Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Charles R. Mackay"'
Autor:
Juliana Echevarria-Lima, Leandro Araujo Lobo, Charles R. Mackay, Dario S. Zamboni, Robson Coutinho-Silva, Ana Carolina Oliveira, Julio Scharfstein, Regina Maria Cavalcanti Pilotto Domingues, Aline Cristina Abreu Moreira-Souza, Eliana Mariño, Erivan Schnaider Ramos-Junior, Maria Bellio, Eliane de Oliveira Ferreira, Juliana P Castelpoggi, Bruno Jennings-Almeida
Publikováno v:
The Journal of Immunology. 206:2441-2452
Intestinal barrier is essential for dietary products and microbiota compartmentalization and therefore gut homeostasis. When this barrier is broken, cecal content overflows into the peritoneal cavity, leading to local and systemic robust inflammatory
Publikováno v:
Science China Life Sciences. 64:1829-1841
There is growing recognition that neutrophils play an important role in cancer initiation, progression and metastasis. Although they are typically characterized as short-lived effector cells, neutrophils have been shown to acquire immunosuppressive a
Autor:
Matthew Snelson, Gavin W. Lambert, Assam El-Osta, Grant R Drummond, D. Donner, Melinda T. Coughlan, Helen Kiriazis, Aanthony Vinh, Duncan Horlock, Charles R. Mackay, Waled A. Shihata, Hamdi A. Jama, Beverly Giam, Tim D. Spector, Chad Johnson, Mark Ziemann, Xiao-Jun Du, April Fiedler, Kirill Tsyganov, Francine Z. Marques, David M. Kaye, Sarah E. Phillips, Amrita Vijay, Ana M. Valdes
Publikováno v:
Circulation. 141:1393-1403
Background: High blood pressure (BP) continues to be a major, poorly controlled but modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet poor in fiber is associated with prevalence of high BP. The impact of lac
Autor:
Sara Bordbar, Charles R. Mackay, Stephen M. Twigg, Eliana Mariño, Shannon Brodie, Sonia Saad, Marc R. Wilkins, Barbara Fazekas de St Groth, Long T. Nguyen, Emma E. Hamilton-Williams, Bree J. Tillett, Susan M. Corley, Courtney J. Wright, Helen M. McGuire, Yu Anne Yap, Kirstine J. Bell, Sussan Duong, Esteban Nicolas Gurzov, Leonard C. Harrison
BackgroundShort-chain fatty acids (SCFAs) produced by the gut microbiota have beneficial anti-inflammatory and gut homeostasis effects and prevent type 1 diabetes (T1D) in mice. Reduced SCFA production indicates a loss of beneficial bacteria, commonl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d99ceb0bb773c049b35a111f8cd051
https://doi.org/10.1101/2021.09.15.21263059
https://doi.org/10.1101/2021.09.15.21263059
Autor:
Madeleine Paterson, Evany Dinakis, Liang Xie, Ekaterina Salimova, Charles R. Mackay, Francine Z Marques, Caroline Ang, Hamdi A. Jama, Rikeish R. Muralitharan, Michael E Nakai, Alex Cheng Guan Peh, Remy Robert
Publikováno v:
Hypertension. 78
High fibre (HF) diet protects against hypertension via the production of acidic metabolites, e.g. short-chain fatty acids, by the gut microbiota. While these metabolites have a direct role in blood pressure (BP) regulation, their acidic nature may ac
Autor:
Melinda T. Coughlan, Waled A. Shihata, Louise M Burrell, Charles R. Mackay, Francine Z. Marques, Rikeish R. Muralitharan, Michael E Nakai, Matthew Snelson, David M. Kaye, Hamdi A. Jama, Chad Johnson, Evany Dinakis
Publikováno v:
Hypertension. 77
Autor:
