Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Tanja D de Gruijl"'
Autor:
Nathalie van Leeuwen-Kerkhoff, Shahram Kordasti, Theresia M. Westers, Giovanni A M Povoleri, Tanja D. de Gruijl, Pino J Poddighe, Arjan A. van de Loosdrecht, Jessica A Timms
Publikováno v:
Haematologica, 107(3), 655-667. Ferrata Storti Foundation
van Leeuwen-Kerkhoff, N, Westers, T M, Poddighe, P J, Povoleri, G A M, Timms, J A, Kordasti, S, de Gruijl, T D & van de Loosdrecht, A A 2022, ' Reduced frequencies and functional impairment of dendritic cell subsets and non-classical monocytes in myelodysplastic syndromes ', Haematologica, vol. 107, no. 3, pp. 655-667 . https://doi.org/10.3324/haematol.2020.268136
van Leeuwen-Kerkhoff, N, Westers, T M, Poddighe, P J, Povoleri, G A M, Timms, J A, Kordasti, S, de Gruijl, T D & van de Loosdrecht, A A 2022, ' Reduced frequencies and functional impairment of dendritic cell subsets and non-classical monocytes in myelodysplastic syndromes ', Haematologica, vol. 107, no. 3, pp. 655-667 . https://doi.org/10.3324/haematol.2020.268136
In myelodysplastic syndromes (MDS) the immune system is involved in pathogenesis as well as in disease progression. Dendritic cells (DC) are key players of the immune system by serving as regulators of immune responses. Their function has been scarce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5391dba937cb802184434c01c08a37
https://research.vumc.nl/en/publications/db725181-9627-4bb8-b6d6-30678dae82ff
https://research.vumc.nl/en/publications/db725181-9627-4bb8-b6d6-30678dae82ff
Autor:
Iris de Weerdt, Tanja D. de Gruijl, Jurjen M Ruben, Hans van Vliet, Mark-David Levin, Lisa A King, Roeland Lameris, Arnon P. Kater, Paul W. H. I. Parren, Renate de Boer, Jan Kloosterman
Publikováno v:
de Weerdt, I, Lameris, R, Ruben, J M, de Boer, R, Kloosterman, J, King, L A, Levin, M-D, Parren, P W H I, de Gruijl, T D, Kater, A P & van der Vliet, H J 2021, ' A bispecific single-domain antibody boosts autologous Vg9Vd2-T cell responses toward CD1d in chronic lymphocytic leukemia ', Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 27, no. 6, pp. 1744-1755 . https://doi.org/10.1158/1078-0432.CCR-20-4576
Clinical cancer research : an official journal of the American Association for Cancer Research, 27(6), 1744-1755. American Association for Cancer Research Inc.
Clinical cancer research, 27(6), 1744-1755. American Association for Cancer Research Inc.
Clinical Cancer Research, 27(6), 1744-1755. AMER ASSOC CANCER RESEARCH
Clinical cancer research : an official journal of the American Association for Cancer Research, 27(6), 1744-1755. American Association for Cancer Research Inc.
Clinical cancer research, 27(6), 1744-1755. American Association for Cancer Research Inc.
Clinical Cancer Research, 27(6), 1744-1755. AMER ASSOC CANCER RESEARCH
Purpose: Although considerable progress has been made with autologous T cell–based therapy in B-cell malignancies, application in chronic lymphocytic leukemia (CLL) lags behind due to disappointing response rates as well as substantial toxicity tha
Autor:
Hans van Vliet, Paul W. H. I. Parren, Rieneke van de Ven, Jana Vree, Roeland Lameris, Tanja D. de Gruijl, Renate de Boer, Anita G.M. Stam, George L. Scheffer, Arnon P. Kater, Steven T. Pals, Mark-David Levin, Rob C. Roovers, Iris de Weerdt
Publikováno v:
Cancer immunology research, 9(1), 50-61. American Association for Cancer Research Inc.
