Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Charles F McHugh"'
Autor:
Anastasia Wyce, Gopinath Ganji, Kimberly N Smitheman, Chun-Wa Chung, Susan Korenchuk, Yuchen Bai, Olena Barbash, BaoChau Le, Peter D Craggs, Michael T McCabe, Karen M Kennedy-Wilson, Lydia V Sanchez, Romain L Gosmini, Nigel Parr, Charles F McHugh, Dashyant Dhanak, Rab K Prinjha, Kurt R Auger, Peter J Tummino
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72967 (2013)
BET family proteins are epigenetic regulators known to control expression of genes involved in cell growth and oncogenesis. Selective inhibitors of BET proteins exhibit potent anti-proliferative activity in a number of hematologic cancer models, in p
Externí odkaz:
https://doaj.org/article/edc29a7e49b54f8688b20ca3340035d5
Autor:
Peter A. Jones, Ashley K. Wiseman, Helai P. Mohammad, Christopher S. Kershaw, Bryan W. King, Ian D. Waddell, Thau F. Ho, Stephen B. Baylin, Morris Muliaditan, Marcus Bantscheff, Elisabeth A. Minthorn, Thilo Werner, Alan P. Graves, Wendy A. Kellner, Phil Chapman, Mehul Patel, Anthony J. Jurewicz, Allan M. Jordan, Emma E. Fairweather, Rab K. Prinjha, Nino Campobasso, Anna Rutkowska, H. Christian Eberl, Ryan G. Kruger, Charles F. McHugh, Michael T. McCabe, Kristin M. Goldberg, Jon Paul Jaworski, Christopher L. Carpenter, Michael Steidel, Stuart Paul Romeril, Dirk A. Heerding, Lourdes Rueda, David T. Fosbenner, Amy N. Taylor, Jacques Briand, Shawn W. Foley, Arthur Groy, Andrew B. Benowitz, Xiaodong Cheng, Donald J. Ogilvie, Paola Grandi, Cunyu Zhang, Mei Li, Sarath Pathuri, Aidan G. Gilmartin, Christian S. Sherk, Juan I. Luengo, Mark Cockerill, Ali Raoof, Alexandra Stowell, Kathryn Keenan, Melissa B. Pappalardi, Makda Mebrahtu, Kristen Wong, Xing Zhang, Jessica L. Handler, Roger J. Butlin, John R. Horton, Susan Merrihew, Charlotte Burt, Dean E. McNulty
Publikováno v:
Nature Cancer. 2:1002-1017
DNA methylation, a key epigenetic driver of transcriptional silencing, is universally dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as the cytidine analogs decitabine or azacytidine, has demonstrated clinical ben
Autor:
Helai P. Mohammad, Francesca Zappacosta, Steven P. Piccoli, Craig D. Wagner, Paul B. Noto, Charles F. McHugh, Caretha L. Creasy, Matthew Szapacs, Timothy W. Sikorski, Yan Liu, Rocio Montes de Oca, Roland S. Annan
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Scientific Reports
Scientific Reports
Arginine methylation has been recognized as a post-translational modification with pleiotropic effects that span from regulation of transcription to metabolic processes that contribute to aberrant cell proliferation and tumorigenesis. This has brough
Autor:
Ryan G. Kruger, William H. Miller, Louis V. LaFrance, Celine Duquenne, Alan P. Graves, Heidi M. Ott, Dashyant Dhanak, Christine Thompson, Xinrong Tian, Martin Brandt, Michael T. McCabe, Charles F. McHugh, Mellinger Mark, Susan Korenchuk, Anthony Della Pietra, Peter J. Tummino, Yan Liu, Caretha L. Creasy, Sharad K. Verma, Elsie Diaz, Gopinath Ganji, Glenn S. Van Aller
Publikováno v:
Nature. 492:108-112
EZH2, the catalytic subunit of the polycomb repressive complex 2 (PRC2), is involved in repressing gene expression through methylation of histone H3 on lysine 27 (H3K27). Overexpression of EZH2 is implicated in tumorigenesis, and mutations within its
Autor:
Kristen Wong, Jessica L. Handler, Michael T. McCabe, Helai P. Mohammad, Bryan W. King, Dirk A. Heerding, Melissa B. Pappalardi, Ryan G. Kruger, Lourdes Rueda, Mehul Patel, David T. Fosbenner, Allan M. Jordan, Elisabeth A. Minthorn, Andrew B. Benowitz, Kathryn Keenan, Christian S. Sherk, Ali Raoof, Charlotte Burt, Alexandra Stowell, Mark Cockerill, Jacques Briand, Charles F. McHugh, Rab K. Prinjha
