Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Bernard, Malissen"'
Autor:
Céline Genton, Adrien Kissenpfennig, Michael Mingueneau, Hans Acha-Orbea, Marie Malissen, Sylvie Richelme, Ying Wang, Pierre Perrin, Stéphane Chevrier, Bruno Lucas, James P. DiSanto, Bernard Malissen
Publikováno v:
Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2008, 180 (3), pp.1565-75. ⟨10.4049/jimmunol.180.3.1565⟩
Journal of Immunology, 2008, 180 (3), pp.1565-75. ⟨10.4049/jimmunol.180.3.1565⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2008, 180 (3), pp.1565-75. 〈10.4049/jimmunol.180.3.1565〉
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2008, 180 (3), pp.1565-75. ⟨10.4049/jimmunol.180.3.1565⟩
Journal of Immunology, 2008, 180 (3), pp.1565-75. ⟨10.4049/jimmunol.180.3.1565⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2008, 180 (3), pp.1565-75. 〈10.4049/jimmunol.180.3.1565〉
Mutant mice where tyrosine 136 of linker for activation of T cells (LAT) was replaced with a phenylalanine (LatY136F mice) develop a fast-onset lymphoproliferative disorder involving polyclonal CD4 T cells that produce massive amounts of Th2 cytokine
Autor:
Dominique Housset, Bernard Malissen
Publikováno v:
Trends in Immunology. 24:429-437
MHC-encoded molecules govern immune responses by presenting antigenic peptides to T-cell receptors (TCRs). Several crystal structures of TCR–pMHC (peptide–MHC) complexes have unveiled the atomic details of this interaction, which is crucial to T-
Autor:
Claudine Darnault, Alice Kearney, Thomas Mosser, Dominique Housset, Jean-Baptiste Reiser, G. Mazza, Juan C. Fontecilla-Camps, Claude Grégoire, P. Anton van der Merwe, Bernard Malissen
Publikováno v:
Nature Immunology. 4:241-247
T cell receptor (TCR) binding degeneracy lies at the heart of several physiological and pathological phenomena, yet its structural basis is poorly understood. We determined the crystal structure of a complex involving the BM3.3 TCR and an octapeptide
Autor:
Jean Baptiste Reiser, Thomas Mosser, Anne-Marie Schmitt-Verhulst, Juan C. Fontecilla-Camps, Dominique Housset, G. Mazza, Annick Guimezanes, Claudine Darnault, Claude Grégoire, Bernard Malissen
Publikováno v:
Immunity. 16:345-354
The elongated complementary-determining region (CDR) 3β found in the unliganded KB5-C20 TCR protrudes from the antigen binding site and prevents its docking onto the peptide/MHC (pMHC) surface according to a canonical diagonal orientation. We now pr
Autor:
Annick Guimezanes, Thomas Mosser, Dominique Housset, Juan C. Fontecilla-Camps, Claude Grégoire, G. Mazza, Bernard Malissen, Claudine Darnault, Anne-Marie Schmitt-Verhulst, Jean-Baptiste Reiser
Publikováno v:
Nature Immunology. 1:291-297
Many T cell receptors (TCRs) that are selected to respond to foreign peptide antigens bound to self major histocompatibility complex (MHC) molecules are also reactive with allelic variants of self-MHC molecules. This property, termed alloreactivity,
Autor:
Claude Grégoire, Christaiane Delarbre, Benedikt M. Kessler, Jean Charles Cerottini, Immanuel F. Luescher, Irina Apostolou, Olivier Michielin, Gabriel Gachelin, Christopher L. Blanchard, Bernard Malissen, Martin Karplus, Florian M. Wurm
Publikováno v:
Journal of Biological Chemistry. 274:3622-3631
To elucidate the structural basis of T cell recognition of hapten-modified antigenic peptides, we studied the interaction of the T1 T cell antigen receptor (TCR) with its ligand, the H-2Kd-bound Plasmodium berghei circumsporozoite peptide 252-260 (SY
Autor:
Pierre Bongrand, Bernard Malissen
Publikováno v:
ResearcherID
T lymphocytes circulate continually throughout the peripheral lymphoid organs, where they scrutinize the surface of cells to detect the presence of nonself protein fragments. During the last years, many facets of T-cell function have been unravelled.
Autor:
Bernard Malissen, Jean-Pierre Abastado, Fabrice Lemaître, Claude Grégoire, Jérôme Delon, Philippe Kourilsky, Sylvie Darche, Alain Trautmann
Publikováno v:
Immunity. 9(4):467-473
Physiologically, TCR signaling is unlikely to result from the cross-linking of TCR-CD3 complexes, given the low density of specific peptide-MHC complexes on antigen-presenting cells. We therefore have tested directly an alternative model for antigen
Autor:
Eric Vivier, Bernard Malissen, Jérôme Delon, Immanuel F. Luescher, Alain Trautmann, Valery Renard
Publikováno v:
Scopus-Elsevier
T cell activation is triggered by the specific recognition of cognate peptides presented by MHC molecules. Altered peptide ligands are analogs of cognate peptides which have a high affinity for MHC molecules. Some of them induce complete T cell respo
Publikováno v:
Proceedings of the National Academy of Sciences. 93:7184-7189
We used stepwise photochemical cross-linking for specifically assembling soluble and covalent complexes made of a T-cell antigen receptor (TCR) and a class I molecule of the major histocompatibility complex (MHC) bound to an antigenic peptide. For th