Zobrazeno 81 - 90
of 6 449
pro vyhledávání: '"11"'
Publikováno v:
The American journal of surgical pathology. 12(12)
Pathological and clinical features in early localized mucinous and nonmucinous bronchiolo-alveolar carcinomas (BAC) have not been adequately compared. In an attempt to characterize such lesions, we studied the clinicopathological, ultrastructural, an
Publikováno v:
Virchows Archiv. B, Cell pathology. 3(4)
Studies of changes in the ground substance of sarcoid lesions were made with the electron microscope in tissues from eleven patients with sarcoidosis of the following sites: lymph nodes, skin, and lungs. Comparison was made on the one hand between ul
Autor:
Kian Fan Chung, Chantal Donovan, Martha R. Tyas, Graeme Milligan, Philip M. Hansbro, Elisa Alvarez-Curto, Latifa Chachi, Davinder Kaur, Coen Wiegman, Zhaoyang Dong, Abdulrahman Ghali M. Alharbi, Andrew B. Tobin, Trond Ulven, Christopher E. Brightling, Eloise Euston, Richard Kim, Rudi Prihandoko, Jack G. Lowe
Publikováno v:
Prihandoko, R, Kaur, D, Wiegman, C H, Alvarez-Curto, E, Donovan, C, Chachi, L, Ulven, T, Tyas, M R, Euston, E, Dong, Z, Alharbi, A G M, Kim, R Y, Lowe, J G, Hansbro, P M, Chung, K F, Brightling, C E, Milligan, G & Tobin, A B 2020, ' Pathophysiological regulation of lung function by the free fatty acid receptor FFA4 ', Science Translational Medicine, vol. 12, no. 557, 9009 . https://doi.org/10.1126/scitranslmed.aaw9009
Increased prevalence of inflammatory airway diseases including asthma and chronic obstructive pulmonary disease (COPD) together with a significant number of patients being inadequately controlled by current frontline treatments means that there is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ec3c16cfc0be37561e10eb3daf21bc
https://eprints.gla.ac.uk/225258/1/225258.pdf
https://eprints.gla.ac.uk/225258/1/225258.pdf
Autor:
Sabine Bartel, Philip M. Hansbro, Ian M. Adcock, Hermelijn H. Smits, Frank R. M. Stassen, Pieter S. Hiemstra, Robert P. Dickson, Ken R. Bracke, Reinoud Gosens, Susanne Krauss-Etschmann
Publikováno v:
European Respiratory Journal, 56(2):1902320. EUROPEAN RESPIRATORY SOC JOURNALS LTD
The European Respiratory Journal
article-version (VoR) Version of Record
European Respiratory Journal, 56(2). EUROPEAN RESPIRATORY SOC JOURNALS LTD
EUROPEAN RESPIRATORY JOURNAL
European Respiratory Journal, 56(2):1902320. European Respiratory Society
The European Respiratory Journal
article-version (VoR) Version of Record
European Respiratory Journal, 56(2). EUROPEAN RESPIRATORY SOC JOURNALS LTD
EUROPEAN RESPIRATORY JOURNAL
European Respiratory Journal, 56(2):1902320. European Respiratory Society
Chronic respiratory diseases are highly prevalent worldwide and will continue to rise in the foreseeable future. Despite intensive efforts over recent decades, the development of novel and effective therapeutic approaches has been slow. However, ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1f86b3a309283ac41882f065557a5a
https://hdl.handle.net/1887/3184024
https://hdl.handle.net/1887/3184024
Autor:
Sabrina Bajwah, Athol U. Wells, Polly Edmonds, Steffen T. Simon, Irene J Higginson, Richard P Towers, Michael Kreuter, David C. Currow, Surinder S. Birring, Miriam J. Johnson, Andrew Wilcock, Wendy Prentice, Elisabeth Bendstrup, Claudia Bausewein, Massimo Costantini
Publikováno v:
Bajwah, S, Wilcock, A, Towers, R, Costantini, M, Bausewein, C, Simon, S T, Bendstrup, E, Prentice, W, Johnson, M J, Currow, D C, Kreuter, M, Wells, A U, Birring, S S, Edmonds, P & Higginson, I J 2020, ' Managing the supportive care needs of those affected by COVID-19 ', The European Respiratory Journal, vol. 55, no. 4, 2000815 . https://doi.org/10.1183/13993003.00815-2020