Publikováno v:
Cancer Research. 78:2994-2994
Aberrant DNA hypermethylation within promoter regions and subsequent gene silencing are near universal hallmarks of human cancer. Reversal of DNA methylation by a hypomethylating agent, such as decitabine (Dacogen) or azacytidine (Vidaza), has shown
Autor:
Thau F. Ho, Yan Liu, Xinrong Tian, Patrick McDevitt, Michael Butticello, Timothy K. Hart, Kimberly N. Smitheman, David Soong, Jessica L. Schneck, Peter J. Tummino, Christine L. Hann, Glenn S. Van Aller, Yuchen Bai, Nestor O. Concha, Kasparec Jiri, Melissa B. Pappalardi, Christopher L. Carpenter, Mcnulty Kenneth C, Kelly Federowicz, Jeffrey D. Carson, William H. Miller, Johnson Neil W, Chandrashekhar D. Kamat, Rouse Meagan B, Charles F. McHugh, Michael T. McCabe, Ryan G. Kruger, Dashyant Dhanak, Helai P. Mohammad, Michelle Crouthamel, Yan Degenhardt, William G. Bonnette, Shelby A. Gorman
Publikováno v:
Cancer cell. 28(1)
SummaryEpigenetic dysregulation has emerged as an important mechanism in cancer. Alterations in epigenetic machinery have become a major focus for targeted therapies. The current report describes the discovery and biological activity of a cyclopropyl
Autor:
Kwok-Kin Wong, Ling Wang, Teresa Ezponda, Ryan G. Kruger, Heidi M. Ott, Relja Popovic, Rita Shaknovich, Glenn S. Van Aller, Ari Melnick, Sharad K. Verma, Wendy Béguelin, Yanwen Jiang, Young Rock Chung, Omar Abdel-Wahab, Jonathan D. Licht, Shao Ning Yang, Leandro Cerchietti, Ross L. Levine, Neil L. Kelleher, Monica Rosen, Olivier Elemento, Michael T. McCabe, Caretha L. Creasy, David Scott, Charles F. McHugh, Karen L. Bunting, Eva Martinez-Garcia, Yupeng Zheng, Haikuo Zhang, Yan Liu, Randy D. Gascoyne, Matt Teater, Hao Shen
Publikováno v:
Cancer cell. 23(5)
SummaryThe EZH2 histone methyltransferase is highly expressed in germinal center (GC) B cells and targeted by somatic mutations in B cell lymphomas. Here, we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions. E
Autor:
Dashyant Dhanak, Romain Luc Marie Gosmini, Olena Barbash, Rab K. Prinjha, BaoChau Le, Gopinath Ganji, Kimberly N. Smitheman, Chun-wa Chung, Karen M. Kennedy-Wilson, Nigel J. Parr, Peter D. Craggs, Charles F. McHugh, Lydia V. Sanchez, Peter J. Tummino, Yuchen Bai, Anastasia Wyce, Susan Korenchuk, Kurt R. Auger, Michael T. McCabe
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72967 (2013)
PLoS ONE
PLoS ONE
BET family proteins are epigenetic regulators known to control expression of genes involved in cell growth and oncogenesis. Selective inhibitors of BET proteins exhibit potent anti-proliferative activity in a number of hematologic cancer models, in p
Autor:
Victoria Ortiz, Melissa C. Musso, Olena Barbash, Christopher L. Carpenter, Lijoy K. Mathew, Xi-Ping Zhang, Charles F. McHugh, Anastasia Wyce, Peter J. Tummino, Susan Korenchuk, Daniel J. Felitsky, Melissa Stern, Ramona Plant, Jeanne J. Matteo, Yan Degenhardt, Sakina Khaku, Kathryn Keenan
Publikováno v:
Cancer Research. 76:4709-4709
BET (bromodomain and extra-terminal) family proteins are epigenetic readers that modulate expression genes involved in cell growth and oncogenesis. Selective small molecule BET inhibitors, such as the GSK I-BETs (I-BET762, I-BET151), abrogate binding
Autor:
Nicholas Smithers, Susan Korenchuk, Charles F. McHugh, Olena Barbash, Jeanne J. Matteo, Peter Ernest Soden, Anastasia Wyce, Daniel J. Felitsky, Christopher L. Carpenter, Kathryn Keenan, Gary Thripp, Rab K. Prinjha
Publikováno v:
Cancer Research. 76:4693-4693
NUT midline carcinoma (NMC) is a highly aggressive squamous cell cancer that responds poorly to standard chemotherapuetic approaches. NMC is characterized by translocations involving the NUT (nuclear protein in testes) protein, which in a majority of