Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Yiwei Chu"'
Publikováno v:
Journal of Leukocyte Biology. 110:271-281
Recent accumulating evidence supports the hypothesis that the intricate interaction between gut microbiota and the immune system profoundly affects health and disease in humans and mice. In this context, microbiota plays an important role in educatin
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Chimeric antigen receptors (CARs) or bispecific antibodies (bsAbs) redirected T cell against tumors is one of the most promising immunotherapy approaches. However, insufficient clinical outcomes are still observed in treatments of both solid and non-
Publikováno v:
Biomacromolecules. 19:2098-2108
Immune checkpoint blockade by anti-PD-L1 monoclonal antibody (αPD-L1) has achieved unprecedented clinical benefits in certain cancers, whereas the therapeutic efficacy is often hindered by immunosuppressive tumor microenvironment mediated by tumor-a
Publikováno v:
Free radical biologymedicine. 142
Reactive oxygen species (ROS) are indispensable for determining the fate of immune cells in both physiological and pathogenic environments, thus stimulating the interest of immunologists and clinicians. B cells are essential in maintaining immune hom
Autor:
Yiwei Chu, Jiawen Qian, Yanqing Wang, Jun Liu, Lumin Zhang, Hiromi Kubagawa, Ji-Yang Wang, Takeshi Tsubata, Ermeng Xiong, Hanying Zhu
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, Vol 9 (2018)
The marginal zone B cells (MZB) are located at the interface between the circulation and lymphoid tissue and as a gatekeeper play important roles in both innate and adaptive immune responses. We have previously found that MZB are significantly reduce
Autor:
Xunbin Wei, Yuanzhen Suo, Yiwei Chu, Ji-Yang Wang, Zhichao Fan, Yuting Deng, Wei Lin, Min Zhang
Publikováno v:
Immunology & Cell Biology. 93:99-110
The immunological synapse (IS) is a supermolecular activation cluster formed between T cells and antigen-presenting cells. Although diverse IS structures have been reported, the function of the IS in T-cell activation remains unclear. Here, we found
Autor:
Jinping Zhang, Yiwei Chu, Ying Wang, Sidong Xiong, Xian'An Shao, Yanping Gong, Wei Xu, Ruihua Zhang
Publikováno v:
DNA and Cell Biology. 26:19-27
Although fetal thymus organ culture (FTOC) has become widely used to investigate T-cell development, the differences between thymocyte development in vivo and in vitro (in FTOC) remain largely unknown. In this study, the viability and numbers of thym
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 194(7)
The IgM FcR (FcμR) promotes B cell survival, but the molecular mechanism remains largely unknown. We show using FcμR−/− and wild-type mice that FcμR specifically enhanced B cell survival induced by BCR cross-linking with F(ab′)2-anti-IgM Abs
Autor:
Yiwei Chu, Tingting Qian, Yuting Deng, Luman Wang, Yijie Zheng, Ronghua Liu, Enyu Huang, Ji-Yang Wang, Xuechao Jiang, Fengkai Xu, Xiaoming Liu
Publikováno v:
Hepatology (Baltimore, Md.). 62(5)
Increasing evidence in recent years has suggested that B cells act as a crucial regulator in autoimmune diseases. However, little is known about their role in autoimmune hepatitis (AIH) and the underlying regulatory mechanisms. In this study, we show
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 10, p e109095 (2014)
PLoS ONE, Vol 9, Iss 10, p e109095 (2014)
Systemic lupus erythematosus (SLE) is characterized by prominent autoinflammatory tissue damage associated with impaired removal of dying cells and DNA. Self DNA-containing immune complexes are able to activate both innate and adaptive immune respons