Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lorenz, M."'
Autor:
Denny Schanze, Friedrich G. Kapp, Martin Zenker, Uta Matysiak, Annegret Holm, Jochen Rößler, Charlotte M. Niemeyer, Ilse Wieland, Lorenz M Bell, Wolfgang Driever
Publikováno v:
Human molecular genetics. 31(1)
Vascular malformations are most often caused by somatic mutations of the PI3K/mTOR and the RAS signaling pathways, which can be identified in the affected tissue. Venous malformations commonly harbor PIK3CA and TEK mutations, whereas arteriovenous ma
Autor:
Anna-Lina Cavallo, Mohammad Bohlooly-Y, Lorenz M. Mayr, Maryam Clausen, Ryan Hicks, Amir Taheri-Ghahfarokhi, Fredrik Karlsson, Katja Madeyski-Bengtson, Roberto Nitsch, Marcello Maresca, Anders Lundin, Benjamin J. M. Taylor
Publikováno v:
Nucleic Acids Research. 46:8417-8434
The mutation patterns at Cas9 targeted sites contain unique information regarding the nuclease activity and repair mechanisms in mammalian cells. However, analytical framework for extracting such information are lacking. Here, we present a novel comp
Autor:
Leif Aasehaug, Lisa U. Magnusson, Amir Taheri-Ghahfarokhi, Roberto Nitsch, Frank Seeliger, Mohammad Bohlooly-Y, Marcello Maresca, Lorenz M. Mayr, Elke Ericson, Therese Admyre, Maryam Clausen, Michelle J. Porritt, John Wiseman, Mikael Bjursell
Publikováno v:
EBioMedicine, Vol 29, Iss, Pp 104-111 (2018)
EBioMedicine
EBioMedicine
α1-antitrypsin (AAT) is a circulating serine protease inhibitor secreted from the liver and important in preventing proteolytic neutrophil elastase associated tissue damage, primarily in lungs. In humans, AAT is encoded by the SERPINA1 (hSERPINA1) g
Autor:
Luca Pinello, M. Kendell Clement, Mikael Bjursell, Michelle J. Porritt, Mohammad Bohlooly-Y, Lorenz M. Mayr, Tania Baccega, Jimmy A. Guo, Pinar Akcakaya, Martin J. Aryee, J. Keith Joung, Jose Malagon Lopez, Mick D. Fellows, Frank Seeliger, Maggie L. Bobbin, Marcello Maresca, Shengdar Q. Tsai, Roberto Nitsch, Nhu T. Nguyen, Alba Carreras, Mike Firth, Sara P. Garcia
CRISPR-Cas genome-editing nucleases hold substantial promise for human therapeutics1–5 but identifying unwanted off-target mutations remains an important requirement for clinical translation6, 7. For ex vivo therapeutic applications, previously pub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecbdcbc3134b6540f2cb620ed94cb75
https://doi.org/10.1101/272724
https://doi.org/10.1101/272724
Publikováno v:
Current Opinion in Structural Biology. 23:393-402
Protein production for structural and biophysical studies, functional assays, biomarkers, mechanistic studies in vitro and in vivo, but also for therapeutic applications in pharma, biotech and academia has evolved into a mature discipline in recent y
Autor:
Mehryar Habibi Roudkenar, Saeid Bouzari, Mana Oloomi, Ali Jahanian-Najafabadi, Lorenz M. Mayr
Publikováno v:
Bioscience, Biotechnology and Biochemistry
Bioscience, Biotechnology and Biochemistry, Taylor & Francis, 2012, 76 (4), pp.749-54. ⟨10.1271/bbb.110862⟩
Bioscience, Biotechnology and Biochemistry, Taylor & Francis, 2012, 76 (4), pp.749-54. ⟨10.1271/bbb.110862⟩
International audience; Immunotoxins are fusion proteins consisting of two elements, a targeting and a toxin moiety, and are designed for specific elimination of tumor cells. Previously we expressed a recombinant fusion protein consisting of the toxi
Autor:
Mary Ann Cielo V. Relucio-San Diego, Windell L. Rivera, Christine Aubrey C. Justo, Lorenz M. Loyola
Publikováno v:
Journal of Microbiology, Immunology and Infection, Vol 50, Iss 5, Pp 669-676 (2017)
Background/Purpose The flagellated protozoon Trichomonas vaginalis that parasitizes the urogenital tract of humans was reported to harbor double-stranded RNA (dsRNA) viruses. These viruses, identified as Trichomonas vaginalis virus (TVV), belong to t
Publikováno v:
Protein Expression and Purification. 59:232-241
We describe a cloning and expression system which is based on the Escherichia coli T7 expression system and Gateway recombination technology. We have produced numerous destination vectors with selected fusion tags and an additional set of entry vecto
Autor:
Lorenz M. Mayr, Franz X. Schmid
Publikováno v:
Protein Expression and Purification. 4:52-58
We present a new procedure for the rapid production of ribonuclease T1 variants with decreased stability which could not be purified in satisfying amounts by the existing methods. The major changes from the established procedures are the following. (
Autor:
Imre Berger, Lorenz M. Mayr
Publikováno v:
Current Opinion in Structural Biology. 23:317-318