Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Edward A. Dratz"'
Autor:
Edward A. Dratz, Karina Balan, Gal Keren-Aviram, Shruti Bagla, Fabien Dachet, Jeffrey A. Loeb
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195639 (2018)
PLoS ONE
PLoS ONE
Epilepsy is a common neurological disorder, which is not well understood at the molecular level. Exactly why some brain regions produce epileptic discharges and others do not is not known. Patients who fail to respond to antiseizure medication (refra
Autor:
Laleh Saadat, Tibor Valyi-Nagy, Edward A. Dratz, Gal Keren-Aviram, Fei Song, Karina Balan, Fabien Dachet, Shruti Bagla, Jeffrey A. Loeb, William J. Kupsky, Andrew R. Morton
Publikováno v:
Brain : a journal of neurology. 138(Pt 2)
Although epilepsy is associated with a variety of abnormalities, exactly why some brain regions produce seizures and others do not is not known. We developed a method to identify cellular changes in human epileptic neocortex using transcriptional clu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1429:187-207
The structure of laminin peptide 11 (CDPGYIGSR-NH2) contains valuable information for the design of mimetic compounds with anti-invasive and anti-metastatic properties. An alanine scan replacement experiment identified Tyr5, Ile6 and Arg9 residues as
Autor:
Edward A. Dratz, Daniel W. Siemsen, Mark T. Quinn, John G. Linner, Algirdas J. Jesaitis, E S Buescher
Publikováno v:
Journal of Leukocyte Biology. 57:415-421
Oxidants generated by the NADPH oxidase of activated neutrophils can react with a number of tissue targets to form toxic metabolites such as 4-hydroxynonenal (4-HNE). 4-HNE is a lipid peroxidation product generated by free radical attack on ω-6 poly
Publikováno v:
Analytical Biochemistry. 198:104-111
A new method has been developed for the quantitation of lipid peroxidation products by gas chromatography-mass spectrometry. An important advantage over existing gas chromatography-mass spectrometry methods is the elimination of autoxidation during s
Publikováno v:
Experimental Eye Research. 34:339-369
Male Sprague-Dawley rats were maintained, from weaning, on diets deficient either in vitamin E, selenium, chromium and sulfur amino acids (−E−Se−S−Cr), or only in vitamin E and selenium (−E−Se+S+Cr). Control animals (+E+Se+S+Cr) received
Autor:
William L. Stone, Edward A. Dratz
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 631:503-506
Rats fed a diet deficient in vitamin E and selenium show an increased activity of glutathione-S-transferase (EC 2.5.1.18) in all tissues tested, with the possible exception of the retina. Glutathione-S-transferases are detoxifying enzymes that are in
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 552:281-293
The fatty acid composition of retinal tissues was measured in rats maintained for 26–32 weeks on each of the following diets: a purified basal diet deficient in α-tocopherol and selenium, an identical control diet supplemented with α-tocopherol a
Publikováno v:
The American Journal of Clinical Nutrition. 43:382-387
Vitamin E was administered orally (400 IU twice a day) to adult male humans for 28 days as either dl-alpha-tocopheryl acetate (all-rac-alpha-tocopheryl acetate) or d-alpha-tocopheryl acetate (RRR-alpha-tocopheryl acetate). Plasma alpha-tocopherol ros
Autor:
Garry J. Handelman, L J Machlin, William L. Epstein, Edward A. Dratz, Frederik J.G.M. van Kuijk
Publikováno v:
Lipids. 23:598-604
An adaptation of the needle biopsy procedure of Beynen and Katan for human adipose tissue, which yields 2-10 mg adipose samples, is described and evaluated. Micromethods are presented for the analysis of alpha-tocopherol, cholesterol and fatty acids