Zobrazeno 1 - 10
of 63
pro vyhledávání: '"William R. Wilson"'
Publikováno v:
Vascular and Endovascular Surgery. 55:196-199
COVID-19 has to date affected over 5 million people worldwide and caused in excess of 300000 deaths. One of the principal finding is that of a thrombotic tendency within the lungs leading to high mortality. There have been increasing number of report
Autor:
William R. Wilson, Catherine S Y Lecat, Neil Rabin, Jonathan Sive, Lydia Lee, Ashutosh D. Wechalekar, Brendan Wisniowski, Ke Xu, Louise Ainley, Xenofon Papanikolaou, Shameem Mahmood, Lara Howells, Emma Dowling, Nuno Correia, Charalampia Kyriakou, Kwee Yong, Selina J Chavda, Emilie Sanchez, Annabel McMillan, Wei Yee Chan, Rakesh Popat, Eleni Nastouli
Publikováno v:
British Journal of Haematology
Autor:
Richard G. Jenner, Roger G. Owen, Lydia Eccersley, Laura Clifton-Hadley, Rakesh Popat, William R. Wilson, Elizabeth H Phillips, Selina J Chavda, Kwee Yong, Marie Scully, Michael Sheaff, Matthew Streetly, Gavin Pang, Karthik Ramasamy, Ceri Bygrave, Andres Virchis, James D. Cavenagh, Jonathan Sive, Gordon Cook, Sumaiya Kamora, Marquita Camilleri, Maria José Cuadrado, Michael A Chapman, Reuben Benjamin
Publikováno v:
Phillips, E 2021, ' Thrombotic microangiopathy in untreated myeloma patients receiving carfilzomib, cyclophosphamide and dexamethasone on the CARDAMON study. ', British Journal of Haematology, vol. 193, no. 4, pp. 750-760 . https://doi.org/10.1111/bjh.17377
Proteasome inhibitors have been associated with thrombotic microangiopathy (TMA) - a group of disorders characterised by occlusive microvascular thrombosis causing microangiopathic haemolytic anaemia, thrombocytopenia and end-organ damage. To date, c
Autor:
Simon Rule, William R. Wilson, Richard Lush, Deborah Turner, Andrew P. Haynes, Laura Clifton-Hadley, Mark Bishton, Andrew McMillan, Russell Patmore
Publikováno v:
British journal of haematologyReferences. 190(4)
We present a long-term follow-up of the UK chlorambucil, mitoxantrone and dexamethasone (CMD) versus fludarabine, mitoxantrone and dexamethasone (FMD) for untreated advanced, symptomatic follicular lymphoma (FL). This trial was the first to prospecti
Autor:
Kathryn Evans, Raushan T. Kurmasheva, William R. Wilson, Donya Moradi Manesh, Ashlee Hedrick, Catherine A. Billups, Cara E. Toscan, Hernan Carol, Peter J. Houghton, Glenn M. Marshall, Jennifer Richmond, Rosemary Sutton, Lauryn S. Bracken, Jad El-Hoss, Malcolm A. Smith, Richard B. Lock
Publikováno v:
Blood. 126:1193-1202
PR-104, a phosphate ester of the nitrogen mustard prodrug PR-104A, has shown evidence of efficacy in adult leukemia clinical trials. Originally designed to target hypoxic cells, PR-104A is independently activated by aldo-keto-reductase 1C3 (AKR1C3).
Autor:
William R. Wilson, Naval Daver, Peter F. Thall, Hagop M. Kantarjian, Tapan M. Kadia, Naveen Pemmaraju, Jennie Feliu, Andrew Coveler, John Gutheil, Sergej Konoplev, Caimiao Wei, Carlos E. Bueso-Ramos, Stefan Faderl, Hongbo Lu, Cecilia Arana Yi, Hoang Q. Nguyen, Juliana Benito, Farhad Ravandi, Jorge E. Cortes, Deborah A. Thomas, Yongchuan Gu, Michael Andreeff, Teresa J. Melink, Marina Konopleva, Elihu H. Estey, Elias Jabbour, Steven M. Kornblau, Gautam Borthakur
Publikováno v:
Haematologica. 100:927-934
We previously demonstrated vast expansion of hypoxic areas in the leukemic microenvironment and provided a rationale for using hypoxia-activated prodrugs. PR104 is a phosphate ester that is rapidly hydrolyzed in vivo to the corresponding alcohol PR-1
Autor:
Kevin O. Hicks, William R. Wilson, Michael P. Hay, Jagdish K. Jaiswal, Jingli Wang, Yongchuan Gu
Publikováno v:
Journal of Pharmaceutical Sciences. 103:3464-3472
SN30000 is a benzotriazine di-N-oxide which is selectively toxic to radio-resistant hypoxic cells in tumours. Given the complex photochemistry of some aromatic N-oxides, we evaluated the potential for photodegradation of SN30000 solutions. Initial st
Publikováno v:
Journal of Shoulder and Elbow Surgery. 22:856-861
Purpose Anterior shoulder anatomy is as complex and variable as its descriptive terminology. A detailed understanding of normal anatomic variability is critical to accurate performance, description, and evaluation of the procedures involving the rota
Autor:
William R. Wilson, Kathleen G. Mountjoy, Ralph J. Stevenson, Moana Tercel, Stephen Mark Stribbling, Rebecca N. Marnane, Guo-Liang Lu, William A. Denny, Michele A. Tatnell
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:734-749
Quaternary salt analogues based on the DNA minor groove binder and adenine N3 alkylating agent 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indole (aminoCBI) show remarkable effects on the body weight of mice (a long-term failure to gain weight rel
Autor:
H. D. Sarath Liyanage, Bronwyn G. Siim, William R. Wilson, Rita Patel, William A. Denny, Kevin O. Hicks, Frederik B. Pruijn, Mary Jo Dorie, Jagdish K. Jaiswal, Annie M. Fraser, J. Martin Brown, Alison Hogg, Michael P. Hay
Publikováno v:
Clinical Cancer Research. 16:4946-4957
Purpose: Tirapazamine (TPZ) has attractive features for targeting hypoxic cells in tumors but has limited clinical activity, in part because of poor extravascular penetration. Here, we identify improved TPZ analogues by using a spatially resolved pha