Cancer Immunology Research, 9(1), 50-61. AMER ASSOC CANCER RESEARCH
de Weerdt, I, Lameris, R, Scheffer, G L, Vree, J, de Boer, R, Stam, A G, van de Ven, R, Levin, M-D, Pals, S T, Roovers, R C, Parren, P W H I, de Gruijl, T D, Kater, A P & van der Vliet, H J 2021, ' A Bispecific Antibody Antagonizes Prosurvival CD40 Signaling and Promotes Vγ9Vδ2 T cell-Mediated Antitumor Responses in Human B-cell Malignancies ', Cancer Immunology Research, vol. 9, no. 1, pp. 50-61 . https://doi.org/10.1158/2326-6066.CIR-20-0138
Cancer Immunology Research, 9(1), 50-61. American Association for Cancer Research Inc.
Cancer Immunology Research, 9(1), 50-61. AMER ASSOC CANCER RESEARCH
de Weerdt, I, Lameris, R, Scheffer, G L, Vree, J, de Boer, R, Stam, A G, van de Ven, R, Levin, M-D, Pals, S T, Roovers, R C, Parren, P W H I, de Gruijl, T D, Kater, A P & van der Vliet, H J 2021, ' A Bispecific Antibody Antagonizes Prosurvival CD40 Signaling and Promotes Vγ9Vδ2 T cell-Mediated Antitumor Responses in Human B-cell Malignancies ', Cancer Immunology Research, vol. 9, no. 1, pp. 50-61 . https://doi.org/10.1158/2326-6066.CIR-20-0138
Cancer Immunology Research, 9(1), 50-61. American Association for Cancer Research Inc.
Novel T cell-based therapies for the treatment of B-cell malignancies, such as chronic lymphocytic leukemia (CLL) and multiple myeloma (MM), are thought to have strong potential. Progress, however, has been hampered by low efficacy and high toxicity.
Autor:
A. Marijne Heeren, Ekaterina S. Jordanova, Constantijne H. Mom, Maaike C G Bleeker, Henry Zijlmans, Tanja D. de Gruijl, Sinéad M. Lougheed, Anita G.M. Stam, Noëlle Pocorni, Awa A Gassama, G.G. Kenter, Jossie Rotman
Publikováno v:
Clinical Cancer Research, 26(14), 3791-3802. American Association for Cancer Research Inc.
Rotman, J, Heeren, A M, Gassama, A A, Lougheed, S M, Pocorni, N, Stam, A G M, Bleeker, M C G, Zijlmans, H J M A A, Mom, C H, Kenter, G G, Jordanova, E S & de Gruijl, T D 2020, ' Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8 + T Cells and Elevated β-Catenin Activation Compared with Squamous Cell Carcinoma ', Clinical Cancer Research, vol. 26, no. 14, pp. 3791-3802 . https://doi.org/10.1158/1078-0432.CCR-19-3826
Clinical cancer research, 26(14), 3791-3802. American Association for Cancer Research Inc.
Rotman, J, Heeren, A M, Gassama, A A, Lougheed, S M, Pocorni, N, Stam, A G M, Bleeker, M C G, Zijlmans, H J M A A, Mom, C H, Kenter, G G, Jordanova, E S & de Gruijl, T D 2020, ' Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8 + T Cells and Elevated β-Catenin Activation Compared with Squamous Cell Carcinoma ', Clinical Cancer Research, vol. 26, no. 14, pp. 3791-3802 . https://doi.org/10.1158/1078-0432.CCR-19-3826
Clinical cancer research, 26(14), 3791-3802. American Association for Cancer Research Inc.
