Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Joseph H. Nadeau"'
Autor:
Naoki Hirose, Genevieve Blanchet, Yasuhiro Yamauchi, Abigail C. Snow, Robin Friedman, Carmen Y. Khoo, Christine W. Lary, Monika A. Ward, Joseph H. Nadeau
Publikováno v:
Scientific reports. 12(1)
Meiosis, recombination, and gametogenesis normally ensure that gametes combine randomly. But in exceptional cases, fertilization depends on the genetics of gametes from both females and males. A key question is whether their non-random union results
Autor:
Sabine Schaefer, Joseph H. Nadeau
Publikováno v:
The Quarterly Review of Biology. 90:381-415
Organisms adapt developmental and physiological features to local and transient conditions in part by modulating transcription, translation, and protein functions, usually without changing DNA sequences. Remarkably, these epigenetic changes sometimes
Autor:
Joseph H, Nadeau
Publikováno v:
Genetics. 207(2)
A fundamental tenet of inheritance in sexually reproducing organisms such as humans and laboratory mice is that gametes combine randomly at fertilization, thereby ensuring a balanced and statistically predictable representation of inherited variants
Germ cell pluripotency, premature differentiation and susceptibility to testicular teratomas in mice
Autor:
Patricia A. Conrad, Joseph H. Nadeau, Megan V. Michelson, Jason D. Heaney, Jennifer L. Zechel, Ericka L. Anderson, David C. Page
Publikováno v:
Development. 139:1577-1586
Testicular teratomas result from anomalies in germ cell development during embryogenesis. In the 129 family of inbred strains of mice, teratomas initiate around embryonic day (E) 13.5 during the same developmental period in which female germ cells in
Autor:
David G. Harrison, Allen W. Cowley, Jose M. Ordovas, Moshe Szyf, Weiqun Peng, Gary H. Gibbons, Kathleen H. Berecek, H. Eser Tolunay, Katherine C. Wood, Peter W. Nathanielsz, Joseph H. Nadeau, Andrea A. Baccarelli, Zorina S. Galis, Mingyu Liang, Marcelo B. Soares, Myriam Fornage, Daniel T. O'Connor, Keji Zhao
Publikováno v:
Hypertension. 59:899-905
Hypertension, defined as a condition associated with ≥140-mm Hg systolic blood pressure or ≥90-mm Hg diastolic blood pressure, affects >1 billion people worldwide,1 and in 2009 it cost the US healthcare system more than $73 billion.2 Despite the
Autor:
Soha Yazbek, Joseph H. Nadeau, Colleen M. Croniger, Jonathan M. Geisinger, Gabriel E. Zentner, Sabrina H. Spiezio, David A. Buchner, Lindsay C. Burrage, Chang-Wen Hsieh, Peter C. Scacheri
Publikováno v:
Genome Research. 21:1065-1073
Although central to many studies of phenotypic variation and disease susceptibility, characterizing the genetic architecture of complex traits has been unexpectedly difficult. For example, most of the susceptibility genes that contribute to highly he
Publikováno v:
Development. 138:23-32
Human germ cell tumors show a strong sensitivity to genetic background similar to Dnd1(Ter/Ter) mutant mice, where testicular teratomas arise only on the 129/SvJ genetic background. The introduction of the Bax mutation onto mixed background Dnd1(Ter/
Autor:
David DeSantis, John D. Lambris, Annie E. Hill-Baskin, Maciej M. Markiewski, David A. Buchner, Haifeng Shao, Nathan A. Berger, Shankar Subramaniam, Gene Hsiao, Joseph H. Nadeau, Colleen M. Croniger
Publikováno v:
Human Molecular Genetics. 18:2975-2988
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide, with approximately 70% of cases resulting from hepatitis B and C viral infections, aflatoxin exposure, chronic alcohol use or genetic liver diseases. The remaining
Publikováno v:
Cancer Research. 69:3614-3618
Testicular germ cell tumors (TGCT) are sex limited, occurring only in males with a Y chromosome. Recently, the gr/gr deletion on the human Y chromosome was associated with increased risk of TGCTs. In addition, the presence of Y chromosome sequences i
Publikováno v:
Developmental Biology. 328:377-383
A homozygous nonsense mutation (Ter) in murine Dnd1 (Dnd1Ter/Ter) results in a significant early loss of primordial germ cells (PGCs) prior to colonization of the gonad in both sexes and all genetic backgrounds tested. The same mutation also leads to