Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Abigail Ngoepe"'
Autor:
Robert Krause, Jumari Snyman, Hwa Shi-Hsia, Daniel Muema, Farina Karim, Yashica Ganga, Abigail Ngoepe, Yenzekile Zungu, Inbal Gazy, Mallory Bernstein, Khadija Khan, Matilda Mazibuko, Ntombifuthi Mthabela, Dirhona Ramjit, COMMIT-KZN Team, Oliver Limbo, Joseph Jardine, Devin Sok, Ian A Wilson, Willem Hanekom, Alex Sigal, Henrik Kløverpris, Thumbi Ndung'u, Alasdair Leslie
Publikováno v:
eLife, Vol 11 (2022)
Background: HIV infection dysregulates the B cell compartment, affecting memory B cell formation and the antibody response to infection and vaccination. Understanding the B cell response to SARS-CoV-2 in people living with HIV (PLWH) may explain the
Externí odkaz:
https://doaj.org/article/9e85d121845c4a7ba7f4e109a7030fe9
Autor:
Rabiah Fardoos, Osaretin E. Asowata, Nicholas Herbert, Sarah K. Nyquist, Yenzekile Zungu, Alveera Singh, Abigail Ngoepe, Ian M. Mbano, Ntombifuthi Mthabela, Dirhona Ramjit, Farina Karim, Warren Kuhn, Fusi G. Madela, Vukani T. Manzini, Frank Anderson, Bonnie Berger, Tune H. Pers, Alex K. Shalek, Alasdair Leslie, Henrik N. Kløverpris
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
SARS-CoV-2 infects epithelial cells of the human gastrointestinal (GI) tract and causes related symptoms. HIV infection impairs gut homeostasis and is associated with an increased risk of COVID-19 fatality. To investigate the potential link between t
Externí odkaz:
https://doaj.org/article/393306dcc3c24409b817c7996c447f25
Autor:
Osaretin E. Asowata, Alveera Singh, Abigail Ngoepe, Nicholas Herbert, Rabiah Fardoos, Kavidha Reddy, Yenzekile Zungu, Faith Nene, Ntombifuthi Mthabela, Dirhona Ramjit, Farina Karim, Katya Govender, Thumbi Ndung’u, J. Zachary Porterfield, John H. Adamson, Fusi G. Madela, Vukani T. Manzini, Frank Anderson, Alasdair Leslie, Henrik N. Kløverpris
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
HIV infection in the human gastrointestinal (GI) tract is thought to be central to HIV progression, but knowledge of this interaction is primarily limited to cohorts within Westernized countries. Here, we present a large cohort recruited from high HI
Externí odkaz:
https://doaj.org/article/37e416fff28f48b7afb827c4e765515f
Autor:
Khadija Khan, Gila Lustig, Farina Karim, Bernadett I Gosnell, Suzaan Marais, Prakash Jeena, Rohen Harrichandparsad, Anne Derache, Sandile Cele, Mahomed-Yunus S. Moosa, Ravindra K. Gupta, Katya Govender, Alex Sigal, Ntombi Ntshuba, Abigail Ngoepe, Vinod B. Patel, John H. Adamson, Henrik N. Kløverpris
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009871 (2021)
Lustig, G, Cele, S, Karim, F, Derache, A, Ngoepe, A, Khan, K, Gosnell, B I, Moosa, M Y S, Ntshuba, N, Marais, S, Jeena, P M, Govender, K, Adamson, J, Kløverpris, H, Gupta, R K, Harrichandparsad, R, Patel, V B & Sigal, A 2021, ' T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy ', PLOS Pathogens, vol. 17, no. 9, e1009871 . https://doi.org/10.1371/journal.ppat.1009871
PLoS Pathogens
Lustig, G, Cele, S, Karim, F, Derache, A, Ngoepe, A, Khan, K, Gosnell, B I, Moosa, M Y S, Ntshuba, N, Marais, S, Jeena, P M, Govender, K, Adamson, J, Kløverpris, H, Gupta, R K, Harrichandparsad, R, Patel, V B & Sigal, A 2021, ' T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy ', PLOS Pathogens, vol. 17, no. 9, e1009871 . https://doi.org/10.1371/journal.ppat.1009871
