Zobrazeno 1 - 10
of 65
pro vyhledávání: '"ZHAO LI"'
Publikováno v:
Journal of Separation Science. 44:3799-3809
Herba Lysimachiae inhibits synovial damage in osteoarthritis via regulating two biolabels (integrin alpha 2b/beta 3). However, the relevant active ingredients are still unknown. Here, the active ingredients of herbal medicines were analyzed based on
Autor:
Zhao Li, Wen-Jun Duan, Hai-Zhi Liu, Xiao-Xiao Li, Yu-Lin Guo, Dan-Hua Lu, Rong-Rong He, Xiao-Hui Ma, Yi-Fang Li, Hiroshi Kurihara, Wei Bi
Publikováno v:
Acta Pharmacol Sin
GM1 ganglioside is particularly abundant in the mammalian central nervous system and has shown beneficial effects on neurodegenerative diseases. In this study, we investigated the therapeutic effect of GM1 ganglioside in experimental models of Parkin
Autor:
Yunbo Sun, Peng Ruiyun, Yu Chao, Shuchen Liu, Chen Junjun, Jing Zhang, Xueyan Zhang, Hui Wang, Hongmei Zhou, Wang Haoyu, Yao Binwei, Ji Dong, Zhao Li, Xu Xinping
Publikováno v:
Environmental Science and Pollution Research. 27:40787-40794
Studies from our group and others have reported that 30 mW/cm2 microwave could damage the structures of rat hippocampus, as well as impair the neuronal functions. The neuroprotective effects of astragaloside, purified from Astragalus membranaceus, ha
Autor:
Xuemei Deng, Yong-Xing He, Weifan Jiang, Tao Shi, Zhen Wang, Hanzhong Feng, Dan Liu, Honghua Zhang, Yingmei Lu, Yiyue Feng, Jian Zhang, Junfang Li, Zhao Li
Publikováno v:
European journal of medicinal chemistry. 227
Although gastric cancer has become a major public health problem, oral agents applied in clinics for gastric cancer therapy are scarce. Therefore, to explore new oral chemical entities with high efficiency and low toxicity, 41 o-aminobenzamide deriva
RIP3/MLKL pathway‐regulated necroptosis: A new mechanism of paclitaxel‐induced peripheral neuropathy
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 35
Paclitaxel (PTX) chemotherapy treatment often leads to neuropathic pain, which is resistant to available analgesic treatments. Death of cells and neuroinflammatory response are associated with PTX-induced peripheral neuropathy (PIPN). Necroptosis is
Publikováno v:
International Journal of Molecular Medicine
Epigallocatechin-3-gallate (EGCG) has been demonstrated to exhibit anticancer effects; however, the mechanisms behind these are not yet clear. The objective of the present study was to assess the effect of EGCG on smoking-induced, precancerous, bronc
Autor:
Xiao-Yang Zhang, Jian-Jun Wang, Guang-Ying Li, Hong-Zhao Li, Chang-Zheng Zhang, Qian-Xing Zhuang, Kang Xi, Jing-Ning Zhu, Bin Li
Publikováno v:
Journal of Clinical Investigation. 128:5413-5427
The subthalamic nucleus (STN) is an effective therapeutic target for deep brain stimulation (DBS) for Parkinson's disease (PD), and histamine levels are elevated in the basal ganglia in PD patients. However, the effect of endogenous histaminergic mod
Autor:
Tao Sun, Hongju Zhang, Su Wang, Yutong Cheng, Zhao Li, Chengqian Yin, Zhi-Zhong Li, Jingmei Zhang, Ying Tao
Publikováno v:
Journal of Cellular Biochemistry. 120:3709-3715
Acute statin treatment has been reported to be critical in protecting the cardiac cells against ischemia/reperfusion injury by activating PI3K/Akt signal pathway. In vitro rat myocardial ischemia/reperfusion model, chronic statin treatment led to upr
Publikováno v:
Brazilian Journal of Medical and Biological Research v.54 n.5 2021
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Vol 54, Iss 5 (2021)
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Vol 54, Iss 5 (2021)
This study aimed to explore the effect of microRNA (miR)-146a inhibition on regulating cell apoptosis, total neurite outgrowth, inflammation, and STAT1/MYC pathway in Alzheimer's disease (AD). PC12 and cortical neuron cellular AD models were construc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956986fe75a06310cafc9b248896731a
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021000500604
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021000500604
Autor:
Yiyue Feng, Xiaoling Hu, Tao Shi, Zhen Wang, Zhao Li, Honghua Zhang, Weifan Jiang, Junfang Li, Yingmei Lu
Publikováno v:
European Journal of Medicinal Chemistry. 227:113908
Highly efficacious and tolerable agents for the treatment of glioblastoma (GBM), the most common and aggressive primary brain tumor, are urgently needed. Herein, we reveal the design, synthesis and biological evaluation of several piperazine based be