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pro vyhledávání: '"Thomas C. Foster"'
Publikováno v:
Neurobiology of Aging. 70:184-193
A redox-mediated decrease in N-methyl-D-aspartate (NMDA) receptor function contributes to psychiatric diseases and impaired cognition during aging. Inflammation provides a potential source of reactive oxygen species for inducing NMDA receptor hypofun
Publikováno v:
Neurobiology of Aging. 35:1459-1468
Overexpression of superoxide dismutase 1 (SOD1) in the hippocampus results in age-dependent impaired cognition and altered synaptic plasticity suggesting a possible model for examining the role of oxidative stress in senescent neurophysiology. Howeve
Publikováno v:
Neuroscience. 113:89-97
Estradiol influences Ca(2+) regulation and Ca(2+)-dependent synaptic plasticity, suggesting estrogenic effects on Ca(2+)-dependent enzymes that regulate synaptic plasticity may mediate hormonal influences on cognition. In ovariectomized female rats,
Publikováno v:
Brain Research. 736:243-250
An increase in medial perforant synaptic strength can be observed for hippocampal slices from rats exposed to environmental enrichment. The expression of enhanced synaptic strength exhibits properties similar to long-term potentiation (LTP), a physio
Publikováno v:
The Journal of Neuroscience. 16:5382-5392
Homosynaptic long-term depression (LTD) and reversal of long-term potentiation (LTP) were examined extracellularly at CA3–CA1 synapses in stratum radiatum of slices from adult (6–9 months) and aged (20–24 months) Fischer 344 rats. Prolonged low
Publikováno v:
Proceedings of the National Academy of Sciences. 91:4830-4834
The electrical excitability of Schaffer collateral axons and/or terminals was studied in hippocampal slices by monitoring single, CA3 pyramidal neurons activated antidromically from CA1 stratum radiatum. At 22 degrees C, weak, repetitive stimulation
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(5)
The contribution of the NMDA receptors (NMDARs) to synaptic plasticity declines during aging, and the decline is thought to contribute to memory deficits. Here, we demonstrate that an age-related shift in intracellular redox state contributes to the
Autor:
Thomas C. Foster, Bruce L. McNaughton
Publikováno v:
Hippocampus. 1:79-91
Quantal components of Schaffer collateral synaptic transmission recorded intracellularly from CA1 pyramidal cells were examined using 2 methods: simultaneous recordings of CA3-CA1 cell-pairs, and minimal electrical stimulation in stratum radiatum. Qu
Autor:
Thomas C. Foster, Ashok Kumar
Publikováno v:
Brain research. 1031(1)
Release of Ca(2+) from intracellular Ca(2+) stores (ICS) is involved in age-related changes in the induction of long-term potentiation. However, the role of this Ca(2+) source for the increased susceptibility to long-term depression (LTD) with advanc
Publikováno v:
Brain research. 871(1)
This study examined the involvement of N-methyl-D-aspartate receptors (NMDARs) in experience-dependent synaptic plasticity. Rats chronically received an NMDA receptor antagonist (AP5) or saline (SAL) and were exposed to individual cages (IC) or envir