Globally, the number of people affected by coronavirus disease 2019 (COVID-19) is rapidly increasing. In most (>80%), the illness is relatively mild and can be self-managed out of hospital. However, in about 20% the illness causes respiratory comprom
Autor:
Andrew S. Cowburn, Shanhai Xie, David Macías, Alexander J.T. Wood, Stephen Moore, Alexi Crosby, Xinlin Du, Wallace Eli M, Arlette Vassallo, Mark Southwood, Huiling Tan
Publikováno v:
The European Respiratory Journal
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Pulmonary arterial hypertension (PAH) is a destructive disease of the pulmonary vasculature often leading to right heart failure and death. Current therapeutic intervention strategies only slow disease progression. The role of aberrant hypoxia-induci
Autor:
Phuwanat Sakornsakolpat, James F. Wilson, María Soler Artigas, Beate Stubbe, Nicholas J. Wareham, James D. Crapo, Victoria E. Jackson, Eleftheria Zeggini, Olga G. Troyanskaya, Medea Imboden, A. Mesut Erzurumluoglu, Adam S. Butterworth, Carl A. Melbourne, Ian Sayers, Lars Lind, Stefan Weiss, Margaret M. Parker, Timmers Prhj, Edwin K. Silverman, John C. Whittaker, Ian P. Hall, Ozren Polasek, Mika Kähönen, Katherine A. Fawcett, Anna Hansell, Liming Li, David J. Porteous, Louise V. Wain, Robert A. Scott, Richard Packer, Richard J. Allen, Robin G Walters, Anna L. Guyatt, Terho Lehtimäki, Nicole Probst-Hensch, Shona M. Kerr, Christian Gieger, Matthias Wielscher, Rajesh Rawal, Jing Hua Zhao, John E. Hokanson, Holger Schulz, Nicola F. Reeve, Claudia Langenberg, Ke Hao, Corry-Anke Brandsma, Megan L. Paynton, Vitart, Dmitry Prokopenko, Jennie Hui, Eugene R. Bleecker, Ma'en Obeidat, John Danesh, Ralf Ewert, Benjamin B. Sun, Frank Dudbridge, Jian Zhou, Brian D. Hobbs, Blair H. Smith, Don D. Sin, Dawn L. DeMeo, Joseph C. Maranville, Ida Surakka, Alison Catherine Murray, Nicholas Locantore, Katherine A. Kentistou, Terri H. Beaty, Igor Rudan, Kuang Lin, Amund Gulsvik, Ian J. Deary, Ruth Tal-Singer, Kijoung Song, David C. Nickle, Michael H. Cho, Jian'an Luan, Joshua D. Hoffman, Georg Homuth, Zhengming Chen, Dandi Qiao, Heiko Runz, Per Bakke, Chiara Batini, Caroline Hayward, Stefan Karrasch, Alan James, Andrew P. Morris, Prescott G. Woodruff, Laura M Yerges Armstrong, David Sparrow, Ulf Gyllensten, James P. Cook, Jonathan Marten, Olli T. Raitakari, Nick Shrine, Deborah A. Meyers, Tobin, Ruth Boxall, Marjo-Riitta Järvelin, David P. Strachan, Sarah E. Harris, Philippe Joubert, Stefan Enroth, Xingnan Li, van den Berge M, Anubha Mahajan, Yohan Bossé, Peter K. Joshi
Publikováno v:
Nature genetics
Nat. Genet. 51, 481-493 (2019)
Shrine, N R G, Guyatt, A, Erzurumluoglu, A M, Jackson, V E, Hobbs, B D, Melbourne, C, Batini, C, Fawcett, K A, Song, K, Sakornsakolpat, P, Li, X, Boxall, R, Reeve, N F, Obeidat, M, Zhao, J H, Wielscher, M, Weiss, S, Kentistou, K, Cook, J P, Sun, B B, Zhou, J, Hui, J, Karrasch, S, Imboden, M, Harris, S, Marten, J, Enroth, S, Kerr, S, Surakka, I, Vitart, V, Lehtimäki, T, Allen, R J, Bakke, P S, Beaty, T H, Bleecker, E R, Bossé, Y, Brandsma, C-A, Chen, Z, Crapo, J D, Danesh, J, Demeo, D L, Dudbridge, F, Ewert, R, Gieger, C, Gulsvik, A, Hansell, A L, Hao, K, Hoffman, J D, Hokanson, J E, Homuth, G, Joshi, P, Joubert, P, Langenberg, C, Li, X, Li, L, Lin, K, Lind, L, Locantore, N, Luan, J, Mahajan, A, Maranville, J C, Murray, A, Nickle, D C, Packer, R, Parker, M M, Paynton, M L, Porteous, D, Prokopenko, D, Qiao, D, Rawal, R, Runz, H, Sayers, I, Sin, D D, Smith, B H, Soler Artigas, M, Sparrow, D, Tal-Singer, R, Timmers, P RHJ, van den Berge, M, Woodruff, P G, Yerges-Armstrong, L M, Troyanskaya, O G, Raitakar, O, Kähönen, M, Polasek, O, Rudan, I, Deary, I, Probst-Hensch, N M, Schulz, H, James, A L, Wilson, J F, Stubbe, B, Zeggini, E, Jarvelin, M-R, Wareham, N, Silverman, E K, Hayward, C, Morris, A P, Butterworth, A S, Scott, R A, Walters, R G, Meyers, D A, Cho, M H, Strachan, D P, Hall, I P & Tobin, M D & Wain, L V 2019, ' New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries ', Nature Genetics, vol. 51, pp. 481–493 . https://doi.org/10.1038/s41588-018-0321-7
