Zobrazeno 1 - 10
of 459
pro vyhledávání: '"Anna Mae Diehl"'
Autor:
Fabian Heinemann, Peter Gross, Svetlana Zeveleva, Hu Sheng Qian, Jon Hill, Anne Höfer, Danny Jonigk, Anna Mae Diehl, Manal Abdelmalek, Martin C. Lenter, Steven S. Pullen, Paolo Guarnieri, Birgit Stierstorfer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Non-alcoholic fatty liver disease (NAFLD) affects about 24% of the world's population. Progression of early stages of NAFLD can lead to the more advanced form non-alcoholic steatohepatitis (NASH), and ultimately to cirrhosis or liver cancer.
Externí odkaz:
https://doaj.org/article/d03e21bdb66a47cf83dafba82490bd38
Autor:
Tinsay A. Woreta, Mark L. Van Natta, Mariana Lazo, Arunkumar Krishnan, Brent A. Neuschwander-Tetri, Rohit Loomba, Anna Mae Diehl, Manal F. Abdelmalek, Naga Chalasani, Samer Gawrieh, Srinivasan Dasarathy, Raj Vuppalanchi, Mohammad S. Siddiqui, Kris V. Kowdley, Arthur McCullough, Norah A. Terrault, Cynthia Behling, David E. Kleiner, Mark Fishbein, Paula Hertel, Laura A. Wilson, Emily P. Mitchell, Laura A. Miriel, Jeanne M. Clark, James Tonascia, Arun J. Sanyal, for the NASH Clinical Research Network
Publikováno v:
PLoS ONE, Vol 17, Iss 4 (2022)
Background and aims Management of patients with NASH who are at elevated risk of progressing to complications of cirrhosis (at-risk NASH) would be enhanced by an accurate, noninvasive diagnostic test. The new FAST™ score, a combination of FibroScan
Externí odkaz:
https://doaj.org/article/3774c2ebe409441cbe22e53a5e30eba8
Publikováno v:
JCI Insight, Vol 5, Iss 22 (2020)
Adult liver has enormous regenerative capacity; it can regenerate after losing two-thirds of its mass while sustaining essential metabolic functions. How the liver balances dual demands for increased proliferative activity with maintenance of organ f
Externí odkaz:
https://doaj.org/article/dcda33acc6254bc694933c95496be6d5
Autor:
Ko Maung, Sendhilnathan Ramalingam, Mohammad Chaudhry, Yi Ren, Sin-Ho Jung, Kristi Romero, Kelly Corbet, Nelson J Chao, Taewoong Choi, Anna Mae Diehl, Louis Diehl, Cristina Gasparetto, Mitchell Horwitz, Gwynn Douglas Long, Richard D Lopez, David A Rizzieri, Stefanie Sarantopoulos, Keith M Sullivan, Mustafa R Bashir, Anthony D Sung
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238824 (2020)
Allogeneic-HCT (allo-HCT), while potentially curative, can result in significant complications including graft versus host disease (GVHD). Prior studies suggest that metabolic syndrome may be one risk factor for GVHD. We hypothesized that hepatic ste
Externí odkaz:
https://doaj.org/article/ebf9b78ac6c540739ed63938ecd872d4
Autor:
Jieun Kim, Jeongeun Hyun, Sihyung Wang, Chanbin Lee, Jae-Wook Lee, Eun-Yi Moon, Heejae Cha, Anna Mae Diehl, Youngmi Jung
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract The molecular mechanisms of thymosin beta-4 (TB4) involved in regulating hepatic stellate cell (HSC) functions remain unclear. Therefore, we hypothesize that TB4 influences HSC activation through hedgehog (Hh) pathway. HSC functions declined
Externí odkaz:
https://doaj.org/article/de1193bb16be4930b317ead645d89755
Autor:
Kara Wegermann, Ricardo Henao, Anna Mae Diehl, Susan K Murphy, Manal F Abdelmalek, Cynthia A Moylan
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204308 (2018)
BACKGROUND AND OBJECTIVES:Although the burden of non-alcoholic fatty liver disease (NAFLD) continues to increase worldwide, genetic factors predicting progression to cirrhosis and decompensation in NAFLD remain poorly understood. We sought to determi
Externí odkaz:
https://doaj.org/article/caba766bc364413c8f5cba9619c0a480
Autor:
Mariana Verdelho Machado, Gregory Alexander Michelotti, Guanhua Xie, Thiago Pereira de Almeida, Jerome Boursier, Brittany Bohnic, Cynthia D Guy, Anna Mae Diehl
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0132315 (2015)
Externí odkaz:
https://doaj.org/article/883a0922c13d4b01a43173b36eef9f15
Autor:
Mariana Verdelho Machado, Gregory Alexander Michelotti, Guanhua Xie, Thiago Almeida Pereira, Jerome Boursier, Brittany Bohnic, Cynthia D Guy, Anna Mae Diehl
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127991 (2015)
Non-alcoholic steatohepatitis (NASH), the potentially progressive form of nonalcoholic fatty liver disease (NAFLD), is the pandemic liver disease of our time. Although there are several animal models of NASH, consensus regarding the optimal model is
Externí odkaz:
https://doaj.org/article/c16fccce6b5542afaa24c0d18fe3aaa2
Autor:
Sahar Pourhoseini, Ratanesh Kumar Seth, Suvarthi Das, Diptadip Dattaroy, Maria B Kadiiska, Guanhua Xie, Gregory A Michelotti, Mitzi Nagarkatti, Anna Mae Diehl, Saurabh Chatterjee
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0116780 (2015)
Sinusoidal endothelial dysfunction (SED) has been found to be an early event in nonalcoholic steatohepatitis (NASH) progression but the molecular mechanisms underlying its causation remains elusive. We hypothesized that adipokine leptin worsens sinus
Externí odkaz:
https://doaj.org/article/bc6886eb254b42b69ee1d751665f6df6
Autor:
Gamze Karaca, Marzena Swiderska-Syn, Guanhua Xie, Wing-Kin Syn, Leandi Krüger, Mariana Verdelho Machado, Katherine Garman, Steve S Choi, Gregory A Michelotti, Linda C Burkly, Begoña Ochoa, Anna Mae Diehl
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83987 (2014)
Pro-inflammatory cytokines are important for liver regeneration after partial hepatectomy (PH). Expression of Fibroblast growth factor-inducible 14 (Fn14), the receptor for TNF-like weak inducer of apoptosis (TWEAK), is induced rapidly after PH and r
Externí odkaz:
https://doaj.org/article/f3b2fa19edd2491e96cb68d9232fcb0a