Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ajay Nirula"'
Autor:
Gregory D. Huhn, Dipak R. Patel, Bharat Mocherla, Daniel Skovronsky, Kenneth L. Custer, Paul Klekotka, Imad Shawa, Andrew E. Schade, Janelle Sabo, Nicole L. Kallewaard, Michael Durante, Andrew C. Adams, Timothy R. Holzer, Ajay Nirula, Joseph Boscia, Masoud Azizad, Jose Cardona, Princy Kumar, Chad Crystal, Lei Shen, Peter Chen, Russell Perry, Corey Hebert, Richard E. Higgs, Robert L. Gottlieb, Matan C. Dabora, Philip J. Ebert, Jacob Van Naarden, Gerard J. Oakley, Jason Morris, Michael Dougan, Awawu Igbinadolor, Barry Heller
Publikováno v:
The New England Journal of Medicine
Background Patients with underlying medical conditions are at increased risk for severe coronavirus disease 2019 (Covid-19). Whereas vaccine-derived immunity develops over time, neutralizing monoclonal-antibody treatment provides immediate, passive i
Autor:
Charles Benson, Emmanuel Chigutsa, Amit Saxena, Paul Klekotka, Peter Chen, Gourab Datta, Ariel Kay, Josh Poorbaugh, Mark J. Mulligan, William A. Fischer, Ying Grace Li, Karen L. Price, Patricia Brown-Augsburger, Ajay Nirula, Robert J. Benschop, Nadine Rouphael, Jenny Y. Chien, Jeffrey Fill, Michael Dougan
Publikováno v:
Clinical Pharmacology and Therapeutics
Therapeutics for patients hospitalized with coronavirus disease 2019 (COVID-19) are urgently needed during the pandemic. Bamlanivimab is a potent neutralizing monoclonal antibody that blocks severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2
Autor:
Brian J. Nickoloff, Silvia Ottaviani, Jonathan T. Sims, Nicoletta Bivi, Richard E. Higgs, Ajay Nirula, Venkatesh Krishnan, George H. Rodgers, Giacomo Casalini, Robert J. Benschop, Anabela Cardoso, Justin Stebbing, Mario Corbellino, Sarah M. Engle, Ching Yun Chang, Robert J. Konrad, Stephanie de Bono
Publikováno v:
The Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Background Physicians treating COVID-19 patients increasingly believe that the hyperinflammatory acute stage of COVID-19 results in a cytokine storm. The circulating biomarkers seen across the spectrum of COVID-19 have not been characterized compared
Autor:
Lin Zhang, Josh Poorbaugh, Michael Dougan, Peter Chen, Robert L. Gottlieb, Gregory Huhn, Stephanie Beasley, Montanea Daniels, Thi Ngoc Vy Trinh, Melissa Crisp, Joshua Joaquin Freitas, Peter Vaillancourt, Dipak R. Patel, Ajay Nirula, Nicole L. Kallewaard, Richard E. Higgs, Robert J. Benschop
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
BackgroundNeutralizing monoclonal antibodies (mAbs) to SARS-CoV-2 are clinically efficacious when administered early, decreasing hospitalization and mortality in patients with mild or moderate COVID-19. We investigated the effects of receiving mAbs (
Autor:
Andrew C. Adams, Jose Cardona, Barry Heller, Nicole L. Kallewaard, Jason Morris, Michael Durante, Bharat Mocherla, Richard E. Higgs, Valentina Stosor, Daniel Skovronsky, Joseph Boscia, Paul Klekotka, Princy Kumar, Imad Shawa, Robert L. Gottlieb, Ajay Nirula, Timothy R. Holzer, Lei Shen, Philip J. Ebert, Jacob Van Naarden, Gerard J. Oakley, Dipak R. Patel, Kenneth L. Custer, Andrew E. Schade, Janelle Sabo, Peter Chen, Gregory D. Huhn
Publikováno v:
JAMA. 325(7)
