Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Peter J. Murray"'
Publikováno v:
Cell Metabolism. 33:1726-1743
Wound healing requires cooperation between different cell types, among which macrophages play a central role. In particular, inflammatory macrophages are engaged in the initial response to wounding, and alternatively activated macrophages are essenti
Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis
Autor:
Daniela Schloesser, Laura Lindenthal, Julia Sauer, Kyoung-Jin Chung, Triantafyllos Chavakis, Eva Griesser, Praveen Baskaran, Ulrike Maier-Habelsberger, Katrin Fundel-Clemens, Ines Schlotthauer, Carolin Kirsten Watson, Lee Kim Swee, Frederik Igney, John Edward Park, Markus S. Huber-Lang, Matthew-James Thomas, Karim Christian El Kasmi, Peter J. Murray
Publikováno v:
The Journal of cell biology. 222(2)
Progressive accrual of senescent cells in aging and chronic diseases is associated with detrimental effects in tissue homeostasis. We found that senescent fibroblasts and epithelia were not only refractory to macrophage-mediated engulfment and remova
Autor:
David E. Sanin, Yan Ge, Emilija Marinkovic, Agnieszka M. Kabat, Angela Castoldi, George Caputa, Katarzyna M. Grzes, Jonathan D. Curtis, Elizabeth A. Thompson, Sebastian Willenborg, Stefanie Dichtl, Susanne Reinhardt, Andreas Dahl, Erika L. Pearce, Sabine A. Eming, Alexander Gerbaulet, Axel Roers, Peter J. Murray, Edward J. Pearce
Publikováno v:
Science Immunology
Macrophages populate every organ during homeostasis and disease, displaying features of tissue imprinting and heterogeneous activation. The disconnected picture of macrophage biology that has emerged from these observations is a barrier for integrati
Autor:
Stefanie Dichtl, David E Sanin, Carolin K Koss, Sebastian Willenborg, Andreas Petzold, Maria C Tanzer, Andreas Dahl, Agnieszka M Kabat, Laura Lindenthal, Leonie Zeitler, Sabrina Satzinger, Alexander Strasser, Matthias Mann, Axel Roers, Sabine A Eming, Karim C El Kasmi, Edward J Pearce, Peter J Murray
Publikováno v:
Life science alliance
Life Science Alliance
Life Science Alliance
Pro-inflammatory TNF is a highly gene-selective inhibitor of the gene expression program of tissue repair and wound healing macrophages.
Anti-TNF therapies are a core anti-inflammatory approach for chronic diseases such as rheumatoid arthritis a
Anti-TNF therapies are a core anti-inflammatory approach for chronic diseases such as rheumatoid arthritis a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45144e5db41308cf90fc2f15244db4d
https://hdl.handle.net/21.11116/0000-000D-15D2-E21.11116/0000-000D-15D0-0
https://hdl.handle.net/21.11116/0000-000D-15D2-E21.11116/0000-000D-15D0-0
Autor:
Antonie Lechner, Fiona D.R. Henkel, Franziska Hartung, Sina Bohnacker, Francesca Alessandrini, Ekaterina O. Gubernatorova, Marina S. Drutskaya, Carlo Angioni, Yannick Schreiber, Pascal Haimerl, Yan Ge, Dominique Thomas, Agnieszka M. Kabat, Edward J. Pearce, Caspar Ohnmacht, Sergei A. Nedospasov, Peter J. Murray, Adam M. Chaker, Carsten B. Schmidt-Weber, Julia Esser-von Bieren
Publikováno v:
The journal of allergy and clinical immunology : official publication of the American Academy of Allergy, Asthma and Immunology
J. Allergy Clin. Immunol. 149, 2078-2090 (2022)
J. Allergy Clin. Immunol. 149, 2078-2090 (2022)
Background: Infectious agents can reprogram or "train" macrophages and their progenitors to respond more readily to subsequent insults. However, whether such an inflammatory memory exists in type 2 inflammatory conditions such as allergic asthma was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c374208395edc1cbaa04a3948a2f5dd
https://publica.fraunhofer.de/handle/publica/429629
https://publica.fraunhofer.de/handle/publica/429629
Autor:
Stefanie Dichtl, Birgit Strobl, Karim C. El Kasmi, Laura Lindenthal, Leonie Zeitler, Peter J. Murray, Kristina Behnke, Daniela Schlösser, Jürgen Scheller
Publikováno v:
Science Advances
Inflammation induces macrophage histone lactylation uncoupled from arginine metabolism or M2 polarization.
Lactate is an end point of Warburg-type metabolism found in inflammatory macrophages. Recently, lactate was shown to modify histones of li
Lactate is an end point of Warburg-type metabolism found in inflammatory macrophages. Recently, lactate was shown to modify histones of li
Autor:
Peter J. Murray
Publikováno v:
Journal of Experimental Medicine
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Morphometric characterization of TAMs in human colorectal liver metastases captures individual populations, corresponding to single-cell clusters and associated with distinct clinical outcome and transcriptional profiles. Quantitative analysis of mac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc5ea16b6de3e978bca6b87d2176ef8
https://hdl.handle.net/21.11116/0000-0007-8C70-D21.11116/0000-0007-8C72-B
https://hdl.handle.net/21.11116/0000-0007-8C70-D21.11116/0000-0007-8C72-B
Autor:
Peter J, Murray
Publikováno v:
Nature reviews. Immunology. 20(2)
Autor:
Peter J. Murray
Publikováno v:
Seminars in Immunology. 35:12-18
Monocytes emerging from the bone marrow are the progenitors of monocyte-derived macrophages. An essential function of monocytes is to seed tissues with sufficient macrophages to replace loss from infection and tissue damage. Recent work from diverse
Autor:
Peter J, Murray
Publikováno v:
Annual Review of Physiology. 79:541-566
Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues,