Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Thomas C. Foster"'
Autor:
Marcelo Febo, Luis M. Colon-Perez, Thomas C. Foster, Jolie D. Barter, Ashok V. Kumar, Asha Rani
Publikováno v:
Molecular Neurobiology. 57:4045-4059
Markers of brain aging and cognitive decline are thought to be influenced by peripheral inflammation. This study compared the effects of repeated lipopolysaccharide (LPS) treatment in young rats to age-related changes in hippocampal-dependent cogniti
Publikováno v:
J Neurosci
Age-related cognitive impairments are associated with differentially expressed genes (DEGs) linked to defined neural systems; however, studies examining multiple regions of the hippocampus fail to find links between behavior and transcription in the
Autor:
Ashok Kumar, Thomas C. Foster
Publikováno v:
The Journal of Neuroscience. 33:15710-15715
NMDA receptors (NMDARs) play a critical role in learning and memory; however, there is a lack of evidence for a direct relationship between a well characterized decline in NMDAR function and impaired cognition during aging. The present study was desi
Autor:
Kristina K. Aenlle, Thomas C. Foster, Asha Rani, Xiaoxia Han, Ashok Kumar, Linda A. Bean, Susan L. Semple-Rowland
Publikováno v:
The Journal of Neuroscience. 33:2671-2683
The expression of the ERα and ERβ estrogen receptors in the hippocampus may be important in the etiology of age-related cognitive decline. To examine the role of ERα and ERβ in regulating transcription and learning, ovariectomized wild-type (WT)
Autor:
Ling Jin, Brenna L Brim, N.M. Ellinwood, R. Haskell, Kathy R. Magnusson, Arvind Kumar, Thomas C. Foster, R. Awedikian
Publikováno v:
Behavioural Brain Research. 238:211-226
The GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor shows age-related declines in expression across the frontal cortex and hippocampus. This decline is strongly correlated to age-related memory declines. This study was designed to determin
Autor:
Brandi K. Ormerod, Jessica M. Pastoriza, Rachel B. Speisman, Jamie E. Severance, Asha Rani, Ashok Kumar, Thomas C. Foster
Publikováno v:
Neurobiology of Aging. 34:263-274
Strategies combatting cognitive decline among the growing aging population are vital. We tested whether environmental enrichment could reverse age-impaired rapid spatial search strategy acquisition concomitantly with hippocampal neurogenesis in rats.
Autor:
Linda A. Bean, Pedro E. Cruz, Asha Rani, Awilda M. Rosario, Thomas C. Foster, Mike Guidi, Todd E. Golde, Ashok Kumar
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(49)
A decline in estradiol (E2)-mediated cognitive benefits denotes a critical window for the therapeutic effects of E2, but the mechanism for closing of the critical window is unknown. We hypothesized that upregulating the expression of estrogen recepto
Autor:
Thomas C. Foster, Ashok Kumar
Publikováno v:
Neurobiology of Learning and Memory. 87:522-535
The current study employed aged and young male Fischer 344 rats to examine the relationship between long-term depression (LTD), age, and memory. Memory performance was measured on two tasks that are sensitive to hippocampal function; inhibitory avoid
Autor:
Ivan Usynin, Rattanavijit Vijitruth, Georgy Bakalkin, Dong-Young Choi, James Masse, Thomas C. Foster, Cynthia Kulik, Ashok V. Kumar, Guoying Bing, Mei Liu, Xuan V. Nguyen
Publikováno v:
Behavioural Brain Research. 161:254-262
Dynorphins, endogenous kappa-opioid agonists widely expressed in the central nervous system, have been reported to increase following diverse pathophysiological processes, including excitotoxicity, chronic inflammation, and traumatic injury. These pe
Autor:
Thomas C. Foster, Philip W. Landfield, Kuey-Chu Chen, Nada M. Porter, Keith M Sharrow, James P. Herman, Eric M. Blalock
Publikováno v:
The Journal of Neuroscience. 23:3807-3819
Gene expression microarrays provide a powerful new tool for studying complex processes such as brain aging. However, inferences from microarray data are often hindered by multiple comparisons, small sample sizes, and uncertain relationships to functi