Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Itaru Kojima"'
Autor:
Motochika Asano, Shotaro Kamata, Yoshiko Banno, Toshiko Kajita, Ichiro Mori, Itaru Kojima, Isao Ishii, Tatsuo Ishizuka, Masahiro Yamauchi, Hiroyuki Morita, Mikako Kawashima, Jerold Chun, Takahide Ikeda, Yoshihiko Kitada, Koichiro Taguchi, Kazuo Kajita
Publikováno v:
Endocrinology. 157:1839-1851
Sphingosine 1-phosphate (S1P) is known to regulate insulin resistance in hepatocytes, skeletal muscle cells, and pancreatic β-cells. Among its 5 cognate receptors (S1pr1–S1pr5), S1P seems to counteract insulin signaling and confer insulin resistan
Autor:
Toshiko Kajita, Tsutomu Sasaki, Tatsuo Ishizuka, Ichiro Mori, Itaru Kojima, Kazuo Kajita, Takayuki Hanamoto, Hideyuki Okada, Takashi Sato, Taro Usui, Tadahiro Kitamura, Yoshihiko Kitada, Koichiro Taguchi, Hiroyuki Morita, Takahide Ikeda
Publikováno v:
FEBS Letters. 588:1935-1941
Androgen reduces fat mass, although the underlying mechanisms are unknown. Here, we examined the effect of testosterone on heat production and mitochondrial biogenesis. Testosterone-treated mice exhibited elevated heat production. Treatment with test
Autor:
Toshiyuki Takeuchi, Itaru Kojima, Hiromi Hashimoto, Satoko Yamada, Izumi Takei, Etsuko Hisanaga, Kee Yong Park, Kazuo Umezawa, Masaharu Seno, Masatomo Mori
Publikováno v:
Endocrine Journal. 55:535-543
The present study was conducted to establish a method to induce differentiation of bone marrow (MB)-derived mesenchymal cells into insulin-producing cells. When mouse BM-derived mesenchymal cells were cultured for 60 days in medium containing 10% fet
Publikováno v:
Journal of Biological Chemistry. 281:28499-28507
Although the stimulatory effect of glucagon-like peptide 1 (GLP-1), a cAMP-generating agonist, on Ca(2+) signal and insulin secretion is well established, the underlying mechanisms remain to be fully elucidated. We recently discovered that Ca(2+) inf
Autor:
Tsutomu Kodera, Satoko Yamada, Itaru Kojima, Yoritsuna Yamamoto, Masahiro Nagasawa, Akemi Hara
Publikováno v:
Endocrine Journal. 53:789-795
Adenovirus-mediated gene transfer of pancreatic duodenal homeobox transcription factor PDX-1, especially its super-active version (PDX-1/VP16), induces the expression of pancreatic hormones in murine liver and reverses streptozotocin-induced hypergly
Publikováno v:
Endocrine Journal. 53:73-78
The present study was conducted to compare the effects of exogenous follistatin and activin A on liver regeneration in 90% hepatectomized rats. Intraportal administration of follistatin markedly accelerated liver regeneration, and nuclear BrdU labeli
Publikováno v:
Endocrine Journal. 51:381-386
The present study was conducted in an attempt to treat streptozotocin (STZ)-induced hyperglycemia by transplanting beta cells derived from pancreatic ductal cells. Ductal cells obtained from neonatal rats were cultured in vitro. Approximately 70% of
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 285:E577-E583
Betacellulin (BTC) induces differentiation of pancreatic beta-cells and promotes regeneration of beta-cells in experimental diabetes. The present study was conducted to determine if BTC improved glucose metabolism in severe diabetes induced by a high
Autor:
Kuniaki Takata, Masatoshi Makuuchi, Hiroshi Yorifuji, Toshiyuki Matsuzaki, Hiroyuki Kuwano, Itaru Kojima, Kimitaka Kogure
Publikováno v:
Journal of hepato-biliary-pancreatic sciences. 21(12)
Background The aim of the present study was to clarify the anatomy between the left triangular ligament (LTL) and the appendix fibrosa hepatis (AFH) in order not to sever the AFH when dissecting the LTL. Methods Totals of 43 and 27 cadaveric livers w
Autor:
Toshio Akimoto, Yuko Nakagawa, Jinhui Ma, Kunihisa Hamano, Anya Medina, Longfei Li, Yuzo Ninomiya, Itaru Kojima
Publikováno v:
Endocrine journal. 61(8)
We reported recently that the taste type 1 receptor 3 (T1R3), a subunit of the sweet taste receptor, functions as a cell-surface glucose-sensing receptor in pancreatic β-cells. In the present study, we investigated the expression of T1R3 in pancreat