Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Henry J. Schiller"'
Autor:
Jeffrey M. Halter, Henry J. Schiller, Louis A. Gatto, Jay Steinberg, Gary F. Nieman, Lucio A. Pavone, Hsi-Ming Lee
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 169:57-63
Intratracheal instillation of Tween causes a heterogeneous surfactant deactivation in the lung, with areas of unstable alveoli directly adjacent to normal stable alveoli. We employed in vivo video microscopy to directly assess alveolar stability in n
Autor:
Ulysse G. McCann, David E. Carney, Henry J. Schiller, Jay Steinberg, Gary F. Nieman, Louis A. Gatto
Publikováno v:
Critical Care Medicine. 30:1315-1321
OBJECTIVES Hypoxic pulmonary vasoconstriction is the primary physiologic mechanism that maintains a proper ventilation/perfusion match, but it fails in diffuse lung injuries such as acute respiratory distress syndrome. Acute respiratory distress synd
Autor:
David E. Carney, Jay Steinberg, Henry J. Schiller, Ulysse G. McCann, Gary F. Nieman, Louis A. Gatto
Publikováno v:
Critical Care Medicine. 29:1049-1055
OBJECTIVES: Alterations in alveolar mechanics (i.e., the dynamic change in alveolar size during tidal ventilation) are thought to play a critical role in acute lung injuries such as acute respiratory distress syndrome (ARDS). In this study, we descri
Autor:
Jeffrey M. Halter, Lorne M. Golub, Jay Steinberg, Henry J. Schiller, David E. Carney, Hsi-Ming Lee, Louis A. Gatto, Gary F. Nieman
Publikováno v:
Shock (Augusta, Ga.). 24(4)
Sepsis causes more than with 215,000 deaths per year in the United States alone. Death can be caused by multiple system organ failure, with the lung, in the form of the acute respiratory distress syndrome (ARDS), often being the first organ to fail.
Publikováno v:
Shock (Augusta, Ga.). 23(2)
Numerous clinical trials using anti-inflammatory agents for patients with acute respiratory distress syndrome (ARDS) have failed despite efficacy in acute animal models. This underscores the necessity of developing a clinically relevant model of ARDS
Autor:
Louis A. Gatto, Gary F. Nieman, Henry J. Schiller, Jeffrey M. Halter, Dave Carney, Monica Dasilva, Ulysse G. McCann, Jay Steinberg
Publikováno v:
Critical care medicine. 31(4)
Lower and upper inflection points on the quasi-static curve representing a composite of pressure/volume from the whole lung are hypothesized to represent initial alveolar recruitment and overdistension, respectively, and are currently utilized to adj
Autor:
Jeffrey M. Halter, Monica Dasilva, Henry J. Schiller, Gary F. Nieman, Louis A. Gatto, Steve K. Landas, Jay Steinberg
Publikováno v:
American journal of respiratory and critical care medicine. 167(12)
We tested the hypothesis that collapsed alveoli opened by a recruit- induced improvement in oxygenation is recruitment and ment maneuver would be unstable or recollapse without adequate stabilization of collapsed lung regions (8, 9), this has never p
Autor:
Louis A. Gatto, Henry J. Schiller, Monica Dasilva, Jay Steinberg, Ulysse G. McCann, Marcelo B. P. Amato, Gary F. Nieman, Jeffrey M. Halter
Publikováno v:
Critical care medicine. 30(12)
OBJECTIVE We utilized microscopy to measure the impact of increasing tidal volume on individual alveolar mechanics (i.e., the dynamic change in alveolar size during tidal ventilation) in the living porcine lung. DESIGN In three anesthetized, mechanic
Autor:
Andrew M. Paskanik, Henry J. Schiller, Lorne M. Golub, Anthony L. Picone, Kathy Snyder, N.S. Ramamurthy, David E. Carney, Charles J. Lutz, Christine Finck, Gary F. Nieman, Louis A. Gatto, Bruce Searles, Sanford R. Simon
Publikováno v:
Circulation. 100(4)
Background —Acute lung injury (ALI) after cardiopulmonary bypass (CPB) results from sequential priming and activation of neutrophils. Activated neutrophils release neutral serine, elastase, and matrix metalloproteinases (MMPs) and oxygen radical sp
Autor:
Scott P. Albert, David E. Carney, Hsi-Ming Lee, Louis A. Gatto, Jeffrey M. Halter, Gary F. Nieman, Joseph DiRocco, Henry J. Schiller, Jay Steinberg, Lucio A. Pavone
Publikováno v:
Critical Care
Introduction One potential mechanism of ventilator-induced lung injury (VILI) is due to shear stresses associated with alveolar instability (recruitment/derecruitment). It has been postulated that the optimal combination of tidal volume (Vt) and posi