Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Veijola, Juha"'
Autor:
Pardiñas, Antonio F., Smart, Sophie E., Corvin, Aiden, Freimer, Nelson B., Friedl, Marion, Friedman, Joseph I., Fromer, Menachem, Genovese, Giulio, Georgieva, Lyudmila, Gershon, Elliot S., Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Fanous, Ayman H., Goldstein, Jacqueline I., Golimbet, Vera, Gopal, Srihari, Gratten, Jacob, Haan, Lieuwe de, Hammer, Christian, Hamshere, Marian L., Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Frank, Josef, Hartmann, Annette M., Henskens, Frans A., Herms, Stefan, Hirschhorn, Joel N., Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V., Hougaard, David M., Ikeda, Masashi, Joa, Inge, Kelly, Brian, Julià, Antonio, Kahn, René S., Kalaydjieva, Luba, Karachanak-Yankova, Sena, Karjalainen, Juha, Kavanagh, David, Keller, Matthew C., Kennedy, James L., Khrunin, Andrey, Kim, Yunjung, McQuillin, Andrew, Klovins, Janis, Knowles, James A., Konte, Bettina, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kuzelova-Ptackova, Hana, Kähler, Anna K., Laurent, Claudine, Keong, Jimmy Lee Chee, Lee, S. Hong, Melle, Ingrid, Lerer, Bernard, Li, Miaoxin, Li, Tao, Liang, Kung-Yee, Lieberman, Jeffrey, Limborska, Svetlana, Loughland, Carmel M., Lubinski, Jan, Lönnqvist, Jouko, Macek, Milan, Mortensen, Preben B., Magnusson, Patrik K. E., Maher, Brion S., Maier, Wolfgang, Mallet, Jacques, Marsal, Sara, Mattheisen, Manuel, Mattingsdal, Morten, McCarley, Robert W., McDonald, Colm, McIntosh, Andrew M., Mowry, Bryan J., Meier, Sandra, Meijer, Carin J., Melegh, Bela, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mokrab, Younes, Pato, Carlos N., Morris, Derek W., Mors, Ole, Murphy, Kieran C., Myin-Germeys, Inez, Müller-Myhsok, Bertram, Nelis, Mari, Nenadic, Igor, Nertney, Deborah A., Nestadt, Gerald, Nicodemus, Kristin K., Periyasamy, Sathish, Nikitina-Zake, Liene, Nisenbaum, Laura, Nordin, Annelie, O’Callaghan, Eadbhard, O’Dushlaine, Colm, O’Neill, F. Anthony, Oh, Sang-Yun, Olincy, Ann, Olsen, Line, Os, Jim Van, Willcocks, Isabella R., Rietschel, Marcella, Pantelis, Christos, Papadimitriou, George N., Papiol, Sergi, Parkhomenko, Elena, Pato, Michele T., Paunio, Tiina, Pejovic-Milovancevic, Milica, Perkins, Diana O., Pietiläinen, Olli, Pimm, Jonathan, Rujescu, Dan, Pocklington, Andrew J., Powell, John, Price, Alkes, Pulver, Ann E., Purcell, Shaun M., Quested, Digby, Rasmussen, Henrik B., Reichenberg, Abraham, Reimers, Mark A., Richards, Alexander L., Simonsen, Carmen, Roffman, Joshua L., Roussos, Panos, Ruderfer, Douglas M., Salomaa, Veikko, Sanders, Alan R., Schall, Ulrich, Schubert, Christian R., Schulze, Thomas G., Schwab, Sibylle G., Scolnick, Edward M., St Clair, David, Scott, Rodney J., Seidman, Larry J., Shi, Jianxin, Sigurdsson, Engilbert, Silagadze, Teimuraz, Silverman, Jeremy M., Sim, Kang, Slominsky, Petr, Smoller, Jordan W., So, Hon-Cheong, Tooney, Paul, Spencer, Chris C. A., Stahl, Eli A., Stefansson, Hreinn, Steinberg, Stacy, Stogmann, Elisabeth, Straub, Richard E., Strengman, Eric, Strohmaier, Jana, Stroup, T. Scott, Subramaniam, Mythily, Wu, Jing Qin, Suvisaari, Jaana, Svrakic, Dragan M., Szatkiewicz, Jin P., Söderman, Erik, Thirumalai, Srinivas, Toncheva, Draga, Tosato, Sarah, Veijola, Juha, Waddington, John, Walsh, Dermot, Andreassen, Ole A., Wang, Dai, Wang, Qiang, Webb, Bradley T., Weiser, Mark, Wildenauer, Dieter B., Williams, Nigel M., Williams, Stephanie, Witt, Stephanie H., Wolen, Aaron R., Wong, Emily H. M., Kowalec, Kaarina, Wormley, Brandon K., Xi, Hualin Simon, Zai, Clement C., Zheng, Xuebin, Zimprich, Fritz, Wray, Naomi R., Stefansson, Kari, Visscher, Peter M., Adolfsson, Rolf, Blackwood, Douglas H. R., Sullivan, Patrick F., Bramon, Elvira, Buxbaum, Joseph D., Børglum, Anders D., Cichon, Sven, Darvasi, Ariel, Domenici, Enrico, Ehrenreich, Hannelore, Esko, Tõnu, Gejman, Pablo V., Gill, Michael, Murray, Robin M., Gurling, Hugh, Hultman, Christina M., Iwata, Nakao, Jablensky, Assen V., Jönsson, Erik G., Kendler, Kenneth S., Kirov, George, Knight, Jo, Lencz, Todd, Levinson, Douglas F., Holmans, Peter A., Owen, Michael J., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., McCarroll, Steven A., Moran, Jennifer L., Nöthen, Markus M., Ophoff, Roel A., Palotie, Aarno, Petryshen, Tracey L., MacCabe, James H., Posthuma, Danielle, Riley, Brien P., Sham, Pak C., Sklar, Pamela, Clair, David St, Weinberger, Daniel R., Wendland, Jens R., Werge, Thomas, Daly, Mark J., Agbedjro, Deborah, O’Donovan, Michael C., Stahl, Daniel, Kapur, Shitij, Millgate, Edward, Kepinska, Adrianna, Kravariti, Eugenia, Ajnakina, Olesya, Alameda, Luis, Barnes, Thomas R. E., Berardi, Domenico, Bonora, Elena, Walters, James T. R., Camporesi, Sara, Cleusix, Martine, Conus, Philippe, Crespo-Facorro, Benedicto, D’Andrea, Giuseppe, Demjaha, Arsime, Do, Kim Q., Doody, Gillian A., Eap, Chin B., Ferchiou, Aziz, Ripke, Stephan, Di Forti, Marta, Guidi, Lorenzo, Homman, Lina, Jenni, Raoul, Joyce, Eileen M., Kassoumeri, Laura, Khadimallah, Inès, Lastrina, Ornella, Muratori, Roberto, Noyan, Handan, Neale, Benjamin M., O’Neill, Francis A., Pignon, Baptiste, Restellini, Romeo, Richard, Jean-Romain, Schürhoff, Franck, Španiel, Filip, Szöke, Andrei, Tarricone, Ilaria, Tortelli, Andrea, Üçok, Alp, Farh, Kai-How, Vázquez-Bourgon, Javier, Lee, Phil, Bulik-Sullivan, Brendan, Collier, David A., Dennison, Charlotte A., Huang, Hailiang, Pers, Tune H., Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A ., Lynham, Amy J., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Black, Donald W., Bruggeman, Richard, Buccola, Nancy G., Buckner, Randy L., Byerley, William, Cahn, Wiepke, Cai, Guiqing, Legge, Sophie E., Campion, Dominique, Cantor, Rita M., Carr, Vaughan J., Carrera, Noa, Catts, Stanley V., Chambert, Kimberly D., Chan, Raymond C. K., Chen, Ronald Y. L., Chen, Eric Y. H., Cheng, Wei, Baune, Bernhard T., Cheung, Eric F. C., Chong, Siow Ann, Cloninger, C. Robert, Cohen, David, Cohen, Nadine, Cormican, Paul, Craddock, Nick, Crowley, James J., Curtis, David, Davidson, Michael, Bigdeli, Tim B., Davis, Kenneth L., Degenhardt, Franziska, Favero, Jurgen Del, DeLisi, Lynn E., Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Cairns, Murray J., Duan, Jubao, Dudbridge, Frank, Durmishi, Naser, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Farrell, Martilias S., Franke, Lude, Freedman, Robert
Publikováno v:
JAMA psychiatry 79(3), 260-269 (2022). doi:10.1001/jamapsychiatry.2021.3799
JAMA psychiatry, vol. 79, no. 3, pp. 260-269
JAMA Psychiatry
