Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Susanna M. Hofmann"'
Autor:
Carmelo Quarta, Kerstin Stemmer, Aaron Novikoff, Bin Yang, Felix Klingelhuber, Alex Harger, Mostafa Bakhti, Aimee Bastidas-Ponce, Eric Baugé, Jonathan E. Campbell, Megan Capozzi, Christoffer Clemmensen, Gustav Collden, Perla Cota, Jon Douros, Daniel J. Drucker, Barent DuBois, Annette Feuchtinger, Cristina Garcia-Caceres, Gerald Grandl, Nathalie Hennuyer, Stephan Herzig, Susanna M. Hofmann, Patrick J. Knerr, Konxhe Kulaj, Fanny Lalloyer, Heiko Lickert, Arek Liskiewicz, Daniela Liskiewicz, Gandhari Maity, Diego Perez-Tilve, Sneha Prakash, Miguel A. Sanchez-Garrido, Qian Zhang, Bart Staels, Natalie Krahmer, Richard D. DiMarchi, Matthias H. Tschöp, Brian Finan, Timo D. Müller
Publikováno v:
Quarta, C, Stemmer, K, Novikoff, A, Yang, B, Klingelhuber, F, Harger, A, Bakhti, M, Bastidas-Ponce, A, Baugé, E, Campbell, J E, Capozzi, M, Clemmensen, C, Collden, G, Cota, P, Douros, J, Drucker, D J, DuBois, B, Feuchtinger, A, Garcia-Caceres, C, Grandl, G, Hennuyer, N, Herzig, S, Hofmann, S M, Knerr, P J, Kulaj, K, Lalloyer, F, Lickert, H, Liskiewicz, A, Liskiewicz, D, Maity, G, Perez-Tilve, D, Prakash, S, Sanchez-Garrido, M A, Zhang, Q, Staels, B, Krahmer, N, DiMarchi, R D, Tschöp, M H, Finan, B & Müller, T D 2022, ' GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice ', Nature Metabolism, vol. 4, no. 8, pp. 1071-1083 . https://doi.org/10.1038/s42255-022-00617-6
Nature Metabolism
Nat. Metab. 4, 1071-1083 (2022)
Nature Metabolism
Nat. Metab. 4, 1071-1083 (2022)
Dual agonists activating the peroxisome proliferator-activated receptors alpha and gamma (PPARɑ/ɣ) have beneficial effects on glucose and lipid metabolism in patients with type 2 diabetes, but their development was discontinued due to potential adv
Autor:
Mostafa Bakhti, Diego Perez-Tilve, Konxhe Kulaj, Beata Legutko, Susanna M. Hofmann, Dominik Lutter, Kerstin Stemmer, Gerd Luippold, Stephanie A. Mowery, Marta Tarquis Medina, Stephan Herzig, Gustav Collden, Robert Augustin, Timo D. Müller, Cristina Garcia Caceres, Christian Wolfrum, Richard D. DiMarchi, Susanne Keipert, Xue Liu, Qian Zhang, Alexandra Harger, Cassie Holleman, Brian Finan, Maximilian Kleinert, Emilija Malogajski, Ciro Salinno, Matthias H. Tschöp, Andreas Blutke, Martin Jastroch, Gerald Grandl, Annette Feuchtinger, Patrick J. Knerr, Daniel J. Drucker, Laura Sehrer, Challa Tenagne Delessa, Heiko Lickert
Publikováno v:
Cell Metabolism, 33 (4)
Cell Metabolism
Cell Metab. 33, 833-844.e5 (2021)
Cell Metabolism
Cell Metab. 33, 833-844.e5 (2021)
Summary Uncertainty exists as to whether the glucose-dependent insulinotropic polypeptide receptor (GIPR) should be activated or inhibited for the treatment of obesity. Gipr was recently demonstrated in hypothalamic feeding centers, but the physiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad196864aba83940728afa229ef093f
https://hdl.handle.net/20.500.11850/478121
https://hdl.handle.net/20.500.11850/478121
Autor:
Anna Kerege, Bryan C. Bergman, Allison Strauss, Dominik Lutter, Daniel H. Bessesen, Darcy E. Kahn, Kathleen A. Harrison, Leigh Perreault, Tzu L. Phang, Sean A. Newsom, Elisabeth Graf, Jan Krumsiek, Simona Zarini, Stephan Sachs, Thomas Schwarzmayr, Susanna M. Hofmann, Jonathan A. Schoen
Publikováno v:
Am. J. Physiol. Endocrinol. Metab. 316, E866-E879 (2019)
Am J Physiol Endocrinol Metab
Am J Physiol Endocrinol Metab
Intermuscular adipose tissue (IMAT) is negatively related to insulin sensitivity, but a causal role of IMAT in the development of insulin resistance is unknown. IMAT was sampled in humans to test for the ability to induce insulin resistance in vitro
Autor:
Martin Hrabě de Angelis, Anja Böhm, Susanna M. Hofmann, Bernhard Raedle, Louise Fritsche, Lucia Berti, Martin Jastroch, Hans-Ulrich Häring, Michaela Keuper, Andreas Fritsche, Harald Staiger, Stephan Sachs
Publikováno v:
Molecular Metabolism
Mol. Metab. 20, 28-37 (2019)
Molecular Metabolism, Vol 20, Iss, Pp 28-37 (2019)
Mol. Metab. 20, 28-37 (2019)
Molecular Metabolism, Vol 20, Iss, Pp 28-37 (2019)
Background/Objectives Although the prevalence of obesity and its associated metabolic disorders is increasing in both sexes, the clinical phenotype differs between men and women, highlighting the need for individual treatment options. Mitochondrial d
Autor:
Timo D. Müller, Stephan Sachs, Sebastian Cucuruz, Susanna M. Hofmann, Anna Götz, Yuanqing Gao, Samuel D. Wright, Maarit Lehti, Matthias H. Tschöp, Elizabeth Donelan, Stephen C. Woods, Chun-Xia Yi, Cynthia Striese
Publikováno v:
J. Lipid Res. 59, 1649-1659 (2018)
Journal of Lipid Research, Vol 59, Iss 9, Pp 1649-1659 (2018)
Journal of lipid research, 59(9), 1649-1659. American Society for Biochemistry and Molecular Biology Inc.
Journal of Lipid Research, Vol 59, Iss 9, Pp 1649-1659 (2018)
Journal of lipid research, 59(9), 1649-1659. American Society for Biochemistry and Molecular Biology Inc.
Meta-inflammation of hypothalamic areas governing energy homeostasis has recently emerged as a process of potential pathophysiological relevance for the development of obesity and its metabolic sequelae. The current model suggests that diet-induced n
Autor:
Brian Finan, Annette Feuchtinger, Nicolai J. Wewer Albrechtsen, Matthias Mann, Sigrid Jall, Kerstin Stemmer, Richard D. DiMarchi, Timo D. Müller, Maximilian Kleinert, Lili Niu, Matthias H. Tschöp, Philipp E. Geyer, Susanna M. Hofmann, Markus Brielmeier, Stephan Sachs
Publikováno v:
Sachs, S, Niu, L, Geyer, P, Jall, S, Kleinert, M, Feuchtinger, A, Stemmer, K, Brielmeier, M, Finan, B, DiMarchi, R D, Tschop, M H, Wewer Albrechtsen, N, Mann, M, Mueller, T D & Hofmann, S M 2020, ' Plasma proteome profiles treatment efficacy of incretin dual agonism in diet-induced obese female and male mice ', Diabetes, Obesity and Metabolism, vol. 23, no. 1, pp. 195-207 . https://doi.org/10.1111/dom.14215
Diabetes, Obesity and Metabolism
Diabetes Obes. Metab. 23, 195-207 (2021)
Diabetes, Obesity and Metabolism
Diabetes Obes. Metab. 23, 195-207 (2021)
Aims Unimolecular peptides targeting the receptors for glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) (GLP-1/GIP co-agonist) have been shown to outperform each single peptide in the treatment of obesity and car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e6d1a64a945e745aa7744bd69aa262
https://curis.ku.dk/portal/da/publications/plasma-proteome-profiles-treatment-efficacy-of-incretin-dual-agonism-in-dietinduced-obese-female-and-male-mice(004d7da5-5a05-4452-bdbe-11f41064a5a0).html
https://curis.ku.dk/portal/da/publications/plasma-proteome-profiles-treatment-efficacy-of-incretin-dual-agonism-in-dietinduced-obese-female-and-male-mice(004d7da5-5a05-4452-bdbe-11f41064a5a0).html