PLoS Pathogens
HIV cerebrospinal fluid (CSF) escape, where HIV is suppressed in blood but detectable in CSF, occurs when HIV persists in the CNS despite antiretroviral therapy (ART). To determine the virus producing cell type and whether lowered CSF ART levels are
Autor:
Alessandra Nardin, Rajhmun Madansein, Amanda Ardain, Khadija Khan, Kaylesh J. Dullabh, Alveera Singh, Taryn Naidoo, Alessandro Sette, Farina Karim, Samuel M. Behar, Alasdair Leslie, Paul T. Elkington, Liku B. Tezera, Duran Ramsuran, Michael G. Fehlings, Abigail Ngoepe, Paul Ogongo, Cecilia S. Lindestam Arlehamn, Henrik N. Kløverpris, Shepherd Nhamoyebonde, Adrie J. C. Steyn, Boon Heng Lee
Publikováno v:
The Journal of Clinical Investigation
Ogongo, P, Tezera, L B, Ardain, A, Nhamoyebonde, S, Ramsuran, D, Singh, A, Ng’oepe, A, Karim, F, Naidoo, T, Khan, K, Dullabh, K J, Fehlings, M, Lee, B H, Nardin, A, Lindestam Arlehamn, C S, Sette, A, Behar, S M, Steyn, A J C, Madansein, R, Kløverpris, H N, Elkington, P T & Leslie, A 2021, ' Tissue-resident-like CD4 + T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung ', Journal of Clinical Investigation, vol. 131, no. 10, e142014 . https://doi.org/10.1172/JCI142014
Ogongo, P, Tezera, L B, Ardain, A, Nhamoyebonde, S, Ramsuran, D, Singh, A, Ng’oepe, A, Karim, F, Naidoo, T, Khan, K, Dullabh, K J, Fehlings, M, Lee, B H, Nardin, A, Lindestam Arlehamn, C S, Sette, A, Behar, S M, Steyn, A J C, Madansein, R, Kløverpris, H N, Elkington, P T & Leslie, A 2021, ' Tissue-resident-like CD4 + T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung ', Journal of Clinical Investigation, vol. 131, no. 10, e142014 . https://doi.org/10.1172/JCI142014
T cell immunity is essential for the control of tuberculosis (TB), an important disease of the lung, and is generally studied in humans using peripheral blood cells. Mounting evidence, however, indicates that tissue-resident memory T cells (Trms) are
Autor:
Alasdair Leslie, Nicholas Herbert, Henrik N. Kløverpris, Alveera Singh, Fusi G. Madela, Thumbi Ndung'u, Vukani T. Manzini, Katya Govender, Ntombifuthi Mthabela, Kavidha Reddy, Frank Anderson, Farina Karim, John H. Adamson, Yenzekile Zungu, Faith Nene, Rabiah Fardoos, J Zachary Porterfield, Abigail Ngoepe, Dirhona Ramjit, Osaretin E. Asowata
Publikováno v:
JCI Insight
Asowata, O E, Singh, A, Ngoepe, A, Herbert, N, Fardoos, R, Reddy, K, Zungu, Y, Nene, F, Mthabela, N, Ramjit, D, Karim, F, Govender, K, Ndung’u, T, Zachary Porterfield, J, Adamson, J H, Madela, F G, Manzini, V T, Anderson, F, Leslie, A & Kløverpris, H N 2021, ' Irreversible depletion of intestinal CD4 + T cells is associated with T cell activation during chronic HIV infection ', JCI insight, vol. 6, no. 22, e146162 . https://doi.org/10.1172/jci.insight.146162
JCI Insight.
Asowata, O E, Singh, A, Ngoepe, A, Herbert, N, Fardoos, R, Reddy, K, Zungu, Y, Nene, F, Mthabela, N, Ramjit, D, Karim, F, Govender, K, Ndung’u, T, Zachary Porterfield, J, Adamson, J H, Madela, F G, Manzini, V T, Anderson, F, Leslie, A & Kløverpris, H N 2021, ' Irreversible depletion of intestinal CD4 + T cells is associated with T cell activation during chronic HIV infection ', JCI insight, vol. 6, no. 22, e146162 . https://doi.org/10.1172/jci.insight.146162
JCI Insight.
