Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sergio Lilla"'
Autor:
Fernanda G. Kugeratski, Raghu Kalluri, Sergio Lilla, Kathleen M. McAndrews, Xunian Zhou, Rosa F. Hwang, Kelly Hodge, Sara Zanivan
Publikováno v:
Nat Cell Biol
Exosomes are extracellular vesicles derived from the endosomal compartment with potential involvement in intercellular communication. We found that frequently used biomarkers of exosomes are heterogeneous and do not exhibit universal utility across d
Autor:
Sara Zanivan, Rafael S. Martinez, William C. Clark, Paul Peixoto, Sergio Lilla, Colin Nixon, Laura C. A. Galbraith, Eric Hervouet, Ladan Fazli, Ann Hedley, Sonia H.Y. Kung, Luke Gaughan, Linda K. Rushworth, Hing Y. Leung, Martin E. Gleave, Gillian M. Mackay, Chara Ntala, Mark Salji, David Sumpton, Arnaud Blomme, Giovanny Rodriguez Blanco, Elodie Renaude
Publikováno v:
Cancer Research. 81:3664-3678
Androgen deprivation therapy (ADT) is the standard of care for treatment of nonresectable prostate cancer. Despite high treatment efficiency, most patients ultimately develop lethal castration-resistant prostate cancer (CRPC). In this study, we perfo
Autor:
Arnaud Blomme, Coralie Peter, Ernest Mui, Giovanny Rodriguez Blanco, Ning An, Louise M Mason, Lauren E Jamieson, Grace H McGregor, Sergio Lilla, Chara Ntala, Rachana Patel, Marc Thiry, Sonia H Y Kung, Marine Leclercq, Catriona A Ford, Linda K Rushworth, David J McGarry, Susan Mason, Peter Repiscak, Colin Nixon, Mark J Salji, Elke Markert, Gillian M MacKay, Jurre J Kamphorst, Duncan Graham, Karen Faulds, Ladan Fazli, Martin E Gleave, Edward Avezov, Joanne Edwards, Huabing Yin, David Sumpton, Karen Blyth, Pierre Close, Daniel J Murphy, Sara Zanivan, Hing Y Leung
Publikováno v:
EMBO Molecular Medicine. 14
Despite the clinical benefit of androgen-deprivation therapy (ADT), the majority of patients with advanced prostate cancer (PCa) ultimately develop lethal castration-resistant prostate cancer (CRPC). In this study, we identified thioesterase superfam
Autor:
Louise Mitchell, John R. P. Knight, Sara Zanivan, Sarah Slater, Chara Ntala, Janis Fleming, Joanne Edwards, Karen Blyth, Carl S. Goodyear, Ann Hedley, Kirsteen J. Campbell, Noor Akmar Nam, Mark Salji, Sheila Bryson, Hing Y. Leung, Craig N. Robson, Carolyn J. Loveridge, Rachana Patel, Imran Ahmad, Douglas Strathdee, Colin Nixon, Sergio Lilla, Matthew Neilson, Peter Repiscak
Publikováno v:
Loveridge, C J, Slater, S, Campbell, K J, Nam, N A, Knight, J, Ahmad, I, Hedley, A, Lilla, S, Repiscak, P, Patel, R, Salji, M, Fleming, J, Mitchell, L, Nixon, C, Strathdee, D, Neilson, M, Ntala, C, Bryson, S, Zanivan, S, Edwards, J, Robson, C N, Goodyear, C S, Blyth, K & Leung, H Y 2020, ' BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration ', Oncogene, vol. 39, no. 8, pp. 1797-1806 . https://doi.org/10.1038/s41388-019-1106-x
Oncogene
Oncogene
BRF1 is a rate-limiting factor for RNA Polymerase III-mediated transcription and is elevated in numerous cancers. Here, we report that elevated levels of BRF1 associate with poor prognosis in human prostate cancer. In vitro studies in human prostate
Autor:
Tamas Yelland, Jennifer P. Morton, Eva C Freckmann, Sara Zanivan, Lynn McGarry, Shehab Ismail, Hing Y. Leung, Konstantina Nikolatou, Laura C. A. Galbraith, Karen Blyth, Rachana Patel, David M. Bryant, Álvaro Román-Fernández, Marisa Nacke, Elke Markert, Sergio Lilla, Emma Shanks, Emma Sandilands, Susan M. Mason
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
The signalling pathways underpinning cell growth and invasion use overlapping components, yet how mutually exclusive cellular responses occur is unclear. Here, we report development of 3-Dimensional culture analyses to separately quantify growth and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6204b48306f528abf451c21e7b06e083
https://lirias.kuleuven.be/handle/123456789/678577
https://lirias.kuleuven.be/handle/123456789/678577
Autor:
Duncan Graham, Paul Peixoto, Mélanie Planque, Mark Salji, Karen Faulds, Hing Y. Leung, Ernest Mui, Catriona A. Ford, David Sumpton, Giovanny Rodriguez Blanco, Colin Nixon, Luke Gaughan, Sara Zanivan, Chara Ntala, Sergio Lilla, Elke Markert, Gillian M. Mackay, Rachana Patel, Jurre J. Kamphorst, Peter Repiscak, Arnaud Blomme, Grace McGregor, Lauren E. Jamieson, Sarah-Maria Fendt, Eric Hervouet
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2508. ⟨10.1038/s41467-020-16126-7⟩
Nature Communications, 2020, 11 (1), pp.2508. ⟨10.1038/s41467-020-16126-7⟩
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2508. ⟨10.1038/s41467-020-16126-7⟩
Nature Communications, 2020, 11 (1), pp.2508. ⟨10.1038/s41467-020-16126-7⟩
Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) progression. In this study, we perform a comprehensive unbiased characteri
Autor:
Ewan J. McGhee, Kirsty J. Martin, Laura M. Machesky, Sergio Lilla, Nikolaj Gadegaard, Gabriela Kalna, Jim C. Norman, Peter A. Thomason, Yvette W. H. Koh, Gillian M. Mackay, Matthew Neilson, Heather J. Spence, Amelie Juin, Robert H. Insall, Loic Fort, Marie F.A. Cutiongco
Publikováno v:
Cutiongco, M 2019, ' N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis ', Developmental cell . https://doi.org/10.1016/j.devcel.2019.09.018
Pancreatic ductal adenocarcinoma is one of the most invasive and metastatic cancers and has a dismal 5-year survival rate. We show that N-WASP drives pancreatic cancer metastasis, with roles in both chemotaxis and matrix remodeling. lysophosphatidic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5528fa73ea330570a305078fecd9db4
https://eprints.gla.ac.uk/201664/9/201664.pdf
https://eprints.gla.ac.uk/201664/9/201664.pdf
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
Reactive oxygen species (ROS) are increasingly recognised as important signalling molecules through oxidation of protein cysteine residues. Comprehensive identification of redox-regulated proteins and pathways is crucial to understand ROS-mediated ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1af6cb7cda16f8519112f6520bf1905
https://eprints.gla.ac.uk/161544/1/161544.pdf
https://eprints.gla.ac.uk/161544/1/161544.pdf
Publikováno v:
Biochimie. 88:1947-1959
Bothrops snake venoms contain a variety of phospholipases (PLA(2)), some of which are myotoxic. In this work, we used reverse-phase HPLC and mass spectrometry to purify and sequence two PLA(2) from the venom of Bothrops insularis. The two enzymes, de
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Aims The relationship between the activity of eosinophils and platelets has been observed in recent decades by many scientists. These observations include increased numbers of eosinophils associated with platelet disorders, including changes in the c