Genetics Workstream of the Schizophrenia Treatment Resistance and Therapeutic Advances (STRATA) Consortium and the Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC) 2022, ' Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia ', JAMA psychiatry, vol. 79, no. 3, pp. 260-269 . https://doi.org/10.1001/jamapsychiatry.2021.3799
JAMA Psychiatry 2022; 79 (3): 260-269
Pardiñas, A F, Smart, S E, Willcocks, I R, Holmans, P A, Dennison, C A, Lynham, A J, Legge, S E, Baune, B T, Bigdeli, T B, Cairns, M J, Corvin, A, Fanous, A H, Frank, J, Kelly, B, McQuillin, A, Melle, I, Mortensen, P B, Mowry, B J, Pato, C N, Periyasamy, S, Rietschel, M, Rujescu, D, Simonsen, C, St Clair, D, Tooney, P, Wu, J Q, Andreassen, O A, Kowalec, K, Sullivan, P F, Murray, R M, Owen, M J, Maccabe, J H, O'Donovan, M C, Walters, J T R, The Genetics Workstream of the Schizophrenia Treatment Resistance and Therapeutic Advances (STRATA) Consortium & The Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC) 2022, ' Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants with Treatment Resistance in Schizophrenia ', JAMA Psychiatry, vol. 79, no. 3, pp. 260-269 . https://doi.org/10.1001/jamapsychiatry.2021.3799
Genetics Workstream of the Schizophrenia Treatment Resistance and Therapeutic Advances (STRATA) Consortium and the Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC) 2022, ' Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia ', JAMA Psychiatry . https://doi.org/10.1001/jamapsychiatry.2021.3799
JAMA psychiatry, vol. 79, no. 3, pp. 260-269
JAMA Psychiatry
Genetics Workstream of the Schizophrenia Treatment Resistance and Therapeutic Advances (STRATA) Consortium and the Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC) 2022, ' Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia ', JAMA psychiatry, vol. 79, no. 3, pp. 260-269 . https://doi.org/10.1001/jamapsychiatry.2021.3799
JAMA Psychiatry 2022; 79 (3): 260-269
Pardiñas, A F, Smart, S E, Willcocks, I R, Holmans, P A, Dennison, C A, Lynham, A J, Legge, S E, Baune, B T, Bigdeli, T B, Cairns, M J, Corvin, A, Fanous, A H, Frank, J, Kelly, B, McQuillin, A, Melle, I, Mortensen, P B, Mowry, B J, Pato, C N, Periyasamy, S, Rietschel, M, Rujescu, D, Simonsen, C, St Clair, D, Tooney, P, Wu, J Q, Andreassen, O A, Kowalec, K, Sullivan, P F, Murray, R M, Owen, M J, Maccabe, J H, O'Donovan, M C, Walters, J T R, The Genetics Workstream of the Schizophrenia Treatment Resistance and Therapeutic Advances (STRATA) Consortium & The Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC) 2022, ' Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants with Treatment Resistance in Schizophrenia ', JAMA Psychiatry, vol. 79, no. 3, pp. 260-269 . https://doi.org/10.1001/jamapsychiatry.2021.3799
Genetics Workstream of the Schizophrenia Treatment Resistance and Therapeutic Advances (STRATA) Consortium and the Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC) 2022, ' Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia ', JAMA Psychiatry . https://doi.org/10.1001/jamapsychiatry.2021.3799
[Importance] About 20% to 30% of people with schizophrenia have psychotic symptoms that do not respond adequately to first-line antipsychotic treatment. This clinical presentation, chronic and highly disabling, is known as treatment-resistant schizop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073d06a5f9a51c3442ad360857f1ebaa
https://hdl.handle.net/2128/31365
https://hdl.handle.net/2128/31365
Autor:
Ramsay, Hugh, Surcel, Heljä-Marja, Björnholm, Lassi, Kerkelä, Martta, Khandaker, Golam M, Veijola, Juha
Prenatal infection is associated with brain structural and functional abnormalities and may increase the risk for psychosis through a direct effect on neurodevelopment. Various infections may exert their effect through a proinflammatory immune respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05fbf0726da69ff9c0896eed197b490
Autor:
Kamitaki, Nolan, Sekar, Aswin, Consortium, Schizophrenia Working Group of the Psychiatric Genomics, Friedman, Joseph I, Fromer, Menachem, Genovese, Giulio, Georgieva, Lyudmila, Gershon, Elliot S, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I, Golimbet, Vera, Boehnke, Michael, Gopal, Srihari, Gratten, Jacob, de Haan, Lieuwe, Mitjans, Marina, Hamshere, Marian L, Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M, Henskens, Frans A, Kimberly, Robert P, Herms, Stefan, Hirschhorn, Joel N, Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V, Hougaard, David M, Ikeda, Masashi, Joa, Inge, Julià, Antonio, Kahn, René S, Kaufman, Kenneth M, Kalaydjieva, Luba, Karachanak-Yankova, Sena, Karjalainen, Juha, Kavanagh, David, Keller, Matthew C, Kelly, Brian J, Kennedy, James L, Khrunin, Andrey, Kim, Yunjung, Klovins, Janis, Harley, John B, Knowles, James A, Konte, Bettina, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kuzelova-Ptackova, Hana, Kähler, Anna K, Laurent, Claudine, Keong, Jimmy Lee Chee, Lee, S Hong, Legge, Sophie E, Langefeld, Carl D, Lerer, Bernard, Li, Miaoxin, Li, Tao, Liang, Kung-Yee, Lieberman, Jeffrey, Limborska, Svetlana, Loughland, Carmel M, Lubinski, Jan, Lönnqvist, Jouko, Macek, Milan, Seidman, Christine E, Magnusson, Patrik K E, Maher, Brion S, Maier, Wolfgang, Mallet, Jacques, Marsal, Sara, Mattheisen, Manuel, Mattingsdal, Morten, McCarley, Robert W, McDonald, Colm, McIntosh, Andrew M, Pato, Michele T, Meier, Sandra, Meijer, Carin J, Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I, Metspalu, Andres, Michie, Patricia T, Milani, Lili, Milanova, Vihra, Mokrab, Younes, Pato, Carlos N, Morris, Derek W, Mors, Ole, Murphy, Kieran C, Murray, Robin M, Myin-Germeys, Inez, Müller-Myhsok, Bertram, Nelis, Mari, Nenadic, Igor, Nertney, Deborah A, Nestadt, Gerald, Ophoff, Roel A, Nicodemus, Kristin K, Nikitina-Zake, Liene, Nisenbaum, Laura, Nordin, Annelie, O'Callaghan, Eadbhard, O'Dushlaine, Colm, O'Neill, F Anthony, Oh, Sang-Yun, Olincy, Ann, Olsen, Line, Handsaker, Robert E, Graham, Robert R, Van Os, Jim, Pantelis, Christos, Papadimitriou, George N, Steixner, Agnes A, Parkhomenko, Elena, Paunio, Tiina, Pejovic-Milovancevic, Milica, Perkins, Diana O, Pietiläinen, Olli, Criswell, Lindsey A, Pimm, Jonathan, Pocklington, Andrew J, Powell, John, Price, Alkes, Pulver, Ann E, Purcell, Shaun M, Quested, Digby, Rasmussen, Henrik B, Reichenberg, Abraham, Reimers, Mark A, Vyse, Timothy J, Richards, Alexander L, Roffman, Joshua L, Roussos, Panos, Ruderfer, Douglas M, Salomaa, Veikko, Sanders, Alan R, Schall, Ulrich, Schubert, Christian R, Schulze, Thomas