Purpose:Adenocarcinoma of the uterine cervix is the second most common type of cervical cancer after squamous cell carcinoma (SCC). Although both subtypes are treated similarly, patients with adenocarcinoma have a worse prognosis. In this study, immu
Autor:
Arjan A. van de Loosdrecht, Tanja D. de Gruijl, Nathalie van Leeuwen-Kerkhoff, Theresia M. Westers, Pino J. Poddighe, Shahram Kordasti
Publikováno v:
Haematologica
van Leeuwen-Kerkhoff, N, Westers, T M, Poddighe, P J, de Gruijl, T D, Kordasti, S & van de Loosdrecht, A A 2020, ' Thrombomodulin expressing monocytes are associated with low risk features in myelodysplastic syndromes and dampen excessive immune activation ', Haematologica, vol. 105, no. 4, pp. 961-970 . https://doi.org/10.3324/haematol.2019.219303
Haematologica, 105(4), 961-970. Ferrata Storti Foundation
van Leeuwen-Kerkhoff, N, Westers, T M, Poddighe, P J, de Gruijl, T D, Kordasti, S & van de Loosdrecht, A A 2020, ' Thrombomodulin expressing monocytes are associated with low risk features in myelodysplastic syndromes and dampen excessive immune activation ', Haematologica, vol. 105, no. 4, pp. 961-970 . https://doi.org/10.3324/haematol.2019.219303
Haematologica, 105(4), 961-970. Ferrata Storti Foundation
The bone marrow of patients with low-risk myelodysplastic syndromes (MDS) is often an inflammatory environment and associated with an active cellular immune response. An active immune response generally contributes to antitumor responses and may prev
Autor:
Hans van Vliet, Tanja D. de Gruijl, Henk M.W. Verheul, Lisa A. King, Roeland Lameris, Abdolkarim Sheikhi, Bruce Walcheck, Elisa C. Toffoli, Jan Spanholtz, Jurriaan B. Tuynman, Amanda A. van Vliet
Publikováno v:
Cancers
Volume 13
Issue 21
Toffoli, E C, Sheikhi, A, Lameris, R, King, L A, van Vliet, A, Walcheck, B, Verheul, H M W, Spanholtz, J, Tuynman, J, de Gruijl, T D & van der Vliet, H J 2021, ' Enhancement of nk cell antitumor effector functions using a bispecific single domain antibody targeting cd16 and the epidermal growth factor receptor ', Cancers, vol. 13, no. 21, 5446 . https://doi.org/10.3390/cancers13215446
Cancers, Vol 13, Iss 5446, p 5446 (2021)
Cancers, 13(21):5446. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 13
Cancers, 13, 21
Volume 13
Issue 21
Toffoli, E C, Sheikhi, A, Lameris, R, King, L A, van Vliet, A, Walcheck, B, Verheul, H M W, Spanholtz, J, Tuynman, J, de Gruijl, T D & van der Vliet, H J 2021, ' Enhancement of nk cell antitumor effector functions using a bispecific single domain antibody targeting cd16 and the epidermal growth factor receptor ', Cancers, vol. 13, no. 21, 5446 . https://doi.org/10.3390/cancers13215446
Cancers, Vol 13, Iss 5446, p 5446 (2021)
Cancers, 13(21):5446. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 13
Cancers, 13, 21
Simple Summary Strategies to enhance the preferential accumulation and activation of Natural Killer (NK) cells in the tumor microenvironment can be expected to increase the efficacy of NK cell-based cancer immunotherapy. In this study, we report that
Autor:
Alsya J. Affandi, Katarzyna Olesek, Joanna Grabowska, Maarten K. Nijen Twilhaar, Ernesto Rodríguez, Anno Saris, Eline S. Zwart, Esther J. Nossent, Hakan Kalay, Michael de Kok, Geert Kazemier, Johannes Stöckl, Alfons J. M. van den Eertwegh, Tanja D. de Gruijl, Juan J. Garcia-Vallejo, Gert Storm, Yvette van Kooyk, Joke M. M. den Haan
Publikováno v:
Frontiers in Immunology, 12
European Journal of Immunology, 51, 409-409. Wiley-VCH Verlag
Frontiers in immunology, 12:697840. Frontiers Media S.A.
