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Autor:
Surendran, P., Drenos, F., Young, R., Warren, H., Cook, J.P., Manning, A.K., Grarup, N., Sim, X., Barnes, D.R., Witkowska, K., Staley, J.R., Tragante, V., Tukiainen, T., Yaghootkar, H., Masca, N., Freitag, D.F., Ferreira, T., Giannakopoulou, O., Tinker, A., Harakalova, M., Mihailov, E., Liu, C., Kraja, A.T., Nielsen, S.F., Rasheed, A., Samue, M., Zhao, W., Bonnycastle, L.L., Jackson, A.U., Narisu, N., Swift, A.J., Southam, L., Marten, J., Huyghe, J.R., Stancakova, A., Fava, C., Ohlsson, T., Matchan, A., Stirrups, K.E., Bork-Jensen, J., Gjesing, A.P., Kontto, J., Perola, M., Shaw-Hawkins, S., Havulinna, A.S., Zhang, H., Donnelly, L.A., Groves, C.J., Rayner, N.W., Neville, M.J., Robertson, N.R., Yiorkas, A.M., Herzig, K.H., Kajantie, E., Zhang, W., Willems, S.M., Lannfelt, L., Malerba, G., Soranzo, N., Trabetti, E., Verweij, N., Evangelou, E., Moayyeri, A., Vergnaud, A.C., Nelson, C.P., Poveda, A., Varga, T.V., Caslake, M., Craen, A.J.M. de, Trompet, S., Luan, J., Scott, R.A., Harris, S.E., Liewald, D.C.M., Marioni, R., Menni, C., Farmaki, A.E., Hallmans, G., Renstrom, F., Huffman, J.E., Hassinen, M., Burgess, S., Vasan, R.S., Felix, J.F., Uria-Nickelsen, M., Malarstign, A., Reilly, D.F., Hoek, M., Vogt, T.F., Lin, H.H., Lieb, W., Traylor, M., Markus, H.S., Highland, H.M., Justice, A.E., Marouli, E., Lindstrom, J., Uusitupa, M., Komulainen, P., Lakka, T.A., Rauramaa, R., Polasek, O., Rudan, I., Rolandsson, O., Franks, P.W., Dedoussis, G., Spector, T.D., Jousilahti, P., Mannisto, S., Deary, I.J., Starr, J.M., Langenberg, C., Wareham, N.J., Brown, M.J., Dominiczak, A.F., Connell, J.M., Jukema, J.W., Sattar, N., Ford, I., Packard, C.J., Esko, T., Magi, R., Metspalu, A., Boer, R.A. de, Meer, P. van der, Harst, P. van der, Gambaro, G., Ingelsson, E., Lind, L., Bakker, P.I.W. de, Numans, M.E., Brandslund, I., Christensen, C., Petersen, E.R.B., Korpi-Hyovalti, E., Oksa, H., Chambers, J.C., Kooner, J.S., Blakemore, A.I.F., Franks, S., Jarvelin, M.R., Husemoen, L.L., Linneberg, A., Skaaby, T., Thuesen, B., Karpe, F., Tuomilehto, J., Doney, A.S.F., Morris, A.D., Palmer, C.N.A., Holmen, O.L., Hveem, K., Willer, C.J., Tuomi, T., Groop, L., Karajamaki, A., Palotie, A., Ripatti, S., Salomaa, V., Alam, D.S., Majmnder, A.A.S., Angelantonio, E. di, Chowdhury, R., McCarthy, M.I., Poulter, N., Stanton, A.V., Sever, P., Amouyel, P., Arveiler, D., Blankenberg, S., Ferrieres, J., Kee, F., Kuulasmaa, K., Muller-Nurasyid, M., Veronesi, G., Virtamo, J., Deloukas, P., Elliott, P., Zeggini, E., Kathiresan, S., Melander, O., Kuusisto, J., Laakso, M., Padmanabhan, S., Porteous, D.J., Hayward, C., Scotland, G., Collins, F.S., Mohlke, K.L., Hansen, T., Pedersen, O., Boehnke, M., Stringham, H.M., Frossard, P., Newton-Cheh, C., Tobin, M.D., Nordestgaard, B.G., Caulfield, M.J., Mahajan, A., Morris, A.P., Tomaszewski, M., Samani, N.J., Saleheen, D., Asselbergs, F.W., Lindgren, C.M., Danesh, J., Wain, L.V., Butterworth, A.S., Howson, J.M.M., Munroe, P.B., CHARGE Heart Failure Consortiumm, EchoGen Consortiumm, Metastroke Consortiumm, Giant Consortiumm, EPIC-InterAct Consortium, Lifelines Cohort Study, Wellcome Trust Case Control Consor, Understanding Soc Sci Grp, EPIC-CVD Consortium, CHARGE Exome Chip Blood Pressure C, T2D-GENES Consortium, GoT2DGenes Consortium, ExomeBP Consortium, CHD Exome Consortium
Publikováno v:
Nature Genetics, 48(10), 1151-1161. Nature Publishing Group
Nature Genetics, 48(10), 1151-1161
Nature Genetics, 48(10), 1151. Nature Publishing Group
NATURE GENETICS
Nature genetics
CHARGE-Heart Failure Consortium, EchoGen Consortium, METASTROKE Consortium, GIANT Consortium, EPIC-InterAct Consortium, Lifelines Cohort Study, Wellcome Trust Case Control Consortium, Understanding Society Scientific Group, Generation Scotland, EPIC-CVD Consortium, CHARGE+ Exome Chip Blood Pressure Consortium, T2D-GENES Consortium, GoT2DGenes Consortium, ExomeBP Consortium & CHD Exome+ Consortium 2016, ' Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension ', Nature Genetics, vol. 48, no. 10, pp. 1151-1161 . https://doi.org/10.1038/ng.3654
Surendran, P, Drenos, F, Young, R, Warren, H, Cook, J P, Manning, A K, Grarup, N, Sim, X, Barnes, D R, Witkowska, K, Staley, J R, Tragante, V, Tukiainen, T, Yaghootkar, H, Masca, N, Freitag, D F, Ferreira, T, Giannakopoulou, O, Tinker, A, Harakalova, M, Mihailov, E, Liu, C, Kraja, A T, Nielsen, S F, Rasheed, A, Samuel, M, Zhao, W, Bonnycastle, L L, Jackson, A U, Narisu, N, Swift, A J, Southam, L, Marten, J, Huyghe, J R, Stančáková, A, Fava, C, Ohlsson, T, Matchan, A, Stirrups, K E, Bork-Jensen, J, Gjesing, A P, Kontto, J, Perola, M, Shaw-Hawkins, S, Havulinna, A S, Zhang, H, Donnelly, L A, Groves, C J, Rayner, N W, Neville, M J, Robertson, N R, Yiorkas, A M, Herzig, K H, Kajantie, E, Zhang, W, Willems, S M, Lannfelt, L, Malerba, G, Soranzo, N, Trabetti, E, Verweij, N, Evangelou, E, Moayyeri, A, Vergnaud, A C, Nelson, C P, Poveda, A, Varga, T V, Caslake, M, De Craen, A J M, Trompet, S, Luan, JA, Scott, R A, Harris, S E, Liewald, D C M, Marioni, R, Menni, C, Farmaki, A E, Hallmans, G, Renström, F, Huffman, J E, Hassinen, M, Burgess, S, Vasan, R S, Felix, J F, Uria-Nickelsen, M, Malarstig, A, Reilly, D F, Hoek, M, Vogt, T F, Lin, H, Lieb, W, Traylor, M, Markus, H S, Highland, H M, Justice, A E, Marouli, E, Lindström, J, Uusitupa, M, Komulainen, P, Lakka, T A, Rauramaa, R, Polasek, O, Rudan, I, Rolandsson, O, Franks, P W, Dedoussis, G, Spector, T D, Jousilahti, P, Männistö, S, Deary, I J, Starr, J M, Langenberg, C, Wareham, N J, Brown, M J, Dominiczak, A F, Connell, J M, Jukema, J W, Sattar, N, Ford, I, Packard, C J, Esko, T, Mägi, R, Metspalu, A, De Boer, R A, Van Der Meer, P, Van Der Harst, P, Gambaro, G, Ingelsson, E, Lind, L, De Bakker, P I W, Numans, M E, Brandslund, I, Christensen, C, Petersen, E R B, Korpi-Hyövälti, E, Oksa, H, Chambers, J C, Kooner, J S, Blakemore, A I F, Franks, S, Jarvelin, M R, Husemoen, L L, Linneberg, A, Skaaby, T, Thuesen, B, Karpe, F, Tuomilehto, J, Doney, A S F, Morris, A D, Palmer, C N A, Holmen, O L, Hveem, K, Willer, C J, Tuomi, T, Groop, L, Käräjämäki, A, Palotie, A, Ripatti, S, Salomaa, V, Alam, D S, Majumder, A A S, Di Angelantonio, E, Chowdhury, R, McCarthy, M I, Poulter, N, Stanton, A V, Sever, P, Amouyel, P, Arveiler, D, Blankenberg, S, Ferrières, J, Kee, F, Kuulasmaa, K, Müller-Nurasyid, M, Veronesi, G, Virtamo, J, Deloukas, P, Elliott, P, Zeggini, E, Kathiresan, S, Melander, O, Kuusisto, J, Laakso, M, Padmanabhan, S, Porteous, D J, Hayward, C, Scotland, G, Collins, F S, Mohlke, K L, Hansen, T, Pedersen, O, Boehnke, M, Stringham, H M, Frossard, P, Newton-Cheh, C, Tobin, M D, Nordestgaard, B G, Caulfield, M J, Mahajan, A, Morris, A P, Tomaszewski, M, Samani, N J, Saleheen, D, Asselbergs, F W, Lindgren, C M, Danesh, J, Wain, L V, Butterworth, A S, Howson, J M M & Munroe, P B 2016, ' Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension ', Nature Genetics, vol. 48, no. 10, pp. 1151-1161 . https://doi.org/10.1038/ng.3654