G, Schwab, Sibylle G, McCarroll, Steven A, Scolnick, Edward M, Scott, Rodney J, Seidman, Larry J, Shi, Jianxin, Sigurdsson, Engilbert, Silagadze, Teimuraz, Silverman, Jeremy M, Sim, Kang, Slominsky, Petr, Smoller, Jordan W, Ripke, Stephan, So, Hon-Cheong, Spencer, Chris C A, Stahl, Eli A, Stefansson, Hreinn, Steinberg, Stacy, Stogmann, Elisabeth, Straub, Richard E, Strengman, Eric, Strohmaier, Jana, Stroup, T Scott, Neale, Benjamin M, Subramaniam, Mythily, Suvisaari, Jaana, Svrakic, Dragan M, Szatkiewicz, Jin P, Söderman, Erik, Thirumalai, Srinivas, Toncheva, Draga, Tooney, Paul A, Tosato, Sarah, Veijola, Juha, Corvin, Aiden, Waddington, John, Walsh, Dermot, Wang, Dai, Wang, Qiang, Webb, Bradley T, Weiser, Mark, Wildenauer, Dieter B, Williams, Nigel M, Williams, Stephanie, Witt, Stephanie H, Walters, James T R, Wolen, Aaron R, Wong, Emily H M, Wormley, Brandon K, Wu, Jing Qin, Xi, Hualin Simon, Zai, Clement C, Zheng, Xuebin, Zimprich, Fritz, Wray, Naomi R, Stefansson, Kari, Farh, Kai-How, Visscher, Peter M, Adolfsson, Rolf, Andreassen, Ole A, Blackwood, Douglas H R, Bramon, Elvira, Buxbaum, Joseph D, Børglum, Anders D, Cichon, Sven, Darvasi, Ariel, Domenici, Enrico, Holmans, Peter A, Ehrenreich, Hannelore, Esko, Tõnu, Gejman, Pablo V, Gill, Michael, Gurling, Hugh, Hultman, Christina M, Iwata, Nakao, Jablensky, Assen V, Jönsson, Erik G, Kendler, Kenneth S, de Rivera, Heather, Lee, Phil, Kirov, George, Knight, Jo, Lencz, Todd, Levinson, Douglas F, Li, Qingqin S, Liu, Jianjun, Malhotra, Anil K, McQuillin, Andrew, Moran, Jennifer L, Bulik-Sullivan, Brendan, Mortensen, Preben B, Mowry, Bryan J, Nöthen, Markus M, Owen, Michael J, Palotie, Aarno, Petryshen, Tracey L, Posthuma, Danielle, Rietschel, Marcella, Collier, David A, Riley, Brien P, Rujescu, Dan, Sham, Pak C, Sklar, Pamela, Clair, David St, Weinberger, Daniel R, Wendland, Jens R, Werge, Thomas, Daly, Mark J, Sullivan, Patrick F, Huang, Hailiang, O'Donovan, Michael C, Pers, Tune H, Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Tooley, Katherine, Bacanu, Silviu A, Begemann, Martin, Belliveau, Richard A, Bene, Judit, Bergen, Sarah E, Bevilacqua, Elizabeth, Bigdeli, Tim B, Black, Donald W, Bruggeman, Richard, Buccola, Nancy G, Morris, David L, Buckner, Randy L, Byerley, William, Cahn, Wiepke, Cai, Guiqing, Cairns, Murray J, Campion, Dominique, Cantor, Rita M, Carr, Vaughan J, Carrera, Noa, Catts, Stanley V, Taylor, Kimberly E, Chambert, Kimberly D, Chan, Raymond C K, Chen, Ronald Y L, Chen, Eric Y H, Cheng, Wei, Cheung, Eric F C, Chong, Siow Ann, Cloninger, C Robert, Cohen, David, Cohen, Nadine, Whelan, Christopher W, Cormican, Paul, Craddock, Nick, Crespo-Facorro, Benedicto, Crowley, James J, Curtis, David, Davidson, Michael, Davis, Kenneth L, Degenhardt, Franziska, Del Favero, Jurgen, DeLisi, Lynn E, Tombleson, Philip, Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Dudbridge, Frank, Durmishi, Naser, Eichhammer, Peter, Loohuis, Loes M Olde, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Fanous, Ayman H, Farrell, Martilias S, Frank, Josef, Franke, Lude, Freedman, Robert, Freimer, Nelson B, Friedl, Marion
Publikováno v:
Nature, 582, 577-581. Nature Publishing Group
Nature, 582(7813), 577-581. Nature Publishing Group
Nature 582(7813), 577-581 (2020). doi:10.1038/s41586-020-2277-x
Nature
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Psychosis Endophenotypes International Consortium & Wellcome Trust Case–Control Consortium 2 2020, ' Complement genes contribute sex-biased vulnerability in diverse disorders ', Nature, vol. 582, no. 7813, pp. 577-581 . https://doi.org/10.1038/s41586-020-2277-x
Nature, vol 582, iss 7813
Nature. Nature Publishing Group
Kamitaki, N, Sekar, A, Handsaker, R E, de Rivera, H, Tooley, K, Morris, D L, Taylor, K E, Whelan, C W, Tombleson, P, Loohuis, L M O, Psychosis Endophenotypes International Consortium, Wellcome Trust Case–Control Consortium 2, Psychosis Endophenotype International Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Boehnke, M, Kimberly, R P, Kaufman, K M, Harley, J B, Langefeld, C D, Seidman, C E, Pato, M T, Pato, C N, Ophoff, R A, Graham, R R, Criswell, L A, Vyse, T J & McCarroll, S A 2020, ' Complement genes contribute sex-biased vulnerability in diverse disorders ', Nature . https://doi.org/10.1038/s41586-020-2277-x
Kamitaki, N, Sekar, A, Handsaker, R E, de Rivera, H, Tooley, K, Morris, D L, Taylor, K E, Whelan, C W, Tombleson, P, Loohuis, L M O, Boehnke, M, Kimberly, R P, Kaufman, K M, Harley, J B, Langefeld, C D, Seidman, C E, Pato, M T, Pato, C N, Ophoff, R A, Graham, R R, Criswell, L A & Vyse, T J & McCarroll, S A 2020, ' Complement genes contribute sex-biased vulnerability in diverse disorders ', Nature, vol. 582, no. 7813, pp. 577-581 . https://doi.org/10.1038/s41586-020-2277-x
Kamitaki, N, Sekar, A, Handsaker, R E, de Rivera, H, Tooley, K, Morris, D L, Taylor, K E, Whelan, C W, Tombleson, P, Loohuis, L M O, Boehnke, M, Kimberly, R P, Kaufman, K M, Harley, J B, Langefeld, C D, Seidman, C E, Pato, M T, Pato, C N, Ophoff, R A, Graham, R R, Criswell, L A, Vyse, T J, McCarroll, S A & Schizophrenia Working Group of the Psychiatric Genomics Consortium 2020, ' Complement genes contribute sex-biased vulnerability in diverse disorders ', Nature, vol. 582, no. 7813, pp. 577-581 . https://doi.org/10.1038/s41586-020-2277-x
Nature, 582(7813), 577-581. Nature Publishing Group
Nature
Nature
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Psychosis Endophenotypes International Consortium & Wellcome Trust Case–Control Consortium 2 2020, ' Complement genes contribute sex-biased vulnerability in diverse disorders ', Nature, vol. 582, no. 7813, pp. 577-581 . https://doi.org/10.1038/s41586-020-2277-x
Nature, vol 582, iss 7813
Nature. Nature Publishing Group
Kamitaki, N, Sekar, A, Handsaker, R E, de Rivera, H, Tooley, K, Morris, D L, Taylor, K E, Whelan, C W, Tombleson, P, Loohuis, L M O, Psychosis Endophenotypes International Consortium, Wellcome Trust Case–Control Consortium 2, Psychosis Endophenotype International Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Boehnke, M, Kimberly, R P, Kaufman, K M, Harley, J B, Langefeld, C D, Seidman, C E, Pato, M T, Pato, C N, Ophoff, R A, Graham, R R, Criswell, L A, Vyse, T J & McCarroll, S A 2020, ' Complement genes contribute sex-biased vulnerability in diverse disorders ', Nature . https://doi.org/10.1038/s41586-020-2277-x
