Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Pan Deng"'
Publikováno v:
Drug Metabolism and Disposition. 47:238-248
Nitrile group biotransformation is an unusual or minor metabolic pathway for most nitrile-containing drugs. However, for some cyanopyrrolidine dipeptidyl peptidase 4 (DPP-4) inhibitors (vildagliptin, anagliptin, and besigliptin, but not saxagliptin),
Publikováno v:
Nanomedicine : nanotechnology, biology, and medicine. 14(6)
This paper reports the multiplexed monitoring of two promising biomarkers, beta-amyloid (Aβ42) and total tau (T-tau), in both buffer and cerebrospinal fluid (CSF) for Alzheimer's disease (AD) using label-free optical nanosensors. It has been found t
Publikováno v:
Drug Metabolism and Disposition. 41:430-444
3-n-Butylphthalide (NBP) is a cardiovascular drug currently used for the treatment of cerebral ischemia. The present study aims to investigate the metabolism, pharmacokinetics, and excretion of NBP in humans and identify the enzymes responsible for t
Publikováno v:
Drug Metabolism and Disposition. 39:1058-1069
Amiodarone is recognized as an effective drug in the treatment of arrhythmias. Previous experiments demonstrated that mono-N-desethylamiodarone (MDEA) was the major circulating metabolite in humans. In addition, dealkylation, hydroxylation, and deami
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 49:848-852
A sensitive and selective liquid chromatography–tandem mass spectrometry method (LC–MS/MS) for the determination of tropisetron in human plasma was developed and validated over the concentration range of 0.100–100 ng/mL. Diphenhydramine was use
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 117
TPN729 has been reported as a novel phosphodiesterase type 5 (PDE5) inhibitor to treat erectile dysfunction, and is currently being tested in clinical trials. In addition to the potent inhibition against PDE5, TPN729 is regarded as a better alternati