Affandi, A J, Olesek, K, Grabowska, J, Nijen Twilhaar, M K, Rodríguez, E, Saris, A, Zwart, E S, Nossent, E J, Kalay, H, de Kok, M, Kazemier, G, Stöckl, J, van den Eertwegh, A J M, de Gruijl, T D, Garcia-Vallejo, J J, Storm, G, van Kooyk, Y & den Haan, J M M 2021, ' CD169 Defines Activated CD14 + Monocytes With Enhanced CD8 + T Cell Activation Capacity ', Frontiers in Immunology, vol. 12, 697840, pp. 697840 . https://doi.org/10.3389/fimmu.2021.697840, https://doi.org/10.3389/fimmu.2021.697840, https://doi.org/10.3389/fimmu.2021.697840
Frontiers in Immunology, 12:697840. Frontiers Research Foundation
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, 12, 1. Frontiers Media S.A.
Frontiers in Immunology, 12:697840. Frontiers Media S.A.
Affandi, A, Olesek, K, Grabowska, J, Twilhaar, M N, Rodriguez, E, Saris, A, Zwart, E, Nossent, E, Kalay, H, De Kok, M, Kazemier, G, Stockl, J, Van den Eertwegh, A, De Gruijl, T, Vallejo, J G, Storm, G, Van Kooyk, Y & Den Haan, J 2021, ' CD169 defines activated CD14+monocytes with enhanced CD8+T cell activation capacity ', European Journal of Immunology, vol. 51, pp. 409-409 .
European Journal of Immunology, 51, 409-409. Wiley-VCH Verlag
Frontiers in immunology, 12:697840. Frontiers Media S.A.
Affandi, A J, Olesek, K, Grabowska, J, Nijen Twilhaar, M K, Rodríguez, E, Saris, A, Zwart, E S, Nossent, E J, Kalay, H, de Kok, M, Kazemier, G, Stöckl, J, van den Eertwegh, A J M, de Gruijl, T D, Garcia-Vallejo, J J, Storm, G, van Kooyk, Y & den Haan, J M M 2021, ' CD169 Defines Activated CD14 + Monocytes With Enhanced CD8 + T Cell Activation Capacity ', Frontiers in Immunology, vol. 12, 697840, pp. 697840 . https://doi.org/10.3389/fimmu.2021.697840, https://doi.org/10.3389/fimmu.2021.697840, https://doi.org/10.3389/fimmu.2021.697840
Frontiers in Immunology, 12:697840. Frontiers Research Foundation
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, 12, 1. Frontiers Media S.A.
Frontiers in Immunology, 12:697840. Frontiers Media S.A.
Affandi, A, Olesek, K, Grabowska, J, Twilhaar, M N, Rodriguez, E, Saris, A, Zwart, E, Nossent, E, Kalay, H, De Kok, M, Kazemier, G, Stockl, J, Van den Eertwegh, A, De Gruijl, T, Vallejo, J G, Storm, G, Van Kooyk, Y & Den Haan, J 2021, ' CD169 defines activated CD14+monocytes with enhanced CD8+T cell activation capacity ', European Journal of Immunology, vol. 51, pp. 409-409 .