Kamitaki, N, Sekar, A, Handsaker, R E, de Rivera, H, Tooley, K, Morris, D L, Taylor, K E, Whelan, C W, Tombleson, P, Loohuis, L M O, Boehnke, M, Kimberly, R P, Kaufman, K M, Harley, J B, Langefeld, C D, Seidman, C E, Pato, M T, Pato, C N, Ophoff, R A, Graham, R R, Criswell, L A & Vyse, T J & McCarroll, S A 2020, ' Complement genes contribute sex-biased vulnerability in diverse disorders ', Nature, vol. 582, no. 7813, pp. 577-581 . https://doi.org/10.1038/s41586-020-2277-x
Kamitaki, N, Sekar, A, Handsaker, R E, de Rivera, H, Tooley, K, Morris, D L, Taylor, K E, Whelan, C W, Tombleson, P, Loohuis, L M O, Boehnke, M, Kimberly, R P, Kaufman, K M, Harley, J B, Langefeld, C D, Seidman, C E, Pato, M T, Pato, C N, Ophoff, R A, Graham, R R, Criswell, L A, Vyse, T J, McCarroll, S A & Schizophrenia Working Group of the Psychiatric Genomics Consortium 2020, ' Complement genes contribute sex-biased vulnerability in diverse disorders ', Nature, vol. 582, no. 7813, pp. 577-581 . https://doi.org/10.1038/s41586-020-2277-x
Many common illnesses, for reasons that have not been identified, differentially affect men and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and Sjögren’s syndrome affect nine times more women than men1, whereas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7964df78d78480c9e0c194493889774
https://pure.amc.nl/en/publications/complement-genes-contribute-sexbiased-vulnerability-in-diverse-disorders(0898353e-9311-41cc-b824-accb09517818).html
https://pure.amc.nl/en/publications/complement-genes-contribute-sexbiased-vulnerability-in-diverse-disorders(0898353e-9311-41cc-b824-accb09517818).html
Autor:
Lieslehto, Johannes, Kiviniemi, Vesa J, Nordström, Tanja, Barnett, Jennifer H, Murray, Graham K, Jones, Peter B, Paus, Tomáš, Veijola, Juha
Development of schizophrenia relates to both genetic and environmental factors. Functional deficits in many cognitive domains, including the ability to communicate in social interactions and impaired recognition of facial expressions, are common for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d1c7d601471e3d2c164011298b2dc8
https://www.repository.cam.ac.uk/handle/1810/285547
https://www.repository.cam.ac.uk/handle/1810/285547
Autor:
Stochl, Jan, Whittier, Anjalene, Wagner, Adam P, Veijola, Juha, Jääskeläinen, Erika, Miettunen, Jouko, Khandaker, Golam M, Jones, Peter B
We investigated relationships between early developmental milestones, schizophrenia incidence and variability in its age at onset. We hypothesized that the period of risk for schizophrenia would be longer for those with later development. The Norther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a525aaff93ba42ee83befc6833c1f071
https://www.repository.cam.ac.uk/handle/1810/289861
https://www.repository.cam.ac.uk/handle/1810/289861
Autor:
Singh, Tarjinder, Kurki, Mitja I, Curtis, David, Purcell, Shaun M, Crooks, Lucy, McRae, Jeremy, Suvisaari, Jaana, Chheda, Himanshu, Blackwood, Douglas, Breen, Gerome, Pietiläinen, Olli, Gerety, Sebastian S, Ayub, Muhammad, Blyth, Moira, Cole, Trevor, Collier, David, Coomber, Eve L, Craddock, Nick, Daly, Mark J, Danesh, John, DiForti, Marta, Foster, Alison, Freimer, Nelson B, Geschwind, Daniel, Johnstone, Mandy, Joss, Shelagh, Kirov, Georg, Körkkö, Jarmo, Kuismin, Outi, Holmans, Peter, Hultman, Christina M, Iyegbe, Conrad, Lönnqvist, Jouko, Männikkö, Minna, McCarroll, Steve A, McGuffin, Peter, McIntosh, Andrew M, McQuillin, Andrew, Moilanen, Jukka S, Moore, Carmel, Murray, Robin M, Newbury-Ecob, Ruth, Ouwehand, Willem, Paunio, Tiina, Prigmore, Elena, Rees, Elliott, Roberts, David, Sambrook, Jennifer, Sklar, Pamela, St Clair, David, Veijola, Juha, Walters, James TR, Williams, Hywel, Swedish Schizophrenia Study, INTERVAL Study, DDD Study, UK10 K Consortium, Sullivan, Patrick F, Hurles, Matthew E, O'Donovan, Michael C, Palotie, Aarno, Owen, Michael J, Barrett, Jeffrey C
Publikováno v:
Nature neuroscience, vol 19, iss 4
By analyzing the whole-exome sequences of 4,264 schizophrenia cases, 9,343 controls and 1,077 trios, we identified a genome-wide significant association between rare loss-of-function (LoF) variants in SETD1A and risk for schizophrenia (P = 3.3 × 10(
Autor:
Roman-Urrestarazu, Andres, Lindholm, Päivi, Moilanen, Irma, Kiviniemi, Vesa, Miettunen, Jouko, Jääskeläinen, Erika, Mäki, Pirjo, Hurtig, Tuula, Ebeling, Hanna, Barnett, Jennifer H., Nikkinen, Juha, Suckling, John, Jones, Peter B., Veijola, Juha, Murray, Graham K.
Publikováno v:
European Child & Adolescent Psychiatry
When adolescents with ADHD enter adulthood, some no longer meet disorder diagnostic criteria but it is unknown if biological and cognitive abnorma lities persist. We tested the hypothesis that people diagnosed with ADHD during adolescence present res
Autor:
Lieslehto, Johannes, Kiviniemi, Vesa, Mäki, Pirjo, Koivukangas, Jenni, Nordström, Tanja, Miettunen, Jouko, Barnett, Jennifer H., Jones, Peter B., Murray, Graham K., Moilanen, Irma, Paus, Tomáš, Veijola, Juha
Publikováno v:
Hum Brain Mapp
Early stressors play a key role in shaping interindividual differences in vulnerability to various psychopathologies, which according to the diathesis‐stress model might relate to the elevated glucocorticoid secretion and impaired responsiveness to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfbbc7454ecd08e64c3c32216fb61970
https://europepmc.org/articles/PMC6866906/
https://europepmc.org/articles/PMC6866906/
Autor:
Maddock, Jane, Zhou, Ang, Cavadino, Alana, Kuźma, Elżbieta, Bao, Yanchun, Smart, Melissa C., Saum, Kai-Uwe, Schöttker, Ben, Engmann, Jorgen, Kjærgaard, Marie, Karhunen, Ville, Zhan, Yiqiang, Lehtimäki, Terho, Rovio, Suvi P., Byberg, Liisa, Lahti, Jari, Marques-Vidal, Pedro, Sen, Abhijit, Perna, Laura, Schirmer, Henrik, Singh-Manoux, Archana, Auvinen, Juha, Hutri-Kähönen, Nina, Kähönen, Mika, Kilander, Lena, Räikkönen, Katri, Melhus, Håkan, Ingelsson, Erik, Guessous, Idris, Petrovic, Katja E, Schmidt, Helena, Schmidt, Reinhold, Vollenweider, Peter, Lind, Lars, Eriksson, Johan G., Michaëlsson, Karl, Raitakari, Olli T., Hägg, Sara, Pedersen, Nancy L., Herzig, Karl-Heinz, Järvelin, Marjo-Riitta, Veijola, Juha, Kivimaki, Mika, Jorde, Rolf, Brenner, Hermann, Kumari, Meena, Power, Chris, Llewellyn, David J., Hyppönen, Elina
Publikováno v:
Scientific Reports
Scientific reports, vol. 7, no. 1, pp. 13230
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Scientific reports, vol. 7, no. 1, pp. 13230
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d07d390169ea534f569a173c6fd42f91
http://urn.fi/urn:nbn:fi-fe2017112050795
http://urn.fi/urn:nbn:fi-fe2017112050795
Autor:
