Zobrazeno 1 - 7
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pro vyhledávání: '"Jain R"'
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Metronomic dosing of chemotherapy - defined as frequent administration at lower doses - has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in the clinic. Although multiple
Publikováno v:
Cancer research
The stress harbored by the solid phase of tumors is known as solid stress. Solid stress can be either applied externally by the surrounding normal tissue or induced by the tumor itself due to its growth. Fluid pressure is the isotropic stress exerted
Publikováno v:
Clinical Cancer Research
Purpose: Although oncolytic viral vectors show promise for the treatment of various cancers, ineffective initial distribution and propagation throughout the tumor mass often limit the therapeutic response. A mathematical model is developed to describ
Publikováno v:
Annual Review of Biomedical Engineering
Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, they can increase cells' inva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31342236a2aef544510573096a5bb0b9
http://gnosis.library.ucy.ac.cy/handle/7/48436
http://gnosis.library.ucy.ac.cy/handle/7/48436
Autor:
Stylianopoulos, T., Jain, R. K.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Blood perfusion in tumors can be significantly lower than that in the surrounding normal tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion reduces oxygen supply and results in a hypoxic microenvironment. Hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59661ae901d22c2be908cf361bbc509
https://europepmc.org/articles/PMC3832007/
https://europepmc.org/articles/PMC3832007/
Autor:
Stylianopoulos, T., Martin, J. D., Chauhan, V. P., Jain, S. R., Diop-Frimpong, B., Bardeesy, N., Smith, B. L., Ferrone, C. R., Hornicek, F. J., Boucher, Y., Munn, L. L., Jain, R. K.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress intratumoral lymphatic and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05428f95247ff422d39554eb53c974f
http://gnosis.library.ucy.ac.cy/handle/7/48862
http://gnosis.library.ucy.ac.cy/handle/7/48862
Autor:
Melody A. Swartz, Paolo A. Netti, Alan J. Grodzinsky, Yves Boucher, Rakesh K. Jain, Christian Brekken, Arja Kaipainen
Publikováno v:
Journal of Biomechanics. 32:1297-1307
Interstitial fluid movement is intrinsically linked to lymphatic drainage. However, their relationship is poorly understood, and associated pathologies are mostly untreatable. In this work we test the hypothesis that bulk tissue fluid movement can be