Leigh Donnellan, Mark E. Cooper, Sih Min Tan, Brooke E. Harcourt, Mark Ziemann, Nicole J. Kellow, Josephine M. Forbes, Karly C. Sourris, Melinda T. Coughlan, David Steer, Rachel E. Clarke, Charles R. Mackay, Assam El-Osta, Sally A. Penfold, Tuong-Vi Nguyen, Matthew Snelson, Michael J. Davies, Cassandra de Pasquale, Vicki Thallas-Bonke, Runa S.J. Lindblom, Permal Deo, Trent M. Woodruff
Publikováno v:
Science Advances
Snelson, M, Tan, S M, Clarke, R E, De Pasquale, C, Thallas-Bonke, V, Nguyen, T V, Penfold, S A, Harcourt, B E, Sourris, K C, Lindblom, R S, Ziemann, M, Steer, D, El-Osta, A, Davies, M J, Donnellan, L, Deo, P, Kellow, N J, Cooper, M E, Woodruff, T M, Mackay, C R, Forbes, J M & Coughlan, M T 2021, ' Processed foods drive intestinal barrier permeability and microvascular diseases ', Science Advances, vol. 7, no. 14, eabe4841 . https://doi.org/10.1126/sciadv.abe4841
Snelson, M, Tan, S M, Clarke, R E, De Pasquale, C, Thallas-Bonke, V, Nguyen, T V, Penfold, S A, Harcourt, B E, Sourris, K C, Lindblom, R S, Ziemann, M, Steer, D, El-Osta, A, Davies, M J, Donnellan, L, Deo, P, Kellow, N J, Cooper, M E, Woodruff, T M, Mackay, C R, Forbes, J M & Coughlan, M T 2021, ' Processed foods drive intestinal barrier permeability and microvascular diseases ', Science Advances, vol. 7, no. 14, eabe4841 . https://doi.org/10.1126/sciadv.abe4841
This study shows how highly processed foods can cause innate immune inflammation that promotes chronic microvascular disease.
Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular disease
Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular disease
Autor:
Duan Ni, Alexandra Sophie Angelatos, Charles R. Mackay, M.C.B. Amian, Claire Daien, Stephen J. Simpson, Remy Robert, M. Duraes, Jian Tan, S. Hoque, Alison K. Gosby, Rosilene V Ribeiro, Lake-Ee Quek, R. Audo, J. Mielle, Gabriela Pinget, A. Parmar, M.J. Alam, Laurence Macia, Frederic Sierro, James R. Krycer, G. Perkins
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 7 (2021)
JCI Insight, Vol 6, Iss 7 (2021)
Autoimmune diseases are characterized by a breakdown of immune tolerance partly due to environmental factors. The short-chain fatty acid acetate, derived mostly from gut microbial fermentation of dietary fiber, promotes antiinflammatory Tregs and pro
Autor:
Charles R. Mackay, Laurence Macia
Publikováno v:
Journal of Allergy and Clinical Immunology. 144:1513-1515
The skin environment controls local dendritic cell differentiation and function through innate IL-13
Autor:
Kerry L Hilligan, Luis Munoz-Erazo, Lisa M Connor, Sally Chappell, Alan Sher, Franca Ronchese, Charles R. Mackay, Olivier Lamiable, Graham Le Gros, Jianping Yang, Dragana Jankovic, Kirsty A. Wakelin, Matthew R. Hepworth, David Eccles, Greta R Webb, Frank Brombacher, Evelyn J Hyde, Jodie Chandler, Samuel I Old, Roxane Tussiwand, Rita G. Domingues, Johannes U Mayer, Shiau-Choot Tang
The signals driving the adaptation of type-2 dendritic cells (DC2s) to diverse peripheral environments are not well understood. We show that the development of CD11blow migratory DC2s, a DC2 population unique to the dermis, requires STAT6- and KLF4-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a3c3ad77cbcaf7b0a32bb495053eddc
https://doi.org/10.1101/2021.01.05.425466
https://doi.org/10.1101/2021.01.05.425466