Johnson, Emma C., Bjelland, Douglas W., Howrigan, Daniel P., Abdellaoui, Abdel, Breen, Gerome, Borglum, Anders, Cichon, Sven, Degenhardt, Franziska, Forstner, Andreas J., Frank, Josef, Genovese, Giulio, Heilmann-Heimbach, Stefanie, Herms, Stefan, Hoffman, Per, Maier, Wolfgang, Mattheisen, Manuel, Morris, Derek, Mowry, Bryan, Müller-Mhysok, Betram, Neale, Benjamin, Nenadic, Igor, Nöthen, Markus M., O’Dushlaine, Colm, Rietschel, Marcella, Ruderfer, Douglas M., Rujescu, Dan, Schulze, Thomas G., Simonson, Matthew A., Stahl, Eli, Strohmaier, Jana, Witt, Stephanie H., Ripke, Stephan, Neale, Benjamin M., Corvin, Aiden, Walters, James T R, Farh, Kai How, Holmans, Peter A., Lee, Phil, Bulik-Sullivan, Brendan, Collier, David A., Huang, Hailiang, Pers, Tune H., Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Bruggeman, Richard, Buccola, Nancy G., Buckner, Randy L., Byerley, William, Cahn, Wiepke, Cai, Guiqing, Campion, Dominique, Cantor, Rita M., Carr, Vaughan J., Carrera, Noa, Catts, Stanley V., Chambert, Kimberly D., Chan, Raymond C K, Chen, Ronald Y L, Chen, Eric Y H, Cheng, Wei, Cheung, Eric F C, Chong, Siow Ann, Robert Cloninger, C., Cohen, David, Cohen, Nadine, Cormican, Paul, Craddock, Nick, Crowley, James J., Curtis, David, Davidson, Michael, Davis, Kenneth L., Del Favero, Jurgen, Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Dudbridge, Frank, Durmishi, Naser, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Fanous, Ayman H., Farrell, Martilias S., Franke, Lude, Freedman, Robert, Freimer, Nelson B., Friedl, Marion, Friedman, Joseph I., Fromer, Menachem, Georgieva, Lyudmila, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., Golimbet, Vera, Gopal, Srihari, Gratten, Jacob, de Haan, Lieuwe, Hammer, Christian, Hamshere, Marian L., Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M., Henskens, Frans A., Hirschhorn, Joel N., Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V., Hougaard, David M., Ikeda, Masashi, Joa, Inge, Julià, Antonio, Kahn, René S., Kalaydjieva, Luba, Karachanak-Yankova, Sena, Karjalainen, Juha, Kavanagh, David, Kennedy, James L., Khrunin, Andrey, Kim, Yunjung, Klovins, Janis, Knowles, James A., Konte, Bettina, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kuzelova-Ptackova, Hana, Kähler, Anna K., Laurent, Claudine, Chee Keong, Jimmy Lee, Hong Lee, S., Legge, Sophie E., Lerer, Bernard, Li, Miaoxin, Li, Tao, Liang, Kung Yee, Lieberman, Jeffrey, Limborska, Svetlana, Loughland, Carmel M., Lubinski, Jan, Lönnqvist, Jouko, Macek, Milan, Magnusson, Patrik K E, Maher, Brion S., Mallet, Jacques, Marsal, Sara, Mattingsdal, Morten, McCarley, Robert W., McDonald, Colm, McIntosh, Andrew M., Meier, Sandra, Meijer, Carin J., Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mokrab, Younes, Morris, Derek W., Mors, Ole, Murphy, Kieran C., Murray, Robin M., Myin-Germeys, Inez, Müller-Myhsok, Bertram, Nelis, Mari, Nertney, Deborah A., Nestadt, Gerald, Nicodemus, Kristin K., Nikitina-Zake, Liene, Nisenbaum, Laura, Nordin, Annelie, O'Callaghan, Eadbhard, O'Dushlaine, Colm, Anthony O'Neill, F., Oh, Sang Yun, Olincy, Ann, Olsen, Line, Van Os, Jim, Pantelis, Christos, Papadimitriou, George N., Papiol, Sergi, Parkhomenko, Elena, Pato, Michele T., Paunio, Tiina, Pejovic-Milovancevic, Milica, Perkins, Diana O., Pietiläinen, Olli, Pimm, Jonathan, Pocklington, Andrew J., Powell, John, Price, Alkes, Pulver, Ann E., Purcell, Shaun M., Quested, Digby, Rasmussen, Henrik B., Reichenberg, Abraham, Reimers, Mark A., Richards, Alexander L., Roffman, Joshua L., Roussos, Panos, Salomaa, Veikko, Sanders, Alan R., Schall, Ulrich, Schubert, Christian R., Schwab, Sibylle G., Scolnick, Edward M., Scott, Rodney J., Seidman, Larry J., Shi, Jianxin, Sigurdsson, Engilbert, Silagadze, Teimuraz, Silverman, Jeremy M., Sim, Kang, Slominsky, Petr, Smoller, Jordan W., So, Hon Cheong, Spencer, Chris C A, Stahl, Eli A., Stefansson, Hreinn, Steinberg, Stacy, Stogmann, Elisabeth, Straub, Richard E., Strengman, Eric, Scott Stroup, T., Subramaniam, Mythily, Suvisaari, Jaana, Svrakic, Dragan M., Szatkiewicz, Jin P., Söderman, Erik, Thirumalai, Srinivas, Toncheva, Draga, Tosato, Sarah, Veijola, Juha, Waddington, John, Walsh, Dermot, Wang, Dai, Wang, Qiang, Webb, Bradley T., Weiser, Mark, Wildenauer, Dieter B., Williams, Nigel M., Williams, Stephanie, Wolen, Aaron R., Wong, Emily H M, Wormley, Brandon K., Xi, Hualin Simon, Zai, Clement C., Zheng, Xuebin, Zimprich, Fritz, Wray, Naomi R., Stefansson, Kari, Visscher, Peter M., Adolfsson, Rolf, Andreassen, Ole A., Blackwood, Douglas H R, Bramon, Elvira, Buxbaum, Joseph D., Børglum, Anders D., Darvasi, Ariel, Domenici, Enrico, Ehrenreich, Hannelore, Esko, Tõnu, Gejman, Pablo V., Gill, Michael, Gurling, Hugh, Hultman, Christina M., Iwata, Nakao, Jablensky, Assen V., Jönsson, Erik G., Kendler, Kenneth S., Kirov, George, Knight, Jo, Lencz, Todd, Levinson, Douglas F., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., McCarroll, Steven A., McQuillin, Andrew, Moran, Jennifer L., Mortensen, Preben B., Mowry, Bryan J., Ophoff, Roel A., Owen, Michael J., Palotie, Aarno, Pato, Carlos N., Petryshen, Tracey L., Posthuma, Danielle, Riley, Brien P., Sham, Pak C., Sklar, Pamela, Clair, David S., Weinberger, Daniel R., Wendland, Jens R., Werge, Thomas, Daly, Mark J., O'Donovan, Michael C., Sullivan, Patrick F., Keller, Matthew C.
Publikováno v:
PLoS Genetics
PLOS GENETICS
Johnson, E C, Bjelland, D W, Howrigan, D P, Abdellaoui, A, Breen, G, Borglum, A, Cichon, S, Degenhardt, F, Forstner, A J, Frank, J, Genovese, G, Heilmann-Heimbach, S, Herms, S, Hoffman, P, Maier, W, Mattheisen, M, Morris, D, Mowry, B, Müller-Myhsok, B, Neale, B M, Nenadic, I, Nöthen, M M, O'Dushlaine, C, Rietschel, M, Ruderfer, D M, Rujescu, D, Schulze, T G, Simonson, M A, Stahl, E, Strohmaier, J, Witt, S H, Sullivan, P F & Keller, M C 2016, ' No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study ', PLoS Genetics, vol. 12, no. 10, e1006343 . https://doi.org/10.1371/journal.pgen.1006343
