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pro vyhledávání: '"Timothy J. Mitchison"'
Autor:
Timothy J. Mitchison
Publikováno v:
Molecular Biology of the Cell
Macromolecule condensates, phase separation, and membraneless compartments have become an important area of cell biology research where new biophysical concepts are emerging. This article discusses the possibility that condensates assemble on multiva
Autor:
James F. Pelletier, Matthew Sonnett, Christine M. Field, Timothy J. Mitchison, Sebastian Fürthauer
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
How bulk cytoplasm generates forces to separate post-anaphase microtubule (MT) asters inXenopus laevisand other large eggs remains unclear. Previous models proposed that dynein-based, inward organelle transport generates length-dependent pulling forc
Autor:
Christine M. Field, Matthew Sonnett, Timothy J. Mitchison, Sebastian Fürthauer, James F. Pelletier
How bulk cytoplasm generates forces to separate post-anaphase microtubule (MT) asters in Xenopus laevis and other large eggs remains unclear. Previous models proposed dynein-based organelle transport generates length-dependent forces on astral MTs th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be47728915fb58532dd6ad82f00e88f0
https://doi.org/10.1101/2020.06.17.154260
https://doi.org/10.1101/2020.06.17.154260
Autor:
J Christine Yuan, Joann Kalabathula, Timothy J. Mitchison, Brian J. Groendyke, Ivana Gasic, Nathanael S. Gray, Radosław P. Nowak, Eric S. Fischer
Publikováno v:
Cells, Vol 9, Iss 1083, p 1083 (2020)
Cells
Volume 9
Issue 5
Cells
Volume 9
Issue 5
Dysregulation of microtubules and tubulin homeostasis has been linked to developmental disorders, neurodegenerative diseases, and cancer. In general, both microtubule-stabilizing and destabilizing agents have been powerful tools for studies of microt
Autor:
Ivana Gasic, Viswanathan Chandrasekaran, Sichen Shao, Ramanujan S. Hegde, Zhewang Lin, Timothy J. Mitchison, Niklas Peters
Publikováno v:
Science
Cell Res
Cell Res
Mechanism of tubulin autoregulation Cells tightly control the abundance of key housekeeping factors, such as ribosomes and chaperones, to maintain them at optimal levels needed for homeostasis. Most abundance control mechanisms involve feedback regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a695974e6ab42103d76764e72e7fde43
https://europepmc.org/articles/PMC6942541/
https://europepmc.org/articles/PMC6942541/
Publikováno v:
Molecular Biology of the Cell
Upon AURKB activation, the AURKB kinase–containing chromosomal passenger complex (CPC) decreases in mass and size, based on density sedimentation and fluorescence correlation spectroscopy in two model organisms. This is attributed to the previously
Autor:
Sangyoon J. Han, Liya Ding, Timothy J. Mitchison, Edgar Gutierrez, Gaudenz Danuser, Alex Groisman, Christoph J. Burckhardt, Nancy Costigliola, Andressa Mota
Publikováno v:
Proceedings of the National Academy of Sciences. 114:5195-5200
The intermediate filament vimentin is required for cells to transition from the epithelial state to the mesenchymal state and migrate as single cells; however, little is known about the specific role of vimentin in the regulation of mesenchymal migra
Publikováno v:
Curr Biol
Summary The large length scale of Xenopus laevis eggs facilitates observation of bulk cytoplasm dynamics far from the cortex during cytokinesis. The first furrow ingresses through the egg midplane, which is demarcated by chromosomal passenger complex
Autor:
Timothy J. Mitchison
Publikováno v:
Molecular Biology of the Cell
Crowding of the subcellular environment by macromolecules is thought to promote protein aggregation and phase separation. A challenge is how to parameterize the degree of crowding of the cell interior or artificial solutions that is relevant to these
We investigated how bulk cytoplasm prepares for cytokinesis inXenopus laeviseggs, which are large, rapidly dividing cells. The egg midplane is demarcated by Chromosomal Passenger Complex (CPC) localized on microtubule bundles between asters. Using an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b975aa35fd9078ecd6203f3b18a94cb8