HIV infection in the human gastrointestinal (GI) tract is thought to be central to HIV progression, but knowledge of this interaction is primarily limited to cohorts within Westernized countries. Here, we present a large cohort recruited from high HI
Autor:
Warren Kuhn, Duran Ramsuran, Maximilian Muenchhoff, Philip J. R. Goulder, Jane Millar, Alasdair Leslie, J Roider, Alex K. Shalek, Thumbi Ndung'u, Henrik N. Kløverpris, Osaretin E. Asowata, Kami C. Krista, Samuel W. Kazer, Amanda Ardain, Farina Karim, Abigail Ngoepe, Rabiah Fardoos, Alveera Singh
Publikováno v:
Cell Reports
Singh, A, Kazer, S W, Roider, J, Krista, K C, Millar, J, Asowata, O E, Ngoepe, A, Ramsuran, D, Fardoos, R, Ardain, A, Muenchhoff, M, Kuhn, W, Karim, F, Ndung'u, T, Shalek, A K, Goulder, P, Leslie, A & Kløverpris, H N 2020, ' Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy ', Cell Reports, vol. 32, no. 11, 108153 . https://doi.org/10.1016/j.celrep.2020.108153
Singh, A, Kazer, S W, Roider, J, Krista, K C, Millar, J, Asowata, O E, Ngoepe, A, Ramsuran, D, Fardoos, R, Ardain, A, Muenchhoff, M, Kuhn, W, Karim, F, Ndung'u, T, Shalek, A K, Goulder, P, Leslie, A & Kløverpris, H N 2020, ' Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy ', Cell Reports, vol. 32, no. 11, 108153 . https://doi.org/10.1016/j.celrep.2020.108153
Summary Innate lymphoid cells (ILCs) are important for response to infection and for immune development in early life. HIV infection in adults depletes circulating ILCs, but the impact on children infected from birth remains unknown. We study vertica
Autor:
Julia Roider, Abigail Ngoepe, Maximilian Muenchhoff, Emily Adland, Andreas Groll, Thumbi Ndung'u, Henrik Kløverpris, Philip Goulder, Alasdair Leslie
Publikováno v:
Frontiers in immunology
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Roider, J, Ngoepe, A, Muenchhoff, M, Adland, E, Groll, A, Ndung'u, T, Kløverpris, H, Goulder, P & Leslie, A 2019, ' Increased regulatory T-cell activity and enhanced T-cell homeostatic signaling in slow progressing HIV-infected children ', Frontiers in Immunology, vol. 10, no. FEB, 213 . https://doi.org/10.3389/fimmu.2019.00213
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Roider, J, Ngoepe, A, Muenchhoff, M, Adland, E, Groll, A, Ndung'u, T, Kløverpris, H, Goulder, P & Leslie, A 2019, ' Increased regulatory T-cell activity and enhanced T-cell homeostatic signaling in slow progressing HIV-infected children ', Frontiers in Immunology, vol. 10, no. FEB, 213 . https://doi.org/10.3389/fimmu.2019.00213
Pediatric slow progressors (PSP) are rare ART-naïve, HIV-infected children who maintain high CD4 T-cell counts and low immune activation despite persistently high viral loads. Using a well-defined cohort of PSP, we investigated the role of regulator
Autor:
Rabiah Fardoos, Alasdair Leslie, Amanda Ardain, Alex K. Shalek, Duran Ramsuran, Alveera Singh, Jane Millar, Warren Kuhn, Thumbi Ndung'u, Henrik N. Kløverpris, Farina Karim, Osaretin E. Asowata, Philip J. R. Goulder, Julia Roider, Abigail Ngoepe, Kami C. Krista, Samuel W. Kazer, Maximilian Muenchhoff
Publikováno v:
SSRN Electronic Journal.
Innate lymphoid cells (ILCs) are important for response to infection and immune development in early life. HIV infection in adults has a profound effect on ILCs, but the impact from birth is unknown. Here we studied vertically HIV infected children f
Autor:
Julia Roider, Takashi Maehara, Abigail Ngoepe, Duran Ramsuran, Maximilian Muenchhoff, Emily Adland, Toby Aicher, Samuel W. Kazer, Pieter Jooste, Farina Karim, Warren Kuhn, Alex K. Shalek, Thumbi Ndung'u, Lynn Morris, Penny L. Moore, Shiv Pillai, Henrik Kløverpris, Philip Goulder, Alasdair Leslie
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Frontiers in immunology
Frontiers
Roider, J, Maehara, T, Ngoepe, A, Ramsuran, D, Muenchhoff, M, Adland, E, Aicher, T, Kazer, S W, Jooste, P, Karim, F, Kuhn, W, Shalek, A K, Ndung'u, T, Morris, L, Moore, P L, Pillai, S, Kløverpris, H, Goulder, P & Leslie, A 2018, ' High-frequency, functional HIV-specific T-follicular helper and regulatory cells are present within germinal centers in children but not adults ', Frontiers in Immunology, vol. 9, 1975 . https://doi.org/10.3389/fimmu.2018.01975
Frontiers in immunology
Frontiers
Roider, J, Maehara, T, Ngoepe, A, Ramsuran, D, Muenchhoff, M, Adland, E, Aicher, T, Kazer, S W, Jooste, P, Karim, F, Kuhn, W, Shalek, A K, Ndung'u, T, Morris, L, Moore, P L, Pillai, S, Kløverpris, H, Goulder, P & Leslie, A 2018, ' High-frequency, functional HIV-specific T-follicular helper and regulatory cells are present within germinal centers in children but not adults ', Frontiers in Immunology, vol. 9, 1975 . https://doi.org/10.3389/fimmu.2018.01975
Broadly neutralizing antibodies (bnAbs) against HIV-1 are an effective means of preventing transmission. To better understand the mechanisms by which HIV-specific bnAbs naturally develop, we investigated blood and lymphoid tissue in pediatric infecti