Johnson, E C, Bjelland, D W, Howrigan, D P, Abdellaoui, A, Breen, G, Borglum, A, Cichon, S, Degenhardt, F, Forstner, A J, Frank, J, Genovese, G, Heilmann-Heimbach, S, Herms, S, Hoffman, P, Maier, W, Mattheisen, M, Morris, D, Mowry, B, Müller-Mhysok, B, Neale, B, Nenadic, I, Nöthen, M M, O’Dushlaine, C, Rietschel, M, Ruderfer, D M, Rujescu, D, Schulze, T G, Simonson, M A, Stahl, E, Strohmaier, J, Witt, S H, Ripke, S, Neale, B M, Corvin, A, Walters, J T R, Farh, K H, Holmans, P A, Lee, P, Bulik-Sullivan, B, Collier, D A, Huang, H, Pers, T H, Agartz, I, Agerbo, E, Albus, M, Alexander, M, Amin, F, Bacanu, S A, Begemann, M, Belliveau, R A, Bene, J, Bergen, S E, Bevilacqua, E, Bigdeli, T B, Black, D W, Bruggeman, R, Buccola, N G, Buckner, R L, Byerley, W, Cahn, W, Cai, G, Campion, D, Cantor, R M, Carr, V J, Carrera, N, Catts, S V, Chambert, K D, Chan, R C K, Chen, R Y L, Chen, E Y H, Cheng, W, Cheung, E F C, Chong, S A, Robert Cloninger, C, Cohen, D, Cohen, N, Cormican, P, Craddock, N, Crowley, J J, Curtis, D, Davidson, M, Davis, K L, Del Favero, J, Demontis, D, Dikeos, D, Dinan, T, Djurovic, S, Donohoe, G, Drapeau, E, Duan, J, Dudbridge, F, Durmishi, N, Eichhammer, P, Eriksson, J, Escott-Price, V, Essioux, L, Fanous, A H, Farrell, M S, Franke, L, Freedman, R, Freimer, N B, Friedl, M, Friedman, J I, Fromer, M, Georgieva, L, Giegling, I, Giusti-Rodríguez, P, Godard, S, Goldstein, J I, Golimbet, V, Gopal, S, Gratten, J, de Haan, L, Hammer, C, Hamshere, M L, Hansen, M, Hansen, T, Haroutunian, V, Hartmann, A M, Henskens, F A, Hirschhorn, J N, Hoffmann, P, Hofman, A, Hollegaard, M V, Hougaard, D M, Ikeda, M, Joa, I, Julià, A, Kahn, R S, Kalaydjieva, L, Karachanak-Yankova, S, Karjalainen, J, Kavanagh, D, Kennedy, J L, Khrunin, A, Kim, Y, Klovins, J, Knowles, J A, Konte, B, Kucinskas, V, Kucinskiene, Z A, Kuzelova-Ptackova, H, Kähler, A K, Laurent, C, Chee Keong, J L, Hong Lee, S, Legge, S E, Lerer, B, Li, M, Li, T, Liang, K Y, Lieberman, J, Limborska, S, Loughland, C M, Lubinski, J, Lönnqvist, J, Macek, M, Magnusson, P K E, Maher, B S, Mallet, J, Marsal, S, Mattingsdal, M, McCarley, R W, McDonald, C, McIntosh, A M, Meier, S, Meijer, C J, Melegh, B, Melle, I, Mesholam-Gately, R I, Metspalu, A, Michie, P T, Milani, L, Milanova, V, Mokrab, Y, Morris, D W, Mors, O, Murphy, K C, Murray, R M, Myin-Germeys, I, Müller-Myhsok, B, Nelis, M, Nertney, D A, Nestadt, G, Nicodemus, K K, Nikitina-Zake, L, Nisenbaum, L, Nordin, A, O'Callaghan, E, O'Dushlaine, C, Anthony O'Neill, F, Oh, S Y, Olincy, A, Olsen, L, Van Os, J, Pantelis, C, Papadimitriou, G N, Papiol, S, Parkhomenko, E, Pato, M T, Paunio, T, Pejovic-Milovancevic, M, Perkins, D O, Pietiläinen, O, Pimm, J, Pocklington, A J, Powell, J, Price, A, Pulver, A E, Purcell, S M, Quested, D, Rasmussen, H B, Reichenberg, A, Reimers, M A, Richards, A L, Roffman, J L, Roussos, P, Salomaa, V, Sanders, A R, Schall, U, Schubert, C R, Schwab, S G, Scolnick, E M, Scott, R J, Seidman, L J, Shi, J, Sigurdsson, E, Silagadze, T, Silverman, J M, Sim, K, Slominsky, P, Smoller, J W, So, H C, Spencer, C C A, Stahl, E A, Stefansson, H, Steinberg, S, Stogmann, E, Straub, R E, Strengman, E, Scott Stroup, T, Subramaniam, M, Suvisaari, J, Svrakic, D M, Szatkiewicz, J P, Söderman, E, Thirumalai, S, Toncheva, D, Tosato, S, Veijola, J, Waddington, J, Walsh, D, Wang, D, Wang, Q, Webb, B T, Weiser, M, Wildenauer, D B, Williams, N M, Williams, S, Wolen, A R, Wong, E H M, Wormley, B K, Xi, H S, Zai, C C, Zheng, X, Zimprich, F, Wray, N R, Stefansson, K, Visscher, P M, Adolfsson, R, Andreassen, O A, Blackwood, D H R, Bramon, E, Buxbaum, J D, Børglum, A D, Darvasi, A, Domenici, E, Ehrenreich, H, Esko, T, Gejman, P V, Gill, M, Gurling, H, Hultman, C M, Iwata, N, Jablensky, A V, Jönsson, E G, Kendler, K S, Kirov, G, Knight, J, Lencz, T, Levinson, D F, Li, Q S, Liu, J, Malhotra, A K, McCarroll, S A, McQuillin, A, Moran, J L, Mortensen, P B, Mowry, B J, Nöthen, M M, Ophoff, R A, Owen, M J, Palotie, A, Pato, C N, Petryshen, T L, Posthuma, D, Riley, B P, Sham, P C, Sklar, P, Clair, D S, Weinberger, D R, Wendland, J R, Werge, T, Daly, M J, O'Donovan, M C, Sullivan, P F & Keller, M C 2016, ' No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study ', PL o S Genetics, vol. 12, no. 10, e1006343 . https://doi.org/10.1371/journal.pgen.1006343
PLoS Genetics, 12(10):e1006343. Public Library of Science
PLoS Genetics, Vol 12, Iss 10, p e1006343 (2016)
Schizophrenia Working Group of the Psychiatric Genomics Consortium 2016, ' No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study ', PLoS Genetics, vol. 12, no. 10, e1006343 . https://doi.org/10.1371/journal.pgen.1006343
Johnson, E C, Bjelland, D W, Howrigan, D P, Abdellaoui, A, Breen, G, Borglum, A D, Cichon, S, Degenhardt, F, Forstner, A J, Frank, J, Genovese, G, Heilmann-Heimbach, S, Herms, S, Hoffman, P, Maier, W, Mattheisen, M, Morris, D W, Mowry, B J, Müller-Mhysok, B, Neale, B M, Nenadic, I, Nöthen, M M, O’Dushlaine, C, Rietschel, M, Ruderfer, D M, Rujescu, D, Schulze, T G, Simonson, M A, Stahl, E A, Strohmaier, J, Witt, S H, Ripke, S, Neale, B M, Corvin, A, Walters, J T R, Farh, K-H, Holmans, P A, Lee, P H, Bulik-Sullivan, B, Collier, D A, Huang, H, Pers, T H, Agartz, I, Agerbo, E, Albus, M, Alexander, M, Amin, F, Bacanu, S-A, Begemann, M, Belliveau, R A, Bene, J, Bergen, S E, Bevilacqua, E, Bigdeli, T B, Black, D W, Bruggeman, R, Buccola, N G, Buckner, R L, Byerley, W F, Cahn, W, Cai, G, Campion, D, Cantor, R M, Carr, V J, Carrera, N, Catts, S V, Chambert, K D, Chan, R C K, Chen, R Y L, Chen, E Y H, Cheng, W, Cheung, E F C, Chong, S A, Robert Cloninger, C, Cohen, D, Cohen, N, Cormican, P, Craddock, N, Crowley, J J, Curtis, D, Davidson, M, Davis, K L, Del-Favero, J, Demontis, D, Dikeos, D, Dinan, T, Djurovic, S, Donohoe, G, Drapeau, E, Duan, J, Dudbridge, F, Durmishi, N, Eichhammer, P, Eriksson, J, Escott-Price, V, Essioux, L, Fanous, A H, Farrell, M S, Franke, L, Freedman, R, Freimer, N B, Friedl, M, Friedman, J I, Fromer, M, Georgieva, L, Giegling, I, Giusti-Rodríguez, P, Godard, S, Goldstein, J I, Golimbet, V, Gopal, S, Gratten, J, de Haan, L, Hammer, C, Hamshere, M L, Hansen, M, Hansen, T, Haroutunian, V, Hartmann, A M, Henskens, F A, Hirschhorn, J N, Hoffmann, P, Hofman, A, Hollegaard, M V, Hougaard, D M, Ikeda, M, Joa, I, Julià, A, Kahn, R S, Kalaydjieva, L, Karachanak-Yankova, S, Karjalainen, J, Kavanagh, D, Kennedy, J L, Khrunin, A, Kim, Y, Klovins, J, Knowles, J A, Konte, B, Kucinskas, V, Kucinskiene, Z A, Kuzelova-Ptackova, H, Kähler, A K, Laurent, C, Chee Keong, J L, Hong Lee, S, Legge, S E, Lerer, B, Li, M, Li, T, Liang, K-Y, Lieberman, J, Limborska, S, Loughland, C M, Lubinski, J, Lönnqvist, J, Macek, M, Magnusson, P K E, Maher, B S, Mallet, J, Marsal, S, Mattingsdal, M, McCarley, R W, McDonald, C, McIntosh, A M, Meier, S M, Meijer, C J, Melegh, B, Melle, I, Mesholam-Gately, R I, Metspalu, A, Michie, P T, Milani, L, Milanova, V, Mokrab, Y, Morris, D W, Mors, O, Murphy, K C, Murray, R M, Myin-Germeys, I, Müller-Myhsok, B, Nelis, M, Nertney, D A, Nestadt, G, Nicodemus, K K, Nikitina-Zake, L, Nisenbaum, L, Nordin, A, O'Callaghan, E, O'Dushlaine, C