Nature Genetics
Surendran, P, Drenos, F, Young, R, Warren, H, Cook, J P, Manning, A K, Grarup, N, Sim, X, Barnes, D R, Witkowska, K, Staley, J R, Tragante, V, Tukiainen, T, Yaghootkar, H, Masca, N, Freitag, D F, Ferreira, T, Giannakopoulou, O, Tinker, A, Harakalova, M, Mihailov, E, Liu, C, Kraja, A T, Nielsen, S F, Rasheed, A, Samuel, M, Zhao, W, Bonnycastle, L L, Jackson, A U, Narisu, N, Swift, A J, Southam, L, Marten, J, Huyghe, J R, Stančáková, A, Fava, C, Ohlsson, T, Matchan, A, Stirrups, K E, Bork-Jensen, J, Harris, S E, Liewald, D C M, Marioni, R, Polasek, O, Rudan, I, Deary, I J, Starr, J M, Morris, A D & Porteous, D J & Hayward, C 2016, ' Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension ', Nature Genetics . https://doi.org/10.1038/ng.3654
Nature Genetics, 48(10), 1151-1161
Nature Genetics, 48(10), 1151. Nature Publishing Group
NATURE GENETICS
Nature genetics
CHARGE-Heart Failure Consortium, EchoGen Consortium, METASTROKE Consortium, GIANT Consortium, EPIC-InterAct Consortium, Lifelines Cohort Study, Wellcome Trust Case Control Consortium, Understanding Society Scientific Group, Generation Scotland, EPIC-CVD Consortium, CHARGE+ Exome Chip Blood Pressure Consortium, T2D-GENES Consortium, GoT2DGenes Consortium, ExomeBP Consortium & CHD Exome+ Consortium 2016, ' Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension ', Nature Genetics, vol. 48, no. 10, pp. 1151-1161 . https://doi.org/10.1038/ng.3654
Surendran, P, Drenos, F, Young, R, Warren, H, Cook, J P, Manning, A K, Grarup, N, Sim, X, Barnes, D R, Witkowska, K, Staley, J R, Tragante, V, Tukiainen, T, Yaghootkar, H, Masca, N, Freitag, D F, Ferreira, T, Giannakopoulou, O, Tinker, A, Harakalova, M, Mihailov, E, Liu, C, Kraja, A T, Nielsen, S F, Rasheed, A, Samuel, M, Zhao, W, Bonnycastle, L L, Jackson, A U, Narisu, N, Swift, A J, Southam, L, Marten, J, Huyghe, J R, Stančáková, A, Fava, C, Ohlsson, T, Matchan, A, Stirrups, K E, Bork-Jensen, J, Gjesing, A P, Kontto, J, Perola, M, Shaw-Hawkins, S, Havulinna, A S, Zhang, H, Donnelly, L A, Groves, C J, Rayner, N W, Neville, M J, Robertson, N R, Yiorkas, A M, Herzig, K H, Kajantie, E, Zhang, W, Willems, S M, Lannfelt, L, Malerba, G, Soranzo, N, Trabetti, E, Verweij, N, Evangelou, E, Moayyeri, A, Vergnaud, A C, Nelson, C P, Poveda, A, Varga, T V, Caslake, M, De Craen, A J M, Trompet, S, Luan, JA, Scott, R A, Harris, S E, Liewald, D C M, Marioni, R, Menni, C, Farmaki, A E, Hallmans, G, Renström, F, Huffman, J E, Hassinen, M, Burgess, S, Vasan, R S, Felix, J F, Uria-Nickelsen, M, Malarstig, A, Reilly, D F, Hoek, M, Vogt, T F, Lin, H, Lieb, W, Traylor, M, Markus, H S, Highland, H M, Justice, A E, Marouli, E, Lindström, J, Uusitupa, M, Komulainen, P, Lakka, T A, Rauramaa, R, Polasek, O, Rudan, I, Rolandsson, O, Franks, P W, Dedoussis, G, Spector, T D, Jousilahti, P, Männistö, S, Deary, I J, Starr, J M, Langenberg, C, Wareham, N J, Brown, M J, Dominiczak, A F, Connell, J M, Jukema, J W, Sattar, N, Ford, I, Packard, C J, Esko, T, Mägi, R, Metspalu, A, De Boer, R A, Van Der Meer, P, Van Der Harst, P, Gambaro, G, Ingelsson, E, Lind, L, De Bakker, P I W, Numans, M E, Brandslund, I, Christensen, C, Petersen, E R B, Korpi-Hyövälti, E, Oksa, H, Chambers, J C, Kooner, J S, Blakemore, A I F, Franks, S, Jarvelin, M R, Husemoen, L L, Linneberg, A, Skaaby, T, Thuesen, B, Karpe, F, Tuomilehto, J, Doney, A S F, Morris, A D, Palmer, C N A, Holmen, O L, Hveem, K, Willer, C J, Tuomi, T, Groop, L, Käräjämäki, A, Palotie, A, Ripatti, S, Salomaa, V, Alam, D S, Majumder, A A S, Di Angelantonio, E, Chowdhury, R, McCarthy, M I, Poulter, N, Stanton, A V, Sever, P, Amouyel, P, Arveiler, D, Blankenberg, S, Ferrières, J, Kee, F, Kuulasmaa, K, Müller-Nurasyid, M, Veronesi, G, Virtamo, J, Deloukas, P, Elliott, P, Zeggini, E, Kathiresan, S, Melander, O, Kuusisto, J, Laakso, M, Padmanabhan, S, Porteous, D J, Hayward, C, Scotland, G, Collins, F S, Mohlke, K L, Hansen, T, Pedersen, O, Boehnke, M, Stringham, H M, Frossard, P, Newton-Cheh, C, Tobin, M D, Nordestgaard, B G, Caulfield, M J, Mahajan, A, Morris, A P, Tomaszewski, M, Samani, N J, Saleheen, D, Asselbergs, F W, Lindgren, C M, Danesh, J, Wain, L V, Butterworth, A S, Howson, J M M & Munroe, P B 2016, ' Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension ', Nature Genetics, vol. 48, no. 10, pp. 1151-1161 . https://doi.org/10.1038/ng.3654
Nature Genetics
Surendran, P, Drenos, F, Young, R, Warren, H, Cook, J P, Manning, A K, Grarup, N, Sim, X, Barnes, D R, Witkowska, K, Staley, J R, Tragante, V, Tukiainen, T, Yaghootkar, H, Masca, N, Freitag, D F, Ferreira, T, Giannakopoulou, O, Tinker, A, Harakalova, M, Mihailov, E, Liu, C, Kraja, A T, Nielsen, S F, Rasheed, A, Samuel, M, Zhao, W, Bonnycastle, L L, Jackson, A U, Narisu, N, Swift, A J, Southam, L, Marten, J, Huyghe, J R, Stančáková, A, Fava, C, Ohlsson, T, Matchan, A, Stirrups, K E, Bork-Jensen, J, Harris, S E, Liewald, D C M, Marioni, R, Polasek, O, Rudan, I, Deary, I J, Starr, J M, Morris, A D & Porteous, D J & Hayward, C 2016, ' Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension ', Nature Genetics . https://doi.org/10.1038/ng.3654
High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-
Autor:
Warren, Helen R., Evangelou, Evangelos, Cabrera, Claudia P., Gao, Ren, Meixia, Mifsud, Borbala, Ntalla, Ioanna, Surendran, Praveen, Liu, Chunyu, Cook, James P., Kraja, Aldi T., Drenos, Fotios, Loh, Marie, Verweij, Niek, Marten, Jonathan, Karaman, Ibrahim, Lepe, Marcelo P. Segura, O'Reilly, Paul F., Knight, Joanne, Snieder, Harold, Kato, Norihiro, Jiang, Tai, E. Shyong, Said, M. Abdullah, Porteous, David, Alver, Maris, Poulter, Neil, Farrall, Martin, Gansevoort, Ron T., Padmanabhan, Sandosh, Magi, Reedik, Stanton, Alice, Connell, John, Bakker, Stephan J. L., Metspalu, Andres, Shields, Denis C., Thom, Simon, Brown, Morris, Sever, Peter, Esko, Tonu, Hayward, Caroline, van der Harst, Pim, Saleheen, Danish, Chowdhury, Rajiv, Chambers, John C., Chasman, Daniel I., Chakravarti, Aravinda, Newton-Cheh, Christopher, Lindgren, Cecilia M., Levy, Daniel, Kooner, Jaspal S., Keavney, Bernard, Tomaszewski, Maciej, Samani, Nilesh J., Howson, Joanna M. M., Tobin, Martin D., Munroe, Patricia B., Ehret, Georg B., Wain, Louise V., Barnes, Michael R., Tzoulaki, Joanna, Caulfield, Mark J., Elliott, Paul, Vaez, Ahmad, Jansen, Rick, Joehanes, Roby, van der Most, Peter J., Erzurumluoglu, A. Mesut, Rose, Lynda M., Verwoert, Germaine C., Hottenga, Jouke-Jan, Strawbridge, Rona J., Arking, Dan E., Hwang, Shih-Jen, Guo, Xiuqing, Kutalik, Zoltan, Trompet, Stella, Shrine, Nick, Teumer, Alexander, Ried, Janina S., Bis, Joshua C., Smith, Albert V., Amin, Najaf, Nolte, Ilja M., Lyytikainen, Leo-Pekka, Mahajan, Anubha, Wareham, Nicholas J., Hofer, Edith, Joshi, Peter K., Kristiansson, Kati, Traglia, Michela, Havulinna, Aki S., Goel, Anuj, Nalls, Mike A., Sober, Siim, Vuckovic, Dragana, Luan, Jian'an, Del Greco M, Fabiola, Ayers, Kristin L., Marrugat, Jaume, Ruggiero, Daniela, Lopez, Lorna M., Niiranen, Teemu, Enroth, Stefan, Jackson, Anne U., Nelson, Christopher P., Huffman, Jennifer E., Zhang, Weihua, Gandin, Ilaria, Harris, Sarah E., Zemonik, Tatijana, Yingchang, Shah, Nabi, de Borst, Martin H., Mangino, Massimo, Prins, Bram P., Campbell, Archie, Li-Gao, Ruifang, Chauhan, Ganesh, Oldmeadow, Abecasis, Goncalo, Abedi, Maryam, Barbieri, Caterina M., Batini, Chiara, Blake, Tineka, Boehnke, Michael, Bottinger, Erwin P., Braund, Peter S., Brumat, Marco, Harry, Cocca, Massimiliano, Collins, Francis, Cordell, Heather J., Damman, Jeffrey J., Davies, Gail, de Geus, Eco J., de Mutsert, Renee, Deelen, Joris, Demirkale, Yusuf, Doney, Alex S. F., Dorr, Marcus, Ferreira, Teresa, Franberg, Mattias, Giedraitis, Vilmantas, Gieger, Christian, Giulianini, Franco, Gow, Alan J., Hamsten, Anders, Tamara B., Hofman, Albert, Holliday, Elizabeth G., Jarvelin, Marjo-Riitta, Johansson, Asa, Johnson, Andrew D., Jousilahti, Pekka, Jula, Antti, Kahonen, Mika, Kathiresan, Sekar, Khaw, Kay-Tee, Kolcic, Ivana, Koskinen, Seppo, Langenberg, Claudia, Larson, Marty, Launer, Lenore J., Lehne, Benjamin, Liewald, David C. M., Lin, Lind, Lars, Mach, Francois, Mamasoula, Chrysovalanto, Menni, Cristina, Milaneschi, Yuri, Morgan, Anna, Morrison, Alanna C., Munson, Nandakumar, Priyanka, Quang Tri Nguyen, Nutile, Oldehinkel, Albertine J., Oostra, Ben A., Org, Elin, Palotie, Aarno, Pare, Guillaume, Pattie, Alison, Penninx, Brenda W. J. H., Pramstaller, Peter P., Raitakari, Olli T., Rice, Kenneth, Ridker, Paul M., Riese, Harriette, Ripatti, Samuli, Robino, Antonietta, Rotter, Jerome I., Rudan, Igor, Saba, Yasaman, Saint Pierre, Aude, Sala, Cinzia F., Sarin, Antti-Pekka, Schmidt, Reinhold, Scott, Rodney, Seelen, Marc A., Siscovick, Sorice, Rossella, Stott, David J., Sundstrom, Johan, Swertz, Taylor, Kent D., Tzourio, Christophe, Uitterlinden, Andre G., Volker, Uwe, Vollenweider, Wild, Sarah, Willemsen, Gonneke, Wright, Alan F., Yao, Jie, Theriault, Sebastien, Conen, Attia, Debette, Stephanie, Mook-Kanamori, Dennis O., Zeggini, Eleftheria, Spector, Tim D., Palmer, Colin N. A., Vergnaud, Anne-Claire, Loos, Ruth J. F., Polasek, Ozren, Starr, John M., Girotto, Giorgia, Cecila M., Vitart, Veronique, Tuomilehto, Jaakko, Gyllensten, Ulf, Knekt, Deary, Ian J., Ciullo, Marina, Elosua, Roberto, Bernard D., Hicks, Andrew A., Robert A., Gasparini, Paolo, Laan, YongMei, Watkins, Hugh, Hartman, Catharina A., Salomaa, Veikko, Toniolo, Perola, Markus, Wilson, James F., Helena, Zhao, Jing Hua, Lehtimaki, Terho, van Duijn, Cornelia M., Gudnason, Vilmundur, Psaty, Bruce M., Peters, Annette, Rettig, Rainer, James, Alan, Jukema, J. Wouter, Strachan, David P., Palmas, Walter, Ingelsson, Erik, Boomsma, Dorret I., Oscar H., Bochud, Murielle, Andrew P., Int Consortium Blood Pressure ICBP, CHD Exome Consortium, ExomeBP Consortium, T2D-GENES Consortium, GoT2D Genes Consortium, CHARGE BP Exome Consortium, iGEN-BP Consortium, UK Biobank CardioMetab Consortium, BIOS Consortium, Lifelines Cohort Study, Understanding Soc Sci Grp
Publikováno v:
Warren, H R, Evangelou, E, Cabrera, C P, Gao, H, Ren, M, Mifsud, B, Ntalla, I, Surendran, P, Liu, C, Cook, J P, Kraja, A T, Drenos, F, Loh, M, Verweij, N, Marten, J, Karaman, I, Lepe, M P S, O'Reilly, P F, Knight, J, Snieder, H, Kato, N, He, J, Tai, E S, Said, M A, Porteous, D, Alver, M, Poulter, N, Farrall, M, Gansevoort, R T, Padmanabhan, S, Mägi, R, Stanton, A, Connell, J, Bakker, S J L, Metspalu, A, Shields, D C, Thom, S, Brown, M, Sever, P, Esko, T, Hayward, C, van der Harst, P, Saleheen, D, Chowdhury, R, Chambers, J C, Chasman, D I, Chakravarti, A, Newton-Cheh, C, Tobin, M D, Wain, L V 2017, ' Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk ', Nature Genetics, vol. 49, no. 3, pp. 403-415 . https://doi.org/10.1038/ng.3768
Nature Genetics, 49(3), 403-415
Nature genetics
Nature genetics, vol. 49, no. 3, pp. 403-415
The UK Biobank Cardio-metabolic Traits Consortium Blood Pressure Working Group, Keavney, B & Tomaszewski, M 2017, ' Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk ', Nature Genetics, vol. 49, pp. 403-415 . https://doi.org/10.1038/ng.3768
NATURE GENETICS
Nature genetics, 49(3), 403-415. Nature Publishing Group
Nature Genetics
Warren, H R, Evangelou, E, Cabrera, C P, Gao, H, Ren, M, Mifsud, B, Ntalla, I, Surendran, P, Liu, C, Cook, J P, Kraja, A T, Drenos, F, Loh, M, Verweij, N, Marten, J, Karaman, I, Segura Lepe, M P, O'Reilly, P, Knight, J, Snieder, H, Kato, N, He, J, Shyong Tai, E, Abdullah Said, M, Porteous, D, Alver, M, Poulter, N, Farrall, M, Gansevoort, R T, Padmanabhan, S, Mägi, R, Stanton, A, Connell, J, Bakker, S J L, Metspalu, A, Shields, D C, Thom, S, Brown, M, Sever, P, Esko, T, Hayward, C, van der Harst, P, Saleheen, D, Chowdhury, R, Chambers, J C, Chasman, D I, Chakravarti, A, Jansen, R, Milaneschi, Y, Penninx, B W J H, The International Consortium of Blood Pressure (ICBP) 1000G Analyses, The CHD Exome+ Consortium, The ExomeBP Consortium, The T2D-GENES Consortium, The GoT2DGenes Consortium, The Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium, The International Genomics of Blood Pressure (iGEN-BP) Consortium, for The UK Biobank CardioMetabolic Consortium BP working group Louise, BIOS Consortium, Lifelines Cohort Study & Understanding Society Scientific group 2017, ' Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk ', Nature Genetics, vol. 49, no. 3, pp. 403-415 . https://doi.org/10.1038/ng.3768
