Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Jun-ichi Iga"'
Autor:
Hiroshi Kumon, Yoshihiro Miyake, Yuta Yoshino, Jun-ichi Iga, Keiko Tanaka, Hidenori Senba, Eizen Kimura, Takashi Higaki, Bunzo Matsuura, Ryuichi Kawamoto, Shu-ichi Ueno
Publikováno v:
Canadian Journal of Diabetes. 46:829-834
The relationship between alanine-glyoxylate aminotransferase 2 (AGXT2) single-nucleotide polymorphisms (SNPs) and diabetes mellitus (DM) has not been investigated. Therefore, we performed a case-control study to examine this relationship.The study su
Autor:
Mariko Ueno, Yuta Yoshino, Hiroaki Mori, Yu Funahashi, Hiroshi Kumon, Shinichiro Ochi, Tomoki Ozaki, Ayumi Tachibana, Taku Yoshida, Hideaki Shimizu, Takaaki Mori, Jun-ichi Iga, Shu-ichi Ueno
Publikováno v:
Journal of Alzheimer's Disease. 87:863-871
Background: Late-onset Alzheimer’s disease (LOAD) is a complex disease in which neuroinflammation plays an important pathophysiological role, and exposure to neurotoxic substrates such as aldehydes may contribute. Blood mRNA expression levels of ne
Autor:
Hideaki Shimizu, Yuta Yoshino, Yuki Ozaki, Taku Yoshida, Hiroshi Kumon, Shu-ichi Ueno, Jun-ichi Iga, Takaaki Mori, Shinichiro Ochi, Kiyohiro Yamazaki, Hiroaki Mori, Ayumi Tachibana, Yu Funahashi
Publikováno v:
Journal of Alzheimer's Disease
Background: Cyclin-dependent kinase inhibitor 2A (CDKN2A) is an important gene in cellular senescence and aging. Objective: This study assessed the utility of blood CDKN2A mRNA expression levels and methylation status as a potential biomarker for agi
Autor:
Hiroaki Mori, Masahiro Nomoto, Jun-ichi Iga, Mariko Ueno, Hiroshi Kumon, Masahiro Nagai, Yu Funahashi, Shu-ichi Ueno, Kiyohiro Yamazaki, Takaaki Mori, Yuki Ozaki, Shinichiro Ochi, Yuta Yoshino
Publikováno v:
Journal of Alzheimer's Disease
Background: Phosphatidylinositol-binding clathrin assembly protein (PICALM) is a validated genetic risk factor for late-onset Alzheimer’s disease (AD) and is associated with other neurodegenerative diseases. However, PICALM expression in the blood
Autor:
Hiroshi Kumon, Yu Funahashi, Takaaki Mori, Yuki Ozaki, Shinichiro Ochi, Yuta Yoshino, Kiyohiro Yamazaki, Shu-ichi Ueno, Jun-ichi Iga, Hiroaki Mori
Publikováno v:
Molecular Neurobiology
The testing of pathological biomarkers of Alzheimer’s disease (AD), such as amyloid beta and tau, is time-consuming, expensive, and invasive. Here, we used 3xTg-AD mice to identify and validate putative novel blood transcriptome biomarkers of AD th
Autor:
Hideo Morino, Yukiyo Miyoshi, Shu-ichi Ueno, Masayuki Nakamura, Shinichiro Ochi, Hokuto Omachi, Naoya Takeda, Yuta Yoshino, Yuki Ozaki, Taku Yoshida, Saori Inoue, Yumina Tachibana, Noriko Yamauchi, Mutsuhiko Mizobuchi, Jun-ichi Iga, Masao Abe
Publikováno v:
BMC Psychiatry, Vol 20, Iss 1, Pp 1-10 (2020)
BMC Psychiatry
BMC Psychiatry
Background We recently reported that older patients with schizophrenia (SZ) show possible idiopathic normal pressure hydrocephalus (iNPH) more frequently than the general population. In this study, we estimated the prevalence of iNPH in a larger numb
Autor:
Tetsuro Ohmori, Hiroshi Terada, Toshifumi Kishimoto, Haruko Terada, Hideaki Tabuse, Ken Inada, Jun-ichi Iga, Kiyoshi Fujita, Nakao Iwata, Shotatsu Koretsune, Kanji Sekiyama, Taro Kishi, Kazutaka Ohi, Yoshiki Kanda, Toshiaki Shichijo, Yuichiro Tsutsumi, Jun Ishigooka, Kazuyuki Nakagome, Yuka Kikuchi
Publikováno v:
Psychiatry and clinical neurosciences. 76(1)
AIM Globally, evidence from short-term studies is insufficient for the guidelines to uniformly recommend a particular antipsychotic(s) for the maintenance treatment of schizophrenia. Therefore, long-term comprehensive evaluation of antipsychotics is
Autor:
Kayo Ichihashi, Yoshitaka Kyou, Naomi Hasegawa, Norio Yasui-Furukori, Yoshihito Shimizu, Hikaru Hori, Naoki Hashimoto, Kenta Ide, Yayoi Imamura, Hisashi Yamada, Shinichiro Ochi, Jun-ichi Iga, Yoshikazu Takaesu, Kazutaka Ohi, Takashi Tsuboi, Hitoshi Iida, Hirotaka Yamagata, Akitoyo Hishimoto, Tadasu Horai, Masahide Usami, Manabu Makinodan, Tatsuya Nagasawa, Hiroshi Komatsu, Mikio Kido, Hiroyuki Muraoka, Kiyokazu Atake, Masahiro Takeshima, Chika Kubota, Takahiko Inagaki, Shinichiro Tamai, Taishiro Kishimoto, Ryuji Furihata, Junya Matsumoto, Kenichiro Miura, Ken Inada, Koichiro Watanabe, Kiyoto Kasai, Ryota Hashimoto
Publikováno v:
Asian Journal of Psychiatry. 69:103007
Although several guidelines indicate that daily pharmacotherapy is an important part of the treatment of schizophrenia and major depressive disorder, there are few reports regarding pro re nata (PRN) prescriptions. The purpose of this study is to cla
Autor:
Kiyohiro Yamazaki, Takaaki Mori, Yoko Mori, Yu Funahashi, Jun-ichi Iga, Yuki Ozaki, Shunsuke Nakata, Shu-ichi Ueno, Taku Yoshida, Shinichiro Ochi, Yuta Yoshino
Publikováno v:
Journal of Psychiatric Research. 107:79-85
The neuroprotective effect of ghrelin has recently been reported in Alzheimer's disease (AD). Ghrelin is converted from des-acyl ghrelin to the activated form, acyl ghrelin, by membrane bound o-acyltransferase 4 (MBOAT4), and then binds to growth hor
Autor:
Hiroshi Kumon, Naoki Abe, Jun-ichi Iga, Shuken Boku, Keisuke Sekiya, Shu-ichi Ueno, Tasuku Nishihara, Yuta Yoshino, Yu Funahashi, Shinichiro Ochi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
The pathophysiology of delayed carbon monoxide (CO) encephalopathy remains unclear. In this study, the effects of CO exposure on the dentate gyrus (DG) were investigated in a Wistar rat model by histochemical and molecular methods. Model rats showed