Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kiyonaga Fujii"'
Autor:
Norihito Shibata, Mikihiko Naito, Takahito Ito, Yuta Yanase, Yasushi Saeki, Kengo Hamamura, Kiyonaga Fujii, Hidetomo Yokoo, Yosuke Demizu, Yuki Murakami, Akinori Endo, Kosuke Aritake
Publikováno v:
Journal of Medicinal Chemistry. 64:15868-15882
Targeted protein degradation by proteolysis-targeting chimera (PROTAC) is one of the exciting modalities for drug discovery and biological discovery. It is important to select an appropriate linker, an E3 ligase ligand, and a target protein ligand in
Autor:
Hiroyuki Kimura, Saeko Naruki, Toshihide Nishimura, György Marko-Varga, Masayuki Takagi, Hiroki Sakai, Tomoyuki Miyazawa, Kiyonaga Fujii, Harubumi Kato, Hisashi Saji, Haruhiko Nakamura, Naoki Furuya
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
No therapeutic targets have been identified for lung squamous cell cancer (SqCC) which is the second most prevalent lung cancer because its molecular profiles remain unclear. This study aimed to unveil disease-related protein networks by proteomic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa1c9bec483ad7f8260474d7932c153
https://doi.org/10.21203/rs.3.rs-798490/v1
https://doi.org/10.21203/rs.3.rs-798490/v1
Autor:
Masayuki Takagi, Kien Thiam Tan, Saeko Naruki, Shu-Jen Chen, Harubumi Kato, Hisashi Saji, Kiyonaga Fujii, Hirotaka Koizumi, Toshihide Nishimura, Haruhiko Nakamura, De-Wei Zhuo, Yasufumi Kato, Naoki Furuya
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
The tumourigenesis of early lung adenocarcinomas, including adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and lepidic predominant invasive adenocarcinoma (LPA), remains unclear. This study aimed to capture disease-related mol
Autor:
Haruhiko Nakamura, Hisashi Saji, Ayako Yachie, Takeshi Hase, Toshihide Nishimura, Saeko Naruki, Harubumi Kato, Masayuki Takagi, Kiyonaga Fujii, Hirotaka Koizumi, Yukiko Matsuoka, Naoki Furuya
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
It is unclear how epidermal growth factor receptor EGFR major driver mutations (L858R or Ex19del) affect downstream molecular networks and pathways. This study aimed to provide information on the influences of these mutations. The study assessed 36 p
Autor:
Yuka Miyata, Masahiro Hoshikawa, Tomoyuki Miyazawa, Hisashi Saji, Hiroki Sakai, Kouhei Tsumoto, Saeko Naruki, Hiroko Hata, Haruhiko Nakamura, Masayuki Takagi, Hirotaka Koizumu, Ikuya Takahashi, Vipul Gupta, Kiyonaga Fujii, Toshihide Nishimura
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0217105 (2019)
PLoS ONE, Vol 14, Iss 6, p e0217105 (2019)
Small-cell lung carcinoma (SCLC) and large-cell neuroendocrine lung carcinoma (LCNEC) are high-grade lung neuroendocrine tumors (NET). However, comparative protein expression within SCLC and LCNEC remains unclear. Here, protein expression profiles we
Autor:
Kiyonaga Fujii, Hisashi Saji, Toshihide Nishimura, Hirotaka Koizumi, Yuka Miyata, Ikuya Takahashi, Haruhiko Nakamura, Masayuki Takagi, Masahiro Hoshikawa
Publikováno v:
Proteomics. Clinical applications. 12(6)
Purpose The molecular underpinnings that may prognosticate survival and increase our understanding of tumor development and progression are still poorly understood. This study aimed to define the molecular signatures for malignancy in small cell lung
Autor:
Yuji Nishikawa, Yasuharu Nagahama, Hiroyuki Furukawa, Takako Ooshio, Kiyonaga Fujii, Bing Xin, Xi Chen, Yoko Okada, Masahiro Yamamoto
Publikováno v:
Cancer Science
オープンアクセス
Hepatocellular carcinoma develops in either chronically injured or seemingly intact livers. To explore the tumorigenic mechanisms underlying these different conditions, we compared the mRNA expression profiles of mouse h
Hepatocellular carcinoma develops in either chronically injured or seemingly intact livers. To explore the tumorigenic mechanisms underlying these different conditions, we compared the mRNA expression profiles of mouse h
Autor:
Tohru Onogawa, Takashi Minowa, Tatsuyuki Takadate, Kiyonaga Fujii, Sayaka Mikami, Shinichi Egawa, Yasuhiko Bando, Toshihide Nishimura, Hideo Ohtsuka, Makoto Kihara, Yu Katayose, Kazuyuki Ishida, Takashi Suzuki, Nobutaka Hanagata, Michiaki Unno, Fuyuhiko Motoi, Shimpei Maeda, Tetsuya Fukuda
Publikováno v:
International Journal of Cancer. 132:1368-1382
Pancreatic cancer is among the most lethal malignancies worldwide. We aimed to identify novel prognostic markers by applying mass spectrometry (MS)-based proteomic analysis to formalin-fixed paraffin-embedded (FFPE) tissues. Resectable, node positive
Autor:
Kiyonaga Fujii, Toshihide Nishimura, Sayaka Mikami, Yasuhiko Bando, Masahiro Tsuboi, Takeshi Kawamura, Norihiko Ikeda, Makoto Kihara, György Marko-Varga, Masaharu Nomura, Takashi Hirano, Hiromasa Tojo, Harubumi Kato
Publikováno v:
Journal of Proteome Research. 10:51-57
In Japan, rising costs have impacted the framework of maintaining an efficient and effective healthcare system. Today, urgent implementation of programs to address this need have led to a rebuilding of the entire approach of medical evaluation and cl
Autor:
Sayaka Mikami, Takeshi Kawamura, Hiroko Hamasaki, Harubumi Kato, Toshihide Nishimura, Kiyonaga Fujii, Hiromasa Tojo, Yasuhiko Bando, Masaharu Nomura
Publikováno v:
Journal of Proteomics. 73:1089-1099
We used formalin-fixed paraffin-embedded (FFPE) materials for biomarker discovery in cases of lung cancer using proteomic analysis. We conducted a retrospective global proteomic study in order to characterize protein expression reflecting clinical st