glycopeptides) exhibiting approximately equal affinity and efficacy at δ opioid receptors (DORs) and μ opioid receptors (MORs).
Autor:
Anne-Cécile Hiebel,†,‡, Yong Sok Lee, Everette L. May, K. C. Rice, Denise Giuvelis, and Arthur E. Jacobson, Kejun Cheng, Louis S. Harris, Mario D. Aceto, Damon A. Parrish, Andrew Coop, John S. Partilla, Richard B. Rothman, Edward J. Bilsky, Christina M. Dersch, Jeffrey R. Deschamps
Publikováno v:
Journal of Medicinal Chemistry. 50:3765-3776
Both of the enantiomers of 5-(3-hydroxyphenyl)-N-phenylethylmorphan with C9alpha-methyl, C9-methylene, C9-keto, and C9alpha- and C9beta-hydroxy substituents were synthesized and pharmacologically evaluated. Three of the 10 compounds, (1R,5R,9S)-(-)-9
Publikováno v:
The FASEB Journal. 29
Traditional drug development efforts to diminish the problem of chronic pain rely heavily on pain-evoked assays that can yield false positives, leading to confounding assessments of novel drugs. To avoid this, we are looking at burrowing as a novel r