Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Clare M. Waterman"'
Publikováno v:
Molecular Biology of the Cell
Cancer cells migrating in confined microenvironments exhibit plasticity of migration modes. Confinement of contractile cells in a nonadhesive environment drives “leader bleb–based migration” (LBBM), morphologically characterized by a long bleb
Autor:
Patrick Münzer, Roberto Negro, Shoichi Fukui, Lucas di Meglio, Karen Aymonnier, Long Chu, Deya Cherpokova, Sarah Gutch, Nicoletta Sorvillo, Lai Shi, Venkat Giri Magupalli, Alexander N. R. Weber, Rüdiger E. Scharf, Clare M. Waterman, Hao Wu, Denisa D. Wagner
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human disorders. While NETosis is known to be regulated by peptidylarginine deimina
Autor:
Anne E. Goldman, Clare M. Waterman, Denisa D. Wagner, Robert D. Goldman, Amir Vahabikashi, Hawa Racine Thiam, Mark Kittisopikul, Rong Qiu, Siu Ling Wong
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
We used quantitative, high-resolution live-cell imaging of neutrophil-like human cells (dHL60) and mouse and human blood-derived polymorphonuclear neutrophils (PMNs) stimulated with ionomycin, lipopolysaccharide (LPS), or Candida albicans to identify
Autor:
Clare M. Waterman, Komudi Singh, Ilker Tunc, Robert S. Fischer, Fayaz Seifuddin, Vijender Chaitankar, Yun-Ching Chen, Michelle A. Baird, Mehdi Pirooznia
Publikováno v:
Cancers
Volume 12
Issue 2
Cancers, Vol 12, Iss 2, p 458 (2020)
Volume 12
Issue 2
Cancers, Vol 12, Iss 2, p 458 (2020)
Melanoma is among the most malignant cutaneous cancers and when metastasized results in dramatically high mortality. Despite advances in high-throughput gene expression profiling in cancer transcriptomic studies, our understanding of mechanisms drivi
Autor:
Shalin B. Mehta, Vinay Swaminathan, David Baker, Talley J. Lambert, Pontus Nordenfelt, Jennifer C. Waters, Joseph Mathew Kalappurakkal, Timothy A. Springer, Clare M. Waterman, Tomomi Tani, Travis I. Moore, Rudolf Oldenbourg, Nobuyasu Koga, Satyajit Mayor
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications
Nature Communications
Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here, we test whether the integrin, when engaged to an extracellular ligand and the cytoskeleton, adopts a specific orientation d
Autor:
Lucas di Meglio, Nicoletta Sorvillo, Venkat Giri Magupalli, Robert D. Goldman, Denisa D. Wagner, Karen M. Ridge, Shoichi Fukui, Roberto Negro, Hao Wu, Deya Cherpokova, Patrick Münzer, Long Chu, Clare M. Waterman
Publikováno v:
SSRN Electronic Journal.
Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of disorders. We hypothesized that NLRP3 inflammasome may participate in NETosis. Usin
Publikováno v:
Journal of Biological Chemistry. 291:6096-6110
Cell-cell contact inhibition and the mechanical environment of cells have both been shown to regulate YAP nuclear localization to modulate cell proliferation. Changes in cellular contractility by genetic, pharmacological, and matrix stiffness perturb
Autor:
Christopher S. Chen, Lin Gao, Robert S. Adelstein, Ravi A. Desai, Kenneth A. Myers, Hunter L. Elliott, Clare M. Waterman, Gaudenz Danuser, Robert S. Fischer
Publikováno v:
Nature Cell Biology. 17:137-147
In many cases, cell function is intimately linked to cell shape control. We used endothelial cell branching morphogenesis as a model to understand the role of myosin II in shape control of invasive cells migrating in 3D collagen gels. We applied prin
Publikováno v:
Nature Protocols. 7:2056-2066
Regulation of cell functions by the physical properties of the extracellular matrix (ECM) has emerged as a crucial contributor to development and disease. Two specific physical properties of the ECM, stiffness and dimensionality, each influence cell
Autor:
Michael W. Davidson, Gregory M. Alushin, Hawa Racine Thiam, Colleen T. Skau, Anthony T. Tubbs, Patricia S. Steeg, Pinar S. Gurel, Matthieu Piel, Michelle A. Baird, Clare M. Waterman, Robert S. Fischer, André Nussenzweig
Publikováno v:
Cell. 173:529
Cell migration in confined 3D tissue microenvironments is critical for both normal physiological functions and dissemination of tumor cells. We discovered a cytoskeletal structure that prevents damage to the nucleus during migration in confined micro