Nature Genetics, 49(3), 403-415. Nature Publishing Group
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Warren, H R, Evangelou, E, Cabrera, C P, Gao, H, Ren, M, Mifsud, B, Ntalla, I, Surendran, P, Liu, C, Cook, J P, Kraja, A T, Drenos, F, Loh, M, Verweij, N, Marten, J, Karaman, I, Lepe, M P S, O'Reilly, P F, Knight, J, Snieder, H, Kato, N, He, J, Tai, E S, Said, M A, Porteous, D, Alver, M, Poulter, N, Farrall, M, Gansevoort, R T, Padmanabhan, S, Mägi, R, Stanton, A, Connell, J, Bakker, S J L, Metspalu, A, Shields, D C, Thom, S, Brown, M, Sever, P, Esko, T, Hayward, C, van der Harst, P, Saleheen, D, Chowdhury, R, Chambers, J C, Chasman, D I, International Consortium of Blood Pressure (ICBP) 1000G Analyses, Hottenga, J J, de Geus, E, Willemsen, G & Boomsma, D I 2017, ' Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk ', Nature Genetics, vol. 49, no. 3, pp. 403-415 . https://doi.org/10.1038/ng.3768
Warren, H R, Evangelou, E, Cabrera, C P, Gao, H, Ren, M, Mifsud, B, Ntalla, I, Surendran, P, Liu, C, Cook, J P, Kraja, A T, Drenos, F, Loh, M, Verweij, N, Marten, J, Karaman, I, Lepe, M P S, O'Reilly, P F, Knight, J, Snieder, H, Kato, N, He, J, Tai, E S, Said, M A, Porteous, D, Alver, M, Poulter, N, Farrall, M, Gansevoort, R T, Padmanabhan, S, Magi, R, Hayward, C, Joshi, P K, Lopez, L M, Marten, J, Harris, S E, Campbell, A, Campbell, H & Davies, G & Gow, A J & Liewald, D C M & Morris, A D & Pattie, A & Rudan, I & Wright, A F & Starr, J M & Hayward, C & Vitart, V & Deary, I J & Wilson, J F 2017, ' Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk ', Nature Genetics, vol. 49, no. 3, pp. 403-415 . https://doi.org/10.1038/ng.3768
49 (2017): 403–415. doi:10.1038/ng.3768
info:cnr-pdr/source/autori:Warren, Helen R. and Evangelou, Evangelos and Cabrera, Claudia P. and Gao, He and Ren, Meixia and Mifsud, Borbala and Ntalla, Ioanna and Surendran, Praveen and Liu, Chunyu and Cook, James P. and Kraja, Aldi T. and Drenos, Fotios and Loh, Marie and Verweij, Niek and Marten, Jonathan and Karaman, Ibrahim and Lepe, Marcelo P. Segura and O'Reilly, Paul F. and Knight, Joanne and Snieder, Harold and Kato, Norihiro and He, Jiang and Tai, E. Shyong and Said, M. Abdullah and Porteous, David and Alver, Maris and Poulter, Neil and Farrall, Martin and Gansevoort, Ron T. and Padmanabhan, Sandosh and Magi, Reedik and Stanton, Alice and Connell, John and Bakker, Stephan J. L. and Metspalu, Andres and Shields, Denis C. and Thom, Simon and Brown, Morris and Sever, Peter and Esko, Tonu and Hayward, Caroline and van der Harst, Pim and Saleheen, Danish and Chowdhury, Rajiv and Chambers, John C. and Chasman, Daniel I. and Chakravarti, Aravinda and Newton-Cheh, Christopher and Lindgren, Cecilia M. and Levy, Daniel and Kooner, Jaspal S. and Keavney, Bernard and Tomaszewski, Maciej and Samani, Nilesh J. and Howson, Joanna M. M. and Tobin, Martin D. and Munroe, Patricia B. and Ehret, Georg B. and Wain, Louise V. and Barnes, Michael R. and Tzoulaki, Joanna and Caulfield, Mark J. and Elliott, Paul and Wain, Louise V. and Vaez, Ahmad and Jansen, Rick and Joehanes, Roby and van der Most, Peter J. and Erzurumluoglu, A. Mesut and O'Reilly, Paul and Cabrera, Claudia P. and Warren, Helen R. and Rose, Lynda M. and Verwoert, Germaine C. and Hottenga, Jouke-Jan and Strawbridge, Rona J. and Esko, Tonu and Arking, Dan E. and Hwang, Shih-Jen and Guo, Xiuqing and Kutalik, Zoltan and Trompet, Stella and Shrine, Nick and Teumer, Alexander and Ried, Janina S. and Bis, Joshua C. and Smith, Albert V. and Amin, Najaf and Nolte, Ilja M. and Lyytikainen, Leo-Pekka and Mahajan, Anubha and Wareham, Nicholas J. and Hofer, Edith and Joshi, Peter K. and Kristiansson, Kati and Traglia, Michela and Havulinna, Aki S. and Goel, Anuj and Nalls, Mike A. and Sober, Siim and Vuckovic, Dragana and Luan, Jian'an and Del Greco M, Fabiola and Ayers, Kristin L. and Marrugat, Jaume and Ruggiero, Daniela and Lopez, Lorna M. and Niiranen, Teemu and Enroth, Stefan and Jackson, Anne U. and Nelson, Christopher P. and Huffman, Jennifer E. and Zhang, Weihua and Marten, Jonathan and Gandin, Ilaria and Harris, Sarah E. and Zemonik, Tatijana and Lu, Yingchang and Evangelou, Evangelos and Shah, Nabi and de Borst, Martin H. and Mangino, Massimo and Prins, Bram P. and Campbell, Archie and Li-Gao, Ruifang and Chauhan, Ganesh and Oldmeadow, Christopher and Abecasis, Goncalo and Abedi, Maryam and Barbieri, Caterina M. and Barnes, Michael R. and Batini, Chiara and Blake, Tineka and Boehnke, Michael and Bottinger, Erwin P. and Braund, Peter S. and Brown, Morris and Brumat, Marco and Campbell, Harry and Chambers, John C. and Cocca, Massimiliano and Collins, Francis and Connell, John and Cordell, Heather J. and Damman, Jeffrey J. and Davies, Gail and de Geus, Eco J. and de Mutsert, Renee and Deelen, Joris and Demirkale, Yusuf and Doney, Alex S. F. and Dorr, Marcus and Farrall, Martin and Ferreira, Teresa and Franberg, Mattias and Gao, He and Giedraitis, Vilmantas and Gieger, Christian and Giulianini, Franco and Gow, Alan J. and Hamsten, Anders and Harris, Tamara B. and Hofman, Albert and Holliday, Elizabeth G. and Jarvelin, Marjo-Riitta and Johansson, Asa and Johnson, Andrew D. and Jousilahti, Pekka and Jula, Antti and Kahonen, Mika and Kathiresan, Sekar and Khaw, Kay-Tee and Kolcic, Ivana and Koskinen, Seppo and Langenberg, Claudia and Larson, Marty and Launer, Lenore J. and Lehne, Benjamin and Liewald, David C. M. and Lin, Li and Lind, Lars and Mach, Francois and Mamasoula, Chrysovalanto and Menni, Cristina and Mifsud, Borbala and Milaneschi, Yuri and Morgan, Anna and Morris, Andrew D. and Morrison, Alanna C. and Munson, Peter J. and Nandakumar, Priyanka and Quang Tri Nguyen and Nutile, Teresa and Oldehinkel, Albertine J. and Oostra, Ben A. and Org, Elin and Padmanabhan, Sandosh and Palotie, Aarno and Pare, Guillaume and Pattie, Alison and Penninx, Brenda W. J. H. and