T, Anthony O'Neill, F, Oh, S Y, Olincy, A, Olsen, L, van Os, J, Pantelis, C, Papadimitriou, G N, Papiol, S, Parkhomenko, E, Pato, M T, Paunio, T, Pejovic-Milovancevic, M, Perkins, D O, Pietiläinen, O, Pimm, J, Pocklington, A J, Powell, J, Price, A L, Pulver, A E, Purcell, S M, Quested, D, Rasmussen, H B, Reichenberg, A, Reimers, M A, Richards, A L, Roffman, J L, Roussos, P, Salomaa, V, Sanders, A R, Schall, U, Schubert, C R, Schwab, S G, Scolnick, E M, Scott, R J, Seidman, L J, Shi, J, Sigurdsson, E, Silagadze, T, Silverman, J M, Sim, K, Slominsky, P, Smoller, J W, So, H C, Spencer, C C A, Stahl, E A, Stefansson, H, Steinberg, S, Stogmann, E, Straub, R E, Strengman, E, Scott Stroup, T, Subramaniam, M, Suvisaari, J, Svrakic, D M, Szatkiewicz, J P, Söderman, E, Thirumalai, S, Toncheva, D, Tosato, S, Veijola, J, Waddington, J, Walsh, D, Wang, D, Wang, Q, Webb, B T, Weiser, M, Wildenauer, D B, Williams, N M, Watts-Williams, S J, Wolen, A R, Wong, E H M, Wormley, B K, Xi, H S, Zai, C C, Zheng, X, Zimprich, F, Wray, N R, Stefansson, K, Visscher, P M, Adolfsson, R, Andreassen, O A, Blackwood, D H R, Bramon, E, Buxbaum, J D, Børglum, A D, Darvasi, A, Domenici, E, Ehrenreich, H, Esko, T, Gejman, P V, Gill, M, Gurling, H, Hultman, C M, Iwata, N, Jablensky, A V, Jönsson, E G, Kendler, K S, Kirov, G, Knight, J, Lencz, T, Levinson, D F, Li, Q S, Liu, J, Malhotra, A K, McCarroll, S A, McQuillin, A, Moran, J L, Mortensen, P B, Mowry, B J, Nöthen, M M, Ophoff, R A, Owen, M J, Palotie, A, Pato, C N, Petryshen, T L, Posthuma, D, Riley, B P, Sham, P-C, Sklar, P, St Clair, D, Weinberger, D R, Wendland, J R, Werge, T, Daly, M J, O'Donovan, M C, Sullivan, P F & Keller, M C 2016, ' No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study ', PLOS Genetics, vol. 12, no. 10, e1006343 . https://doi.org/10.1371/journal.pgen.1006343
Johnson, E C, Bjelland, D W, Howrigan, D P, Abdellaoui, A, Breen, G, Borglum, A, Cichon, S, Degenhardt, F, Forstner, A J, Frank, J, Genovese, G, Heilmann-Heimbach, S, Herms, S, Hoffman, P, Maier, W, Mattheisen, M, Morris, D, Mowry, B, Müller-Mhysok, B, Neale, B, Nenadic, I, Nöthen, M M, O'Dushlaine, C, Rietschel, M, Ruderfer, D M, Rujescu, D, Schulze, T G, Simonson, M A, Stahl, E, Strohmaier, J, Witt, S H, Sullivan, P F, Keller, M C & Schizophrenia Working Group of the Psychiatric Genomics Consortium 2016, ' No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study ', P L o S Genetics, vol. 12, no. 10, pp. e1006343 . https://doi.org/10.1371/journal.pgen.1006343
PLOS GENETICS
Johnson, E C, Bjelland, D W, Howrigan, D P, Abdellaoui, A, Breen, G, Borglum, A, Cichon, S, Degenhardt, F, Forstner, A J, Frank, J, Genovese, G, Heilmann-Heimbach, S, Herms, S, Hoffman, P, Maier, W, Mattheisen, M, Morris, D, Mowry, B, Müller-Myhsok, B, Neale, B M, Nenadic, I, Nöthen, M M, O'Dushlaine, C, Rietschel, M, Ruderfer, D M, Rujescu, D, Schulze, T G, Simonson, M A, Stahl, E, Strohmaier, J, Witt, S H, Sullivan, P F & Keller, M C 2016, ' No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study ', PLoS Genetics, vol. 12, no. 10, e1006343 . https://doi.org/10.1371/journal.pgen.1006343
Johnson, E C, Bjelland, D W, Howrigan, D P, Abdellaoui, A, Breen, G, Borglum, A, Cichon, S, Degenhardt, F, Forstner, A J, Frank, J, Genovese, G, Heilmann-Heimbach, S, Herms, S, Hoffman, P, Maier, W, Mattheisen, M, Morris, D, Mowry, B, Müller-Mhysok, B, Neale, B, Nenadic, I, Nöthen, M M, O’Dushlaine, C, Rietschel, M, Ruderfer, D M, Rujescu, D, Schulze, T G, Simonson, M A, Stahl, E, Strohmaier, J, Witt, S H, Ripke, S, Neale, B M, Corvin, A, Walters, J T R, Farh, K H, Holmans, P A, Lee, P, Bulik-Sullivan, B, Collier, D A, Huang, H, Pers, T H, Agartz, I, Agerbo, E, Albus, M, Alexander, M, Amin, F, Bacanu, S A, Begemann, M, Belliveau, R A, Bene, J, Bergen, S E, Bevilacqua, E, Bigdeli, T B, Black, D W, Bruggeman, R, Buccola, N G, Buckner, R L, Byerley, W, Cahn, W, Cai, G, Campion, D, Cantor, R M, Carr, V J, Carrera, N, Catts, S V, Chambert, K D, Chan, R C K, Chen, R Y L, Chen, E Y H, Cheng, W, Cheung, E F C, Chong, S A, Robert Cloninger, C, Cohen, D, Cohen, N, Cormican, P, Craddock, N, Crowley, J J, Curtis, D, Davidson, M, Davis, K L, Del Favero, J, Demontis, D, Dikeos, D, Dinan, T, Djurovic, S, Donohoe, G, Drapeau, E, Duan, J, Dudbridge, F, Durmishi, N, Eichhammer, P, Eriksson, J, Escott-Price, V, Essioux, L, Fanous, A H, Farrell, M S, Franke, L, Freedman, R, Freimer, N B, Friedl, M, Friedman, J I, Fromer, M, Georgieva, L, Giegling, I, Giusti-Rodríguez, P, Godard, S, Goldstein, J I, Golimbet, V, Gopal, S, Gratten, J, de Haan, L, Hammer, C, Hamshere, M L, Hansen, M, Hansen, T, Haroutunian, V, Hartmann, A M, Henskens, F A, Hirschhorn, J N, Hoffmann, P, Hofman, A, Hollegaard, M V, Hougaard, D M, Ikeda, M, Joa, I, Julià, A, Kahn, R S, Kalaydjieva, L, Karachanak-Yankova, S, Karjalainen, J, Kavanagh, D, Kennedy, J L, Khrunin, A, Kim, Y, Klovins, J, Knowles, J A, Konte, B, Kucinskas, V, Kucinskiene, Z A, Kuzelova-Ptackova, H, Kähler, A K, Laurent, C, Chee Keong, J L, Hong Lee, S, Legge, S E, Lerer, B, Li, M, Li, T, Liang, K Y, Lieberman, J, Limborska, S, Loughland, C M, Lubinski, J, Lönnqvist, J, Macek, M, Magnusson, P K E, Maher, B S, Mallet, J, Marsal, S, Mattingsdal, M, McCarley, R W, McDonald, C, McIntosh, A M, Meier, S, Meijer, C J, Melegh, B, Melle, I, Mesholam-Gately, R I, Metspalu, A, Michie, P T, Milani, L, Milanova, V, Mokrab, Y, Morris, D W, Mors, O, Murphy, K C, Murray, R M, Myin-Germeys, I, Müller-Myhsok, B, Nelis, M, Nertney, D A, Nestadt, G, Nicodemus, K K, Nikitina-Zake, L, Nisenbaum, L, Nordin, A, O'Callaghan, E, O'Dushlaine, C, Anthony O'Neill, F, Oh, S Y, Olincy, A, Olsen, L, Van Os, J, Pantelis, C, Papadimitriou, G N, Papiol, S, Parkhomenko, E, Pato, M T, Paunio, T, Pejovic-Milovancevic, M, Perkins, D O, Pietiläinen, O, Pimm, J, Pocklington, A J, Powell, J, Price, A, Pulver, A E, Purcell, S M, Quested, D, Rasmussen, H B, Reichenberg, A, Reimers, M A, Richards, A L, Roffman, J L, Roussos, P, Salomaa, V, Sanders, A R, Schall, U, Schubert, C R, Schwab, S G, Scolnick, E M, Scott, R J, Seidman, L J, Shi, J, Sigurdsson, E, Silagadze, T, Silverman, J M, Sim, K, Slominsky, P, Smoller, J W, So, H C, Spencer, C C A, Stahl, E A, Stefansson, H, Steinberg, S, Stogmann, E, Straub, R E, Strengman, E, Scott Stroup, T, Subramaniam, M, Suvisaari, J, Svrakic, D M, Szatkiewicz, J P, Söderman, E, Thirumalai, S, Toncheva, D, Tosato, S, Veijola, J, Waddington, J, Walsh, D, Wang, D, Wang, Q, Webb, B T, Weiser, M, Wildenauer, D B, Williams, N M, Williams, S, Wolen, A R, Wong, E H M, Wormley, B K, Xi, H S, Zai, C C, Zheng, X, Zimprich, F, Wray, N R, Stefansson, K, Visscher, P M, Adolfsson, R, Andreassen, O A, Blackwood, D H R, Bramon, E, Buxbaum, J D, Børglum, A D, Darvasi, A, Domenici, E, Ehrenreich, H, Esko, T, Gejman, P V, Gill, M, Gurling, H, Hultman, C M, Iwata, N, Jablensky, A V, Jönsson, E G, Kendler, K S, Kirov, G, Knight, J, Lencz, T, Levinson, D F, Li, Q S, Liu, J, Malhotra, A K, McCarroll, S A, McQuillin, A, Moran, J L, Mortensen, P B, Mowry, B J, Nöthen, M M, Ophoff, R A, Owen, M J, Palotie, A, Pato, C N, Petryshen, T L, Posthuma, D, Riley, B P, Sham, P C, Sklar, P, Clair, D S, Weinberger, D R, Wendland, J R, Werge, T, Daly, M J, O'Donovan, M C, Sullivan, P F & Keller, M C 2016, ' No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study ', PL o S Genetics, vol. 12, no. 10, e1006343 . https://doi.org/10.1371/journal.pgen.1006343