Autor:
Martin Irmler, Carola W. Meyer, I P Fischer, M. H. Tschöp, M. Hrabě de Angelis, Frauke Neff, Johannes Beckers, Siegfried Ussar, Stephan Sachs, Susanna M. Hofmann
Publikováno v:
Int. J. Obes. 42, 507-517 (2018)
International Journal of Obesity (2005)
International Journal of Obesity (2005)
Background/Objectives: Dieting is a popular yet often ineffective way to lower body weight, as the majority of people regain most of their pre-dieting weights in a relatively short time. The underlying molecular mechanisms driving weight regain and t
Autor:
Timo D. Müller, Matthias H. Tschöp, Richard D. DiMarchi, Brian Finan, Sigrid Jall, Frauke Neff, Christoffer Clemmensen, Stephan Sachs, Susanna M. Hofmann
Publikováno v:
Molecular Metabolism
Mol. Metab. 6, 440-446 (2017)
Molecular Metabolism, Vol 6, Iss 5, Pp 440-446 (2017)
Mol. Metab. 6, 440-446 (2017)
Molecular Metabolism, Vol 6, Iss 5, Pp 440-446 (2017)
Objective Obesity is a major health threat that affects men and women equally. Despite this fact, weight-loss potential of pharmacotherapies is typically first evaluated in male mouse models of diet-induced obesity (DIO). To address this disparity we
Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Autor:
Peter V. Treit, Nicolai J. Wewer Albrechtsen, Stephan Sachs, Kerstin Stemmer, Jens J. Holst, Anders Ellekær Junker, Matthias H. Tschöp, Alberto Santos, Tina Vilsbøll, Filip K. Knop, Timo D. Müller, Susanna M. Hofmann, Lili Niu, Philipp E. Geyer, Sophia Doll, Matthias Mann, Lise Lotte Gluud
Publikováno v:
Mol. Syst. Biol. 15:e8793 (2019)
Molecular Systems Biology
BASE-Bielefeld Academic Search Engine
Niu, L, Geyer, P E, Albrechtsen, N J W, Gluud, L L, Santos, A, Doll, S, Treit, P V, Holst, J J, Knop, F K, Vilsbøll, T, Junker, A, Sachs, S, Stemmer, K, Müller, T D, Tschöp, M H, Hofmann, S M & Mann, M 2019, ' Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease ', Molecular Systems Biology, vol. 15, e8793 . https://doi.org/10.15252/msb.20188793
Molecular Systems Biology
BASE-Bielefeld Academic Search Engine
Niu, L, Geyer, P E, Albrechtsen, N J W, Gluud, L L, Santos, A, Doll, S, Treit, P V, Holst, J J, Knop, F K, Vilsbøll, T, Junker, A, Sachs, S, Stemmer, K, Müller, T D, Tschöp, M H, Hofmann, S M & Mann, M 2019, ' Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease ', Molecular Systems Biology, vol. 15, e8793 . https://doi.org/10.15252/msb.20188793
Non‐alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis with limited treatment options. As the liver secretes most of the blood plasma proteins, liver disease may affect the plasma proteome. Plasma prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e2972462557b1d88f6da1f82359f42
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55606
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55606
Autor:
Christoffer, Clemmensen, Brian, Finan, Timo D, Müller, Richard D, DiMarchi, Matthias H, Tschöp, Susanna M, Hofmann
Publikováno v:
Nature reviews. Endocrinology. 15(2)
Obesity and its comorbidities, such as type 2 diabetes mellitus and cardiovascular disease, constitute growing challenges for public health and economies globally. The available treatment options for these metabolic disorders cannot reverse the disea