Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Gwendolyn Binder-Scholl"'
Autor:
Travis Wood, Dawn A. Maier, Andrea L. Brennan, Gabriela Plesa, Carl H. June, Gary Lee, Julio Cotte, Elena E. Perez, Bruce L. Levine, S. Kaye Spratt, Carmine Carpenito, Richard G. Carroll, Zhaohui Zheng, Philip D. Gregory, Michael C. Holmes, Gwendolyn Binder-Scholl, James L. Riley, Dale Ando, Shuguang Jiang
Publikováno v:
Human Gene Therapy. 24:245-258
Since HIV requires CD4 and a co-receptor, most commonly C-C chemokine receptor 5 (CCR5), for cellular entry, targeting CCR5 expression is an attractive approach for therapy of HIV infection. Treatment of CD4(+) T cells with zinc-finger protein nuclea
Autor:
Carl H. June, Edward A. Stadtmauer, Sunita Philip, Nicholas J. Pumphrey, Saul Yanovich, Tom Holdich, Bent K. Jakobsen, Lilliam Ribeiro, Alan D. Bennett, Helen K. Tayton-Martin, Joanna E. Brewer, Andrew B. Gerry, Dan T. Vogl, Irina Kulikovskaya, Luca Melchiori, Minnal Gupta, Gwendolyn Binder-Scholl, Alfred L. Garfall, Olga Goloubeva, Naseem Kerr, Michael Kalos, Sanjoy K. Sinha, Sandra Westphal, Ashraf Badros, Aaron P. Rapoport, Shari Kronsberg, Simon F. Lacey, Brendan M. Weiss, Jean A. Yared, Jeffrey Finklestein, Bruce L. Levine, Daniel Williams, Nancy M. Hardy, Don L. Siegel, Sarah Bond
Publikováno v:
Nature medicine
Despite recent therapeutic advances, multiple myeloma (MM) remains largely incurable. Herein we report results of a phase I/II trial to evaluate the safety and activity of autologous T-cells engineered to express an affinity-enhanced T-cell receptor
Autor:
Gwendolyn Binder-Scholl, Ronald G. Collman, Michael Kalos, Ian Frank, Philip D. Gregory, Geoff Nichol, Bruce L. Levine, S. Kaye Spratt, Dale G. Ando, Michael C. Holmes, Pablo Tebas, Winson Tang, Gabriela Plesa, Shelley Wang, Gary Lee, Carl H. June, David Stein, Martin Giedlin, Wei-Ting Hwang, Richard T. Surosky
Publikováno v:
The New England journal of medicine. 370(10)
CCR5 is the major coreceptor for human immunodeficiency virus (HIV). We investigated whether site-specific modification of the gene ("gene editing")--in this case, the infusion of autologous CD4 T cells in which the CCR5 gene was rendered permanently
Autor:
Alan D. Bennett, Joanna E. Brewer, Namir J. Hassan, Gerald P. Linette, Leslie A. Litzky, Gwendolyn Binder-Scholl, Helen K. Tayton-Martin, Michael Kalos, Patrick J. Cimino, Nick Pumphrey, Edward A. Stadtmauer, Adam Bagg, Aaron P. Rapoport, Bruce L. Levine, Marcela V. Maus, Joseph Dukes, Dominic P. Smethurst, Carl H. June, Bent K. Jakobsen, Jane Harper, Lyndsey Emery, Beatriz M. Carreno, Andrew B. Gerry
An obstacle to cancer immunotherapy has been that the affinity of T-cell receptors (TCRs) for antigens expressed in tumors is generally low. We initiated clinical testing of engineered T cells expressing an affinity-enhanced TCR against HLA-A*01–re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db4b1b764b63316916d1897b42a8b11
https://europepmc.org/articles/PMC3743463/
https://europepmc.org/articles/PMC3743463/
Autor:
Elizabeth Veloso, Zhaohui Zheng, Faten Aberra, Adonna Mackley, Jenny Zhan, Julio Cotte, Jean D. Boyer, Wei-Ting Hwang, Andrea L. Brennan, Ronald G. Collman, Troy Brady, Bruce L. Levine, Carl H. June, Tessio Rebello, Pablo Tebas, Luis J. Montaner, Rithun Mukherjee, Gwendolyn Binder-Scholl, David Stein, Michael Kalos, Daniel Schullery, Farida Shaheen, Vladimir Slepushkin, Frederic D. Bushman, Emmanouil Papasavvas, Laurent Humeau
Publikováno v:
Blood. 121(9)
We report the safety and tolerability of 87 infusions of lentiviral vector–modified autologous CD4 T cells (VRX496-T; trade name, Lexgenleucel-T) in 17 HIV patients with well-controlled viremia. Antiviral effects were studied during analytic treatm