Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sally, John"'
Autor:
Christopher D. Whelan, Jimmy Z. Liu, Magdalena Zimon, Yunfeng Huang, Bernd Klaus, Peter Blattmann, Ellen A. Tsai, Wolfgang Huber, Anthi Trasta, David Sexton, Aliaksandr Halavatyi, Heiko Runz, Chia-Yen Chen, Rainer Pepperkok, Sally John
SUMMARYGenetic interactions (GIs), the joint impact of different genes or variants on a phenotype, are foundational to the genetic architecture of complex traits. However, identifying GIs through human genetics is challenging since it necessitates ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0db1c9cd53c5cc3daacb96af042842d
https://doi.org/10.1101/2020.10.29.360818
https://doi.org/10.1101/2020.10.29.360818
Autor:
Dongdong Lin, Avi Orr-Urtreger, Mali Gana-Weisz, Nir Giladi, Nurit Omer, Orly Goldstein, Yael Mordechai, Yedael Y Waldman, Tamara Shiner, Jing Zhu, Sally John, Avner Thaler, Hila Meltzer-Fridrich, Patrick Cullen, Anat Mirelman, Fergal Casey, Anat Bar-Shira, Or Yaacov
Publikováno v:
Journal of genetics and genomics = Yi chuan xue bao. 48(4)
Autor:
Adam S. Butterworth, Sally John, Wei V. Chen, Peter K. Gregersen, Carol J. Etzel, Jane Worthington, Christopher I. Amos, Damini Jawaheer, Alan J. Silman, Neil Shephard, Michael F. Seldin
Publikováno v:
Arthritis & Rheumatism. 54:1482-1490
Objective HLA is the most strongly associated locus in rheumatoid arthritis (RA), accounting for up to one-third of the genetic contribution. Conditioning on the effect of true disease loci such as HLA can lead to increased power to detect effects at
Publikováno v:
Arthritis & Rheumatism. 43:2771-2775
Objective. To seek potential autoimmune disease susceptibility loci by testing for linkage and linkage disequilibrium between insulin-dependent diabetes mellitus (IDDM) susceptibility loci and rheumatoid arthritis (RA). Methods. Five IDDM susceptibil
Autor:
Jane Worthington, Sheila A. Fisher, Chandrabala Shah, M S Fife, William E R Ollier, Cathryn M. Lewis, Jerry S. Lanchbury, Sally John, Gabriel S. Panayi
Publikováno v:
Arthritis & Rheumatism. 43:1673-1678
Objective Rheumatoid arthritis (RA) is the most common disabling autoimmune disease, affecting ∼1% of the population. The disease etiology is unknown, but it involves inflammation and immune dysregulation and is influenced by genetic variation at b
Publikováno v:
Arthritis and rheumatism. 52(3)
Objective Recent studies of 2 complex diseases, rheumatoid arthritis (RA) and Crohn's disease (CD), showed associations with genes mapping to the cytokine gene cluster on 5q31. In particular, a functional single-nucleotide polymorphism (SNP) mapping
Autor:
Anne Barton, Sally John, W. E. R. Ollier, Clive Hawkins, D Ward, Anne Hinks, Stephen Eyre, J Worthington, Anthony A. Fryer, Richard C. Strange, John Woolmore
Publikováno v:
Brain : a journal of neurology. 127(Pt 8)
Twin, family and adoption studies suggest that susceptibility to multiple sclerosis is substantially mediated by genetic factors. Linkage to human chromosome 17q, homologous to a locus linked to experimental animal models of multiple sclerosis, has b
Autor:
Jenny Barrett, John C. Bell, Sally John, Stephen Eyre, D Lee, Anita Milicic, Anne Myerscough, Sarah White, William E R Ollier, Anne Barton, Jane Worthington, Alan J. Silman, Paul Wordsworth, S. Laval, Matthew A. Brown, K MacKay
Publikováno v:
Arthritis and rheumatism. 46(3)
Objective To undertake a systematic whole-genome screen to identify regions exhibiting genetic linkage to rheumatoid arthritis (RA). Methods Two hundred fifty-two RA-affected sibling pairs from 182 UK families were genotyped using 365 highly informat
Autor:
Philip Roby, Stephen Eyre, Alan J. Silman, Sally John, Ali H. Hajeer, Anne Myerscough, Jane Worthington, William E R Ollier
Publikováno v:
Arthritis and rheumatism. 42(8)
Objective To test for the presence of linkage of the estrogen synthase (CYP19) locus to rheumatoid arthritis (RA) in affected sibling pair (ASP) families. Methods Two data sets of RA ASPs (225 ASPs and 107 ASPs) were genotyped for a polymorphic tetra
Autor:
F. S. Di Giovine, Gordon W. Duff, Sally John, Nicola J. Camp, Mark Dale, Alan J. Silman, Jane Worthington, Chris Cannings, Wer Ollier, Angela Cox
Publikováno v:
Human molecular genetics. 8(9)
Rheumatoid arthritis (RA) is a common disease of unknown aetiology which usually causes progressive destruction of the joints. Familial aggregation, twin studies and segregation analyses suggest that there is a genetic component to RA and the HLA-DRB