Poulter, Neil and Pramstaller, Peter P. and Raitakari, Olli T. and Ren, Meixia and Rice, Kenneth and Ridker, Paul M. and Riese, Harriette and Ripatti, Samuli and Robino, Antonietta and Rotter, Jerome I. and Rudan, Igor and Saba, Yasaman and Saint Pierre, Aude and Sala, Cinzia F. and Sarin, Antti-Pekka and Schmidt, Reinhold and Scott, Rodney and Seelen, Marc A. and Shields, Denis C. and Siscovick, David and Sorice, Rossella and Stanton, Alice and Stott, David J. and Sundstrom, Johan and Swertz, Morris and Taylor, Kent D. and Thom, Simon and Tzoulaki, Ioanna and Tzourio, Christophe and Uitterlinden, Andre G. and Volker, Uwe and Vollenweider, Peter and Wild, Sarah and Willemsen, Gonneke and Wright, Alan F. and Yao, Jie and Theriault, Sebastien and Conen, David and John, Attia and Sever, Peter and Debette, Stephanie and Mook-Kanamori, Dennis O. and Zeggini, Eleftheria and Spector, Tim D. and van der Harst, Pim and Palmer, Colin N. A. and Vergnaud, Anne-Claire and Loos, Ruth J. F. and Polasek, Ozren and Starr, John M. and Girotto, Giorgia and Hayward, Caroline and Kooner, Jaspal S. and Lindgren, Cecila M. and Vitart, Veronique and Samani, Nilesh J. and Tuomilehto, Jaakko and Gyllensten, Ulf and Knekt, Paul and Deary, Ian J. and Ciullo, Marina and Elosua, Roberto and Keavney, Bernard D. and Hicks, Andrew A. and Scott, Robert A. and Gasparini, Paolo and Laan, Maris and Liu, YongMei and Watkins, Hugh and Hartman, Catharina A. and Salomaa, Veikko and Toniolo, Daniela and Perola, Markus and Wilson, James F. and Schmidt, Helena and Zhao, Jing Hua and Lehtimaki, Terho and van Duijn, Cornelia M. and Gudnason, Vilmundur and Psaty, Bruce M. and Peters, Annette and Rettig, Rainer and James, Alan and Jukema, J. Wouter and Strachan, David P. and Palmas, Walter and Metspalu, Andres and Ingelsson, Erik and Boomsma, Dorret I. and Franco, Oscar H. and Bochud, Murielle and Newton-Cheh, Christopher and Munroe, Patricia B. and Elliott, Paul and Chasman, Daniel I. and Chakravarti, Aravinda and Knight, Joanne and Morris, Andrew P. and Levy, Daniel and Tobin, Martin D. and Snieder, Harold and Caulfield, Mark J. and Ehret, Georg B. and Int Consortium Blood Pressure ICBP and CHD Exome Consortium and ExomeBP Consortium and T2D-GENES Consortium and GoT2D Genes Consortium and CHARGE BP Exome Consortium and iGEN-BP Consortium and UK Biobank CardioMetab Consortium and BIOS Consortium and Lifelines Cohort Study and Understanding Soc Sci Grp/titolo:Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk/doi:10.1038%2Fng.3768/rivista:Nature genetics (Print)/anno:2017/pagina_da:403/pagina_a:415/intervallo_pagine:403–415/volume:49
Nature Genetics, 49(3), 403-415
Nature genetics
Nature genetics, vol. 49, no. 3, pp. 403-415
The UK Biobank Cardio-metabolic Traits Consortium Blood Pressure Working Group, Keavney, B & Tomaszewski, M 2017, ' Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk ', Nature Genetics, vol. 49, pp. 403-415 . https://doi.org/10.1038/ng.3768
NATURE GENETICS
Nature genetics, 49(3), 403-415. Nature Publishing Group
Nature Genetics
Warren, H R, Evangelou, E, Cabrera, C P, Gao, H, Ren, M, Mifsud, B, Ntalla, I, Surendran, P, Liu, C, Cook, J P, Kraja, A T, Drenos, F, Loh, M, Verweij, N, Marten, J, Karaman, I, Segura Lepe, M P, O'Reilly, P, Knight, J, Snieder, H, Kato, N, He, J, Shyong Tai, E, Abdullah Said, M, Porteous, D, Alver, M, Poulter, N, Farrall, M, Gansevoort, R T, Padmanabhan, S, Mägi, R, Stanton, A, Connell, J, Bakker, S J L, Metspalu, A, Shields, D C, Thom, S, Brown, M, Sever, P, Esko, T, Hayward, C, van der Harst, P, Saleheen, D, Chowdhury, R, Chambers, J C, Chasman, D I, Chakravarti, A, Jansen, R, Milaneschi, Y, Penninx, B W J H, The International Consortium of Blood Pressure (ICBP) 1000G Analyses, The CHD Exome+ Consortium, The ExomeBP Consortium, The T2D-GENES Consortium, The GoT2DGenes Consortium, The Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium, The International Genomics of Blood Pressure (iGEN-BP) Consortium, for The UK Biobank CardioMetabolic Consortium BP working group Louise, BIOS Consortium, Lifelines Cohort Study & Understanding Society Scientific group 2017, ' Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk ', Nature Genetics, vol. 49, no. 3, pp. 403-415 . https://doi.org/10.1038/ng.3768
Nature Genetics, 49(3), 403-415. Nature Publishing Group
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Warren, H R, Evangelou, E, Cabrera, C P, Gao, H, Ren, M, Mifsud, B, Ntalla, I, Surendran, P, Liu, C, Cook, J P, Kraja, A T, Drenos, F, Loh, M, Verweij, N, Marten, J, Karaman, I, Lepe, M P S, O'Reilly, P F, Knight, J, Snieder, H, Kato, N, He, J, Tai, E S, Said, M A, Porteous, D, Alver, M, Poulter, N, Farrall, M, Gansevoort, R T, Padmanabhan, S, Mägi, R, Stanton, A, Connell, J, Bakker, S J L, Metspalu, A, Shields, D C, Thom, S, Brown, M, Sever, P, Esko, T, Hayward, C, van der Harst, P, Saleheen, D, Chowdhury, R, Chambers, J C, Chasman, D I, International Consortium of Blood Pressure (ICBP) 1000G Analyses, Hottenga, J J, de Geus, E, Willemsen, G & Boomsma, D I 2017, ' Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk ', Nature Genetics, vol. 49, no. 3, pp. 403-415 . https://doi.org/10.1038/ng.3768
Warren, H R, Evangelou, E, Cabrera, C P, Gao, H, Ren, M, Mifsud, B, Ntalla, I, Surendran, P, Liu, C, Cook, J P, Kraja, A T, Drenos, F, Loh, M, Verweij, N, Marten, J, Karaman, I, Lepe, M P S, O'Reilly, P F, Knight, J, Snieder, H, Kato, N, He, J, Tai, E S, Said, M A, Porteous, D, Alver, M, Poulter, N, Farrall, M, Gansevoort, R T, Padmanabhan, S, Magi, R, Hayward, C, Joshi, P K, Lopez, L M, Marten, J, Harris, S E, Campbell, A, Campbell, H & Davies, G & Gow, A J & Liewald, D C M & Morris, A D & Pattie, A & Rudan, I & Wright, A F & Starr, J M & Hayward, C & Vitart, V & Deary, I J & Wilson, J F 2017, ' Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk ', Nature Genetics, vol. 49, no. 3, pp. 403-415 . https://doi.org/10.1038/ng.3768
49 (2017): 403–415. doi:10.1038/ng.3768
