Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Weihong Song"'
Autor:
Hua-Dong Zhou, Yu-Hui Liu, Weihong Song, Jun Wang, Zhi-Qiang Xu, Fan Zeng, Jin-Tai Yu, Peng Lei, Yan-Jiang Wang, Noralyn B. Mañucat-Tan, Xiu-Qing Yao, Xian-Le Bu, Wei-Wei Li, Xin-Fu Zhou, Chi Zhu, Changyue Yue Gao, Larisa Bobrovskaya, Shi-Hao Gao, Lin-Lin Shen
Publikováno v:
Molecular Psychiatry. 23:1813-1824
Tau pathology is characterized as a form of frontotemporal lobar degeneration (FTLD) known as FTLD-tau. The underlying pathogenic mechanisms are not known and no therapeutic interventions are currently available. Here, we report that the neurotrophin
Autor:
Jingwen Xu, Heng Liu, Yan Yun, Zonglai Liang, Xiao Yu, Jinfan Zheng, Yun Zhang, Juan Zhao, Weihong Song, Xiulian Sun, Fuchen Liu, Qianwen Sun
Publikováno v:
Molecular Psychiatry. 23:1542-1554
Potassium channel Kv2.1 regulates potassium current in cortical neurons and potassium efflux is necessary for cell apoptosis. As a major component of delayed rectifier current potassium channels, Kv2.1 forms clusters in the membrane of hippocampal ne
Autor:
Liyan Huang, Chen Zhang, Pin Wang, Yun Zhang, Yan Yun, Weihong Song, Xiulian Sun, Shichuan Tan, Carles Vilariño-Güell
Publikováno v:
Molecular psychiatry. 26(4)
Posttranscriptional regulation of gene expression plays an important role in the maturation, transport, stability and translation of coding and noncoding RNAs. RNA-binding protein (RBP) is a key factor of the regulation. Regulator of calcineurin 1 (R
Publikováno v:
Molecular Neurobiology. 50:1085-1097
AD, a devastating neurodegenerative disorder, is the most common cause of dementia in the elderly. Patients with AD are characterized by three hallmarks of neuropathology including neuritic plaque deposition, neurofibrillary tangle formation, and neu
Autor:
Filippo Martinelli-Boneschi, Mary Encarnacion, Weihong Song, Jacqueline A. Quandt, Federica Esposito, Carles Vilariño-Güell, Laura Leyva, Denis Gris, Elena Urcelay, Jordan Follett, Angela Deutschländer, Elisabetta Mascia, Alexander Zimprich, Tobias Zrzavy, Guillermo Izquierdo, Fuencisla Matesanz, Anthony Traboulsee, Patricia Urbaneja-Romero, Alfredo Antigüedad, Andrea Zauli, Zhe Wang, Jorge Mena, Antonio Alcina, Charbel Massaad, Bruno Herculano, Koen Vandenbroeck, A. Dessa Sadovnick, Jesús Ortega-Pinazo, Maria G. Criscuoli, Cecily Q. Bernales, Irene M. Yee, Eva M. Reinthaler, Laura Espino-Paisán
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Genetics, Vol 15, Iss 6, p e1008180 (2019)
Addi. Archivo Digital para la Docencia y la Investigación
PLoS Genetics
instname
PLoS Genetics, Vol 15, Iss 6, p e1008180 (2019)
Addi. Archivo Digital para la Docencia y la Investigación
PLoS Genetics
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system characterized by myelin loss and neuronal dysfunction. Although the majority of patients do not present familial aggregation, Mendelian forms have been described. We per
Autor:
Xiulian Sun, Yili Wu, Bin Chen, Zhuohua Zhang, Weihui Zhou, Yigang Tong, Junying Yuan, Kun Xia, Hinrich Gronemeyer, Richard A. Flavell, Weihong Song
Publikováno v:
Journal of Biological Chemistry. 286:9049-9062
Individuals with Down syndrome (DS) will inevitably develop Alzheimer disease (AD) neuropathology sometime after middle age, which may be attributable to genes triplicated in individuals with DS. The characteristics of AD neuropathology include neuri
Publikováno v:
Nature Medicine. 8:600-606
The mechanism by which dopaminergic neurons are selectively lost in Parkinson disease (PD) is unknown. Here we show that accumulation of alpha-synuclein in cultured human dopaminergic neurons results in apoptosis that requires endogenous dopamine pro
Publikováno v:
Molecular neurobiology. 51(1)
The macrophage migration inhibitory factor (MIF) is a multifaceted cytokine involved in many processes, including cellular responses to ischemia/reperfusion injury in the heart and brain. This study was undertaken to determine whether human MIF expre
Publikováno v:
ResearcherID
Alzheimer's disease (AD) is characterized by senile plaques (SP) of extracellular amyloid β peptides(Aβ), neurofibrillary tangles (NFT) of intracellular hyper-phosphorylated tau and widespread loss of neurons. Apoptosis is the main reason of neuron
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95471 (2014)
PLoS ONE
PLoS ONE
Down Syndrome (DS) patients develop characteristic Alzheimer's Disease (AD) neuropathology after their middle age. Prominent neuronal loss has been observed in the cortical regions of AD brains. However, the underlying mechanism leading to this neuro