Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Leandro F. Vendruscolo"'
Autor:
Sophia Khom, Larry Rodriguez, Pauravi Gandhi, Dean Kirson, Michal Bajo, Christopher S. Oleata, Leandro F. Vendruscolo, Barbara J. Mason, Marisa Roberto
Publikováno v:
Neurobiology of Disease, Vol 164, Iss, Pp 105610-(2022)
Aberrant glucocorticoid signaling via glucocorticoid receptors (GR) plays a critical role in alcohol use disorder (AUD). Acute alcohol withdrawal and protracted abstinence in dependent rats are associated with increased GR signaling and changes in GR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e958c6866dd172648d1433168a0d55
https://doi.org/10.1016/j.nbd.2022.105610
https://doi.org/10.1016/j.nbd.2022.105610
Autor:
Brendan J. Tunstall, Adriana Gregory-Flores, George F. Koob, Olivier George, Joel E. Schlosburg, Giordano de Guglielmo, Leandro F. Vendruscolo, M. Adrienne McGinn, Hazel Hunt, Barbara J. Mason
Publikováno v:
Neuropharmacology
Alcohol use disorder (AUD) is associated with the dysregulation of brain stress and reward systems, including glucocorticoid receptors (GRs). The mixed glucocorticoid/progesterone receptor antagonist mifepristone and selective GR antagonist CORT11317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc96816bd8932829ce0f439c87e1cbd9
https://escholarship.org/uc/item/28w4t2f1
https://escholarship.org/uc/item/28w4t2f1
Autor:
Deon M. Harvey, Fatemeh Akhlaghi, Adriana Gregory-Flores, Hui Sun, Mary R. Lee, Bharath K. Mani, Jacob E. Moose, Leandro F. Vendruscolo, Mehdi Farokhnia, Lorenzo Leggio, Renata C. N. Marchette, James L. Hougland, Eliot L. Gardner, Zhi-Bing You, Marisa Roberto, Sara L. Deschaine, Jeffrey M. Zigman, Lia J. Zallar, Brendan J. Tunstall, George F. Koob
Publikováno v:
Addict Biol
Ghrelin is a gastric-derived peptide hormone with demonstrated impact on alcohol intake and craving, but the reverse side of this bidirectional link, that is, the effects of alcohol on the ghrelin system, remains to be fully established. To further c
Autor:
Caroline B. Pantazis, Luis A. Gonzalez, Brendan J. Tunstall, Stephanie A. Carmack, George F. Koob, Leandro F. Vendruscolo
Publikováno v:
Science Advances
Cues associated with negative reinforcement can stimulate relapse and contribute to opioid use disorder.
Opioid use disorder (OUD) is a debilitating disorder that affects millions of people. Neutral cues can acquire motivational properties when
Opioid use disorder (OUD) is a debilitating disorder that affects millions of people. Neutral cues can acquire motivational properties when
Autor:
Eleanor B. Towers, George F. Koob, Leandro F. Vendruscolo, Brendan J. Tunstall, Mandy McCracken
Publikováno v:
Neuropharmacology
Opioid use disorder is a serious public health issue in the United States. Animal models of opioid dependence are fundamental for studying the etiology of addictive behaviors. We tested the hypothesis that extended access to heroin self-administratio
Autor:
Leandro F. Vendruscolo, Janaina C. M. Vendruscolo, Hanbing Lu, Robin J. Keeley, Stephanie A. Carmack, Elliot A. Stein, Emily G. Lowery-Gionta, George F. Koob
Publikováno v:
Journal of Clinical Investigation. 129:2480-2484
Opioid use disorder (OUD) is associated with the emergence of persistent negative emotional states during drug abstinence that drive compulsive drug taking and seeking. Functional magnetic resonance imaging (fMRI) in rats identified neurocircuits tha
Autor:
Kim D. Janda, Ritika Gautam, Leandro F. Vendruscolo, Lorenzo Leggio, Bin Zhou, Cody J. Wenthur
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
The peptide hormone acyl-ghrelin and its receptor, GHSR1a, represent intriguing therapeutic targets due to their actions in metabolic homeostasis and reward activity. However, this pleotropic activity makes it difficult to intervene in this system wi
Autor:
Caroline Smith, Leandro F. Vendruscolo, Michael A. Arends, Sophie K. Elvig, M. Adrienne McGinn, George F. Koob
Publikováno v:
Pharmacol Biochem Behav
Alcohol tolerance refers to a lower effect of alcohol with repeated exposure. Although alcohol tolerance has been historically included in diagnostic manuals as one of the key criteria for a diagnosis of alcohol use disorder (AUD), understanding its
Autor:
Yuan Ru Yang, Leandro F. Vendruscolo, Brandon A. Blank, Pal Pacher, Ji Soo Lee, Eszter Trojnar, Nehal N. Mehta, George F. Koob, Csaba Mátyás, Alexander V. Sorokin, Janaina C. M. Vendruscolo, Partha Mukhopadhyay, Cody Savage, Falk W. Lohoff, János Pálóczi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Alcoholic liver disease (ALD) causes significant morbidity and mortality, and pharmacological treatment options are limited. In this study, we evaluated the PCSK9 inhibitor alirocumab, a monoclonal antibody that robustly reduces low-density lipoprote
Autor:
Ehsan Shokri-Kojori, Leandro F. Vendruscolo, Corinde E. Wiers, Dardo Tomasi, Ryan E. Tyler, Elizabeth A Cabrera, Tyler Stodden, Gene-Jack Wang, Veronica Ramirez, Clara Freeman, Min Guo, Sukru B. Demiral, Jeih-San Liow, Yeon Joo Jang, Gregg Miller, Cheryl L. Morse, Elsa Lindgren, George F. Koob, Luke Park, Robert B. Innis, Victor W. Pike, Amna Zehra, Sung Won Kim, Nancy Diazgranados, Nora D. Volkow
Publikováno v:
Neuropsychopharmacology
Neuroinflammation appears to contribute to neurotoxicity observed with heavy alcohol consumption. To assess whether chronic alcohol results in neuroinflammation we used PET and [11C]PBR28, a ligand that binds to the 18-kDa translocator protein (TSPO)