info:cnr-pdr/source/autori:Warren, Helen R. and Evangelou, Evangelos and Cabrera, Claudia P. and Gao, He and Ren, Meixia and Mifsud, Borbala and Ntalla, Ioanna and Surendran, Praveen and Liu, Chunyu and Cook, James P. and Kraja, Aldi T. and Drenos, Fotios and Loh, Marie and Verweij, Niek and Marten, Jonathan and Karaman, Ibrahim and Lepe, Marcelo P. Segura and O'Reilly, Paul F. and Knight, Joanne and Snieder, Harold and Kato, Norihiro and He, Jiang and Tai, E. Shyong and Said, M. Abdullah and Porteous, David and Alver, Maris and Poulter, Neil and Farrall, Martin and Gansevoort, Ron T. and Padmanabhan, Sandosh and Magi, Reedik and Stanton, Alice and Connell, John and Bakker, Stephan J. L. and Metspalu, Andres and Shields, Denis C. and Thom, Simon and Brown, Morris and Sever, Peter and Esko, Tonu and Hayward, Caroline and van der Harst, Pim and Saleheen, Danish and Chowdhury, Rajiv and Chambers, John C. and Chasman, Daniel I. and Chakravarti, Aravinda and Newton-Cheh, Christopher and Lindgren, Cecilia M. and Levy, Daniel and Kooner, Jaspal S. and Keavney, Bernard and Tomaszewski, Maciej and Samani, Nilesh J. and Howson, Joanna M. M. and Tobin, Martin D. and Munroe, Patricia B. and Ehret, Georg B. and Wain, Louise V. and Barnes, Michael R. and Tzoulaki, Joanna and Caulfield, Mark J. and Elliott, Paul and Wain, Louise V. and Vaez, Ahmad and Jansen, Rick and Joehanes, Roby and van der Most, Peter J. and Erzurumluoglu, A. Mesut and O'Reilly, Paul and Cabrera, Claudia P. and Warren, Helen R. and Rose, Lynda M. and Verwoert, Germaine C. and Hottenga, Jouke-Jan and Strawbridge, Rona J. and Esko, Tonu and Arking, Dan E. and Hwang, Shih-Jen and Guo, Xiuqing and Kutalik, Zoltan and Trompet, Stella and Shrine, Nick and Teumer, Alexander and Ried, Janina S. and Bis, Joshua C. and Smith, Albert V. and Amin, Najaf and Nolte, Ilja M. and Lyytikainen, Leo-Pekka and Mahajan, Anubha and Wareham, Nicholas J. and Hofer, Edith and Joshi, Peter K. and Kristiansson, Kati and Traglia, Michela and Havulinna, Aki S. and Goel, Anuj and Nalls, Mike A. and Sober, Siim and Vuckovic, Dragana and Luan, Jian'an and Del Greco M, Fabiola and Ayers, Kristin L. and Marrugat, Jaume and Ruggiero, Daniela and Lopez, Lorna M. and Niiranen, Teemu and Enroth, Stefan and Jackson, Anne U. and Nelson, Christopher P. and Huffman, Jennifer E. and Zhang, Weihua and Marten, Jonathan and Gandin, Ilaria and Harris, Sarah E. and Zemonik, Tatijana and Lu, Yingchang and Evangelou, Evangelos and Shah, Nabi and de Borst, Martin H. and Mangino, Massimo and Prins, Bram P. and Campbell, Archie and Li-Gao, Ruifang and Chauhan, Ganesh and Oldmeadow, Christopher and Abecasis, Goncalo and Abedi, Maryam and Barbieri, Caterina M. and Barnes, Michael R. and Batini, Chiara and Blake, Tineka and Boehnke, Michael and Bottinger, Erwin P. and Braund, Peter S. and Brown, Morris and Brumat, Marco and Campbell, Harry and Chambers, John C. and Cocca, Massimiliano and Collins, Francis and Connell, John and Cordell, Heather J. and Damman, Jeffrey J. and Davies, Gail and de Geus, Eco J. and de Mutsert, Renee and Deelen, Joris and Demirkale, Yusuf and Doney, Alex S. F. and Dorr, Marcus and Farrall, Martin and Ferreira, Teresa and Franberg, Mattias and Gao, He and Giedraitis, Vilmantas and Gieger, Christian and Giulianini, Franco and Gow, Alan J. and Hamsten, Anders and Harris, Tamara B. and Hofman, Albert and Holliday, Elizabeth G. and Jarvelin, Marjo-Riitta and Johansson, Asa and Johnson, Andrew D. and Jousilahti, Pekka and Jula, Antti and Kahonen, Mika and Kathiresan, Sekar and Khaw, Kay-Tee and Kolcic, Ivana and Koskinen, Seppo and Langenberg, Claudia and Larson, Marty and Launer, Lenore J. and Lehne, Benjamin and Liewald, David C. M. and Lin, Li and Lind, Lars and Mach, Francois and Mamasoula, Chrysovalanto and Menni, Cristina and Mifsud, Borbala and Milaneschi, Yuri and Morgan, Anna and Morris, Andrew D. and Morrison, Alanna C. and Munson, Peter J. and Nandakumar, Priyanka and Quang Tri Nguyen and Nutile, Teresa and Oldehinkel, Albertine J. and Oostra, Ben A. and Org, Elin and Padmanabhan, Sandosh and Palotie, Aarno and Pare, Guillaume and Pattie, Alison and Penninx, Brenda W. J. H. and Poulter, Neil and Pramstaller, Peter P. and Raitakari, Olli T. and Ren, Meixia and Rice, Kenneth and Ridker, Paul M. and Riese, Harriette and Ripatti, Samuli and Robino, Antonietta and Rotter, Jerome I. and Rudan, Igor and Saba, Yasaman and Saint Pierre, Aude and Sala, Cinzia F. and Sarin, Antti-Pekka and Schmidt, Reinhold and Scott, Rodney and Seelen, Marc A. and Shields, Denis C. and Siscovick, David and Sorice, Rossella and Stanton, Alice and Stott, David J. and Sundstrom, Johan and Swertz, Morris and Taylor, Kent D. and Thom, Simon and Tzoulaki, Ioanna and Tzourio, Christophe and Uitterlinden, Andre G. and Volker, Uwe and Vollenweider, Peter and Wild, Sarah and Willemsen, Gonneke and Wright, Alan F. and Yao, Jie and Theriault, Sebastien and Conen, David and John, Attia and Sever, Peter and Debette, Stephanie and Mook-Kanamori, Dennis O. and Zeggini, Eleftheria and Spector, Tim D. and van der Harst, Pim and Palmer, Colin N. A. and Vergnaud, Anne-Claire and Loos, Ruth J. F. and Polasek, Ozren and Starr, John M. and Girotto, Giorgia and Hayward, Caroline and Kooner, Jaspal S. and Lindgren, Cecila M. and Vitart, Veronique and Samani, Nilesh J. and Tuomilehto, Jaakko and Gyllensten, Ulf and Knekt, Paul and Deary, Ian J. and Ciullo, Marina and Elosua, Roberto and Keavney, Bernard D. and Hicks, Andrew A. and Scott, Robert A. and Gasparini, Paolo and Laan, Maris and Liu, YongMei and Watkins, Hugh and Hartman, Catharina A. and Salomaa, Veikko and Toniolo, Daniela and Perola, Markus and Wilson, James F. and Schmidt, Helena and Zhao, Jing Hua and Lehtimaki, Terho and van Duijn, Cornelia M. and Gudnason, Vilmundur and Psaty, Bruce M. and Peters, Annette and Rettig, Rainer and James, Alan and Jukema, J. Wouter and Strachan, David P. and Palmas, Walter and Metspalu, Andres and Ingelsson, Erik and Boomsma, Dorret I. and Franco, Oscar H. and Bochud, Murielle and Newton-Cheh, Christopher and Munroe, Patricia B. and Elliott, Paul and Chasman, Daniel I. and Chakravarti, Aravinda and Knight, Joanne and Morris, Andrew P. and Levy, Daniel and Tobin, Martin D. and Snieder, Harold and Caulfield, Mark J. and Ehret, Georg B. and Int Consortium Blood Pressure ICBP and CHD Exome Consortium and ExomeBP Consortium and T2D-GENES Consortium and GoT2D Genes Consortium and CHARGE BP Exome Consortium and iGEN-BP Consortium and UK Biobank CardioMetab Consortium and BIOS Consortium and Lifelines Cohort Study and Understanding Soc Sci Grp/titolo:Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk/doi:10.1038%2Fng.3768/rivista:Nature genetics (Print)/anno:2017/pagina_da:403/pagina_a:415/intervallo_pagine:403–415/volume:49
