Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jain R"'
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Metronomic dosing of chemotherapy - defined as frequent administration at lower doses - has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in the clinic. Although multiple
Publikováno v:
Cancer research
The stress harbored by the solid phase of tumors is known as solid stress. Solid stress can be either applied externally by the surrounding normal tissue or induced by the tumor itself due to its growth. Fluid pressure is the isotropic stress exerted
Autor:
Baish, J. W., Stylianopoulos, T., Lanning, R. M., Kamoun, W. S., Fukumura, D., Munn, L. L., Jain, R. K.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Delivery of blood-borne molecules and nanoparticles from the vasculature to cells in the tissue differs dramatically between tumor and normal tissues due to differences in their vascular architectures. Here we show that two simple measures of vascula
Publikováno v:
Clinical Cancer Research
Purpose: Although oncolytic viral vectors show promise for the treatment of various cancers, ineffective initial distribution and propagation throughout the tumor mass often limit the therapeutic response. A mathematical model is developed to describ
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Addition of anti-VEGF antibody therapy to standard chemotherapies has improved survival and is an accepted standard of care for advanced non-small cell lung cancer (NSCLC). However, the mechanisms by which anti-VEGF therapy increases survival remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb26439ae3e59779b8c80155a43f87b8
http://gnosis.library.ucy.ac.cy/handle/7/48319
http://gnosis.library.ucy.ac.cy/handle/7/48319
Publikováno v:
Cancer research
In solid tumors, angiogenesis occurs in the setting of a defective vasculature and impaired lymphatic drainage that is associated with increased vascular permeability and enhanced tumor permeability. These universal aspects of the tumor microenvironm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c6a59099939ffa8eb56488db65d06c
https://europepmc.org/articles/PMC3876035/
https://europepmc.org/articles/PMC3876035/
Autor:
Stylianopoulos, T., Jain, R. K.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Blood perfusion in tumors can be significantly lower than that in the surrounding normal tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion reduces oxygen supply and results in a hypoxic microenvironment. Hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59661ae901d22c2be908cf361bbc509
https://europepmc.org/articles/PMC3832007/
https://europepmc.org/articles/PMC3832007/
Autor:
Stylianopoulos, T., Martin, J. D., Chauhan, V. P., Jain, S. R., Diop-Frimpong, B., Bardeesy, N., Smith, B. L., Ferrone, C. R., Hornicek, F. J., Boucher, Y., Munn, L. L., Jain, R. K.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress intratumoral lymphatic and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05428f95247ff422d39554eb53c974f
http://gnosis.library.ucy.ac.cy/handle/7/48862
http://gnosis.library.ucy.ac.cy/handle/7/48862
Autor:
Vakoc, B. J., Lanning, R. M., Tyrrell, J. A., Padera, T. P., Bartlett, L. A., Stylianopoulos, T., Munn, L. L., Tearney, G. J., Fukumura, D., Jain, R. K., Bouma, Brett E.
Publikováno v:
Nature medicine
Intravital multiphoton microscopy has provided powerful mechanistic insights into health and disease and has become a common instrument in the modern biological laboratory. The requisite high numerical aperture and exogenous contrast agents that enab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e44b002327ce516e1512b32ccb9c18c
http://gnosis.library.ucy.ac.cy/handle/7/48913
http://gnosis.library.ucy.ac.cy/handle/7/48913
Autor:
Chauhan, V., Boucher, Y., Ferrone, C., Roberge, S., Martin, J., Stylianopoulos, T., Bardeesy, N., DePinho, R., Padera, T., Munn, L., Jain, R.
Publikováno v:
Cancer Cell
Impaired perfusion is a hallmark of solid tumors that promotes progression, immunosuppression and treatment-resistance, and is partly caused by vascular compression from excessive extravascular stresses (Chauhan et al., 2013; Stylianopoulos et al., 2