Importance: Coronavirus disease 2019 (COVID-19) continues to spread rapidly worldwide. Neutralizing antibodies are a potential treatment for COVID-19. Objective: To determine the effect of bamlanivimab monotherapy and combination therapy with bamlani
Autor:
Volker M. Lauschke, Guilherme Rocha, Jorge A. Ross Terres, Venkatesh Krishnan, Sonia Youhanna, Justin Stebbing, Vanessa Monteil, Silvia Ottaviani, Antonella Sarasini, Anabela Cardoso, Yee-Joo Tan, Fausto Baldanti, Brian J. Nickoloff, Stephanie de Bono, Nicole L. Byers, Mario Corbellino, Ali Mirazimi, Peter J. Richardson, Douglas E Schlichting, Richard E. Higgs, Giacomo Casalini, Ajay Nirula
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 8, Pp n/a-n/a (2020)
EMBO Molecular Medicine, Vol 12, Iss 8, Pp n/a-n/a (2020)
Baricitinib, is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA) that was independently predicted, using artificial intelligence (AI)‐algorithms, to be useful for COVID‐19 infection via a proposed
Autor:
Myron S, Cohen, Ajay, Nirula, Mark J, Mulligan, Richard M, Novak, Mary, Marovich, Catherine, Yen, Alexander, Stemer, Stockton M, Mayer, David, Wohl, Blair, Brengle, Brian T, Montague, Ian, Frank, Russell J, McCulloh, Carl J, Fichtenbaum, Brad, Lipson, Nashwa, Gabra, Julio A, Ramirez, Christine, Thai, Wairimu, Chege, Margarita M, Gomez Lorenzo, Nirupama, Sista, Jennifer, Farrior, Meredith E, Clement, Elizabeth R, Brown, Kenneth L, Custer, Jacob, Van Naarden, Andrew C, Adams, Andrew E, Schade, Matan C, Dabora, Jack, Knorr, Karen L, Price, Janelle, Sabo, Jay L, Tuttle, Paul, Klekotka, Lei, Shen, Daniel M, Skovronsky, George, Taffet
Publikováno v:
JAMA. 326:46
IMPORTANCE Preventive interventions are needed to protect residents and staff of skilled nursing and assisted living facilities from COVID-19 during outbreaks in their facilities. Bamlanivimab, a neutralizing monoclonal antibody against SARS-CoV-2, m
Autor:
Chris B. Russell, Mayte Suárez-Fariñas, Lewis Tomalin, Sandra Garcet, Hanne Norsgaard, David Adrian Ewald, James G. Krueger, Ajay Nirula, Paul Klekotka
Publikováno v:
The Journal of allergy and clinical immunology. 145(3)
Background IL-17 antagonists induce impressive clinical benefits in psoriasis, but it is unknown to what extent cellular and molecular psoriasis characteristics are suppressed by a clinically relevant dose/schedule of any IL-17-receptor antagonist. O
Autor:
Ajay Nirula, Philip J. Mease, J. Feng, Hema N. Viswanathan, Ngozi Erondu, Alex Mutebi, Mark C. Genovese, Dina Chau
Publikováno v:
The Journal of Rheumatology. 43:343-349
Objective.To evaluate the effect of brodalumab on psoriasis signs and symptoms assessed by the Psoriasis Symptom Inventory (PSI) in patients with psoriatic arthritis (PsA).Methods.This prespecified analysis of a phase II study (NCT01516957) evaluated
Autor:
Alice B. Gottlieb, James G. Krueger, Ajay Nirula, Gregory Kricorian, Darryl Toth, Andrew Blauvelt, Kim A. Papp, Joanne Li, Kristian Reich, Carle Paul, Diamant Thaçi, Cassandra E Milmont, Richard G. Langley, Chris B. Russell, Paul Klekotka, W. Baran, Chantal Bolduc, J. Cather
Publikováno v:
The British journal of dermatology. 175(2)
SummaryBackground The interleukin-17 cytokine family plays a central role in psoriasis pathogenesis. Objectives To evaluate the efficacy and safety of brodalumab, a human anti-interleukin-17 receptor antibody, in treating patients with moderate-to-se