Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Robin Hurst"'
Publikováno v:
Life Sciences. 33:457-460
Intrathecal (i.t.) administration of the highly delta selective peptide, [D-Pen2, L-Cys5]enkephalin (DPLCE) (1-10 micrograms), effectively inhibited gastrointestinal transit of an orally-given radiolabelled marker in mice. By contrast, the same doses
Autor:
Thomas F. Burks, Victor J. Hruby, Henry I. Yamamura, Kelvin W. Gee, Robin Hurst, James J. Galligan, Henry I. Mosberg
Publikováno v:
Biochemical and Biophysical Research Communications. 106:506-512
The conformationally constrained cyclic enkephalin analogs, [ 2- D - penicillamine , 5- L - cysteine ]- and [2- D - penicillamine , 5- D - cysteine]enkephalinamide were synthesized and their biological activities investigated. Both analogs effectivel
Autor:
Kazufumi Akiyama, Henry I. Yamamura, Henry I. Mosberg, Kelvin W. Gee, Robin Hurst, Thomas F. Burks, James J. Galligan, Victor J. Hruby
Publikováno v:
Life Sciences. 33:447-450
The cyclic, penicillamine (β, β dimethylcysteine)-containing enkephalin analogs, [ D -Cys2, L -Pen5]- and [ D -Cys2, D -Pen5]enkephalin and the corresponding bis-penicillamine analogs, [ D -Pen2, L -Pen5]- and [ D -Pen2, D -Pen5]enkephalin were syn
Publikováno v:
Neuropeptides. 5(4-6)
The interactions of a proposed, selective delta receptor antagonist (ICI 174,864) and selective agonists at mu and delta receptors, [D-Ala2, NMePhe4, Gly-ol]-enkephalin (DAGO) and [D-Pen2, D-Pen5]-enkephalin (DPDPE), respectively, have been studied u
Autor:
Henry I. Yamamura, James J. Galligan, Kelvin W. Gee, Robin Hurst, Victor J. Hruby, Henry I. Mosberg, Thomas F. Burks
Publikováno v:
Life sciences. 32(22)
The enkephalin analogs, [D-Pen2,L-Cys5]- and [D-Pen2,D-Cys5]-enkephalin are cyclic compounds, conformationally constrained by virtue of their 14-membered, disulfide containing rings and by the rigidizing effect of the beta, beta dimethyl substituents