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59595f613a7387760f17841723afd41
https://doi.org/10.1038/ng.3768
https://doi.org/10.1038/ng.3768
Autor:
Benjamin Voight, Guillaume Pare, Ruth Loos, Michael Preuss, Åsa Johansson, Eco De Geus, Michael Weedon, Marjo-Riitta Jarvelin, Joyce Van Meurs, Torben Jørgensen, Kirsi Pietiläinen, Nicole Glazer, Mattias Lorentzon, Braxton Mitchell, Nicole Soranzo, Patricia Munroe, Ozren Polasek, Elisabeth Thiering, Marika Kaakinen, Carla Vogel, Jennie Hui, Elina Hypponen, ROBERTO ELOSUA, Amanda Bennett, Michael Stumvoll, Andrew Hattersley, Peter P Pramstaller, Lambertus Kiemeney, Sophie Visvikis-Siest, Vilmundur Gudnason, John Whittaker, Aroon Hingorani, Thor Aspelund, Dale Nyholt, Mary Feitosa, Vimal Karani, Mika Kähönen, Lachlan Coin, Malcolm Dunlop, Josee Dupuis, Terho Lehtimäki, Peter Visscher, Katja Aben, Daniel Witte, Cyrus Cooper, Stefan Pilz, Willem Ouwehand, Eleanor Wheeler, Peter Kovacs, Debbie A Lawlor, Kevin Jacobs, Evropi Theodoratou, Hana Lango Allen, Rosanda Mulic, Rui Li, Stephen Kritchevsky, Philippe Froguel, Soumya Raychaudhuri, Cornelia Van Duijn, Andrew Wood, Chiara Lanzani, Tonu Esko, Sadaf Farooqi, Reedik Mägi, Gerard Waeber, Claes Ohlsson, André Scherag, Marcus Kleber, Thomas Meitinger, Lina Zgaga, Denise Houston, Karl Michaëlsson, Robert Weyant, Thomas Wang, Paul Elliott, Robert Luben, Albert Vernon Smith, MANUELA UDA, Gonneke Willemsen, Mark McCarthy, Cecilia Lindgren, Olle Melander, Igor Rudan, Maris Teder-Laving, Liesbeth Vandenput
Publikováno v:
Plos Medicine, 10, e1001383
PLoS Medicine
Vimaleswaran, K S, Berry, D J, Lu, C, Tikkanen, E, Pilz, S, Hiraki, L T, Cooper, J D, Dastani, Z, Li, R, Houston, D K, Wood, A R, Michaëlsson, K, Vandenput, L, Zgaga, L, Yerges-Armstrong, L M, McCarthy, M I, Dupuis, J, Kaakinen, M, Kleber, M E, Jameson, K, Arden, N, Raitakari, O, Viikari, J, Lohman, K K, Ferrucci, L, Melhus, H, Ingelsson, E, Byberg, L, Lind, L, Lorentzon, M, Salomaa, V, Campbell, H, Dunlop, M, Mitchell, B D, Herzig, K H, Pouta, A, Hartikainen, A L, Hottenga, J J, de Geus, E J C, Willemsen, G, Boomsma, D I, Penninx, B W J H, Uitterlinden, A G, Visscher, P M, van Duijn, C M, Streeten, E A, Theodoratou, E, Jula, A, Wareham, N J, Ohlsson, C, Frayling, T M, Kritchevsky, S B, Spector, T D, Richards, J B, Lehtimäki, T, Ouwehand, W H, Kraft, P, Cooper, C, März, W, Power, C, Loos, R J, Wang, T J, Järvelin, M R, Whittaker, J C, Hingorani, A D & Hyppönen, E 2013, ' Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts ', PLoS Medicine, vol. 10, no. 2, e1001383 . https://doi.org/10.1371/journal.pmed.1001383
Scopus-Elsevier
PLoS Medicine, 10(2):e1001383. Nature Publishing Group
PLoS Medicine, Vol 10, Iss 2, p e1001383 (2013)
Plos Medicine, 10, 2, pp. e1001383
PLoS Medicine, 10(2):e1001383. Public Library of Science
PLoS Med. 10:e1001383 (2013)
PLOS Medicine, vol. 10, no. 2, pp. e1001383
Vimaleswaran, K S, Berry, D J, Lu, C, Tikkanen, E, Pilz, S, Hiraki, L T, Cooper, J D, Dastani, Z, Li, R, Houston, D K, Wood, A R, Michaëlsson, K, Vandenput, L, Zgaga, L, Yerges-Armstrong, L M, McCarthy, M I, Dupuis, J, Kaakinen, M, Kleber, M E, Jameson, K, Arden, N, Raitakari, O, Viikari, J, Lohman, K K, Ferrucci, L, Melhus, H, Ingelsson, E, Byberg, L, Lind, L, Lorentzon, M, Salomaa, V, Campbell, H, Dunlop, M, Mitchell, B D, Herzig, K-H, Pouta, A, Hartikainen, A-L, Streeten, E A, Theodoratou, E, Jula, A, Wareham, N J, Ohlsson, C, Frayling, T M, Kritchevsky, S B, Spector, T D, Richards, J B, Lehtimäki, T, Ouwehand, W H & Kraft, P & Cooper, C 2013, ' Causal Relationship between Obesity and Vitamin D Status : Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts ', PLoS Medicine, vol. 10, no. 2, e1001383, pp. e1001383 . https://doi.org/10.1371/journal.pmed.1001383
PLoS Medicine
Vimaleswaran, K S, Berry, D J, Lu, C, Tikkanen, E, Pilz, S, Hiraki, L T, Cooper, J D, Dastani, Z, Li, R, Houston, D K, Wood, A R, Michaëlsson, K, Vandenput, L, Zgaga, L, Yerges-Armstrong, L M, McCarthy, M I, Dupuis, J, Kaakinen, M, Kleber, M E, Jameson, K, Arden, N, Raitakari, O, Viikari, J, Lohman, K K, Ferrucci, L, Melhus, H, Ingelsson, E, Byberg, L, Lind, L, Lorentzon, M, Salomaa, V, Campbell, H, Dunlop, M, Mitchell, B D, Herzig, K H, Pouta, A, Hartikainen, A L, Hottenga, J J, de Geus, E J C, Willemsen, G, Boomsma, D I, Penninx, B W J H, Uitterlinden, A G, Visscher, P M, van Duijn, C M, Streeten, E A, Theodoratou, E, Jula, A, Wareham, N J, Ohlsson, C, Frayling, T M, Kritchevsky, S B, Spector, T D, Richards, J B, Lehtimäki, T, Ouwehand, W H, Kraft, P, Cooper, C, März, W, Power, C, Loos, R J, Wang, T J, Järvelin, M R, Whittaker, J C, Hingorani, A D & Hyppönen, E 2013, ' Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts ', PLoS Medicine, vol. 10, no. 2, e1001383 . https://doi.org/10.1371/journal.pmed.1001383
Scopus-Elsevier
PLoS Medicine, 10(2):e1001383. Nature Publishing Group
PLoS Medicine, Vol 10, Iss 2, p e1001383 (2013)
Plos Medicine, 10, 2, pp. e1001383
PLoS Medicine, 10(2):e1001383. Public Library of Science
PLoS Med. 10:e1001383 (2013)
PLOS Medicine, vol. 10, no. 2, pp. e1001383
Vimaleswaran, K S, Berry, D J, Lu, C, Tikkanen, E, Pilz, S, Hiraki, L T, Cooper, J D, Dastani, Z, Li, R, Houston, D K, Wood, A R, Michaëlsson, K, Vandenput, L, Zgaga, L, Yerges-Armstrong, L M, McCarthy, M I, Dupuis, J, Kaakinen, M, Kleber, M E, Jameson, K, Arden, N, Raitakari, O, Viikari, J, Lohman, K K, Ferrucci, L, Melhus, H, Ingelsson, E, Byberg, L, Lind, L, Lorentzon, M, Salomaa, V, Campbell, H, Dunlop, M, Mitchell, B D, Herzig, K-H, Pouta, A, Hartikainen, A-L, Streeten, E A, Theodoratou, E, Jula, A, Wareham, N J, Ohlsson, C, Frayling, T M, Kritchevsky, S B, Spector, T D, Richards, J B, Lehtimäki, T, Ouwehand, W H & Kraft, P & Cooper, C 2013, ' Causal Relationship between Obesity and Vitamin D Status : Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts ', PLoS Medicine, vol. 10, no. 2, e1001383, pp. e1001383 . https://doi.org/10.1371/journal.pmed.1001383
A mendelian randomization study based on data from multiple cohorts conducted by Karani Santhanakrishnan Vimaleswaran and colleagues re-examines the causal nature of the relationship between vitamin D levels and obesity.
