Zobrazeno 1 - 10
of 69
pro vyhledávání: 'Lüllmann-Rauch, Renate'
Autor:
Bernd Knöll, Renate Lüllmann-Rauch, Paul Saftig, Christian Haass, Yasuo Uchiyama, Wolfgang Wurst, Renate Wanner, Anja Capell, Rudi D'Hooge, Georg Werner, Stijn Stroobants, Patrick Lüningschrör, Benedikt Wefers, Daniela Sinske, Soichiro Kakuta, Michael Sendtner, Benjamin Dombert, Markus Damme
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3506-3519.e6 (2020)
Cell reports 30(10), 3506-3519.e6 (2020). doi:10.1016/j.celrep.2020.02.060
Cell reports 30(10), 3506-3519.e6 (2020). doi:10.1016/j.celrep.2020.02.060
Summary: Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and C9orf72-expansion carriers and might play a role in aging. To determine the physiol
Autor:
Dante Neculai, Saskia Heybrock, Sergio Grinstein, Régis Pomès, Renate Lüllmann-Rauch, Ying Meng, Christopher Ing, Kristiina Kanerva, Paul Saftig, Michael Schwake, Joerg Heeren, Wim Annaert, William S. Trimble, Anna Liang, Xialian Weng, Elina Ikonen, Gilbert G. Privé, Richard F. Collins, Young Ah Kim, Zi-Jian Xiong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
The intracellular transport of cholesterol is subject to tight regulation. The structure of the lysosomal integral membrane protein type 2 (LIMP-2, also known as SCARB2) reveals a large cavity that traverses the molecule and resembles the cavity in S
Autor:
Julia Bär, Renate Lüllmann-Rauch, Mahmoud Bassal, André R. A. Marques, Lina Schmidt, Markus Damme, Markus Glatzel, Marina Mikhaylova, Niklas Thießen, Steffen E. Storck, Alessandro Di Spiezio, Udo Bartsch, Jens Fogh, Joachim Grötzinger, Paul Saftig, Claus U. Pietrzik
Publikováno v:
Autophagy
CTSD (cathepsin D) is one of the major lysosomal proteases indispensable for the maintenance of cellular proteostasis by turning over substrates of endocytosis, phagocytosis and autophagy. Consequently, CTSD deficiency leads to a strong impairment of
Autor:
Paul Saftig, Sönke Rudnik, Irm Hermans-Borgmeyer, Markus Glatzel, Thuy Linh Nguyen, Christian Bernreuther, Janna Schneppenheim, Bernd Schröder, Renate Lüllmann-Rauch
Publikováno v:
Oncotarget
// Thuy Linh Nguyen 1 , Janna Schneppenheim 2 , Sonke Rudnik 1 , Renate Lullmann-Rauch 2 , Christian Bernreuther 3 , Irm Hermans-Borgmeyer 4 , Markus Glatzel 3 , Paul Saftig 1 and Bernd Schroder 1 1 Biochemical Institute, Christian Albrechts Universi
Autor:
Wolf, Heike, Damme, Markus, Stroobants, Stijn, D'Hooge, Rudi, Beck, Hans Christian, Hermans-Borgmeyer, Irm, Lüllmann-Rauch, Renate, Dierks, Thomas, Lübke, Torben
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 9, Pp 1015-1028 (2016)
Wolf, H, Damme, M, Stroobants, S, D'Hooge, R, Beck, H C, Hermans-Borgmeyer, I, Lüllmann-Rauch, R, Dierks, T & Lübke, T 2016, ' A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease ', Disease Models & Mechanisms, vol. 9, no. 9, pp. 1015-1028 . https://doi.org/10.1242/dmm.025122
Disease Models & Mechanisms
Wolf, H, Damme, M, Stroobants, S, D'Hooge, R, Beck, H C, Hermans-Borgmeyer, I, Lüllmann-Rauch, R, Dierks, T & Lübke, T 2016, ' A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease ', Disease Models & Mechanisms, vol. 9, no. 9, pp. 1015-1028 . https://doi.org/10.1242/dmm.025122
Disease Models & Mechanisms
Fucosidosis is a rare lysosomal storage disorder caused by the inherited deficiency of the lysosomal hydrolase α-L-fucosidase, which leads to an impaired degradation of fucosylated glycoconjugates. Here, we report the generation of a fucosidosis mou
Autor:
Sandra Kissing, Renate Lüllmann-Rauch, Albert Haas, Uwe Kornak, Eeva-Liisa Eskelinen, Paul Saftig, Sabrina Jabs, Jef K. De Brabander, Atsuhiro Ichihara, Sönke Rudnik, Jörg Heeren, Markus Damme
Publikováno v:
Autophagy, 13(4):670-685
The vacuolar-type H+-translocating ATPase (v-H+-ATPase) has been implicated in the amino acid-dependent activation of the mechanistic target of rapamycin complex 1 (MTORC1), an important regulator of macroautophagy. To reveal the mechanistic links be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2812e53387bd2777d9f343a01c0fab
Autor:
Stijn Stroobants, Paul Saftig, Renate Lüllmann-Rauch, Claes Andersson, Rudi D'Hooge, Meike Lüdemann, Jens Fogh, Willy Morelle, Judith Blanz, Helena Reuterwall, Jean Claude Michalski
Publikováno v:
Human Molecular Genetics. 17:3437-3445
Despite the progress in the treatment of lysosomal storage disorders (LSDs) mainly by enzyme replacement therapy, only limited success was reported in targeting the appropriate lysosomal enzyme into the brain. This prevents efficient clearance of neu
Autor:
Paul Saftig, Michael Schwake, Paulo Gaspar, Friederike Zunke, Johannes M. F. G. Aerts, Renate Lüllmann-Rauch, Dimitri Krainc, Hermann C. Altmeppen, Wouter W. Kallemeijn, Michelle Rothaug, Joseph R. Mazzulli, Michaela Schweizer, Markus Glatzel, Judith Blanz
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 111(43), 15573-15578. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 111(43), 15573-15578
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 111(43), 15573-15578
Mutations within the lysosomal enzyme beta-glucocerebrosidase (GC) result in Gaucher disease and represent a major risk factor for developing Parkinson disease (PD). Loss of GC activity leads to accumulation of its substrate glucosylceramide and alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5541590d14efb928ef9b943c39053fdb
https://hdl.handle.net/1887/51801
https://hdl.handle.net/1887/51801
Autor:
Sandra Kissing, Bernd Schröder, Paul Saftig, Christian Grimm, Franz Bracher, Renate Lüllmann-Rauch, Oliver Griesbeck, Christian Wahl-Schott, Martin Biel, Markus Moser, Saskia Spahn, Simone Jörs, Bernd H. Northoff, Daniel Teupser, Jan Castonguay, Christian A. Luber, Christoph Müller, Cheng-Chang Chen, Hartmut Cuny, Lesca M. Holdt, Matthias Mann, Sami Hassan, Albert Haas, Christina Fendel, Norbert Klugbauer, Elisabeth Butz
Publikováno v:
Nature Communications. 5
Endolysosomal organelles play a key role in trafficking, breakdown and receptor-mediated recycling of different macromolecules such as low-density lipoprotein (LDL)-cholesterol, epithelial growth factor (EGF) or transferrin. Here we examine the role
Publikováno v:
Graefe's Archive for Clinical and Experimental Ophthalmology. 239:788-793
A series of dicationic amphiphilic drugs, most of them immunomodulatory agents, are known to induce generalised lysosomal storage of sulphated glycosaminoglycans (GAGs) in rats and in cultured cells of several species including man. The present study