PLoS Genetics, 12(10):e1006343. Public Library of Science
PLoS Genetics, Vol 12, Iss 10, p e1006343 (2016)
Schizophrenia Working Group of the Psychiatric Genomics Consortium 2016, ' No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study ', PLoS Genetics, vol. 12, no. 10, e1006343 . https://doi.org/10.1371/journal.pgen.1006343
Johnson, E C, Bjelland, D W, Howrigan, D P, Abdellaoui, A, Breen, G, Borglum, A D, Cichon, S, Degenhardt, F, Forstner, A J, Frank, J, Genovese, G, Heilmann-Heimbach, S, Herms, S, Hoffman, P, Maier, W, Mattheisen, M, Morris, D W, Mowry, B J, Müller-Mhysok, B, Neale, B M, Nenadic, I, Nöthen, M M, O’Dushlaine, C, Rietschel, M, Ruderfer, D M, Rujescu, D, Schulze, T G, Simonson, M A, Stahl, E A, Strohmaier, J, Witt, S H, Ripke, S, Neale, B M, Corvin, A, Walters, J T R, Farh, K-H, Holmans, P A, Lee, P H, Bulik-Sullivan, B, Collier, D A, Huang, H, Pers, T H, Agartz, I, Agerbo, E, Albus, M, Alexander, M, Amin, F, Bacanu, S-A, Begemann, M, Belliveau, R A, Bene, J, Bergen, S E, Bevilacqua, E, Bigdeli, T B, Black, D W, Bruggeman, R, Buccola, N G, Buckner, R L, Byerley, W F, Cahn, W, Cai, G, Campion, D, Cantor, R M, Carr, V J, Carrera, N, Catts, S V, Chambert, K D, Chan, R C K, Chen, R Y L, Chen, E Y H, Cheng, W, Cheung, E F C, Chong, S A, Robert Cloninger, C, Cohen, D, Cohen, N, Cormican, P, Craddock, N, Crowley, J J, Curtis, D, Davidson, M, Davis, K L, Del-Favero, J, Demontis, D, Dikeos, D, Dinan, T, Djurovic, S, Donohoe, G, Drapeau, E, Duan, J, Dudbridge, F, Durmishi, N, Eichhammer, P, Eriksson, J, Escott-Price, V, Essioux, L, Fanous, A H, Farrell, M S, Franke, L, Freedman, R, Freimer, N B, Friedl, M, Friedman, J I, Fromer, M, Georgieva, L, Giegling, I, Giusti-Rodríguez, P, Godard, S, Goldstein, J I, Golimbet, V, Gopal, S, Gratten, J, de Haan, L, Hammer, C, Hamshere, M L, Hansen, M, Hansen, T, Haroutunian, V, Hartmann, A M, Henskens, F A, Hirschhorn, J N, Hoffmann, P, Hofman, A, Hollegaard, M V, Hougaard, D M, Ikeda, M, Joa, I, Julià, A, Kahn, R S, Kalaydjieva, L, Karachanak-Yankova, S, Karjalainen, J, Kavanagh, D, Kennedy, J L, Khrunin, A, Kim, Y, Klovins, J, Knowles, J A, Konte, B, Kucinskas, V, Kucinskiene, Z A, Kuzelova-Ptackova, H, Kähler, A K, Laurent, C, Chee Keong, J L, Hong Lee, S, Legge, S E, Lerer, B, Li, M, Li, T, Liang, K-Y, Lieberman, J, Limborska, S, Loughland, C M, Lubinski, J, Lönnqvist, J, Macek, M, Magnusson, P K E, Maher, B S, Mallet, J, Marsal, S, Mattingsdal, M, McCarley, R W, McDonald, C, McIntosh, A M, Meier, S M, Meijer, C J, Melegh, B, Melle, I, Mesholam-Gately, R I, Metspalu, A, Michie, P T, Milani, L, Milanova, V, Mokrab, Y, Morris, D W, Mors, O, Murphy, K C, Murray, R M, Myin-Germeys, I, Müller-Myhsok, B, Nelis, M, Nertney, D A, Nestadt, G, Nicodemus, K K, Nikitina-Zake, L, Nisenbaum, L, Nordin, A, O'Callaghan, E, O'Dushlaine, C T, Anthony O'Neill, F, Oh, S Y, Olincy, A, Olsen, L, van Os, J, Pantelis, C, Papadimitriou, G N, Papiol, S, Parkhomenko, E, Pato, M T, Paunio, T, Pejovic-Milovancevic, M, Perkins, D O, Pietiläinen, O, Pimm, J, Pocklington, A J, Powell, J, Price, A L, Pulver, A E, Purcell, S M, Quested, D, Rasmussen, H B, Reichenberg, A, Reimers, M A, Richards, A L, Roffman, J L, Roussos, P, Salomaa, V, Sanders, A R, Schall, U, Schubert, C R, Schwab, S G, Scolnick, E M, Scott, R J, Seidman, L J, Shi, J, Sigurdsson, E, Silagadze, T, Silverman, J M, Sim, K, Slominsky, P, Smoller, J W, So, H C, Spencer, C C A, Stahl, E A, Stefansson, H, Steinberg, S, Stogmann, E, Straub, R E, Strengman, E, Scott Stroup, T, Subramaniam, M, Suvisaari, J, Svrakic, D M, Szatkiewicz, J P, Söderman, E, Thirumalai, S, Toncheva, D, Tosato, S, Veijola, J, Waddington, J, Walsh, D, Wang, D, Wang, Q, Webb, B T, Weiser, M, Wildenauer, D B, Williams, N M, Watts-Williams, S J, Wolen, A R, Wong, E H M, Wormley, B K, Xi, H S, Zai, C C, Zheng, X, Zimprich, F, Wray, N R, Stefansson, K, Visscher, P M, Adolfsson, R, Andreassen, O A, Blackwood, D H R, Bramon, E, Buxbaum, J D, Børglum, A D, Darvasi, A, Domenici, E, Ehrenreich, H, Esko, T, Gejman, P V, Gill, M, Gurling, H, Hultman, C M, Iwata, N, Jablensky, A V, Jönsson, E G, Kendler, K S, Kirov, G, Knight, J, Lencz, T, Levinson, D F, Li, Q S, Liu, J, Malhotra, A K, McCarroll, S A, McQuillin, A, Moran, J L, Mortensen, P B, Mowry, B J, Nöthen, M M, Ophoff, R A, Owen, M J, Palotie, A, Pato, C N, Petryshen, T L, Posthuma, D, Riley, B P, Sham, P-C, Sklar, P, St Clair, D, Weinberger, D R, Wendland, J R, Werge, T, Daly, M J, O'Donovan, M C, Sullivan, P F & Keller, M C 2016, ' No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study ', PLOS Genetics, vol. 12, no. 10, e1006343 . https://doi.org/10.1371/journal.pgen.1006343
Johnson, E C, Bjelland, D W, Howrigan, D P, Abdellaoui, A, Breen, G, Borglum, A, Cichon, S, Degenhardt, F, Forstner, A J, Frank, J, Genovese, G, Heilmann-Heimbach, S, Herms, S, Hoffman, P, Maier, W, Mattheisen, M, Morris, D, Mowry, B, Müller-Mhysok, B, Neale, B, Nenadic, I, Nöthen, M M, O'Dushlaine, C, Rietschel, M, Ruderfer, D M, Rujescu, D, Schulze, T G, Simonson, M A, Stahl, E, Strohmaier, J, Witt, S H, Sullivan, P F, Keller, M C & Schizophrenia Working Group of the Psychiatric Genomics Consortium 2016, ' No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study ', P L o S Genetics, vol. 12, no. 10, pp. e1006343 . https://doi.org/10.1371/journal.pgen.1006343
It is well known that inbreeding increases the risk of recessive monogenic diseases, but it is less certain whether it contributes to the etiology of complex diseases such as schizophrenia. One way to estimate the effects of inbreeding is to examine