Background Obesity is as
Background Obesity is as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114ff45c9f3c5ccc860e181b421b1f0e
Autor:
Okada, Y, Sim, X, Go, Mj, Wu, Jy, Gu, D, Takeuchi, F, Takahashi, A, Maeda, S, Tsunoda, T, Chen, P, Lim, Sc, Wong, Ty, Liu, J, Young, Tl, Aung, T, Seielstad, M, Teo, Yy, Kim, Yj, Lee, Jy, Han, Bg, Kang, D, Chen, Ch, Tsai, Fj, Chang, Lc, Fann, Sj, Mei, H, Rao, Dc, Hixson, Je, Chen, S, Katsuya, T, Isono, M, Ogihara, T, Chambers, Jc, Zhang, W, Kooner, Js, Kidneygen, Consortium, Ckdgen, Consortium, Albrecht, E, Gugc, Consortium, Yamamoto, K, Kubo, M, Nakamura, Y, Kamatani, N, Kato, N, He, J, Chen, Yt, Cho, Ys, Tai, Es, Tanaka, T., Lord, Gm, van der Harst, P, Lawlor, Da, Sehmi, Js, Gale, Dp, Wass, Mn, Ahmadi, Kr, Bakker, Sj, Beckmann, J, Bilo, Hj, Bochud, M, Brown, Mj, Caulfield, Mj, Connell, Jm, Cook, Ht, Cotlarciuc, I, Smith, Gd, de Silva, R, Deng, G, Devuyst, O, Dikkeschei, Ld, Dimkovic, N, Dockrell, M, Dominiczak, A, Ebrahim, S, Eggermann, T, Farrall, M, Ferrucci, L, Floege, J, Forouhi, Ng, Gansevoort, Rt, Han, X, Hedblad, B, van der Heide JJ, Hepkema, Bg, Hernandez Fuentes, M, Hypponen, E, Johnson, T, de Jong PE, Kleefstra, N, Lagou, V, Lapsley, M, Li, Y, Loos, Rj, Luan, J, Luttropp, K, Maréchal, C, Melander, O, Munroe, Pb, Nordfors, L, Parsa, A, Peltonen, L, Penninx, Bw, Perucha, E, Pouta, A, Prokopenko, I, Roderick, Pj, Ruokonen, A, Samani, Nj, Sanna, S, Schalling, M, Schlessinger, D, Schlieper, G, Seelen, Ma, Shuldiner, Ar, Sjögren, M, Smit, Jh, Snieder, H, Soranzo, N, Spector, Td, Stenvinkel, P, Sternberg, Mj, Swaminathan, R, Tanaka, T, Ubink Veltmaat LJ, Uda, M, Vollenweider, P, Wallace, C, Waterworth, D, Zerres, K, Waeber, G, Wareham, Nj, Maxwell, Ph, Mccarthy, Mi, Jarvelin, Mr, Mooser, V, Abecasis, Gr, Lightstone, L, Scott, J, Navis, G, Elliott, P, Köttgen, A, Pattaro, C, Böger, Ca, Fuchsberger, C, Olden, M, Glazer, Nl, Gao, X, Yang, Q, Smith, Av, O'Connell, Jr, Li, M, Schmidt, H, Isaacs, A, Ketkar, S, Hwang, Sj, Johnson, Ad, Dehghan, A, Teumer, A, Paré, G, Atkinson, Ej, Zeller, T, Lohman, K, Cornelis, Mc, Probst Hensch NM, Kronenberg, F, Tönjes, A, Hayward, C, Aspelund, T, Eiriksdottir, G, Launer, Lj, Harris, Tb, Rampersaud, E, Mitchell, Bd, Arking, De, Boerwinkle, E, Struchalin, M, Cavalieri, M, Singleton, A, Giallauria, F, Metter, J, de Boer IH, Haritunians, T, Lumley, T, Siscovick, D, Psaty, Bm, Zillikens, Mc, Oostra, Ba, Feitosa, M, Province, M, de Andrade, M, Turner, St, Schillert, A, Ziegler, A, Wild, Ps, Schnabel, Rb, Wilde, S, Munzel, Tf, Leak, Ts, Illig, T, Klopp, N, Meisinger, C, Wichmann, He, Koenig, W, Zgaga, L, Zemunik, T, Kolcic, I, Minelli, C, Hu, Fb, Johansson, Å, Igl, W, Zaboli, G, Wild, Sh, Wright, Af, Campbell, H, Ellinghaus, D, Schreiber, S, Aulchenko, Ys, Felix, Jf, Rivadeneira, F, Uitterlinden, Ag, Hofman, A, Imboden, M, Nitsch, D, Brandstätter, A, Kollerits, B, Kedenko, L, Mägi, R, Stumvoll, M, Kovacs, P, Boban, M, Campbell, S, Endlich, K, Völzke, H, Kroemer, Hk, Nauck, M, Völker, U, Polasek, O, Vitart, V, Badola, S, Parker, An, Ridker, Pm, Kardia, Sl, Blankenberg, S, Liu, Y, Curhan, Gc, Franke, A, Rochat, T, Paulweber, B, Wang, W, Gudnason, V, Coresh, J, Schmidt, R, Shlipak, Mg, van Duijn CM, Borecki, I, Krämer, Bk, Rudan, I, Gyllensten, U, Wilson, Jf, Witteman, Jc, Pramstaller, Pp, Rettig, R, Hastie, N, Chasman, Di, Kao, Wh, Heid, Im, Fox, Cs, Krumsiek, J, Hundertmark, C, Pistis, G, Ruggiero, D, O'Seaghdha, M, Haller, T, Kutalik, Z, Shi, J, Middelberg, Ps, Gaffo, Al, Pirastu, N, Li, G, Huffman, J, Yengo, L, Zhao, Jh, Demirkan, A, Feitosa, Mf, Liu, X, Malerba, Giovanni, Lopez, Lm, Li, X, Kleber, Me, Hicks, Aa, Nolte, Im, Johansson, A, Murgia, F, Peden, Jf, Steri, M, Tenesa, A, Salo, P, Mangino, M, Rose, Lm, Lehtimäki, T, Woodward, Om, Tin, A, Müller, C, Oldmeadow, C, Putku, M, Czamara, D, Kraft, P, Frogheri, L, Thun, Ga, Grotevendt, A, Gislason, Gk, Mcardle, P, Schallert, M, Martin, Ng, Montgomery, Gw, Jacobs DR Jr, Liu, K, D'Adamo, P, Ulivi, S, Rotter, Ji, Navaro, P, Balkau, B, Froguel, P, Esko, T, Salumets, A, Khaw, Kt, Langenberg, C, Kraja, A, Zhang, Q, Scott, Rj, Holliday, Eg, Org, E, Viigimaa, M, Bandinelli, S, Metter, Je, Lupo, Antonio, Trabetti, Elisabetta, Sorice, R, Döring, A, Lattka, E, Strauch, K, Theis, F, Waldenberger, M, Davies, G, Gow, Aj, Bruinenberg, M, Stolk, Rp, Winkelmann, Br, Boehm, Bo, Lucae, S, Curhan, G, Mudgal, P, Plenge, Rm, Portas, L, Persico, I, Kirin, M, Mateo Leach, I, van Gilst WH, Goel, A, Ongen, H, von Eckardstein, A, Cucca, F, Nagaraja, R, Piras, Mg, Schurmann, C, Budde, K, Ernst, F, Farrington, Sm, Theodoratou, E, Jula, A, Perola, M, Salomaa, V, Shin, Sy, Sala, C, Kähönen, M, Viikari, J, Hengstenberg, C, Nelson, Cp, Meschia, Jf, Nalls, Ma, Sharma, P, Singleton, Ab, Burnier, M, Attia, J, Laan, M, Hillege, Hl, Kloiber, S, Choi, H, Pirastu, M, Tore, S, Whitfield, Jb, Fornage, M, Gasparini, P, Siscovick, Ds, Bouatia Naji, N, Metspalu, A, Borecki, Ib, Gambaro, G, Deary, Ij, Wolffenbuttel, Bh, März, W, Watkins, H, Schipf, S, Dunlop, Mg, Ripatti, S, Toniolo, D, Raitakari, O, Ciullo, M, Caulfield, M, Gieger, C.
Publikováno v:
Nature genetics, vol. 44, no. 8, pp. 904-909
Nature Genetics, 44(8), 904-+. Nature Publishing Group
Nature Genetics, 44(8), 904-+. Nature Publishing Group
Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genomewide assoc