Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
Christopher J. Schofield, Inga Pfeffer, Anthony Tumber, Michael A. McDonough, Lennart Brewitz
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
The human 2-oxoglutarate dependent oxygenase aspartate/asparagine-β-hydroxylase (AspH) catalyses the hydroxylation of Asp/Asn-residues in epidermal growth factor-like domains (EGFDs). AspH is upregulated on the surface of malign cancer cells; increa
Publikováno v:
Molecular Aspects of Medicine. :54-75
In human cells oxygen levels are 'sensed' by a set of ferrous iron and 2-oxoglutarate dependent dioxygenases. These enzymes regulate a broad range of cellular and systemic responses to hypoxia by catalysing the post-translational hydroxylation of spe
Autor:
Timothy Searls, Kathryn L. Kavanagh, Udo Oppermann, Michael A. McDonough, Danica Butler, Christopher J. Schofield
Refsum disease (RD), a neurological syndrome characterized by adult onset retinitis pigmentosa, anosmia, sensory neuropathy, and phytanic acidaemia, is caused by elevated levels of phytanic acid. Many cases of RD are associated with mutations in phyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30c0ca4b63f2071d7bb84de101270b5
https://doi.org/10.1074/jbc.m507528200
https://doi.org/10.1074/jbc.m507528200
Publikováno v:
Biochemical Society Transactions. 35:870-875
Phytanic acid (PA) is an epimeric metabolite of the isoprenoid side chain of chlorophyll. Owing to the presence of its epimeric beta-methyl group, PA cannot be metabolized by beta-oxidation. Instead, it is metabolized in peroxisomes via alpha-oxidati
Autor:
Marina Demetriades, Roger D. Cox, Myrte Merkestein, Wei Shen Aik, Holger B. Kramer, Christopher J. Schofield, Frances M. Ashcroft, Tertius Hough, Michael A. McDonough, Sara Wells, Daniel S. Andrew, Fiona McMurray, Cheryl L. Scudamore
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121829 (2015)
PLoS ONE
PLoS ONE
In 2007, a genome wide association study identified a SNP in intron one of the gene encoding human FTO that was associated with increased body mass index. Homozygous risk allele carriers are on average three kg heavier than those homozygous for the p
Autor:
Anthony S. Wierzbicki, Ian J. Clifton, Nadia J. Kershaw, Winnie Chien, Mridul Mukherji, Matthew D. Lloyd, Christopher J. Schofield
Publikováno v:
Human Molecular Genetics. 10:1971-1982
Refsum's disease is a neurological syndrome characterized by adult-onset retinitis pigmentosa, anosmia, sensory neuropathy and phytanic acidaemia. Many cases are caused by mutations in peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PAHX) which ca
Autor:
Atsushi Yamamoto, Marion S. Schmidt-Zachmann, Armin Thalhammer, Ming Yang, Gail M. Preston, James S. O. McCullagh, Alexander Wolf, Chia Hua Ho, Phebee Liu-Yi, Adam P. Hardy, Zhihong Zhang, Peter J. Ratcliffe, Adam Zayer, Carol V. Robinson, Tianshu Feng, Benedikt M. Kessler, Nikita D. Loik, Mathew L. Coleman, Rok Sekirnik, Timothy D. W. Claridge, Muhammad Mukram Mohamed Mackeen, Refaat B. Hamed, Miao Jiang, Matthew E. Cockman, Rasheduzzaman Chowdhury, Christoph Loenarz, Christopher J. Schofield, David C. Trudgian, Nicolas Granatino, Wei Ge, Yuliya Gordiyenko, Lingzhi Gong
Publikováno v:
Nature chemical biology. 8(12)
The finding that oxygenase-catalyzed protein hydroxylation regulates animal transcription raises questions as to whether the translation machinery and prokaryotic proteins are analogously modified. Escherichia coli ycfD is a growth-regulating 2-oxogl
Autor:
Anna A. Karkhanina, Michael U. Musheev, Eleanor A.L. Bagg, Sergey N. Krylov, Christopher J. Schofield, Svetlana M. Krylova
Publikováno v:
Analytical Biochemistry.
The AlkB family of oxygenases catalyze the removal of alkyl groups from nucleic acid substrates in an iron and 2-oxoglutarate-dependent manner and have roles including in DNA repair. To understand the biological functions of these DNA-dealkylating en
Autor:
Jasmin Mecinović, Benoît M. R. Liénard, Emily Flashman, Frank Sobott, Nicola Hindley, Kar Kheng Yeoh, Christopher D. Stubbs, Christoph Loenarz, Christopher J. Schofield
Publikováno v:
Journal of medicinal chemistry. 52(9)
Limited proteolysis coupled to matrix-assisted laser desorption/ionization (MALDI) mass spectrometric analyses can be used to screen for compounds that alter protein structure by monitoring stabilizing/destabilizing effects with respect to the rate a
Autor:
Chris Church, Jasmin Mecinović, Sheena Lee, Roger D. Cox, Eleanor A.L. Bagg, Lee Moir, Frances M. Ashcroft, Christopher J. Schofield, Mohamed M. Quwailid, Robert M. J. Deacon, Thomas Gerken, James S. McTaggart, Angela Lee
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 5, Iss 8, p e1000599 (2009)
PLoS Genetics, Vol 5, Iss 8, p e1000599 (2009)
Human FTO gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO expression or splicing are the cause of obesity or if regulatory elements within i