NATURE GENETICS
Understanding Society Scientific Group 2019, ' New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries ', Nature Genetics, vol. 51, no. 3, pp. 481-493 . https://doi.org/10.1038/s41588-018-0321-7
Nature Genetics, 51(3), 481-493. Nature Publishing Group
Nat. Genet. 51, 481-493 (2019)
Shrine, N R G, Guyatt, A, Erzurumluoglu, A M, Jackson, V E, Hobbs, B D, Melbourne, C, Batini, C, Fawcett, K A, Song, K, Sakornsakolpat, P, Li, X, Boxall, R, Reeve, N F, Obeidat, M, Zhao, J H, Wielscher, M, Weiss, S, Kentistou, K, Cook, J P, Sun, B B, Zhou, J, Hui, J, Karrasch, S, Imboden, M, Harris, S, Marten, J, Enroth, S, Kerr, S, Surakka, I, Vitart, V, Lehtimäki, T, Allen, R J, Bakke, P S, Beaty, T H, Bleecker, E R, Bossé, Y, Brandsma, C-A, Chen, Z, Crapo, J D, Danesh, J, Demeo, D L, Dudbridge, F, Ewert, R, Gieger, C, Gulsvik, A, Hansell, A L, Hao, K, Hoffman, J D, Hokanson, J E, Homuth, G, Joshi, P, Joubert, P, Langenberg, C, Li, X, Li, L, Lin, K, Lind, L, Locantore, N, Luan, J, Mahajan, A, Maranville, J C, Murray, A, Nickle, D C, Packer, R, Parker, M M, Paynton, M L, Porteous, D, Prokopenko, D, Qiao, D, Rawal, R, Runz, H, Sayers, I, Sin, D D, Smith, B H, Soler Artigas, M, Sparrow, D, Tal-Singer, R, Timmers, P RHJ, van den Berge, M, Woodruff, P G, Yerges-Armstrong, L M, Troyanskaya, O G, Raitakar, O, Kähönen, M, Polasek, O, Rudan, I, Deary, I, Probst-Hensch, N M, Schulz, H, James, A L, Wilson, J F, Stubbe, B, Zeggini, E, Jarvelin, M-R, Wareham, N, Silverman, E K, Hayward, C, Morris, A P, Butterworth, A S, Scott, R A, Walters, R G, Meyers, D A, Cho, M H, Strachan, D P, Hall, I P & Tobin, M D & Wain, L V 2019, ' New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries ', Nature Genetics, vol. 51, pp. 481–493 . https://doi.org/10.1038/s41588-018-0321-7
NATURE GENETICS
Understanding Society Scientific Group 2019, ' New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries ', Nature Genetics, vol. 51, no. 3, pp. 481-493 . https://doi.org/10.1038/s41588-018-0321-7
Nature Genetics, 51(3), 481-493. Nature Publishing Group
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which ar
Publikováno v:
Chronic Diseases and Translational Medicine, Vol 4, Iss 3, Pp 176-186 (2018)
Air pollution is a world public health problem. Particulate matter (PM), a mix of solid and liquid particles in the air, becomes an increasing concern in the social and economic development of China. For decades, epidemiological studies have confirme
Autor:
Eric Finnemore, C. Magnus Sköld, Maurizio Chioccioli, Xiting Yan, Maor Sauler, Isabel S. Bazan, Jose L. Gomez, Åsa M. Wheelock, Clemente J. Britto, Joann B. Sweasy, Feng Wan, Chuanxing Li, Willy Roque, Veronique Neumeister, Qile Dai, Ranjit S. Bindra, Patty J. Lee, Jessica Nouws, Naftali Kaminski, So-Jin Kim
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 2 (2021)
JCI Insight, Vol 6, Iss 2 (2021)
The pathogenesis of chronic obstructive pulmonary disease (COPD) involves aberrant responses to cellular stress caused by chronic cigarette smoke (CS) exposure. However, not all smokers develop COPD and the critical mechanisms that regulate cellular
Publikováno v:
Molecular aspects of medicine. 85
Inhaled glucocorticoids (GCs) are drugs widely used as treatment for asthma patients. They prevent the recruitment and activation of lung immune and inflammatory cells and, moreover, have profound effects on airway structural cells to reverse the eff