Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Tong, Yang"'
Publikováno v:
Gynecologic Oncology. 162:788-796
Objectives Our study aims to investigate whether PI3K/mTOR dual inhibitor LY3023414 has synergistic effects with carboplatin in suppressing endometrial cancer (EC), and explore the mechanisms and toxicity of combined therapy. Methods The effects of c
Publikováno v:
Acta Biomaterialia. 128:447-461
The combination of chemotherapy and gene therapy has been indicated as a promising approach for cancer therapy. However, this combination strategy is still faced a challenge by the lack of suitable carriers to co-loaded chemotherapeutic drug and gene
Autor:
Yanhua Liu, Yanhui Hou, Rongyue Zhu, Li Li, Yang Lan, Tong Yang, Liu Lu, Yue Sun, Shuangyu Yu, Xueqin Ma
Publikováno v:
Biomaterials Science. 8:5698-5714
The combination therapy of cisplatin (CDDP) and metformin (MET) is a clinical strategy to enhance therapeutic outcomes in lung cancer. However, the efficacy of this combination is limited due to the asynchronous pharmacokinetic behavior of CDDP and M
Autor:
Gabriel Mbalaviele, Yael Alippe, Hongjun Zheng, Chun Wang, Songtao Quan, Robert H. Brophy, Dustin Kress, Jianqiu Xiao, Yousef Abu-Amer, Dingjun Hao, Tong Yang, Gaurav Swarnkar, Audrey McAlinden, Kai Sun, Jie Shen
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-13 (2021)
Arthritis Research & Therapy
Arthritis Research & Therapy
Background Gasdermin D (GSDMD) is cleaved by several proteases including by caspase-1, a component of intracellular protein complexes called inflammasomes. Caspase-1 also converts pro-interleukin-1β (pro-IL-1β) and pro-IL-18 into bioactive IL-1β a
Autor:
Gabriel Mbalaviele, Yael Alippe, Jianqiu Xiao, Tong Yang, Thirumala-Devi Kanneganti, Joseph B. Monahan, Kai Sun, Yousef Abu-Amer, Canxin Xu, Judy Lieberman, Chun Wang
Publikováno v:
Sci Immunol
NOD-like receptor (NLR), family pyrin domain containing 3 (NLRP3) assembles an intracellular protein complex known as the NLRP3 inflammasome upon sensing certain pathogen products or sterile danger signals. Gain-of-function mutations such as the D301
Autor:
Dustin Kress, Jianqiu Xiao, Gabriel Mbalaviele, Yael Alippe, Tong Yang, Yousef Abu-Amer, Biancamaria Ricci, Kai Sun, Chun Wang
Publikováno v:
The FASEB Journal. 35
Overwhelming evidence indicates that excessive stimulation of innate immune receptors of the NOD-like receptor (NLR) family causes significant damage to multiple tissues, yet the role of these proteins in bone metabolism is not well known. Here, we s
Autor:
Wen-Jing Zhong, Cheng Zu, Hui-Ling Jiang, Jia-Hao Tao, Jia-Xi Duan, Jin-Tong Yang, Ping Chen, Xin-Xin Guan, Yu-Biao Liu, Hui-Hui Yang, Chen-Yu Zhang, Yong Zhou
Publikováno v:
International immunopharmacology. 101
Citrate has a prominent role as a substrate in cellular energy metabolism. Recently, citrate has been shown to drive inflammation. However, the role of citrate in lipopolysaccharide (LPS)-induced acute lung injury (ALI) remains unclear. Here, we aime
Publikováno v:
Molecular Pharmaceutics. 16:2502-2510
Intracellular doxorubicin (DOX) pumping out of cells through the P-glycoprotein (P-gp) transporter leads to the reduction of intracellular DOX levels and induces multidrug resistance (MDR). A hyaluronic acid-deoxycholic acid-histidine and Pluronic F1
Publikováno v:
Cell Death and Disease, Vol 10, Iss 4, Pp 1-16 (2019)
Cell Death & Disease
Cell Death & Disease
Renal inflammation significantly contributes to the progression of hepatitis B virus (HBV)-associated glomerulonephritis (HBV-GN), but the mechanisms that control its precise regulation remain largely unknown. In this study, we showed that the lysine
Autor:
E Du, Yong Xu, Yunkai Qie, Zhihong Zhang, Tong Yang, Li Wang, Baomin Qiao, Changwen Zhang, Yan Liu
Publikováno v:
Carcinogenesis. 40:52-60
Ribosomal stress is known to increase cancer risk; however, the molecular mechanism underlying its various effects on cancer remains unclear. To decipher this puzzle, we investigated the upstream signaling pathway that might be involved in promoting