Monocytes are antigen-presenting cells (APCs) that play diverse roles in promoting or regulating inflammatory responses, but their role in T cell stimulation is not well defined. In inflammatory conditions, monocytes frequently show increased express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ecba359f231a1291a57423a4591bfb
https://research.vumc.nl/en/publications/b32063d7-e476-4274-ab71-e89b7d4ea6f0
https://research.vumc.nl/en/publications/b32063d7-e476-4274-ab71-e89b7d4ea6f0
Autor:
Barbara G. Molenkamp, M. Petrousjka van den Tol, Ekaterina J. Jordanova, Rik J. Scheper, Berbel J.R. Sluijter, Paul A. M. van Leeuwen, Saskia Vosslamber, Marta López González, Alfons J. M. van den Eertwegh, Mari F. C. M. van den Hout, Bas D. Koster, Annelies W. Turksma, Tanja D. de Gruijl
Publikováno v:
Journal for Immunotherapy of Cancer, 9(3):e001962. BioMed Central
Koster, B D, López González, M, van den Hout, M F, Turksma, A W, Sluijter, B J, Molenkamp, B G, van Leeuwen, P A, Vosslamber, S, Scheper, R J, van den Eertwegh, A J, van den Tol, M P, Jordanova, E J & de Gruijl, T D 2021, ' T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9A+CD141+ cDC1 and CD14+ antigen-presenting cell recruitment ', Journal for Immunotherapy of Cancer, vol. 9, no. 3, e001962 . https://doi.org/10.1136/jitc-2020-001962
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Koster, B D, López González, M, van den Hout, M F, Turksma, A W, Sluijter, B J, Molenkamp, B G, van Leeuwen, P A, Vosslamber, S, Scheper, R J, van den Eertwegh, A J, van den Tol, M P, Jordanova, E J & de Gruijl, T D 2021, ' T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9A+CD141+ cDC1 and CD14+ antigen-presenting cell recruitment ', Journal for Immunotherapy of Cancer, vol. 9, no. 3, e001962 . https://doi.org/10.1136/jitc-2020-001962
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
BackgroundWe previously reported CpG-B injection at the primary tumor excision site prior to re-excision and sentinel node biopsy to result in immune activation of the sentinel lymph node (SLN), increased melanoma-specific CD8+ T cell rates in periph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c312d68369c6c83fe942376e1d4783
https://research.vumc.nl/en/publications/8d35bb60-3b28-48ad-a3a3-9c9238b47494
https://research.vumc.nl/en/publications/8d35bb60-3b28-48ad-a3a3-9c9238b47494
Publikováno v:
van Pul, K M, Fransen, M F, van de Ven, R & de Gruijl, T D 2021, ' Immunotherapy Goes Local : The Central Role of Lymph Nodes in Driving Tumor Infiltration and Efficacy ', Frontiers in Immunology, vol. 12, 643291, pp. 643291 . https://doi.org/10.3389/fimmu.2021.643291
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Immune checkpoint blockade (ICB) has changed the therapeutic landscape of oncology but its impact is limited by primary or secondary resistance. ICB resistance has been related to a lack of T cells infiltrating into the tumor. Strategies to overcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5daeb36ebe7bc070244de75184778a9
https://research.vumc.nl/en/publications/c1861d0d-26a3-4232-aaf8-661efa5296a2
https://research.vumc.nl/en/publications/c1861d0d-26a3-4232-aaf8-661efa5296a2
Autor:
Martino Ambrosini, Sanne Duinkerken, Juan J. Garcia-Vallejo, Tanja D. de Gruijl, Lisa Rutte, Hakan Kalay, Sophie K. Horrevorts, Yvette van Kooyk
Publikováno v:
Duinkerken, S, Horrevorts, S K, Kalay, H, Ambrosini, M, Rutte, L, de Gruijl, T D, Garcia-Vallejo, J J & van Kooyk, Y 2019, ' Glyco-dendrimers as intradermal anti-tumor vaccine targeting multiple skin DC subsets ', Theranostics, vol. 9, no. 20, pp. 5797-5809 . https://doi.org/10.7150/thno.35059
Theranostics, 9, 5797-5809
Theranostics
Theranostics, 9(20), 5797-5809. Ivyspring International Publisher
Theranostics, 9, 20, pp. 5797-5809
Theranostics, 9, 5797-5809
Theranostics
Theranostics, 9(20), 5797-5809. Ivyspring International Publisher
Theranostics, 9, 20, pp. 5797-5809
Contains fulltext : 215802.pdf (Publisher’s version ) (Open Access) The human skin is an attractive anti-tumor vaccination site due to the vast network of dendritic cell (DC) subsets that carry antigens to the draining lymph nodes and stimulate tum