Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dashyant Dhanak"'
Autor:
Ryan G. Kruger, Yuchen Bai, Yong Jiang, Caretha L. Creasy, Heidi M. Ott, Melissa B. Pappalardi, Edward Dul, Dashyant Dhanak, Michael T. McCabe, Benjamin Schwartz, Roland S. Annan, Peter J. Tummino, Wendy S. Halsey, Arthur Groy, Alan P. Graves, Steven D. Knight, Ashley M. Hughes, Michael J. Huddleston, Sharad K. Verma
Publikováno v:
Molecular Cancer Therapeutics. 13:3062-3073
The EZH2 methyltransferase silences gene expression through methylation of histone H3 on lysine 27 (H3K27). Recently, EZH2 mutations have been reported at Y641, A677, and A687 in non-Hodgkin lymphoma. Although the Y641F/N/S/H/C and A677G mutations ex
Autor:
Martin Brandt, Caretha L. Creasy, Elsie Diaz, Benjamin Schwartz, Peter J. Tummino, Melissa B. Pappalardi, William H. Miller, Glenn S. Van Aller, Ryan G. Kruger, Sharad K. Verma, Heidi M. Ott, Dashyant Dhanak, Michael T. McCabe
Publikováno v:
ACS Chemical Biology. 9:622-629
EZH2/PRC2 catalyzes transcriptionally repressive methylation at lysine 27 of histone H3 and has been associated with numerous cancer types. Point mutations in EZH2 at Tyr641 and Ala677 identified in non-Hodgkin lymphomas alter substrate specificity a
Autor:
Christine Thompson, Daryl A. Scherzer, Ryan G. Kruger, Steven D. Knight, Louis V. LaFrance, Heidi M. Ott, Dashyant Dhanak, Stuart Paul Romeril, Celine Duquenne, Dominic Suarez, William H. Miller, Art Shu, Seth W. Grant, Carl A. Machutta, Joelle Lorraine Burgess, Brackley James, Caretha L. Creasy, Xinrong Tian, Yong Jiang, Sharad K. Verma, Peter J. Tummino, Alan P. Graves, Glenn S. Van Aller, Elsie Diaz, Kenneth A. Newlander, Johnson Neil W, Michael T. McCabe
Publikováno v:
ACS Medicinal Chemistry Letters. 3:1091-1096
The histone H3-lysine 27 (H3K27) methyltransferase EZH2 plays a critical role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. As part of a drug discovery program targeting EZH2, we have ident
Autor:
Ryan G. Kruger, William H. Miller, Louis V. LaFrance, Celine Duquenne, Alan P. Graves, Heidi M. Ott, Dashyant Dhanak, Christine Thompson, Xinrong Tian, Martin Brandt, Michael T. McCabe, Charles F. McHugh, Mellinger Mark, Susan Korenchuk, Anthony Della Pietra, Peter J. Tummino, Yan Liu, Caretha L. Creasy, Sharad K. Verma, Elsie Diaz, Gopinath Ganji, Glenn S. Van Aller
Publikováno v:
Nature. 492:108-112
EZH2, the catalytic subunit of the polycomb repressive complex 2 (PRC2), is involved in repressing gene expression through methylation of histone H3 on lysine 27 (H3K27). Overexpression of EZH2 is implicated in tumorigenesis, and mutations within its
Enhancer of Zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) responsible for the methylation of lysine 27 of histone 3 (H3K27) resulting in chromatin compaction and gene repression. Overexpression of EZH2 to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::071e22abdab964603a270023a2884297
https://doi.org/10.1016/b978-0-12-800206-3.00019-7
https://doi.org/10.1016/b978-0-12-800206-3.00019-7
Autor:
Gustave Bergnes, Pearl S. Huang, Jeffrey R. Jackson, Joel Greshock, Stephen Schauer, Yan Lee, David Sutton, Latesh Lad, Roland S. Annan, William K. Cornwell, Serge Lichtsteiner, Lisa D. Belmont, Chiu-Mei Sun, Roman Sakowicz, Michele Giardiniere, Neysa Nevins, Robert A. Copeland, Richard Wooster, David J. Morgans, Shu-Yun Zhang, Xiangping Qian, Jeffrey T. Finer, Steven D. Knight, Radhika Desai, Justin D. Vidal, Lusong Luo, Katjuša Brejc, Aidan G. Gilmartin, Dashyant Dhanak, Penelope Chua, Melody Diamond, Dean E. McNulty, Leo F. Faucette, Carmen García, Kenneth Wood
Centromere-associated protein-E (CENP-E) is a kinetochore-associated mitotic kinesin that is thought to function as the key receptor responsible for mitotic checkpoint signal transduction after interaction with spindle microtubules. We have identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2536ef86db2edbbcd78abd3682f5fa5
https://europepmc.org/articles/PMC2851928/
https://europepmc.org/articles/PMC2851928/
Autor:
Dashyant Dhanak
Publikováno v:
Cancer Research. 72:SY02-02
Enhance of Zeste Homolog 2 (EZH2) is the biochemical activity of the Polycomb Repressive Complex 2 (PRC2) that transfers a methyl group from the cofactor S-adenosyl methionine (SAM) to histone H3 on lysine 27 (H3K27), resulting in epigenetic silencin
Publikováno v:
Chemical Communications. :671
A novel surfactant based on 6-aminopenicillanic acid is synthesised in good yield, and its physico-chemical properties, such as the critical micellar concentration and the mean aggregation number are determined using fluorescence and capillary electr