Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Achim Schmidtko"'
Autor:
Katharina Moeller, Jan Matthes, Marianne van Cann, Tim Hucho, Dionéia Araldi, Achim Schmidtko, Jörg Isensee, Patrick Despang, Jon D. Levine, Jonas Petersen
Publikováno v:
The Journal of cell biology, vol 220, iss 10
Depolarization drives neuronal plasticity. However, whether depolarization drives sensitization of peripheral nociceptive neurons remains elusive. By high-content screening (HCS) microscopy, we revealed that depolarization of cultured sensory neurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695cbf1fb171326e0739a1c9827aba6f
https://escholarship.org/uc/item/1hd822wj
https://escholarship.org/uc/item/1hd822wj
Publikováno v:
Purinergic Signalling
Previous studies suggest that adenosine A1 receptors (A1R) modulate the processing of pain. The aim of this study was to characterize the distribution of A1R in nociceptive tissues and to evaluate whether targeting A1R with the partial agonist capade
Autor:
Katrin Olbrich, Gerd Geisslinger, Ellen Niederberger, Julia Männich, Achim Schmidtko, Nerea Ferreiros-Bouzas, Katharina M.J. Syhr, Katja Schmitz, Ruirui Lu, Wiebke Kallenborn-Gerhardt
Publikováno v:
Pharmacology Biochemistry and Behavior. 124:389-395
Accumulating evidence indicates that various subtypes of purinergic receptors (P2X and P2Y receptor families) play an essential role in the development and the maintenance of neuropathic pain. However, there is only limited data available about the r
Autor:
Ruirui, Lu, Cathrin, Flauaus, Lea, Kennel, Jonas, Petersen, Oliver, Drees, Wiebke, Kallenborn-Gerhardt, Peter, Ruth, Robert, Lukowski, Achim, Schmidtko
Publikováno v:
Neuropharmacology. 125
Intermediate conductance calcium-activated potassium channels (K
Autor:
Jana E. Lorenz, Gerd Geisslinger, Ruirui Lu, Dominique Thomas, Catherine Isabell Real, Domenico Del Turco, Nancy Lippold, Jessica Schlaudraff, Wiebke Kallenborn-Gerhardt, Aaron Bothe, Nerea Ferreirós, Achim Schmidtko
Publikováno v:
Anesthesiology. 121:372-382
Background: Phosphodiesterase 2A (PDE2A) is an evolutionarily conserved enzyme that catalyzes the degradation of the cyclic nucleotides, cyclic adenosine monophosphate, and/or cyclic guanosine monophosphate. Recent studies reported the expression of
Autor:
Katharina M.J. Syhr, Gerd Geisslinger, Thorsten Bangsow, Juliana Heidler, Achim Schmidtko, Harald von Melchner, Ruirui Lu, Wiebke Kallenborn-Gerhardt
Publikováno v:
Antioxidants & Redox Signaling. 19:2013-2023
Aims: Neuropathic pain is a chronic debilitating disease that is often unresponsive to currently available treatments. Emerging lines of evidence indicate that reactive oxygen species (ROS) are required for the development and maintenance of neuropat
Autor:
Wiebke Kallenborn-Gerhardt, Hee-Young Lim, Sandra Heine, Ruirui Lu, Jessica Weiland, Domenico Del Turco, Irmgard Tegeder, Achim Schmidtko, Martin Biel, Stylianos Michalakis, Gerd Geisslinger, Thomas Deller
Publikováno v:
The Journal of Neuroscience. 31:11184-11192
A large body of evidence indicates that nitric oxide (NO) and cGMP contribute to central sensitization of pain pathways during inflammatory pain. Here, we investigated the distribution of cyclic nucleotide-gated (CNG) channels in the spinal cord, and
Autor:
Ruirui Lu, Wei Gao, Christian Brenneis, Achim Schmidtko, Ronald Schmidt, Gerd Geisslinger, Carlo Angioni
Publikováno v:
European Journal of Pharmacology. 608:28-31
Prostaglandin D 2 (PGD 2 ) is involved in a variety of physiological and pathophysiological processes, but its role in fever is poorly understood. Here we investigated the effects of central PGD 2 administration on body temperature and prostaglandin
Autor:
Achim Schmidtko, Gerd Geisslinger, Wei Gao, Ellen Niederberger, Charlotte von Gall, Corina Ehnert, Irmgard Tegeder, Laura Popp, Horst-Werner Korf, Ovidiu Coste
Publikováno v:
Biochemical and Biophysical Research Communications. 362:75-80
Peripheral noxious stimulation leads to phosphorylation and thereby activation of the transcription factor CREB in the spinal cord. CREB phosphorylation occurs mainly at serine 133, but the phosphorylation site at serine 142 may also be important. We
Autor:
Achim Schmidtko, Ronald Schmidt, Maria Burian, Kosta Altis, Carlo Angioni, Gerd Geisslinger, Katja Hardt, Maurizio Podda
Publikováno v:
Pain. 127:287-295
Induction of a freeze lesion in human skin is an experimental model of hyperalgesia that allows assessing the antihyperalgesic effects of traditional non-steroidal anti-inflammatory drugs (NSAIDs). We have investigated whether this model is also sens