Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Fernando Souza-Fonseca-Guimaraes"'
Autor:
Stefano Mangiola, Martin Modrak, Chayanica Nasa, Natalie Lister, Phil Dundee, Justin S. Peters, Paul J Neeson, Bhupinder Pal, Daniel Blashki, Niall M. Corcoran, Christopher M. Hovens, Anthony J. Costello, Nicholas D. Huntington, Ryan Stuchbery, Scott Williams, Simon Monard, Simon P. Keam, Fernando Souza-Fonseca-Guimaraes, Ken Chow, Patrick McCoy, Michael Kerger, Melanie Le Page, Anthony T. Papenfuss
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-18 (2021)
BMC Cancer
BMC Cancer
Background Prostate cancer is caused by genomic aberrations in normal epithelial cells, however clinical translation of findings from analyses of cancer cells alone has been very limited. A deeper understanding of the tumour microenvironment is neede
Autor:
Ariel Munitz, Kylie Luong, Andrew N. J. McKenzie, Jaring Schreuder, Wei Shi, Minyu Wang, Sharon Grisaru-Tal, Melissa J. Davis, Paul S. Foster, Joseph A. Trapani, Bogoljub Ciric, Sean Macdonald, Kevin Y. T. Thia, Soroor Hediyeh-Zadeh, Cynthia Louis, Ian P. Wicks, Stephen L. Nutt, Qiutong Huang, Jonathan Cebon, Shengbo Zhang, Daniel H.D. Gray, Paul J Neeson, Andreas Behren, Philip M. Hansbro, Cyril Seillet, Michael Chopin, Nicolas Jacquelot, Viktor Umansky, Angela Pizzolla, Joanna R Groom, Fernando Souza-Fonseca-Guimaraes, Mary J Camilleri, Tristan Molden-Hauer, Yang Liao, Eric Vivier, Carolyn A. de Graaf, Gabrielle T. Belz
Publikováno v:
Nature Immunology
Nature Immunology, 2021, 22 (7), pp.851-864. ⟨10.1038/s41590-021-00943-z⟩
Nature immunology
Nature Immunology, 2021, 22 (7), pp.851-864. ⟨10.1038/s41590-021-00943-z⟩
Nature immunology
International audience; Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer, ILC2s can harbor both pro-tumorigenic and anti-tumorigenic functions, but we know little about their underlying mechanisms or wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58b04f1a688fd896b85f7433ff098a9
https://hdl.handle.net/10453/155659
https://hdl.handle.net/10453/155659
Autor:
Andreas Behren, Fernando Souza-Fonseca-Guimaraes, Nicholas D. Huntington, Melissa J. Davis, Joseph Cursons, Soroor Hediyeh-Zadeh, Momeneh Foroutan, Ashley R. Anderson, Frédéric Hollande
Publikováno v:
Cancer Immunology Research. 7:1162-1174
Natural killer (NK) cell activity is essential for initiating antitumor responses and may be linked to immunotherapy success. NK cells and other innate immune components could be exploitable for cancer treatment, which drives the need for tools and m
Autor:
Malcolm J. McConville, Fernando Souza-Fonseca-Guimaraes, Motti Gerlic, Komal Kanojia, Adele Preaudet, Benjamin T. Kile, Marcel R. de Zoete, Man Lyang Kim, Konstantinos A. Kouremenos, Yasunori Ogura, Richard A. Flavell, David P De Souza, Cassandra R. Harapas, Tracy L Putoczki, Stephen Wilcox, Hazel Tye, Seth L. Masters, Graham L. Radford-Smith, Sinéad C. Corr, Martha Zakrzewski, Jocelyn Sietsma Penington, Leesa F. Wockner, Chien-Hsiung Yu, Anthony T. Papenfuss, Lisa A. Simms, Lisa A. Mielke
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, 9(1). Nature Publishing Group
Nature Communications, 9(1). Nature Publishing Group
Anti-microbial signaling pathways are normally triggered by innate immune receptors when detecting pathogenic microbes to provide protective immunity. Here we show that the inflammasome sensor Nlrp1 aggravates DSS-induced experimental mouse colitis b
Autor:
Laura F. Dagley, Yuyan Yang, Damian B D'Silva, Jeffrey J. Babon, Melissa J. Davis, Bogoljub Ciric, Ian P. Wicks, Warren S. Alexander, Eric Vivier, Jai Rautela, Soroor Hediyeh-Zadeh, Cynthia Louis, Seth L. Masters, Tobias Kratina, Fernando Souza-Fonseca-Guimaraes, Nicholas D. Huntington
Publikováno v:
The Journal of Experimental Medicine
Despite increasing recognition of the importance of GM-CSF in autoimmune disease, it remains unclear how GM-CSF is regulated at sites of tissue inflammation. Using GM-CSF fate reporter mice, we show that synovial NK cells produce GM-CSF in autoantibo
Autor:
Marianna, Parlato, François, Philippart, Alexandra, Rouquette, Virginie, Moucadel, Virginie, Puchois, Sophie, Blein, Jean-Pierre, Bedos, Jean-Luc, Diehl, Olfa, Hamzaoui, Djillali, Annane, Didier, Journois, Myriam, Ben Boutieb, Laurent, Estève, Catherine, Fitting, Jean-Marc, Treluyer, Alexandre, Pachot, Minou, Adib-Conquy, Jean-Marc, Cavaillon, Benoît, Misset, Fernando, Souza-Fonseca-Guimaraes
Publikováno v:
Intensive Care Medicine. 44:1061-1070
Sepsis and non-septic systemic inflammatory response syndrome (SIRS) are the same syndromes, differing by their cause, sepsis being secondary to microbial infection. Microbiological tests are not enough to detect infection early. While more than 50 b
Autor:
Rebecca B. Delconte, Andreas Strasser, Vanina Simon, Fernando Souza-Fonseca-Guimaraes, Benjamin T. Kile, Eric Vivier, Yuhao Jiao, Phillip D. Hodgkin, Nicholas D. Huntington, Gabrielle T. Belz, Bruce Beutler, Daniel H.D. Gray, Charlotte Viant, Michael Roger, Jai Rautela, Stephanie Grabow, Claire Bernat, Wilford Goh, Kim Pham, Robert J. Hennessy, Sophie Guia, Sophie Ugolini
Publikováno v:
Journal of Experimental Medicine
Journal of Experimental Medicine, 2017, 214 (2), pp.491-510
The Journal of Experimental Medicine
Journal of Experimental Medicine, 2017, 214 (2), pp.491-510
The Journal of Experimental Medicine
Natural killer (NK) cells eradicate virus-infected and transformed cells. Viant and colleagues describe the hierarchy of survival proteins and their apoptotic partners that govern NK cell survival. These data will inform approaches to harness NK cell
Autor:
Laura Kirby, Shatha AbuHammad, Richard J. Young, Peter Lau, Grant A. McArthur, Claire Martin, Katrina Meeth, Karen E. Sheppard, Jessica Michie, Kelly M Ramsbottom, Nicole M. Haynes, Rachael Walker, Fernando Souza-Fonseca-Guimaraes, Jane Oliaro, Emily J. Lelliott, Carleen Cullinane, Alison Slater
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Both targeted therapy and immunotherapy have been used successfully to treat melanoma, but the development of resistance and poor response rates to the individual therapies has limited their success. Designing rational combinations of targeted therap
Autor:
Mark J. Smyth, Nicholas D. Huntington, Shin Foong Ngiow, Mariapia A. Degli-Esposti, Ann-Marie Patch, Nicola Waddell, Arabella Young, Joel Linden, Laurence Zitvogel, Eric Vivier, Jérôme D. Coudert, Meriem Messaoudene, Deborah S. Barkauskas, Gene Lin, Kimberley Stannard, Fernando Souza-Fonseca-Guimaraes, Yulong Gao
Publikováno v:
Cancer Research
Cancer Research, American Association for Cancer Research, 2018, 78 (4), pp.1003-1016. ⟨10.1158/0008-5472.CAN-17-2826⟩
Cancer Research, 2018, 78 (4), pp.1003-1016. ⟨10.1158/0008-5472.CAN-17-2826⟩
Cancer Research, American Association for Cancer Research, 2018, 78 (4), pp.1003-1016. ⟨10.1158/0008-5472.CAN-17-2826⟩
Cancer Research, 2018, 78 (4), pp.1003-1016. ⟨10.1158/0008-5472.CAN-17-2826⟩
Extracellular adenosine is a key immunosuppressive metabolite that restricts activation of cytotoxic lymphocytes and impairs antitumor immune responses. Here, we show that engagement of A2A adenosine receptor (A2AR) acts as a checkpoint that limits t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc68f1105304da860d7ffc3a4d87cf5f
https://hal-amu.archives-ouvertes.fr/hal-02024322
https://hal-amu.archives-ouvertes.fr/hal-02024322
Autor:
Alexandra Cristina Senegaglia, Lidiane Maria Boldrini Leite, Fernando Guimarães, Paulo Souza-Fonseca-Guimaraes, Fernando Souza-Fonseca-Guimaraes, Caroline Natânia de Souza-Araújo, Anita Nishiyama
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 3; Pages: 616
International Journal of Molecular Sciences, Vol 18, Iss 3, p 616 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 3; Pages: 616
International Journal of Molecular Sciences, Vol 18, Iss 3, p 616 (2017)
Sepsis is a complex systemic inflammatory syndrome, the most common cause of which is attributed to systemic underlying bacterial infection. The complete mechanisms of the dynamic pro- and anti-inflammatory processes underlying the pathophysiology of